The dimorphic fungus Talaromyces marneffei: An opportunistic killer in Southeast Asia

Lottie Brown, Alex Andrianopoulos, Patrick C. Y. Woo, Thuy Le

PLOS Pathogens: published September 10, 2025 | https://doi.org/10.1371/journal.ppat.1013444

The fungal STRIPAK complex: Cellular conductor orchestrating growth and pathogenicity

Patricia P. Peterson, Joseph Heitman

PLOS Pathogens: published September 15, 2025 | https://doi.org/10.1371/journal.ppat.1013500

The devil in more detail: Eco-evolutionary genomics of Tasmanian devil persistence despite range-wide spread of a fatal, transmissible cancer

Andrew Storfer, Marc A. Beer, Dylan Gallinson, Menna E. Jones, Rodrigo Hamede, Hamish McCallum, Mark J. Margres

PLOS Pathogens: published September 24, 2025 | https://doi.org/10.1371/journal.ppat.1013523

Dendritic cells and HIV transmission: roles and subsets of antigen-presenting cells in the human anogenital tract

Daniel J. Buffa, Thomas R. O’Neil, Erica E. Vine, Lara Sarkawt, Freja A. Warner van Dijk, Oscar A. Dong, Najla Nasr, Anthony L. Cunningham, Kirstie M. Bertram, Andrew N. Harman

PLOS Pathogens: published September 10, 2025 | https://doi.org/10.1371/journal.ppat.1013490

Cross-kingdom dialogs in the gut: Integrating bacterial pathogens, helminths, and microbiota interactions for immune homeostasis

Suhui Hu, Zhenzhen Liu, Wenchao Yan, Rongxian Guo

PLOS Pathogens: published September 11, 2025 | https://doi.org/10.1371/journal.ppat.1013494

Antifungal persistence: Clinical relevance and mechanisms

Rui Wang, Jingnan Lv, Liang Chen, Yanan Zhao, Hong Du

PLOS Pathogens: published September 11, 2025 | https://doi.org/10.1371/journal.ppat.1013456

How Klebsiella pneumoniae controls its virulence

To Nguyen Thi Nguyen, Gareth Howells, Francesca L. Short

PLOS Pathogens: published September 15, 2025 | https://doi.org/10.1371/journal.ppat.1013499

Identification of a Kingella kingae factor H binding protein that is the major determinant of serum resistance

Kevin A. Hernandez, Eric A. Porsch, Vanessa L. Muñoz, Joseph W. St. Geme III

PLOS Pathogens: published September 2, 2025 | https://doi.org/10.1371/journal.ppat.1013473

Spatiotemporal coordination of reovirus peripheral core replication to perinuclear whole virus assembly

Justine Kniert, Dante Terino, Heather E. Eaton, Qi Feng Lin, Shiau-Yin Wu, Hilmar Strickfaden, Maya Shmulevitz

PLOS Pathogens: published September 2, 2025 | https://doi.org/10.1371/journal.ppat.1013238

A divergent cyclic nucleotide binding protein promotes Plasmodium ookinete infection of the mosquito

Dominika Kwecka, Zhishuo Wang, Edvardas Eigminas, Lijia Liu, Jennifer C. Regan, Choel Kim, Nisha Philip

PLOS Pathogens: published September 2, 2025 | https://doi.org/10.1371/journal.ppat.1013467

Human papillomavirus genomes associate with active host chromatin during persistent viral infection

Alix Warburton, Tovah E. Markowitz, JJ L. Miranda, Kinjal Majumder, Alison A. McBride

PLOS Pathogens: published September 2, 2025 | https://doi.org/10.1371/journal.ppat.1013454

Versatile roles of rubredoxin reductase of Pseudomonas aeruginosa TBCF10839 in virulence and stress protection

Lutz Wiehlmann, Thorsten Adams, Claus Urbanke, Sonja Horatzek, Doris Jordan, Ilona Rosenboom, Leo Eberl, Burkhard Tümmler

PLOS Pathogens: published September 3, 2025 | https://doi.org/10.1371/journal.ppat.1013465

Glycosylphosphatidylinositol biosynthesis functions as a conserved host defense pathway against coronaviruses via regulation of LY6E

Yanlong Ma, Fei Feng, Hui Feng, Xue Ma, Ziqiao Wang, Yutong Han, Yunkai Zhu, Yuyan Wang, Zhichao Gao, Yuyuan Zhang, Qiang Ding, Jincun Zhao, Rong Zhang

PLOS Pathogens: published September 3, 2025 | https://doi.org/10.1371/journal.ppat.1013441

A close unicellular animal relative and predator of schistosomes exhibits chemokinesis in response to proteins and peptides from its prey

Soniya R. Quick, Jason S. Bains, Catherine Gerdt, Bryan Walker, Eleanor B. Goldstone, Theresa Jakuszeit, Andrew W. Baggaley, Ottavio A. Croze, Joseph P. Gerdt

PLOS Pathogens: published September 3, 2025 | https://doi.org/10.1371/journal.ppat.1013440

The PP2A-2 holoenzyme orchestrates daughter cell emergence during cytokinesis in Toxoplasma gondii

Jin-Lei Wang, Meng Wang, Nian-Zhang Zhang, Ting-Ting Li, Jin Gao, Xiao-Jing Wu, Bao-Quan Fu, Hany M. Elsheikha, Xing-Quan Zhu

PLOS Pathogens: published September 3, 2025 | https://doi.org/10.1371/journal.ppat.1013475

HIV-1 accessory protein Vpr possesses a cryptic p300-dependent transcription-promoting activity that is blocked by histone deacetylases in CD4⁺ T cells

Catherine A. Lewis, David M. Margolis, Edward P. Browne

PLOS Pathogens: published September 3, 2025 | https://doi.org/10.1371/journal.ppat.1013073

Mycobacterium tuberculosis impairs protective cytokine production via transcription factor MafB manipulation

Hiroyuki Saiga, Masaki Ueno, Toshiki Tamura, Yusuke Tsujimura, Masamitsu N. Asaka, Yumiko Tsukamoto, Tetsu Mukai, Michito Hamada, Satoru Takahashi, Takashi Tanaka, Tsuneyasu Kaisho, Yoshimasa Takahashi, Katsuaki Hoshino, Manabu Ato

PLOS Pathogens: published September 4, 2025 | https://doi.org/10.1371/journal.ppat.1013476

Structure-function studies of Vibrio cholerae quorum-sensing receptor CqsR signal recognition

Andrew M. Guarnaccia, Anjali D. Steenhaut, Sandra D. Olenic, Jesse Na, Lark J. Perez, Wai-Leung Ng, Matthew B. Neiditch

PLOS Pathogens: published September 4, 2025 | https://doi.org/10.1371/journal.ppat.1013447

Intracellular formate modulates a motility-invasion switch in Salmonella Typhimurium

Debapriya Mukherjee, Salik Noor, Tamoghna Mukherjee, Mahavir Singh, Dipshikha Chakravortty

PLOS Pathogens: published September 4, 2025 | https://doi.org/10.1371/journal.ppat.1013453

Divergent resistance pathways amongst SARS-CoV-2 PLpro inhibitors highlight the need for scaffold diversity

Xinyu Wu, Shane M. Devine, Margareta Go, Julie V. Nguyen, Bernadine G. C. Lu, Katie Loi, Nathan W. Kuchel, Kym N. Lowes, Jeffrey P. Mitchell, Guillaume Lessene, David Komander, Matthew E. Call, Melissa J. Call

PLOS Pathogens: published September 5, 2025 | https://doi.org/10.1371/journal.ppat.1013468

Genome-wide phenotypic insights into mycobacterial virulence using Drosophila melanogaster

Niruja Sivakumar, Esther Fuentes, Linn-Karina Selvik, Marta Arch, Christina Gabrielsen Ås, Pere-Joan Cardona, Thomas R. Ioerger, Marte Singsås Dragset

PLOS Pathogens: published September 5, 2025 | https://doi.org/10.1371/journal.ppat.1013474

Sialic acid serves as a functional receptor for grass carp reovirus

Qian Wang, Zichao Peng, Bin Gui, Yongming Li, Lanjie Liao, Zuoyan Zhu, Yaping Wang, Libo He

PLOS Pathogens: published September 5, 2025 | https://doi.org/10.1371/journal.ppat.1013481

Immune signatures of SARS-CoV-2 infection resolution in human lung tissues

Devin Kenney, Aoife K. O’Connell, Anna E. Tseng, Jacquelyn Turcinovic, Maegan L. Sheehan, Adam D. Nitido, Paige Montanaro, Hans P. Gertje, Maria Ericsson, John H. Connor, Vladimir Vrbanac, Nicholas A. Crossland, Christelle Harly, Alejandro B. Balazs, Florian Douam

PLOS Pathogens: published September 8, 2025 | https://doi.org/10.1371/journal.ppat.1013469

A dual interaction between RSV NS1 and MED25 ACID domain reshapes antiviral responses

Celia Ait-Mouhoub, Jiawei Dong, Magali Noiray, Jenna Fix, Stepanka Nedvedova, Slim Fourati, Alexis Verger, Jean-Francois Eleouet, Delphyne Descamps, Monika Bajorek, Christina Sizun

PLOS Pathogens: published September 8, 2025 | https://doi.org/10.1371/journal.ppat.1012930

Sec10 suppresses antiviral innate immune response by facilitating STUB1-mediated STAT1 degradation

Fachao Sun, Wenqing Ma, Yanan Xu, Luteng He, Xiao Yu, Xingyu Li, Yingying Li, Daniel Chang He, Hongmei Wang, Hongbin He

PLOS Pathogens: published September 8, 2025 | https://doi.org/10.1371/journal.ppat.1013472

N460S in PB2 and I163T in nucleoprotein synergistically enhance the viral replication and pathogenicity of influenza B virus

Yang Wang, Yu Gao, Tianxin Ma, Yuting Ye, Chenyang Cao, Binqian Zou, Sulan Ye, Qingsheng Huang, Chunguang Yang, Shengfeng Li, Lixi Liang, Hongxuan Zhou, Zhiqi Zeng, Zifeng Yang, Weiqi Pan

PLOS Pathogens: published September 8, 2025 | https://doi.org/10.1371/journal.ppat.1013463

TRIM28 is a target for paramyxovirus V proteins

Gauthier Lieber, Florence Kwaschik, Marie Lork, Nora Schmidt, Benjamin G. Hale

PLOS Pathogens: published September 8, 2025 | https://doi.org/10.1371/journal.ppat.1013487

Fexinidazole and Corallopyronin A target Wolbachia-infected sheath cells present in filarial nematodes

Laura Chappell, Ricardo Peguero, William R. Conner, Sommer Fowler, Brandon S. Cooper, Kenneth Pfarr, Achim Hoerauf, Sara Lustigman, Judy Sakanari, William Sullivan

PLOS Pathogens: published September 8, 2025 | https://doi.org/10.1371/journal.ppat.1012929

Receptor transporter protein 4 (RTP4)-mediated repression of hepatitis C virus replication in mouse cells

Michael P. Schwoerer, Sebastian Carver, Aaron E. Lin, Jianche Liu, Thomas R. Cafiero, Keith A. Berggren, Serene Dhawan, Saori Suzuki, Brigitte Heller, Celeste Rodriguez, Aoife K. O’Connell, Hans P. Gertje, Nicholas A. Crossland, Alexander Ploss

PLOS Pathogens: published September 8, 2025 | https://doi.org/10.1371/journal.ppat.1013412

Activation of PD-1/PD-L1 immune checkpoint by Zika virus

Chenxi Wang, Yubin Xie, Weixin Li, Chon Phin Ong, Hao Ding, Shuofeng Yuan, Gong Cheng, Dong-Yan Jin, Zi-Wei Ye

PLOS Pathogens: published September 8, 2025 | https://doi.org/10.1371/journal.ppat.1013457

Discovery and mechanistic insights of dibenzoylmethane as a broad spectrum inhibitor of coronavirus

Yuan Sun, Xiaoyang Shu, Lu Chen, Weijuan Shang, Yumin Zhang, Gengfu Xiao, Leike Zhang

PLOS Pathogens: published September 8, 2025 | https://doi.org/10.1371/journal.ppat.1013492

Hnf4α integrates AIF and caspase 3/9 signaling to restrict single and coinfecting pathogens in teleosts

Dong Yan, Min Hui Tao, Xiao Man Wu, Jie Zhang, Ming Li, Ming Xian Chang

PLOS Pathogens: published September 8, 2025 | https://doi.org/10.1371/journal.ppat.1013491

Cytotoxic CX3CR1⁺ Vδ₁ T cells clonally expand in an interplay of CMV, microbiota, and HIV-1 persistence in people on antiretroviral therapy

Nived Collercandy, Camille Vellas, Manon Nayrac, Mary Requena, Thomas Richarme, Anne-Laure Iscache, Justine Latour, Karl Barange, Laurent Alric, Guillaume Martin-Blondel, Matteo Serino, Jacques Izopet, Pierre Delobel

PLOS Pathogens: published September 8, 2025 | https://doi.org/10.1371/journal.ppat.1013489

Identification and antiviral mechanism of a novel chicken-derived interferon-related antiviral protein targeting PRDX1

Jing Chen, Peiheng Li, Letian Li, Ju Li, Yuhang Jiang, Wancheng Zou, Pengfei Hao, Zihan Gao, Jiayi Hao, Xiaoshuang Shi, Dongliang Fei, Mingxiao Ma, Guoqing Wang, Chang Li

PLOS Pathogens: published September 8, 2025 | https://doi.org/10.1371/journal.ppat.1013495

The Salmonella phage shock protein system is required for defense against host antimicrobial peptides

Marie-Ange Massicotte, Aline A. Fiebig, Andrei Bogza, Brian K. Coombes

PLOS Pathogens: published September 9, 2025 | https://doi.org/10.1371/journal.ppat.1013132

Assembly of the mitochondrial outer membrane module of the trypanosomal tripartite attachment complex

Philip Stettler, Salome Aeschlimann, Bernd Schimanski, André Schneider

PLOS Pathogens: published September 9, 2025 | https://doi.org/10.1371/journal.ppat.1013506

CK2 derived from brain microvascular endothelial cells induces astrocyte inflammatory response in Escherichia coli-induced meningitis

Dong Huo, Ruicheng Yang, Jiyang Fu, Jiaqi Chen, Chen Tan, Huanchun Chen, Xiangru Wang

PLOS Pathogens: published September 10, 2025 | https://doi.org/10.1371/journal.ppat.1013464

Rapid clearance of inducible HIV-1 proviruses after initiation of antiretroviral therapy

Maria C. Puertas, Lucía Bailón, Víctor Urrea, Maria C. García-Guerrero, Yovaninna Alarcón-Soto, Angel Rivero, Beatriz Mothe, José Moltó, Javier Martinez-Picado, on behalf of the DUALITY study group

PLOS Pathogens: published September 11, 2025 | https://doi.org/10.1371/journal.ppat.1013466

HIV-1 Tat favors the multiplication of Mycobacterium tuberculosis and Toxoplasma by inhibiting clathrin-mediated endocytosis and autophagy

Aurélie Rivault, Audrey Bernut, Myriam Ben-Neji, Magali Abrantes, Maxime Jansen, Sylvaine Huc-Brandt, Sébastien Besteiro, Yann Bordat, Mai Nguyen-Chi, Nelly Audemard, Margaux Mesleard-Roux, David Perrais, Olivier Neyrolles, Geanncarlo Lugo-Villarino, Christel Vérollet, Lucile Espert, Bruno Beaumelle

PLOS Pathogens: published September 11, 2025 | https://doi.org/10.1371/journal.ppat.1013183

Positive allosteric modulation of emodepside sensitive Brugia malayi SLO-1F and Onchocerca volvulus SLO-1A potassium channels by GoSlo-SR-5-69

Mark McHugh, Charity N. Njeshi, Nathaniel Smith, Sudhanva S. Kashyap, Real Datta, Han Sun, Alan P. Robertson, Richard J. Martin

PLOS Pathogens: published September 11, 2025 | https://doi.org/10.1371/journal.ppat.1012946

Unbiased and comprehensive identification of virus-derived circular RNAs in a large range of viral species and families

Alexis S. Chasseur, Maxime Bellefroid, Mathilde Galais, Meijiao Gong, Pierre Lombard, Sarah Mathieu, Amandine Pecquet, Estelle Plant, Camille Ponsard, Laure Vreux, Carlo Yague-Sanz, Benjamin G. Dewals, Nicolas A. Gillet, Benoît Muylkens, Carine M. Van Lint, Damien Coupeau

PLOS Pathogens: published September 11, 2025 | https://doi.org/10.1371/journal.ppat.1013448

Fish TOLLIP manipulates ATG5 for autophagic degradation of STING to attenuate antiviral interferon responses

Meng-Ze Tian, Yang-Yang Wang, Bao-Jie Cui, Xiao Xu, Chu-Jing Zhou, Can Zhang, Zhuo-Cong Li, Meng-Qian Hong, Na Xu, Dan-Dan Chen, Long-Feng Lu, Shun Li

PLOS Pathogens: published September 12, 2025 | https://doi.org/10.1371/journal.ppat.1013512

Coronavirus M protein impairs cilium during early infection by enhancing the AurA-HDAC6 axis

Tenghan Zhuang, Peng Yang, Mengqin Wang, Shiyu Liu, Wei Wang, Boyan Sun, Yue Xu, Li Chen, Xi Bao, Danchen Aaron Yang, Yongqian Zhao, Baochao Fan, Lei Feng, Bin Li

PLOS Pathogens: published September 12, 2025 | https://doi.org/10.1371/journal.ppat.1013515

Chimeric PRR T-cell-engager targeting cell surface β-1,3-glucan for invasive candidiasis

Yu Fang Sun, Shi Yu Guo, Si Qi Wang, Rui Tong Li, Xi Ran Qiu, Xing Chen Dong, Shuang Liu, Hui Shen, Mao Mao An

PLOS Pathogens: published September 15, 2025 | https://doi.org/10.1371/journal.ppat.1013508

The interaction between GCN2 and eIF2 mediates the resistance of cotton bollworm to the Bacillus thuringiensis Cry1Ac toxin

Caihong Zhang, Jizhen Wei, Ningning Li, Zaw Lin Naing, Ei Thinzar Soe, Jinrong Tang, Huan Yu, Fengyun Fang, Gemei Liang

PLOS Pathogens: published September 15, 2025 | https://doi.org/10.1371/journal.ppat.1013510

Differential tissue tropism and transmission efficiency of two dominant influenza D clades with overlapping but distinct receptor binding fine specificities in ferrets

Tirth Uprety, Chithra C. Sreenivasan, Jieshi Yu, Miaoyun Zhao, Runxia Liu, Hai Yu, Ahsan Naveed, Lianne G. Eertink, Shalini Soni, Rebecca E. Ruby, Xi Chen, Radhey S. Kaushik, Zizhang Sheng, Qingsheng Li, Dan Wang, Feng Li

PLOS Pathogens: published September 15, 2025 | https://doi.org/10.1371/journal.ppat.1013493

Regulation of host immunity by a novel Legionella pneumophila E3 ubiquitin ligase

Shuxin Liu, Chunlin He, Yong Zhang, Siyao Liu, Tao-Tao Chen, Chunxiuli Li, Dong Chen, Songying Ouyang, Lei Song, Jiaqi Fu, Zhao-Qing Luo

PLOS Pathogens: published September 15, 2025 | https://doi.org/10.1371/journal.ppat.1013522

Proximity labelling reveals VPS13C as a regulator of Salmonella-containing vacuole fission

Anna K. Waldmann, Dustin A. Ammendolia, Andrew M. Sydor, Ren Li, Jonathan St-Germain, Brian Raught, John H. Brumell

PLOS Pathogens: published September 15, 2025 | https://doi.org/10.1371/journal.ppat.1013507

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A genome-wide analysis of YY1 and TFAP2 competition on overlapping motifs reveals their roles in HPV-induced carcinogenesis

Yi Liu, Shuang Ding, Haibin Liu

PLOS Pathogens: published September 15, 2025 | https://doi.org/10.1371/journal.ppat.1013524

Connecting basal body and mitochondrial DNA: TAC53 and the tubular organization of the tripartite attachment complex

Clirim Jetishi, Salome Aeschlimann, Bernd Schimanski, Sandro Käser, Rachel Mullner, Silke Oeljeklaus, Bungo Akiyoshi, Bettina Warscheid, Falk Butter, André Schneider, Torsten Ochsenreiter

PLOS Pathogens: published September 15, 2025 | https://doi.org/10.1371/journal.ppat.1013521

Single-round infectious rotaviruses with deletions of VP7 or VP4 genes, based on SA11 and WC3 strain backbones, and their potential use as viral vectors

Tomohiro Kotaki, Yuta Kanai, Megumi Onishi, Yusuke Sakai, Daisuke Motooka, Zelin Chen, Yasutaka Enoki, Sayuri Komatsu, Katsuhisa Hirai, Shohei Minami, Takahiro Kawagishi, Hiroshi Ushijima, Takeshi Kobayashi

PLOS Pathogens: published September 15, 2025 | https://doi.org/10.1371/journal.ppat.1013484

A non-canonical activation of the host’s ESCRT machinery is required for the scission of parasitophorous vacuoles and the replication of Leishmania donovani

Javier Rosero, Peter E. Kima

PLOS Pathogens: published September 16, 2025 | https://doi.org/10.1371/journal.ppat.1013513

A single amino acid variant in the variable region I of AAV capsid confers liver detargeting

Ruxiao Xing, Mengyao Xu, Darcy Reil, April Destefano, Mengtian Cui, Nan Liu, Jialing Liang, Guangchao Xu, Li Luo, Meiyu Xu, Fang Zhang, Phillip W.L. Tai, Yuquan Wei, Alisha M. Gruntman, Terence R. Flotte, Guangping Gao, Dan Wang

PLOS Pathogens: published September 17, 2025 | https://doi.org/10.1371/journal.ppat.1013533

Pathogen-induced damage in Drosophila: Uncoupling disease tolerance from resistance

Priscilla A. Akyaw, Tânia F. Paulo, Elvira Lafuente, Élio Sucena

PLOS Pathogens: published September 19, 2025 | https://doi.org/10.1371/journal.ppat.1013482

A PGRPLC1/Rel2-F axis controls Anopheles gambiae resistance to systemic infections with Gram-positive bacteria containing Lys-type peptidoglycan

Amani Audi, Suheir Zeineddine, Sana Jaber, Mike A. Osta

PLOS Pathogens: published September 19, 2025 | https://doi.org/10.1371/journal.ppat.1013527

The F1148 hydrophobic lock: A critical determinant of SARS-CoV-2 spike protein-mediated membrane fusion via the 3H/CH cavity

Fuzhi Lei, Yahan Lei, Zhenghong Yuan, Zhigang Yi

PLOS Pathogens: published September 19, 2025 | https://doi.org/10.1371/journal.ppat.1013526

Endoplasmic reticulum-anchored nonstructural proteins drive human astrovirus replication organelle formation

Brooke Bengert, Samaneh Mehri, Madeline Holliday, Nicholas J. Lennemann

PLOS Pathogens: published September 22, 2025 | https://doi.org/10.1371/journal.ppat.1013538

TisB enables antibiotic tolerance in Salmonella by preventing prophage induction through ATP depletion

Sebastian Braetz, Niclas Nordholt, Andreas Nerlich, Frank Schreiber, Karsten Tedin, Marcus Fulde

PLOS Pathogens: published September 22, 2025 | https://doi.org/10.1371/journal.ppat.1013498

CEPR2 perceives group II CEPs to regulate cell surface receptor-mediated immunity in Arabidopsis

Jakub Rzemieniewski, Patricia Zecua-Ramirez, Sebastian Schade, Zeynep Camgöz, Genc Haljiti, Sukhmannpreet Kaur, Christina Ludwig, Ralph Hückelhoven, Martin Stegmann

PLOS Pathogens: published September 22, 2025 | https://doi.org/10.1371/journal.ppat.1013115

Interprotomer crosstalk in mosaic viral glycoprotein trimers provides insight into polyvalent immunogen co-assembly

Chengbo Chen, Klaus N. Lovendahl, Julie M. Overbaugh, Kelly K. Lee

PLOS Pathogens: published September 22, 2025 | https://doi.org/10.1371/journal.ppat.1013143

The antifungal mechanism of EntV-derived peptides is associated with a reduction in extracellular vesicle release

Giuseppe Buda De Cesare, Melissa R. Cruz, Shane A. Cristy, Luis A. Vega, Robert Zarnowski, Antonino Zito, Shantanu Guha, David R. Andes, Danielle A. Garsin, Michael C. Lorenz

PLOS Pathogens: published September 22, 2025 | https://doi.org/10.1371/journal.ppat.1013519

The viral BCL2 protein BHRF1 of Epstein–Barr virus promotes AIM2 inflammasome activation to facilitate lytic replication

Qingping Lan, Xiaolin Zhang, Yifan Sun, Jing Yang, Xiaojuan Li, Ersheng Kuang

PLOS Pathogens: published September 22, 2025 | https://doi.org/10.1371/journal.ppat.1013509

The hepatitis E virus capsid protein ORF2 counteracts cell-intrinsic antiviral responses to enable persistent replication in cell culture

Ann-Kathrin Mehnert, Sebastian Stegmaier, Carlos Ramirez Alvarez, Elif Toprak, Vladimir Gonçalves Magalhães, Carla Siebenkotten, Jungen Hu, Ana Luisa Costa, Daniel Kirrmaier, Michael Knop, Xianfang Wu, Thibault Tubiana, Carl Herrmann, Marco Binder, Viet Loan Dao Thi

PLOS Pathogens: published September 22, 2025 | https://doi.org/10.1371/journal.ppat.1013516

Monitoring intracellular replication dynamics unveils high proportion of non-replicating antibiotic-tolerant Staphylococcus aureus inside osteoblasts

Florian C. Marro, Jacques Brocard, Allison Faure, Angélique Sion, Paul O. Verhoeven, Laurie Canonne-Desbiolles, Laurence Conraux, Laura Jaffrelot, Chantal Monlong, Ariel J. Blocker, Nelly Dubarry, Frédéric Laurent, Jérôme Josse

PLOS Pathogens: published September 23, 2025 | https://doi.org/10.1371/journal.ppat.1013525

T6SS4 is heterogeneously expressed in Yersinia pseudotuberculosis and is a target for transcriptional and post-transcriptional regulation

Anna Kerwien, Britta Körner, Ines Meyer, Yannick Teschke, Cassandra Sophie Köster, Ileana Paula Salto, Petra Dersch, Anne-Sophie Herbrüggen

PLOS Pathogens: published September 24, 2025 | https://doi.org/10.1371/journal.ppat.1013356

In vivo and in vitro recombinant systems of a novel variant demonstrate cross-reactive neutralization for the HCV model virus, Norway rat hepacivirus

Caroline E. Thorselius, Andreas Kok, Raphael Wolfisberg, Ulrik Fahnøe, Matthew J. Kennedy, Emma A. Lundsgaard, Lotte Mikkelsen, Mads K. Larsen, Satyapramod Murthy, Sheetal Trivedi, Amit Kapoor, Troels K. H. Scheel, Kenn Holmbeck, Jens Bukh

PLOS Pathogens: published September 25, 2025 | https://doi.org/10.1371/journal.ppat.1013127

STK-mediated FadR phosphorylation regulates the acid resistance and virulence of Streptococcus suis

Sen Li, Zhe Ma, Huixing Lin, Fei Pan, Hong Zhou, Jinsheng Tang, Hongjie Fan

PLOS Pathogens: published September 25, 2025 | https://doi.org/10.1371/journal.ppat.1013534

Defined roles for the Staphylococcus aureus POT transporter DtpT in di/tripeptide uptake and glutathione utilisation inside human macrophages

Imran Khan, Sandy J. MacDonald, Sigurbjörn Markússon, Paige J. Kies, Cristina Kraemer-Zimpel, Callum Robson, Joanne L. Parker, Simon Newstead, Dave Boucher, Neal D. Hammer, Marjan Van Der Woude, Gavin H. Thomas

PLOS Pathogens: published September 26, 2025 | https://doi.org/10.1371/journal.ppat.1013535

Liver biopsies obtained throughout SIV infection reveal evolving interferon stimulated protein expression within distinct monocyte/macrophage subsets

Nina Derby, Brooke I. Johnson, Sreya Biswas, Miranda Fischer, Katherine A. Fancher, Cristina Luevano-Santos, Sofiya Yusova, Kimberly A. Meyer, Yohannes M. Abraham, Savannah S. Lutz, Cole Fisher, Maria Cristina Pacheco, Jeremy V. Smedley, Benjamin J. Burwitz, Donald L. Sodora

PLOS Pathogens: published September 26, 2025 | https://doi.org/10.1371/journal.ppat.1013175

Variation in natural infection outcomes and cancer cell release from soft-shell clams (Mya arenaria) with bivalve transmissible neoplasia

Rachael M. Giersch, Jordana K. Sevigny, Sydney A. Weinandt, Carissa Mayo, Fiona E. S. Garrett, Karyn Tindbaek, Marisa A. Yonemitsu, Samuel F. M. Hart, Michael J. Metzger

PLOS Pathogens: published September 29, 2025 | https://doi.org/10.1371/journal.ppat.1013537

The tegument protein VP22 of pseudorabies virus inhibits cGAS condensation by inducing nuclear-to-cytoplasmic translocation of DDX21

Kesen Liu, Wandi Cao, Hanhua Zhang, Xingmiao Yang, Chengyue Wu, Xingya Wang, Qian Sun, Jianxiong Guo, Ting Zhang, Yan Liu, Xing Liu

PLOS Pathogens: published September 29, 2025 | https://doi.org/10.1371/journal.ppat.1013549

Acinetobacter phages use distinct strategies to breach the capsule barrier

Alexis J. McCalla, Forrest C. Walker, Fabiana Bisaro, Miguel Rodriguez-Anavitate, Anna Johannesman, Gisela Di Venanzio, Mario F. Feldman, Michele LeRoux

PLOS Pathogens: published September 29, 2025 | https://doi.org/10.1371/journal.ppat.1013536

Antigenic variation is caused by long plasmid segment conversion in a hard tick-borne relapsing fever Borrelia miyamotoi

Tomohi Takeuchi, Yasuhiro Gotoh, Tetsuya Hayashi, Hiroki Kawabata, Ai Takano

PLOS Pathogens: published September 30, 2025 | https://doi.org/10.1371/journal.ppat.1013514

Commensal to pathogen switch in Streptococcus pneumoniae is influenced by a thermosensing master regulator

Shruti Apte, Greicy K. Bonifacio-Pereira, Sourav Ghosh, Srijit Kumar Mandal, Leena Badgujar, Krithika Gosavi, Elizabeth Pohler, Thomas E. Barton, Sian Pottenger, Alice Blake, Pradeepkumar PI, Daniel R. Neill, Anirban Banerjee

PLOS Pathogens: published September 30, 2025 | https://doi.org/10.1371/journal.ppat.1013545

Correction: Polyamine biosynthesis and eIF5A hypusination are modulated by the DNA tumor virus KSHV and promote KSHV viral infection

Guillaume N. Fiches, Zhenyu Wu, Dawei Zhou, Ayan Biswas, Tai-Wei Li, Weili Kong, Maxime Jean, Netty G. Santoso, Jian Zhu

PLOS Pathogens: published September 11, 2025 | https://doi.org/10.1371/journal.ppat.1013496

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