Representative Picrosirius Red staining of fibrillar collagen in hepatic granulomas from (LEFT) wild-type and (RIGHT) SOX9-deficient mice, revealing the essential role of SOX9 in organising a fibrotic barrier around Schistosoma mansoni eggs. In the absence of SOX9, granulomas are disorganised and poorly contained, leading to diffuse liver injury. Su et al. 2025
Image Credit: Karen Piper Hanley and Elliot Jokl
Pearls
Roles of TLR9: Gatekeeper to fungal infections
PLOS Pathogens: published June 3, 2025 | https://doi.org/10.1371/journal.ppat.1013185
At the genetic crossroads of Leishmania: Emerging hybrids reshaping disease patterns
PLOS Pathogens: published June 3, 2025 | https://doi.org/10.1371/journal.ppat.1013213
Enterohemorrhagic E. coli (EHEC) and the microbiome
PLOS Pathogens: published June 12, 2025 | https://doi.org/10.1371/journal.ppat.1013224
The rise of fungal G-protein coupled receptors in pathogenesis and symbiosis
PLOS Pathogens: published June 12, 2025 | https://doi.org/10.1371/journal.ppat.1013212
Beyond division and morphogenesis: Considering the emerging roles of septins in plasma membrane homeostasis and cell wall integrity in human fungal pathogens
PLOS Pathogens: published June 17, 2025 | https://doi.org/10.1371/journal.ppat.1013226
Host targets of candidalysin
PLOS Pathogens: published June 23, 2025 | https://doi.org/10.1371/journal.ppat.1013284
Research Articles
Trichomonas vaginalis extracellular vesicles activate the NLRP3 inflammasome and TLR3-mediated inflammatory cascades in host cells
PLOS Pathogens: published June 2, 2025 | https://doi.org/10.1371/journal.ppat.1013216
Heterochromatin de novo formation and maintenance in Plasmodium falciparum
PLOS Pathogens: published June 2, 2025 | https://doi.org/10.1371/journal.ppat.1013137
SFTSV NSs degrades SAFA via autophagy to suppress SAFA-dependent antiviral response
PLOS Pathogens: published June 3, 2025 | https://doi.org/10.1371/journal.ppat.1013201
Role of the CTCF binding site in Human T-Cell Leukemia Virus-1 pathogenesis
PLOS Pathogens: published June 3, 2025 | https://doi.org/10.1371/journal.ppat.1012293
The Pseudomonas aeruginosa Tse4 toxin assembles ion-selective and voltage-sensitive ion channels to couple membrane depolarisation with K+ efflux
PLOS Pathogens: published June 4, 2025 | https://doi.org/10.1371/journal.ppat.1012981
Albendazole specifically disrupts microtubules and protein turnover in the tegument of the cestode Mesocestoides corti
PLOS Pathogens: published June 4, 2025 | https://doi.org/10.1371/journal.ppat.1013221
Induction of tunnelling nanotube-like structures by influenza A viruses requires the onset of apoptosis
PLOS Pathogens: published June 5, 2025 | https://doi.org/10.1371/journal.ppat.1013191
Murine modeling of menstruation identifies immune correlates of protection during Chlamydia muridarum challenge
PLOS Pathogens: published June 6, 2025 | https://doi.org/10.1371/journal.ppat.1012276
Multiple introductions of equine influenza virus into the United Kingdom resulted in widespread outbreaks and lineage replacement
PLOS Pathogens: published June 9, 2025 | https://doi.org/10.1371/journal.ppat.1013227
SOX9 plays an essential role in myofibroblast driven hepatic granuloma integrity and parenchymal repair during schistosomiasis-induced liver damage
PLOS Pathogens: published June 9, 2025 | https://doi.org/10.1371/journal.ppat.1012928
Detecting SARS-CoV-2 cryptic lineages using publicly available whole genome wastewater sequencing data
PLOS Pathogens: published June 9, 2025 | https://doi.org/10.1371/journal.ppat.1012850
Antigen-specific CD4+ T cells promote monocyte recruitment and differentiation into glycolytic lung macrophages to control Mycobacterium tuberculosis
PLOS Pathogens: published June 9, 2025 | https://doi.org/10.1371/journal.ppat.1013208
EPHA5 regulates antifungal innate immunity by phosphorylating EPHB2 and Dectin-1
PLOS Pathogens: published June 9, 2025 | https://doi.org/10.1371/journal.ppat.1013179
High prevalence of simian foamy virus infection of South American Indians
PLOS Pathogens: published June 9, 2025 | https://doi.org/10.1371/journal.ppat.1013169
Evolutionary and structural basis of SLAMF1 utilization in morbilliviruses—Implications for host range and cross-species transmission
PLOS Pathogens: published June 10, 2025 | https://doi.org/10.1371/journal.ppat.1012990
A systematic review of the distribution and prevalence of viruses detected in the Peromyscus maniculatus species complex (Rodentia: Cricetidae)
PLOS Pathogens: published June 10, 2025 | https://doi.org/10.1371/journal.ppat.1013125
Plasmodium falciparum expresses fewer var genes at lower levels during asymptomatic dry season infections than clinical malaria cases
PLOS Pathogens: published June 10, 2025 | https://doi.org/10.1371/journal.ppat.1013210
The conserved poxvirus membrane entry-fusion apparatus component OPG147 targets MITA/STING for immune evasion
PLOS Pathogens: published June 11, 2025 | https://doi.org/10.1371/journal.ppat.1013198
White spot syndrome virus immediate-early protein (wsv100) antagonizes the NF-κB pathway to inhibit innate immune response in shrimp
PLOS Pathogens: published June 12, 2025 | https://doi.org/10.1371/journal.ppat.1012828
The snakehead retrovirus promoter functions independently of the 3’ORF protein and its products are maternally inherited in transgenic zebrafish
PLOS Pathogens: published June 12, 2025 | https://doi.org/10.1371/journal.ppat.1013243
Reverse transcription progression and genome length regulate HIV-1 core elasticity and disassembly
PLOS Pathogens: published June 12, 2025 | https://doi.org/10.1371/journal.ppat.1013269
Structural exposure of different microtubule binding domains determines the propagation and toxicity of pathogenic tau conformers in Alzheimer’s disease
PLOS Pathogens: published June 13, 2025 | https://doi.org/10.1371/journal.ppat.1012926
APOE protects against severe infection with Mycobacterium tuberculosis by restraining production of neutrophil extracellular traps
PLOS Pathogens: published June 16, 2025 | https://doi.org/10.1371/journal.ppat.1013267
PHD3-VHL axis controls HIV-2 infection through oxygen-dependent hydroxylation and degradation of Vpx
PLOS Pathogens: published June 16, 2025 | https://doi.org/10.1371/journal.ppat.1013241
Circovirus Rep evades immune restriction by disrupting cGAS oligomerization and phase separation
PLOS Pathogens: published June 16, 2025 | https://doi.org/10.1371/journal.ppat.1013244
Env from EIAV vaccine delicately regulates NLRP3 activation via attenuating NLRP3-NEK7 interaction
PLOS Pathogens: published June 16, 2025 | https://doi.org/10.1371/journal.ppat.1012772
IFN alpha inducible protein 27 (IFI27) acts as a positive regulator of PACT-dependent PKR activation after RNA virus infections
PLOS Pathogens: published June 16, 2025 | https://doi.org/10.1371/journal.ppat.1013246
The zinc metalloprotein MigC impacts cell wall biogenesis through interactions with an essential Mur ligase in Acinetobacter baumannii
PLOS Pathogens: published June 16, 2025 | https://doi.org/10.1371/journal.ppat.1013209
Toxoplasma gondii infection of neurons alters the production and content of extracellular vesicles directing astrocyte phenotype and contributing to the loss of GLT-1 in the infected brain
PLOS Pathogens: published June 16, 2025 | https://doi.org/10.1371/journal.ppat.1012733
Subversion of phosphorylated SR proteins by enterovirus A71 in IRES-dependent translation revealed by RNA-interactome analysis
PLOS Pathogens: published June 16, 2025 | https://doi.org/10.1371/journal.ppat.1013242
TIGIT blockade improves anti-Mycobacterium tuberculosis immunity
PLOS Pathogens: published June 17, 2025 | https://doi.org/10.1371/journal.ppat.1013228
Grains, trade and war in the multimodal transmission of Rice yellow mottle virus: An historical and phylogeographical retrospective
PLOS Pathogens: published June 17, 2025 | https://doi.org/10.1371/journal.ppat.1013168
Experimental evolution of a pathogen confronted with innate immune memory increases variation in virulence
PLOS Pathogens: published June 18, 2025 | https://doi.org/10.1371/journal.ppat.1012839
Microglia-specific NF-κB signaling is a critical regulator of prion-induced glial inflammation and neuronal loss
PLOS Pathogens: published June 18, 2025 | https://doi.org/10.1371/journal.ppat.1012582
Phylogenetics and genomic variation of Hepatocystis isolated from shotgun sequencing of wild primate hosts
PLOS Pathogens: published June 18, 2025 | https://doi.org/10.1371/journal.ppat.1013240
A novel genus of virulent phage targeting Acinetobacter baumannii: Efficacy and safety in a murine model of pulmonary infection
PLOS Pathogens: published June 20, 2025 | https://doi.org/10.1371/journal.ppat.1013268
SARS-CoV-2 remodels the Golgi apparatus to facilitate viral assembly and secretion
PLOS Pathogens: published June 20, 2025 | https://doi.org/10.1371/journal.ppat.1013295
Enterococcal cell wall remodelling underpins pathogenesis via the release of the Enteroccocal Polysaccharide Antigen (EPA)
PLOS Pathogens: published June 23, 2025 | https://doi.org/10.1371/journal.ppat.1012771
Distinct neutralization sensitivity between adult and infant transmitted/founder HIV-1 subtype C viruses to broadly neutralizing monoclonal antibodies
PLOS Pathogens: published June 23, 2025 | https://doi.org/10.1371/journal.ppat.1013245
Kaposi sarcoma-associated herpesvirus cooperates with Epstein-Barr virus to co-transform a small set of human B cells oncogenically
PLOS Pathogens: published June 23, 2025 | https://doi.org/10.1371/journal.ppat.1013281
The structural features and immunological role of biomphalysins in the snail Biomphalaria glabrata
PLOS Pathogens: published June 24, 2025 | https://doi.org/10.1371/journal.ppat.1013225
Infectome analysis of bat kidneys from Yunnan province, China, reveals novel henipaviruses related to Hendra and Nipah viruses and prevalent bacterial and eukaryotic microbes
PLOS Pathogens: published June 24, 2025 | https://doi.org/10.1371/journal.ppat.1013235
Direct and indirect pathways linking the Lon protease to motility behaviors in the pathogen Pseudomonas aeruginosa
PLOS Pathogens: published June 25, 2025 | https://doi.org/10.1371/journal.ppat.1013288
A comprehensive phylogeny of mammalian PRNP gene reveals no influence of prion misfolding propensity on the evolution of this gene
PLOS Pathogens: published June 25, 2025 | https://doi.org/10.1371/journal.ppat.1013257
Discovery of functional factorless internal ribosome entry site-like structures through virome mining
PLOS Pathogens: published June 26, 2025 | https://doi.org/10.1371/journal.ppat.1013255
Polysaccharide synthesis operon modulates Rickettsia-endothelial cell interactions
PLOS Pathogens: published June 26, 2025 | https://doi.org/10.1371/journal.ppat.1013277
IRF6 controls Epstein-Barr virus (EBV) lytic reactivation and differentiation in EBV-infected epithelial cells
PLOS Pathogens: published June 26, 2025 | https://doi.org/10.1371/journal.ppat.1013236
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