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.ploswater .nav-user>li>a:hover,.ploswater .plosone .nav .nav-user li.highlighted>a:hover,.plosone .nav .nav-user .ploswater li.highlighted>a:hover,.ploswater #billboard a,#billboard .ploswater a,.ploswater #submission-links a:hover,#submission-links .ploswater a:hover,.ploswater #social-links ul>li>a:hover,#social-links .ploswater ul>li>a:hover,.ploswater .static-home-marketing a,.static-home-marketing .ploswater a{background-color:#0d3be1;color:#fff}.ploswater .button:hover,.ploswater .button-default:hover,.ploswater .nav .nav-user>li>a:hover,.nav .ploswater .nav-user>li>a:hover,.ploswater .plosone .nav .nav-user li.highlighted>a:hover,.plosone .nav .nav-user .ploswater li.highlighted>a:hover,.ploswater #billboard a:hover,#billboard .ploswater a:hover,.ploswater #submission-links a:hover,#submission-links .ploswater a:hover,.ploswater #social-links ul>li>a:hover,#social-links .ploswater ul>li>a:hover,.ploswater .static-home-marketing a:hover,.static-home-marketing .ploswater a:hover{background-color:#0a2eb1;color:#fff}.ploswater .amendment{background-color:#c4cefd}.ploswater #preprintsLink,.ploswater #protocolsLink{background-color:#0d3be1;color:#fff}.ploswater .static-home-box h2,.ploswater .home-bold-box h2,.ploswater .static-home-box h2:hover,.ploswater .home-bold-box h2:hover,.ploswater .static-home-marketing h2,.ploswater .static-home-marketing h2:hover{color:#0d3be1}.ploswater .home-bold-box{background-color:#0d3be1;color:#fff}.ploswater .home-bold-box h2,.ploswater .home-bold-box h2:hover{color:#fff}.ploswater .home-bold-box h2 a,.ploswater .home-bold-box h2 a:hover,.ploswater .home-bold-box h2:hover a,.ploswater .home-bold-box h2:hover a:hover{color:#fff}.ploswater .home-bold-box a,.ploswater .home-bold-box a:hover{color:#fff}.ploswater .home main .home-bold-box h2 a:hover{color:#fff}.ploswater .hero.overlay-dark>a:before{background:none}.ploswater .hero.overlay-dark .hero-content{background:linear-gradient(to bottom, rgba(22,64,248,0.45) 0, rgba(22,64,248,0.75) 33%, rgba(22,64,248,0.95) 85%, rgba(22,64,248,0.95) 100%)}.ploswater .logo{background:url("/resource/img/water/logo.png") no-repeat 0 0;background-size:contain}@media print{.ploswater .title-block:before{background-image:url("/resource/img/water/logo.png")}}@use "../variables" as *;@use "branding" as *;:global(.ploscollections) .more-icon,:global(.ploscollections) .more-link:after{color:#3c63af}:global(.ploscollections) .block .category,.block :global(.ploscollections) .category,:global(.ploscollections) #article-list .category,#article-list :global(.ploscollections) .category,:global(.ploscollections) #issue .category,#issue :global(.ploscollections) .category,:global(.ploscollections) #article-list h3,#article-list :global(.ploscollections) h3,:global(.ploscollections) .taxonomy-header #subjInfoText a:hover,.taxonomy-header #subjInfoText :global(.ploscollections) a:hover,:global(.ploscollections) .taxonomy-header #subjInfoText a:hover a,.taxonomy-header #subjInfoText a:hover :global(.ploscollections) a,:global(.ploscollections) .more-icon,:global(.ploscollections) .more-link:after,:global(.ploscollections) .top-bar-section .calloutcontainer .callout-content a:hover,.top-bar-section .calloutcontainer .callout-content :global(.ploscollections) a:hover,:global(.ploscollections) .top-bar-section .calloutcontainer .callout-content a:hover a,.top-bar-section .calloutcontainer .callout-content a:hover :global(.ploscollections) a,:global(.ploscollections) .top-bar-section .calloutcontainer .button-contain a.button-link,.top-bar-section .calloutcontainer .button-contain :global(.ploscollections) a.button-link,:global(.ploscollections) .block .blurb a,.block .blurb :global(.ploscollections) a,:global(.ploscollections) #article-list .blurb a,#article-list .blurb :global(.ploscollections) a,:global(.ploscollections) #issue .blurb a,#issue .blurb :global(.ploscollections) a,:global(.ploscollections) .block .blurb a a:hover,.block .blurb a :global(.ploscollections) a:hover,:global(.ploscollections) .block .blurb a:hover a,.block .blurb a:hover :global(.ploscollections) a,:global(.ploscollections) .block .title a:hover,.block .title :global(.ploscollections) a:hover,:global(.ploscollections) #article-list .title a:hover,#article-list .title :global(.ploscollections) a:hover,:global(.ploscollections) #issue .title a:hover,#issue .title :global(.ploscollections) a:hover,:global(.ploscollections) .row.three .row-small-blocks .small .title a:hover,.row.three .row-small-blocks .small .title :global(.ploscollections) a:hover,:global(.ploscollections) #article-list ul.list-plain li a:hover,#article-list ul.list-plain li :global(.ploscollections) a:hover,:global(.ploscollections) .more-link>a,:global(.ploscollections) #issue .boxtitle a:hover,#issue .boxtitle :global(.ploscollections) a:hover,:global(.ploscollections) #submission-links h3,#submission-links :global(.ploscollections) h3,:global(.ploscollections) .carousel-wrap.small .carousel-control .jcarousel-prev:hover,.carousel-wrap.small .carousel-control :global(.ploscollections) .jcarousel-prev:hover,:global(.ploscollections) .carousel-wrap.small .carousel-control .jcarousel-next:hover,.carousel-wrap.small .carousel-control :global(.ploscollections) .jcarousel-next:hover,:global(.ploscollections) .home-email-subscription a,.home-email-subscription :global(.ploscollections) a,:global(.ploscollections) .home-email-subscription form .consent .email_consent a,.home-email-subscription form .consent .email_consent :global(.ploscollections) a{color:#3c63af}:global(.ploscollections) .head-top,:global(.ploscollections) #submission-links{border-color:#3c63af}:global(.ploscollections) .carousel-wrap.small .block-header,.carousel-wrap.small :global(.ploscollections) .block-header,:global(.ploscollections) .pill:hover,:global(.ploscollections) .button-big:hover,:global(.ploscollections) .button-big.highlighted,:global(.ploscollections) .button-default:hover,:global(.ploscollections) .action-label,:global(.ploscollections) .twitter-typeahead .tt-suggestion.tt-cursor,.twitter-typeahead :global(.ploscollections) .tt-suggestion.tt-cursor,:global(.ploscollections) .twitter-typeahead .tt-suggestion:hover,.twitter-typeahead :global(.ploscollections) .tt-suggestion:hover,:global(.ploscollections) .closer-brand,:global(.ploscollections) .nav .nav-user>li>a:hover,.nav :global(.ploscollections) .nav-user>li>a:hover,:global(.ploscollections) .nav .nav-user li.highlighted>a,.nav .nav-user :global(.ploscollections) li.highlighted>a,:global(.ploscollections) .plosone #billboard a:hover,.plosone #billboard :global(.ploscollections) a:hover,:global(.ploscollections) #submission-links a,#submission-links :global(.ploscollections) a,:global(.ploscollections) body.plosone #submission-links a:hover,body.plosone #submission-links :global(.ploscollections) a:hover,:global(.ploscollections) #social-links,:global(.ploscollections) #social-links ul>li>a,#social-links :global(.ploscollections) ul>li>a,:global(.ploscollections) .home-email-subscription .button-default,.home-email-subscription :global(.ploscollections) .button-default,:global(.ploscollections) .plosone .home-email-subscription .button-default:hover,.plosone .home-email-subscription :global(.ploscollections) .button-default:hover,:global(.ploscollections) .plosone .home-email-subscription form label.error,.plosone .home-email-subscription form :global(.ploscollections) label.error{background-color:#3c63af;color:#fff}:global(.ploscollections) .button,:global(.ploscollections) .button-default,:global(.ploscollections) .nav .nav-user>li>a:hover,.nav :global(.ploscollections) .nav-user>li>a:hover,:global(.ploscollections) .plosone .nav .nav-user li.highlighted>a:hover,.plosone .nav .nav-user :global(.ploscollections) li.highlighted>a:hover,:global(.ploscollections) #billboard a,#billboard :global(.ploscollections) a,:global(.ploscollections) #submission-links a:hover,#submission-links :global(.ploscollections) a:hover,:global(.ploscollections) #social-links ul>li>a:hover,#social-links :global(.ploscollections) ul>li>a:hover,:global(.ploscollections) .static-home-marketing a,.static-home-marketing :global(.ploscollections) a{background-color:#3c63af;color:#fff}:global(.ploscollections) .button:hover,:global(.ploscollections) .button-default:hover,:global(.ploscollections) .nav .nav-user>li>a:hover,.nav :global(.ploscollections) .nav-user>li>a:hover,:global(.ploscollections) .plosone .nav .nav-user li.highlighted>a:hover,.plosone .nav .nav-user :global(.ploscollections) li.highlighted>a:hover,:global(.ploscollections) #billboard a:hover,#billboard :global(.ploscollections) a:hover,:global(.ploscollections) #submission-links a:hover,#submission-links :global(.ploscollections) a:hover,:global(.ploscollections) #social-links ul>li>a:hover,#social-links :global(.ploscollections) ul>li>a:hover,:global(.ploscollections) .static-home-marketing a:hover,.static-home-marketing :global(.ploscollections) a:hover{background-color:#2f4e89;color:#fff}:global(.ploscollections) .amendment{background-color:#d0d0d0}:global(.ploscollections) #preprintsLink,:global(.ploscollections) #protocolsLink{background-color:#3c63af;color:#fff}:global(.ploscollections) .static-home-box h2,:global(.ploscollections) .home-bold-box h2,:global(.ploscollections) .static-home-box h2:hover,:global(.ploscollections) .home-bold-box h2:hover,:global(.ploscollections) .static-home-marketing h2,:global(.ploscollections) .static-home-marketing h2:hover{color:#3c63af}:global(.ploscollections) .home-bold-box{background-color:#3c63af;color:#fff}:global(.ploscollections) .home-bold-box h2,:global(.ploscollections) .home-bold-box h2:hover{color:#fff}:global(.ploscollections) .home-bold-box h2 a,:global(.ploscollections) .home-bold-box h2 a:hover,:global(.ploscollections) .home-bold-box h2:hover a,:global(.ploscollections) .home-bold-box h2:hover a:hover{color:#fff}:global(.ploscollections) .home-bold-box a,:global(.ploscollections) .home-bold-box a:hover{color:#fff}:global(.ploscollections) .home main .home-bold-box h2 a:hover{color:#fff}.ploscollections .more-icon,.ploscollections .more-link:after{color:#3c63af}.ploscollections .block .category,.block .ploscollections .category,.ploscollections #article-list .category,#article-list .ploscollections .category,.ploscollections #issue .category,#issue .ploscollections .category,.ploscollections #article-list h3,#article-list .ploscollections h3,.ploscollections .taxonomy-header #subjInfoText a:hover,.taxonomy-header #subjInfoText .ploscollections a:hover,.ploscollections .taxonomy-header #subjInfoText a:hover a,.taxonomy-header #subjInfoText a:hover .ploscollections a,.ploscollections .more-icon,.ploscollections .more-link:after,.ploscollections .top-bar-section .calloutcontainer .callout-content a:hover,.top-bar-section .calloutcontainer .callout-content .ploscollections a:hover,.ploscollections .top-bar-section .calloutcontainer .callout-content a:hover a,.top-bar-section .calloutcontainer .callout-content a:hover .ploscollections a,.ploscollections .top-bar-section .calloutcontainer .button-contain a.button-link,.top-bar-section .calloutcontainer .button-contain .ploscollections a.button-link,.ploscollections .block .blurb a,.block .blurb .ploscollections a,.ploscollections #article-list .blurb a,#article-list .blurb .ploscollections a,.ploscollections #issue .blurb a,#issue .blurb .ploscollections a,.ploscollections .block .blurb a a:hover,.block .blurb a .ploscollections a:hover,.ploscollections .block .blurb a:hover a,.block .blurb a:hover .ploscollections a,.ploscollections .block .title a:hover,.block .title .ploscollections a:hover,.ploscollections #article-list .title a:hover,#article-list .title .ploscollections a:hover,.ploscollections #issue .title a:hover,#issue .title .ploscollections a:hover,.ploscollections .row.three 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.head-top,.ploscollections #submission-links{border-color:#3c63af}.ploscollections .carousel-wrap.small .block-header,.carousel-wrap.small .ploscollections .block-header,.ploscollections .pill:hover,.ploscollections .button-big:hover,.ploscollections .button-big.highlighted,.ploscollections .button-default:hover,.ploscollections .action-label,.ploscollections .twitter-typeahead .tt-suggestion.tt-cursor,.twitter-typeahead .ploscollections .tt-suggestion.tt-cursor,.ploscollections .twitter-typeahead .tt-suggestion:hover,.twitter-typeahead .ploscollections .tt-suggestion:hover,.ploscollections .closer-brand,.ploscollections .nav .nav-user>li>a:hover,.nav .ploscollections .nav-user>li>a:hover,.ploscollections .nav .nav-user li.highlighted>a,.nav .nav-user .ploscollections li.highlighted>a,.ploscollections .plosone #billboard a:hover,.plosone #billboard .ploscollections a:hover,.ploscollections #submission-links a,#submission-links .ploscollections a,.ploscollections body.plosone #submission-links a:hover,body.plosone #submission-links .ploscollections a:hover,.ploscollections #social-links,.ploscollections #social-links ul>li>a,#social-links .ploscollections ul>li>a,.ploscollections .home-email-subscription .button-default,.home-email-subscription .ploscollections .button-default,.ploscollections .plosone .home-email-subscription .button-default:hover,.plosone .home-email-subscription .ploscollections .button-default:hover,.ploscollections .plosone .home-email-subscription form label.error,.plosone .home-email-subscription form .ploscollections label.error{background-color:#3c63af;color:#fff}.ploscollections .button,.ploscollections .button-default,.ploscollections .nav .nav-user>li>a:hover,.nav .ploscollections .nav-user>li>a:hover,.ploscollections .plosone .nav .nav-user li.highlighted>a:hover,.plosone .nav .nav-user .ploscollections li.highlighted>a:hover,.ploscollections #billboard a,#billboard .ploscollections a,.ploscollections #submission-links a:hover,#submission-links .ploscollections a:hover,.ploscollections #social-links ul>li>a:hover,#social-links .ploscollections ul>li>a:hover,.ploscollections .static-home-marketing a,.static-home-marketing .ploscollections a{background-color:#3c63af;color:#fff}.ploscollections .button:hover,.ploscollections .button-default:hover,.ploscollections .nav .nav-user>li>a:hover,.nav .ploscollections .nav-user>li>a:hover,.ploscollections .plosone .nav .nav-user li.highlighted>a:hover,.plosone .nav .nav-user .ploscollections li.highlighted>a:hover,.ploscollections #billboard a:hover,#billboard .ploscollections a:hover,.ploscollections #submission-links a:hover,#submission-links .ploscollections a:hover,.ploscollections #social-links ul>li>a:hover,#social-links .ploscollections ul>li>a:hover,.ploscollections .static-home-marketing a:hover,.static-home-marketing .ploscollections a:hover{background-color:#2f4e89;color:#fff}.ploscollections .amendment{background-color:#d0d0d0}.ploscollections #preprintsLink,.ploscollections #protocolsLink{background-color:#3c63af;color:#fff}.ploscollections .static-home-box h2,.ploscollections .home-bold-box h2,.ploscollections .static-home-box h2:hover,.ploscollections .home-bold-box h2:hover,.ploscollections .static-home-marketing h2,.ploscollections .static-home-marketing h2:hover{color:#3c63af}.ploscollections .home-bold-box{background-color:#3c63af;color:#fff}.ploscollections .home-bold-box h2,.ploscollections .home-bold-box h2:hover{color:#fff}.ploscollections .home-bold-box h2 a,.ploscollections .home-bold-box h2 a:hover,.ploscollections .home-bold-box h2:hover a,.ploscollections .home-bold-box h2:hover a:hover{color:#fff}.ploscollections .home-bold-box a,.ploscollections .home-bold-box a:hover{color:#fff}.ploscollections .home main .home-bold-box h2 a:hover{color:#fff}.ploscollections .logo{background:url("/resource/img/collections/logo.png") no-repeat 0 0;background-size:contain}@media print{.ploscollections .title-block:before{background-image:url("/resource/img/collections/logo.png")}}@use "../variables" as *;@use "branding" as *;:global(.plosclinicaltrials) .more-icon,:global(.plosclinicaltrials) .more-link:after{color:#3c63af}:global(.plosclinicaltrials) .block .category,.block :global(.plosclinicaltrials) .category,:global(.plosclinicaltrials) #article-list .category,#article-list :global(.plosclinicaltrials) .category,:global(.plosclinicaltrials) #issue .category,#issue :global(.plosclinicaltrials) .category,:global(.plosclinicaltrials) #article-list h3,#article-list :global(.plosclinicaltrials) h3,:global(.plosclinicaltrials) .taxonomy-header #subjInfoText a:hover,.taxonomy-header #subjInfoText :global(.plosclinicaltrials) a:hover,:global(.plosclinicaltrials) .taxonomy-header #subjInfoText a:hover a,.taxonomy-header #subjInfoText a:hover :global(.plosclinicaltrials) a,:global(.plosclinicaltrials) .more-icon,:global(.plosclinicaltrials) .more-link:after,:global(.plosclinicaltrials) .top-bar-section .calloutcontainer .callout-content a:hover,.top-bar-section .calloutcontainer .callout-content :global(.plosclinicaltrials) a:hover,:global(.plosclinicaltrials) .top-bar-section .calloutcontainer .callout-content a:hover a,.top-bar-section .calloutcontainer .callout-content a:hover :global(.plosclinicaltrials) a,:global(.plosclinicaltrials) .top-bar-section .calloutcontainer .button-contain a.button-link,.top-bar-section .calloutcontainer .button-contain :global(.plosclinicaltrials) a.button-link,:global(.plosclinicaltrials) .block .blurb a,.block .blurb :global(.plosclinicaltrials) a,:global(.plosclinicaltrials) #article-list .blurb a,#article-list .blurb :global(.plosclinicaltrials) a,:global(.plosclinicaltrials) #issue .blurb a,#issue .blurb :global(.plosclinicaltrials) a,:global(.plosclinicaltrials) .block .blurb a a:hover,.block .blurb a :global(.plosclinicaltrials) a:hover,:global(.plosclinicaltrials) .block .blurb a:hover a,.block .blurb a:hover :global(.plosclinicaltrials) a,:global(.plosclinicaltrials) .block .title a:hover,.block .title :global(.plosclinicaltrials) a:hover,:global(.plosclinicaltrials) #article-list .title a:hover,#article-list .title :global(.plosclinicaltrials) a:hover,:global(.plosclinicaltrials) #issue .title a:hover,#issue .title :global(.plosclinicaltrials) a:hover,:global(.plosclinicaltrials) .row.three .row-small-blocks .small .title a:hover,.row.three .row-small-blocks .small .title :global(.plosclinicaltrials) a:hover,:global(.plosclinicaltrials) #article-list ul.list-plain li a:hover,#article-list ul.list-plain li :global(.plosclinicaltrials) a:hover,:global(.plosclinicaltrials) .more-link>a,:global(.plosclinicaltrials) #issue .boxtitle a:hover,#issue .boxtitle :global(.plosclinicaltrials) a:hover,:global(.plosclinicaltrials) #submission-links h3,#submission-links :global(.plosclinicaltrials) h3,:global(.plosclinicaltrials) .carousel-wrap.small .carousel-control 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