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Tethering organelles

February 20, 2024

Tethering organelles

Proteins require targeting signals to reach their destination. Elena Bittner, Thorsten Stehlik, Jason Lam, Randy Schekman, Johannes Freitag and colleagues reveal that dual affinity proteins which possess targeting signals for different organelles can act as dynamic tether proteins that bridge organelles together to create contact sites.

Image credit: pbio.3002508

PLOS Biologue

Community blog for PLOS Biology, PLOS Genetics and PLOS Computational Biology.

PLOS BIOLOGUE

02/22/2024

Research Article

Anterior cingulate cortex, chronic pain and depression

Neurons in the subthalamic nucleus (STN) are hyperactive in chronic pain and depression but how is their activity regulated? Ying-Di Wang, Shu-Ting Bao, Jun-Li Cao, Cheng Xiao, Chunyi Zhou.and co-authors show that neurons projecting into the STN from the anterior cingulate cortex, which integrates pain signals with negative emotions, regulate the activity of STN neurons.

Image credit: pbio.3002518

Anterior cingulate cortex, chronic pain and depression

Recently Published Articles

Current Issue

Current Issue January 2024

02/16/2024

Research Article

Sequential neuronal processing of decisions

Decision-making needs evaluation of options, deliberation and action-planning. Pooja Viswanathan, Anna Stein and Andreas Nieder show that neurons in the primate prefrontal cortex sequentially delineate these processes to separable components of number values, abstract decision and motor planning.

Image credit: pbio.3002520

Sequential neuronal processing of decisions

02/16/2024

Methods and Resources

Alternative splicing during early embryonic development

Alternative splicing is an essential regulatory mechanism for development and pathogenesis. Chaoyang Wang, Zhuoxing Shi, Xiaoying Fan and co-workers use single cell sequencing of mouse embryos from oocyte to blastocyst stage to reveal large-scale isoform switching and transposable element regulation during the maternal-to-zygotic gene transition.

Image credit: pbio.3002505

Alternative splicing during early embryonic development

02/16/2024

Research Article

Exploration vs exploitation during learning

Humans and animals learn by progressing from a first exploration phase to an exploitation phase. Simon Nougaret, Lorenzo Ferrucci, Aldo Genovesio and co-authors show that neurons in the frontopolar cortex display a specific pattern of activity by representing the learning stage and the goal of the action.

Exploration vs exploitation during learning

Image credit: pbio.3002500

02/15/2024

Research Article

Coping with echoes

Slow temporal modulations in speech are important for its perception, but are absent in the presence of echo, such as during online meetings. Jiaxin Gao, Nai Ding and colleagues study the robustness of human speech perception in echoic environments, showing that speech and its echo are processed separately in the brain to facilitate intelligibility.

Coping with echoes

Image credit: pbio.3002498

02/13/2024

Research Article

How one bacterial species finds another

Bacteria live in social communities, where the ability to sense and respond to interspecies and environmental signals is critical for survival. Kaitlin Yarrington, Tyler Shendruk and Dominique Limoli show that when traveling on surfaces by type IV pilus-mediated motility, the bacterium Pseudomonas aeruginosa uses a designated chemoreceptor, PilJ, to detect and respond to interspecies signals.

How one bacterial species finds another

Image credit: Kaitlin Yarrington

02/22/2024

Unsolved Mystery

The neurobiology of stuttering

How do genetics, interacting neural hierarchies, social context and reward circuitry contribute to the many facets of stuttering? Nicole Neef and Soo-Eun Chang explore these critical questions, which could inspire future avenues of research.

The neurobiology of stuttering

Image credit: pbio.3002492

02/15/2024

Perspective

Using online data to monitor biodiversity

Online digital data from traditional and social media platforms can complement biodiversity monitoring efforts. Andrea Soriano-Redondo and co-authors propose a strategy for integrating these data into current biodiversity datasets.

Using online data to monitor biodiversity

Image credit: pbio.3002497

02/08/2024

Perspective

Will AI lead to the end of mechanistic studies?

AI now enables direct leaps to application without understanding the underlying mechanistic molecular biological principles. Victor de Lorenzo asks whether this will herald a decline in mechanistic studies.

Will AI lead to the end of mechanistic studies?

Image credit: Pixabay user Philippe Delavie

02/07/2024

Unsolved Mystery

How important is EMT for cancer metastasis?

Epithelial-to-mesenchymal transition (EMT) promotes metastasis. Toni CeliĆ -Terrassa and Yibin Kang explore the different types of EMT, cooperative behaviors of tumor cells, and their potential for new therapeutic avenues.

How important is EMT for cancer metastasis?

Image credit: pbio.3002487

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PLOS Biology | ISSN: 1545-7885 (online)