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An early role for Cerebellin-1

November 17, 2022

An early role for Cerebellin-1

Peng Han, Yuanchu She, Samie Jaffrey, Sheng-Jian Ji and co-workers show that the well-known synaptic organizer Cbln1 also plays roles during early neural development, regulating axon growth and guidance in multiple neural regions. See the related Primer by Laura McCormick and Stephanie Gupton.

Image credit: pbio.3001853

PLOS Biologue

Community blog for PLOS Biology, PLOS Genetics and PLOS Computational Biology.

PLOS BIOLOGUE

11/18/2022

Research Article

Are hypermutator mutations different?

Hypermutation can accelerate the development of antibiotic resistance in bacteria, but are the mechanisms the same as in wild-type cells? Augusto Dulanto Chiang, Prashant Patil, John Dekker and colleagues show that mismatch repair-deficient Pseudomonas aeruginosa can evolve novel mechanisms of resistance to two last-line, broad spectrum antibiotics.

Image credit: pbio.3001878

Are hypermutator mutations different?

Recently Published Articles

Current Issue

Current Issue October 2022

11/17/2022

Research Article

The pan-genome of Aspergillus fumigatus

A combined population genomics, phylogenomics, and pan-genomics approach by Lotus Lofgren, Jason Stajich and colleagues reveals evidence for high levels of recombination and metabolic diversity in the opportunistic fungal pathogen Aspergillus fumigatus.

Image credit: pbio.3001890

The pan-genome of Aspergillus fumigatus

11/17/2022

Community Page

Using 'candymations' to teach biological principles

Well-designed animations can help biology students focus on principles and processes rather than relying on rote memorization. Pamela Kalas and Rosemary Redfield highlight question-driven, terminology-free, ‘candymation’ videos that show how and why mitosis and meiosis work the way they do.

Image credit: Rosemary Redfield

Using 'candymations' to teach biological principles

11/17/2022

Meta-Research Article

Masking/blinding and in vivo experiments

In animal experiments, masking (blinding) aims to reduce the risk that staff may consciously or subconsciously influence the outcome. This qualitative review by Natasha Karp, Nathalie Percie du Sert and co-authors explores the implementation of blinding at allocation, intervention, conduct, outcome assessment and data analysis, informing good practice and how to address barriers.

Masking/blinding and in vivo experiments

Image credit: Flickr user Internet Archive Book Images

11/17/2022

Methods and Resources

Human striatal organoids

The striatum links neuronal circuits in the human brain, and its malfunction causes neuronal disorders such as Huntington's disease. Xinyu Chen, Hexige Saiyin, Yang Liu, Lixiang Ma and co-workers show that stable human striatal organoids derived from human pluripotent stem cells mimic fetal striatal development and compartments, providing a novel tool to study striatum-related abnormalities.

Human striatal organoids

Image credit: pbio.3001868

11/17/2022

Research Article

Determining microtubule polarity in dendrites

The neuronal microtubule cytoskeleton is key to establish axon-dendrite polarity, but what are the mechanisms that organize these microtubules with the correct orientation? Liu He, Martin Harterink and colleagues show that local microtubule nucleation and stabilization are important for neuronal polarity establishment in the nematode Caenorhabditis elegans.

Determining microtubule polarity in dendrites

Image credit: pbio.3001855

11/16/2022

Perspective

Urgent action on drug-resistant infections

In a world of multiple crises, this article argues that a renewed focus is needed on global infection prevention and control strategies, diagnosis and good antimicrobial stewardship.

Urgent action on drug-resistant infections

Image credit: Flickr user NIAID

11/16/2022

Research Article

Explaining SARS-CoV-2 variant Alpha's success

Epidemiological data show that SARS-CoV-2 Alpha variant is more transmissible, infectious and pathogenic than previous variants. This functional study identifies a single bronchial cell line that reflects Alpha's enhanced in vivo transmissibility.

Explaining SARS-CoV-2 variant Alpha's success

Image credit: pbio.3001871

11/15/2022

Perspective

Citizen-led expeditions

Citizen-led expeditions have a unique role in fostering close connections between the public and the scientific community. This article calls for greater support and encouragement for such projects to help create multi-level synergistic networks for science.

Citizen-led expeditions

Image credit: Victor Rault

11/15/2022

Research Article

Complementation of segmented viral genomes

Isn't genome segmentation costly for viruses? This study shows that upon co-infection, complementary incomplete bunyavirus particles can reconstitute a complete genome, supporting infection and transmission.

Complementation of segmented viral genomes

Image credit: pbio.3001870

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PLOS Biology | ISSN: 1545-7885 (online)