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Crohn’s disease associated E. coli use macrophage attacks to switch from replicative to non-replicative state and therefore tolerate antibiotics
Adherent Invasive E. coli (AIEC), associated with the dysbiosis observed during Crohn’s disease, survive and replicate inside macrophages. In this aggressive environment they immediately halt their cell cycle thanks to the installation of stringent response. Several hours later, when stringent response dissipates, cell cycle restarts but it frequently leads to new non-replicating bacteria. In this non-replicating state AIEC tolerate antibiotic’s treatment. The image shows non-replicating (green) and replicating (red) AIEC 24 hours post infection of human macrophages (magenta). Demarre, et al.
Image Credit: Demarre G, et al. (2019)