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June 2025

Representative Picrosirius Red staining of fibrillar collagen in hepatic granulomas from (LEFT) wild-type and (RIGHT) SOX9-deficient mice, revealing the essential role of SOX9 in organising a fibrotic barrier around Schistosoma mansoni eggs. In the absence of SOX9, granulomas are disorganised and poorly contained, leading to diffuse liver injury. Su et al. 2025

Image Credit: Karen Piper Hanley and Elliot Jokl

Pearls

Roles of TLR9: Gatekeeper to fungal infections

Elias Barbosa da Silva-Junior, Leonardo Freire-de-Lima, Luciana Polaco Covre, Alexandre Morrot, Herbert Leonel de Matos Guedes, Debora Decote-Ricardo, Celio Geraldo Freire-de-Lima

Enterohemorrhagic E. coli (EHEC) and the microbiome

Quentin Perraud, Vanessa Sperandio

The rise of fungal G-protein coupled receptors in pathogenesis and symbiosis

Max Heinen, Hanna Rovenich, Florian Altegoer

Host targets of candidalysin

Jianfeng Lin, Scott G. Filler

Research Articles

Trichomonas vaginalis extracellular vesicles activate the NLRP3 inflammasome and TLR3-mediated inflammatory cascades in host cells

Ching-Yun Huang, Shu-Fang Chiu, Lichieh Julie Chu, Yuan-Ming Yeh, Po-Jung Huang, Kuo-Lun Lan, Yu-Ling Tsai, Ching-Chun Liu, Chien-Fu F. Chen, Wei-Ning Lin, Kuo-Yang Huang

Heterochromatin de novo formation and maintenance in Plasmodium falciparum

Alba Pérez-Cantero, Oriol Llorà-Batlle, Ingrid Pelaez-Conde, César Martínez-Guardiola, Alfred Cortés

SFTSV NSs degrades SAFA via autophagy to suppress SAFA-dependent antiviral response

Tian-mei Yu, Ze-min Li, Wen-kang Zhang, Bang Li, Qiao Liu, Chuan-min Zhou, Xue-jie Yu

Role of the CTCF binding site in Human T-Cell Leukemia Virus-1 pathogenesis

Ancy Joseph, Xiaogang Cheng, John Harding, Jacob Al-Saleem, Patrick Green, Malachi Griffith, Deborah Veis, Daniel A. Rauch, Lee Ratner

The Pseudomonas aeruginosa Tse4 toxin assembles ion-selective and voltage-sensitive ion channels to couple membrane depolarisation with K+ efflux

Jessica Rojas-Palomino, Carmen Velázquez, Jon Altuna-Alvarez, Amaia González-Magaña, Maialen Zabala-Zearreta, Matthias Müller, María Queralt-Martín, Antonio Alcaraz, David Albesa-Jové

Induction of tunnelling nanotube-like structures by influenza A viruses requires the onset of apoptosis

Daniel Weir, Calum Bentley-Abbot, Jack McCowan, Colin Loney, Edward Roberts, Edward Hutchinson

Murine modeling of menstruation identifies immune correlates of protection during Chlamydia muridarum challenge

Laurel A. Lawrence, Mark Elliott Williams, Paola Vidal, Richa S. Varughese, Zheng-Rong Tiger Li, Thien Duy Chen, Melissa A. Roy, Steven C. Tuske, Anice C. Lowen, Christopher D. Scharer, William M. Shafer, Alison Swaims-Kohlmeier

Multiple introductions of equine influenza virus into the United Kingdom resulted in widespread outbreaks and lineage replacement

Laura Mojsiejczuk, Fleur Whitlock, Hanting Chen, Callum Magill, Elihu Aranday-Cortes, Jordan Bone, Lily Tong, Ana Da Silva Filipe, Neil Bryant, J. Richard Newton, Thomas M. Chambers, Stephanie E. Reedy, Manabu Nemoto, Takashi Yamanaka, Joseph Hughes, Pablo R. Murcia

SOX9 plays an essential role in myofibroblast driven hepatic granuloma integrity and parenchymal repair during schistosomiasis-induced liver damage

Kim Su, Elliot Jokl, Alice Costain, Kara Simpson, Antonn Cheeseman, Alexander Phythian-Adams, Kevin N. Couper, Andrew S. MacDonald, Karen Piper Hanley

Detecting SARS-CoV-2 cryptic lineages using publicly available whole genome wastewater sequencing data

Reinier Suarez, Devon A. Gregory, David A. Baker, Clayton A. Rushford, Torin L. Hunter, Nicholas R. Minor, Clayton M. Russ, Emma E. Copen, David H. O’Connor, Marc C. Johnson

EPHA5 regulates antifungal innate immunity by phosphorylating EPHB2 and Dectin-1

Ru Gao, Heping Wang, Zhihui Cui, Yanyun Du, Ruirui He, Lingyun Feng, Bo Zeng, Yangyang Li, Guoling Huang, Ting Pan, Yuan Wang, Ming Yi, Chenhui Wang

High prevalence of simian foamy virus infection of South American Indians

William M. Switzer, HaoQiang Zheng, Cláudia P. Muniz, Yi Pan, Hongwei Jia, Shaohua Tang, Anupama Shankar, Roxana Cintron, Jan Drobeniuc, Marcelo A. Soares, Walid Heneine

Evolutionary and structural basis of SLAMF1 utilization in morbilliviruses—Implications for host range and cross-species transmission

Ayumu Hyodo, Fumio Seki, Kento Fukuda, Kaede Tashiro, Yuki Kitai, Yukiko Akahori, Hideko Watabe, Hiroshi Katoh, Rikuto Osaki, Daisuke Takaya, Norihito Kawashita, Hideo Fukuhara, Satoshi Ikegame, Tomoki Yoshikawa, Park Eunsil, Shigeru Morikawa, Ryoji Yamaguchi, Benhur Lee, Katsumi Maenaka, Tsuyoshi Shirai, Kaori Fukuzawa, Shigenori Tanaka, Makoto Takeda

Plasmodium falciparum expresses fewer var genes at lower levels during asymptomatic dry season infections than clinical malaria cases

Sukai Ceesay, Martin Kampmann, Lasse Votborg-Novél, Helle Smedegaard Hansson, Rasmus Weisel Jensen, Manuela Carrasquilla, Hamidou Cisse, Louise Turner, Usama Dabbas, Christina Ntalla, Silke Bandermann, Safiatou Doumbo, Didier Doumtabe, Aissata Ongoiba, Kassoum Kayentao, Boubacar Traore, Peter D. Crompton, Thomas Lavstsen, Silvia Portugal

The conserved poxvirus membrane entry-fusion apparatus component OPG147 targets MITA/STING for immune evasion

Xue-Mei Yi, Mi Li, Su-Yun Wang, Shi-Han Wang, Jia-Qing Zeng, Ya-Li Lei, Yu Zhang, Chun-Yu Zhu, Ying Zhang, Jun-Hui Song, Yun-Da Chen, Yun Wang, Hong-Bing Shu, Shu Li, Yan-Yi Wang

White spot syndrome virus immediate-early protein (wsv100) antagonizes the NF-κB pathway to inhibit innate immune response in shrimp

Bang Xiao, Fang Kang, Qianqian Li, Junming Pan, Yue Wang, Jianguo He, Chaozheng Li

The snakehead retrovirus promoter functions independently of the 3’ORF protein and its products are maternally inherited in transgenic zebrafish

Rachel Zamostiano, Odelia Pisanty, Japhette Esther Kembou-Ringert, Reem Abu Rass, Avi Eldar, Marcelo Ehrlich, Yoav Gothilf, Eran Bacharach

Reverse transcription progression and genome length regulate HIV-1 core elasticity and disassembly

Akshay Deshpande, Jiong Shi, Noa Rotem-Dai, Christopher Aiken, Itay Rousso

Structural exposure of different microtubule binding domains determines the propagation and toxicity of pathogenic tau conformers in Alzheimer’s disease

Lenka Hromadkova, Chae Kim, Tracy Haldiman, Mohammad Khursheed Siddiqi, Krystyna Surewicz, Kiley Urquhart, Dur-E-Nayab Sadruddin, Lihua Peng, Xiongwei Zhu, Witold K. Surewicz, Mark L. Cohen, Mark R. Chance, Rohan de Silva, Janna Kiselar, Jiri G. Safar

APOE protects against severe infection with Mycobacterium tuberculosis by restraining production of neutrophil extracellular traps

Dong Liu, Dat Mai, Ana N. Jahn, Tara A. Murray, John D. Aitchison, Benjamin H. Gern, Kevin B. Urdahl, Alan Aderem, Alan H. Diercks, Elizabeth S. Gold

PHD3-VHL axis controls HIV-2 infection through oxygen-dependent hydroxylation and degradation of Vpx

Kei Miyakawa, Kiho Tanaka, Yoko Ino, Yayoi Kimura, Taichi Kameya, Fuminori Mizukoshi, Mayuko Nishi, Masaru Yokoyama, Jun Nakabayashi, Masako Nomaguchi, Hironori Sato, Hirokazu Kimura, Hirofumi Akari, Tomoyuki Miura, Akinori Takaoka, Hideki Hasegawa, Tetsuro Matano, Yoji Andrew Minamishima, Akihide Ryo

Circovirus Rep evades immune restriction by disrupting cGAS oligomerization and phase separation

Hongyan Yin, Zhenchao Zhao, Ye Yuan, Minjie Li, Lvye Chai, Weiyu Qu, Yan Ya, Haiwei Wang, Xin Li

Env from EIAV vaccine delicately regulates NLRP3 activation via attenuating NLRP3-NEK7 interaction

Xing Guo, Cong Liu, Yuhong Wang, Hongxin Li, Saiwen Ma, Lei Na, Huiling Ren, Yuezhi Lin, Xiaojun Wang

IFN alpha inducible protein 27 (IFI27) acts as a positive regulator of PACT-dependent PKR activation after RNA virus infections

Darío López-García, Vanessa Rivero, Laura Villamayor, Marta L. DeDiego

The zinc metalloprotein MigC impacts cell wall biogenesis through interactions with an essential Mur ligase in Acinetobacter baumannii

Jeanette M. Critchlow, Joseph S. Rocchio, Melanie C. McKell, Courtney J. Campbell, Juan P. Barraza, Evan S. Krystofiak, Erin R. Green, Tae Akizuki, Walter J. Chazin, Michael S. VanNieuwenhze, Timothy L. Stemmler, David P. Giedroc, Eric P. Skaar

Toxoplasma gondii infection of neurons alters the production and content of extracellular vesicles directing astrocyte phenotype and contributing to the loss of GLT-1 in the infected brain

Emily Z. Tabaie, Ziting Gao, Nala Kachour, Arzu Ulu, Stacey Gomez, Zoe A. Figueroa, Kristina V. Bergersen, Wenwan Zhong, Emma H. Wilson

Subversion of phosphorylated SR proteins by enterovirus A71 in IRES-dependent translation revealed by RNA-interactome analysis

Kuo-Ming Lee, Chih-Ching Wu, Yu-Ting Fan, Huan-Jung Chiang, Pei-Yi Lien, Jui-Ping Wang, Yhu-Chering Huang, Shin-Ru Shih

TIGIT blockade improves anti-Mycobacterium tuberculosis immunity

Jingyu Zhou, Qingluan Yang, Haoxin Xu, Huaxin Chen, Ning Jiang, Qinfang Ou, Mengqing Qian, Xing Lin, Yixuan Yang, Feiran Zhou, Yuzhen Xu, Qianqian Liu, Yuanyuan Liu, Yan Gao, Wenhong Zhang, Lingyun Shao, Qiaoling Ruan

Grains, trade and war in the multimodal transmission of Rice yellow mottle virus: An historical and phylogeographical retrospective

Innocent Ndikumana, Geoffrey Onaga, Agnès Pinel-Galzi, Pauline Rocu, Judith Hubert, Hassan Karakacha Wéré, Antony Adego, Mariam Nyongesa Wéré, Nils Poulicard, Maxime Hebrard, Simon Dellicour, Philippe Lemey, Erik Gilbert, Marie-José Dugué, François Chevenet, Paul Bastide, Stéphane Guindon, Denis Fargette, Eugénie Hébrard

Experimental evolution of a pathogen confronted with innate immune memory increases variation in virulence

Ana Korša, Moritz Baur, Nora K. E. Schulz, Jaime M. Anaya-Rojas, Alexander Mellmann, Joachim Kurtz

Microglia-specific NF-κB signaling is a critical regulator of prion-induced glial inflammation and neuronal loss

Arielle J. D. Hay, Katriana A. Popichak, Genova Mumford, Jifeng Bian, Payton Shirley, Lauren Wolfrath, Michael Eggers, Eric M. Nicholson, Ronald B. Tjalkens, Mark D. Zabel, Julie A. Moreno

Phylogenetics and genomic variation of Hepatocystis isolated from shotgun sequencing of wild primate hosts

Paige E. Haffener, Helena D. Hopson, Alejandra Herbert-Mainero, Anayansi Ramirez, Ellen M. Leffler

A novel genus of virulent phage targeting Acinetobacter baumannii: Efficacy and safety in a murine model of pulmonary infection

JiaWang Wang, Huan Hu, QingQing Wang, TianZhu Zhu, XiaoHan Ren, WenQian Jiang, XueMei Hou, Jun Lin, XiaoLing Yu

SARS-CoV-2 remodels the Golgi apparatus to facilitate viral assembly and secretion

Jianchao Zhang, Andrew Kennedy, Daniel Macedo de Melo Jorge, Lijuan Xing, Whitney Reid, Sarah Bui, Joseph Joppich, Molly Rose, Sevval Ercan, Qiyi Tang, David Ginsburg, Andrew W. Tai, Yanzhuang Wang

Enterococcal cell wall remodelling underpins pathogenesis via the release of the Enteroccocal Polysaccharide Antigen (EPA)

Robert E. Smith, Bartosz J. Michno, Rene L. Christena, Finn O’Dea, Jessica L. Davis, Ian D.E.A. Lidbury, Marcel G. Alamán-Zárate, Danai Stefanidi, Emmanuel Maes, Hannah Fisher, Tomasz K. Prajsnar, Stéphane Mesnage

Distinct neutralization sensitivity between adult and infant transmitted/founder HIV-1 subtype C viruses to broadly neutralizing monoclonal antibodies

Bongiwe Ndlovu, Kamini Gounder, Nelisiwe Zikhali, Lanish Singh, Ntokozo Ntshangase, Nombali Gumede, Jane Millar, Rebecca T. van Dorsten, Nicholas E. Grayson, David Bonsall, Sandra E. Chaudron, Jennifer Mabuka, Krista L. Dong, Bruce D. Walker, Penny L. Moore, Philip J.R. Goulder, Thumbi Ndung’u

Kaposi sarcoma-associated herpesvirus cooperates with Epstein-Barr virus to co-transform a small set of human B cells oncogenically

Mitchell Hayes, Wei Wang, Isabela Fraga de Andrade, Paul F. Lambert, Bill Sugden

The structural features and immunological role of biomphalysins in the snail Biomphalaria glabrata

Pierre Poteaux, Aline Parpinel, Chantal Ripoll, Amélie Sarrazin, Richard Galinier, Sabine Brugière, Yohann Couté, Lionel Mourey, Patrick C. Hanington, Benjamin Gourbal, Laurent Maveyraud, David Duval

Infectome analysis of bat kidneys from Yunnan province, China, reveals novel henipaviruses related to Hendra and Nipah viruses and prevalent bacterial and eukaryotic microbes

Guopeng Kuang, Tian Yang, Weihong Yang, Jing Wang, Hong Pan, Yuanfei Pan, Qin-yu Gou, Wei-chen Wu, Juan Wang, Lifeng Yang, Xi Han, Yao-qing Chen, John-Sebastian Eden, Edward C. Holmes, Mang Shi, Yun Feng

A comprehensive phylogeny of mammalian PRNP gene reveals no influence of prion misfolding propensity on the evolution of this gene

Cristina Sampedro-Torres-Quevedo, Hasier Eraña, Jorge M. Charco, Carlos M. Díaz-Domínguez, Maitena San-Juan-Ansoleaga, Eva Fernández-Muñoz, Nuno Gonçalves-Anjo, Josu Galarza-Ahumada, Ana R. Cortazar, Roberto F. Nespolo, Julian F. Quintero-Galvis, Africa Manero-Azua, Diego Polanco-Alonso, Adrián Gaite-Reguero, Íñigo Olalde, Urko M. Marigorta, Guiomar Perez de Nanclares, Ana M. Aransay, Joaquín Castilla

Discovery of functional factorless internal ribosome entry site-like structures through virome mining

Subash Chapagain, Nicolas Salcedo-Porras, Amir Abdolahzadeh, Yaohua Zhang, Higor Sette Pereira, Stephane Flibotte, Kevin Low, Christina Young, Yuhang Wu, Shao Wang, Soh Ishiguro, Nozomu Yachie, Trushar Patel, Artem Babaian, Eric Jan

Polysaccharide synthesis operon modulates Rickettsia-endothelial cell interactions

Smruti Mishra, Luke Helminiak, Hwan Keun Kim

IRF6 controls Epstein-Barr virus (EBV) lytic reactivation and differentiation in EBV-infected epithelial cells

Stuart A. Fogarty, Deo R. Singh, Scott E. Nelson, Maria E. Calandranis, Yitao Zhang, Abigail S. Pawelski, Alisha S. Kansra, Sophie White, Shannon C. Kenney

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