Candida auris is emerging as a prevalent urinary pathogen

Alyssa Ann La Bella, Felipe Hiram Santiago-Tirado, Ana Lidia Flores-Mireles

PLOS Pathogens: published May 7, 2025 | https://doi.org/10.1371/journal.ppat.1013138

Fast and flu-rious: How to prevent and treat emerging influenza A viruses

Isabel Sesifredo, Íris Luz Batalha, Maria João Amorim

PLOS Pathogens: published May 16, 2025 | https://doi.org/10.1371/journal.ppat.1013135

Tecovirimat: A journey from discovery to mechanistic insights in poxvirus inhibition

Xue Li, Zhengyang Pan, Leiliang Zhang

PLOS Pathogens: published May 16, 2025 | https://doi.org/10.1371/journal.ppat.1013140

Pericytes: The forgotten controllers of a functional blood–brain barrier

Marshall Roedel, Nia Brooks, Tracey J. Lamb

PLOS Pathogens: published May 19, 2025 | https://doi.org/10.1371/journal.ppat.1013145

Sentinels tracking viruses in various ecosystems: Towards a One Health approach

Léo Blondet, Amour Mouanda Sounda, Matthieu Fritz, Denis Filloux, Michel Yvon, Stéphane Blanc, Arvind Varsani, Roch Fabien Niama, Eric M. Leroy, Philippe Roumagnac

PLOS Pathogens: published May 28, 2025 | https://doi.org/10.1371/journal.ppat.1013141

Coxiella burnetii as a model system for understanding host immune response against obligate intracellular, vacuolar pathogens

Akhila Sasikala, Chandhana Prakash, Mullai Valli Ramamoorthy, Sandhya Ganesan

PLOS Pathogens: published May 28, 2025 | https://doi.org/10.1371/journal.ppat.1013071

TRIM proteins: A ‘swiss army knife’ of antiviral immunity

Elise Chabot, David Durantel, Julie Lucifora

PLOS Pathogens: published May 12, 2025 | https://doi.org/10.1371/journal.ppat.1013147

A GDP-mannose-1-phosphate guanylyltransferase as a potential HIGS target against Sclerotinia sclerotiorum

Cheng Zhang, Yan Xu, Lin Li, Mingsong Wu, Zheyi Fang, Jinyi Tan, Jeffrey A. Rollins, Honghui Lin, Xinyi Huang, Shawn D. Mansfield, Xin Li, Yuelin Zhang

PLOS Pathogens: published May 2, 2025 | https://doi.org/10.1371/journal.ppat.1013129

Interplay between chemotaxis, quorum sensing, and metabolism regulates Escherichia coli-Salmonella Typhimurium interactions in vivo

Leanid Laganenka, Christopher Schubert, Andreas Sichert, Irina Kalita, Manja Barthel, Bidong D. Nguyen, Jana Näf, Thomas Lobriglio, Uwe Sauer, Wolf-Dietrich Hardt

PLOS Pathogens: published May 2, 2025 | https://doi.org/10.1371/journal.ppat.1013156

Evasion of serum antibodies and complement by Salmonella Typhi and Paratyphi A

Fermin E. Guerra, Joyce E. Karlinsey, Stephen J. Libby, Ferric C. Fang

PLOS Pathogens: published May 2, 2025 | https://doi.org/10.1371/journal.ppat.1012917

Trehalose supports the growth of Aedes aegypti cells and modifies gene expression and dengue virus type 2 replication

Andrew D. Marten, Douglas P. Haslitt, Chad A. Martin, Akshitha Karthikeyan, Daniel H. Swanson, Karishma Kalera, Ulysses G. Johnson, Benjamin M. Swarts, Michael J. Conway

PLOS Pathogens: published May 6, 2025 | https://doi.org/10.1371/journal.ppat.1012795

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The impact of fatty acid synthase on HSV-1 infection dynamics

Camilla Albano, Linda Trifirò, Weronika Hewelt-Belka, Dana M. Cairns, Selina Pasquero, Gloria Griffante, Francesca Gugliesi, Greta Bajetto, Dorota Garwolińska, Marika Rossi, Marta Vallino, Mario Malerba, Marco De Andrea, David L. Kaplan, Valentina Dell’Oste, Matteo Biolatti

PLOS Pathogens: published May 6, 2025 | https://doi.org/10.1371/journal.ppat.1013068

Origin, evolution, and success of pbla, the gonococcal beta-lactamase plasmid, and implications for public health

Tabea A. Elsener, Ana Cehovin, Connor Philp, Kate Fortney, Stanely M. Spinola, Martin C. J. Maiden, Christoph M. Tang

PLOS Pathogens: published May 6, 2025 | https://doi.org/10.1371/journal.ppat.1013151

A surface lipoprotein on Pasteurella multocida binds complement factor I to promote immune evasion

Quynh Huong Nguyen, Chun Heng Royce Lai, Michael J. Norris, Dixon Ng, Megha Shah, Christine Chieh-Lin Lai, David E. Isenman, Trevor F. Moraes

PLOS Pathogens: published May 6, 2025 | https://doi.org/10.1371/journal.ppat.1012686

Stomoxys flies (Diptera, Muscidae) are competent vectors of Trypanosoma evansi, Trypanosoma vivax, and other livestock hemopathogens

Julia W. Muita, Joel L. Bargul, JohnMark O. Makwatta, Ernest M. Ngatia, Simon K. Tawich, Daniel K. Masiga, Merid N. Getahun

PLOS Pathogens: published May 6, 2025 | https://doi.org/10.1371/journal.ppat.1012570

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In vivo Dicer-2 interactome during viral infection reveals novel pro and antiviral factors in Drosophila melanogaster

Claire Rousseau, Thomas Morand, Gabrielle Haas, Emilie Lauret, Lauriane Kuhn, Johana Chicher, Philippe Hammann, Carine Meignin

PLOS Pathogens: published May 7, 2025 | https://doi.org/10.1371/journal.ppat.1013093

A genetically engineered therapeutic lectin inhibits human influenza A virus infection and sustains robust virus-specific CD8 T cell expansion

Meng Yu, Ang Lin, Faezzah Baharom, Shuijie Li, Maureen Legendre, Evelyn Covés-Datson, Ebba Sohlberg, Susanne Schlisio, Karin Loré, David M. Markovitz, Anna Smed-Sörensen

PLOS Pathogens: published May 7, 2025 | https://doi.org/10.1371/journal.ppat.1013112

Interferon and TLR genes, but not endogenous bornavirus-like elements, limit BoDV1 replication after intracerebral infection

Rie Koide, Takaya Abe, Taichi Harimoto, Anselmo Jiro Kamada, Yuka Saito, Matteo Guerrini, Asami Fujii, Erica Parrish, Masayuki Horie, Hiroshi Kiyonari, Kazuhiko Yamamoto, Keizo Tomonaga, Nicholas F Parrish

PLOS Pathogens: published May 9, 2025 | https://doi.org/10.1371/journal.ppat.1013165

Evolution of primate T-cell leukemia virus type 1 accessory genes and functional divergence of its antisense proteins

Osama Hussein, Mohamed Mahgoub, Takafumi Shichijo, So Nakagawa, Junko Tanabe, Hirofumi Akari, Tomoyuki Miura, Masao Matsuoka, Jun-ichirou Yasunaga

PLOS Pathogens: published May 9, 2025 | https://doi.org/10.1371/journal.ppat.1013158

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SIRT5-mediated desuccinylation of the porcine deltacoronavirus M protein drives pexophagy to enhance viral proliferation

Zhuang Li, Wenbing Tang, Yinan Lai, Chaoqun Chen, Puxian Fang, Yanrong Zhou, Liurong Fang, Shaobo Xiao

PLOS Pathogens: published May 9, 2025 | https://doi.org/10.1371/journal.ppat.1013163

Reversible host cell surface remodelling limits immune recognition and maximizes survival of Plasmodium falciparum gametocytes

Priscilla Ngotho, Kathleen Dantzler Press, Megan Peedell, William Muasya, Brian Roy Omondi, Stanley E. Otoboh, Jahiro Gomez, Lorena Coronado, Karl B. Seydel, Melissa Kapulu, Miriam Laufer, Terrie Taylor, Teun Bousema, Matthias Marti

PLOS Pathogens: published May 12, 2025 | https://doi.org/10.1371/journal.ppat.1013110

STAT3, MYC, and EBNA1 cooperate through a ZC3H18 transcriptional network to regulate survival and proliferation of EBV-positive lymphomas

Huanzhou Xu, Siva Koganti, Chenglong Li, Michael T. McIntosh, Sumita Bhaduri-McIntosh

PLOS Pathogens: published May 12, 2025 | https://doi.org/10.1371/journal.ppat.1013166

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Candida albicans-stimulated hematopoietic stem and progenitor cells generate trained neutrophils with enhanced mitochondrial ROS production that defend against infection

María Sobén, Paula Guerrero, Andrea Guiu, Alberto Yáñez, María Luisa Gil

PLOS Pathogens: published May 13, 2025 | https://doi.org/10.1371/journal.ppat.1013170

Caspase-1-licensed pyroptosis drives dsRNA-mediated necroptosis and dampens host defense against bacterial pneumonia

Qinyu Luo, Lihua Shen, Shiyue Yang, Yan Zhang, Yihang Pan, Zehua Wu, Qiang Shu, Qixing Chen

PLOS Pathogens: published May 13, 2025 | https://doi.org/10.1371/journal.ppat.1013167

Epstein-Barr virus latent membrane protein 1 subverts IMPDH pathways to drive B-cell oncometabolism

Eric M. Burton, Davide Maestri, Shaowen White, Jin-Hua Liang, Bidisha Mitra, John M. Asara, Benjamin E. Gewurz

PLOS Pathogens: published May 14, 2025 | https://doi.org/10.1371/journal.ppat.1013092

Virus and cell specific HMGB1 secretion and subepithelial infiltrate formation in adenovirus keratitis

Amrita Saha, Mohammad Mirazul Islam, Rahul Kumar, Ashrafali Mohamed Ismail, Emanuel Garcia, Rama R. Gullapali, James Chodosh, Jaya Rajaiya

PLOS Pathogens: published May 14, 2025 | https://doi.org/10.1371/journal.ppat.1013184

Disruption of sulfur transferase complex increases bacterial intramacrophage persistence

Huang Tang, Zuoqiang Wang, Congcong Li, Jingchen Yu, Wanqiu Huang, Tao Zhou, Chuanzhen Zhang, Bingjie Wen, Chengyue Wang, Xiaocen Zhu, Danni Wang, Jing Tao, Jie Lu, Jinjing Ni, Yu-Feng Yao

PLOS Pathogens: published May 14, 2025 | https://doi.org/10.1371/journal.ppat.1013136

PINLYP-mediated phospholipid metabolism reprogramming contributes to chronic herpesvirus infection

Zhangmengxue Lei, Wendi Wei, Mingyu Wang, Yun Xu, Lei Bai, Ying Gao, Congwei Jiang, Fangxia Li, Na Tian, Linlin Kuang, Ruiliang Zhu, Gang Pang, Ke Lan, Suihan Feng, Xiaozhen Liang

PLOS Pathogens: published May 15, 2025 | https://doi.org/10.1371/journal.ppat.1013146

Rev-RRE activity modulates HIV-1 replication and latency reactivation: Implications for viral persistence and cure strategies

Godfrey A. Dzhivhuho, Patrick E. H. Jackson, Ethan S. Honeycutt, Flavio da Silva Mesquita, Jing Huang, Marie-Louise Hammarskjold, David Rekosh

PLOS Pathogens: published May 15, 2025 | https://doi.org/10.1371/journal.ppat.1012885

Host PIK3C3 promotes Shigella flexneri spread from cell to cell through vacuole formation

Steven J. Rolland, Zachary J. Lifschin, Erin A. Weddle, Lauren K. Yum, Tsuyoshi Miyake, Daniel A. Engel, Hervé F. Agaisse

PLOS Pathogens: published May 16, 2025 | https://doi.org/10.1371/journal.ppat.1012707

Hydrogen sulfide (H₂S) coordinates redox balance, carbon metabolism, and mitochondrial bioenergetics to suppress SARS-CoV-2 infection

Ragini Agrawal, Virender Kumar Pal, Suhas K.S., Gopika Jayan Menon, Inder Raj Singh, Nitish Malhotra, Naren C.S., Kailash Ganesh, Raju S. Rajmani, Aswin Sai Narain Seshasayee, Nagasuma Chandra, Manjunath B. Joshi, Amit Singh

PLOS Pathogens: published May 19, 2025 | https://doi.org/10.1371/journal.ppat.1013164

Reduced microbe abundance in an urban larval development container increases Aedes aegypti susceptibility to Zika virus

Margaret V. Becker, Anastasia Accoti, Angel Elma I. Abu, Julia Vulcan, Massamba Sylla, Kamil Khanipov, Laura B. Dickson

PLOS Pathogens: published May 19, 2025 | https://doi.org/10.1371/journal.ppat.1013154

Crop diversity induces trade-offs in microbial biopesticide susceptibility that could delay pest resistance evolution

Rosie M. Mangan, Matthew C. Tinsley, Ester Ferrari, Ricardo A. Polanczyk, Luc F. Bussière

PLOS Pathogens: published May 20, 2025 | https://doi.org/10.1371/journal.ppat.1013150

Unique growth and morphology properties of Clade 5 Clostridioides difficile strains revealed by single-cell time-lapse microscopy

John W. Ribis, César Nieto, Nicholas V. DiBenedetto, Anchal Mehra, Pola Kuhn, Qiwen Dong, Irene Nagawa, Imane El Meouche, Bree B. Aldridge, Mary J. Dunlop, Rita Tamayo, Abhyudai Singh, Aimee Shen

PLOS Pathogens: published May 21, 2025 | https://doi.org/10.1371/journal.ppat.1013155

Development of a replication competent murine norovirus reporter system

Mikayla C. Olson, Linley R. Pierce, Robert C. Orchard

PLOS Pathogens: published May 22, 2025 | https://doi.org/10.1371/journal.ppat.1012834

Fatty acid desaturases link cell metabolism pathways to promote proliferation of Epstein-Barr virus-infected B cells

Emmanuela N. Bonglack, Kaeden K. Hill, Ashley P. Barry, Alexandria Bartlett, Pol Castellano-Escuder, Matthew D. Hirschey, Micah A. Luftig

PLOS Pathogens: published May 22, 2025 | https://doi.org/10.1371/journal.ppat.1012685

Cholesterol metabolism and intrabacterial potassium homeostasis are intrinsically related in Mycobacterium tuberculosis

Yue Chen, Berge Hagopian, Shumin Tan

PLOS Pathogens: published May 22, 2025 | https://doi.org/10.1371/journal.ppat.1013207

Shedding dynamics of a DNA virus population during acute and long-term persistent infection

Sylvain Blois, Benjamin M. Goetz, Anik Mojumder, Christopher S. Sullivan

PLOS Pathogens: published May 23, 2025 | https://doi.org/10.1371/journal.ppat.1013083

Enteropathogenic Escherichia coli induces Entamoeba histolytica superdiffusion movement on fibronectin by reducing traction forces

Yuanning Guo, Jun Ye, Ariel Shemesh, Anas Odeh, Meirav Trebicz-Geffen, Haguy Wolfenson, Serge Ankri

PLOS Pathogens: published May 23, 2025 | https://doi.org/10.1371/journal.ppat.1012618

Transmitted/founder (T/F) HIV-1 derived from sexual contact exhibits greater transmission fitness in human cervical tissue than T/F HIV-1 from blood-to-blood contact: Unique glycan profiles on T/F envelopes associated with transmission phenotypes

Yiying Zhang, Katja Klein, Annette Ratcliff, Sashini Loku Galappaththi, Nicholas Hathaway, Nicholas Twells, Mukti Patel, Stephen Temesy, Jeffrey A. Bailey, Lara K. Mahal, Carole Creuzenet, Eric J. Arts

PLOS Pathogens: published May 23, 2025 | https://doi.org/10.1371/journal.ppat.1013177

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Stylet cuticular gene-directed mutagenesis impairs the pea aphid vector capacity to transmit a plant virus

Yu Fu, Maëlle Deshoux, Bastien Cayrol, Sophie Le Blaye, Emma Achard, Sylvie Hudaverdian, Romuald Cloteau, Elodie Pichon, Elian Strozyk, Nathalie Prunier-Leterme, Emmanuelle Jousselin, Nicolas Sauvion, Gaël Thébaud, Gaël Le Trionnaire, Stefano Colella, Marilyne Uzest

PLOS Pathogens: published May 23, 2025 | https://doi.org/10.1371/journal.ppat.1013192

The polyadenylase PAPI is required for virulence plasmid maintenance in pathogenic bacteria

Katherine Schubert, Jessica Zhang, Michele E. Muscolo, Micah Braly, Joshua W. McCausland, Hanh N. Lam, Karen Hug, Matthew Loven, Santiago Ruiz Solis, Melissa Estrada Escobar, Henry Moore, Derfel Terciano, Diana Fernandez Pacheco, Todd M. Lowe, Cammie F. Lesser, Christine Jacobs-Wagner, Helen Wang, Victoria Auerbuch

PLOS Pathogens: published May 27, 2025 | https://doi.org/10.1371/journal.ppat.1012655

Adaptive morphological changes link to poor clinical outcomes by conferring echinocandin tolerance in Candida tropicalis

Yongqin Wu, Yun Zou, Yuanyuan Dai, Huaiwei Lu, Wei Zhang, Wenjiao Chang, Ying Wang, Zhengchao Nie, Yuanyuan Wang, Xiaohua Jiang

PLOS Pathogens: published May 27, 2025 | https://doi.org/10.1371/journal.ppat.1013220

Long lived liver-resident memory T cells of biased specificities for abundant sporozoite antigens drive malaria protection by radiation-attenuated sporozoite vaccination

Maria N. de Menezes, Zhengyu Ge, Anton Cozijnsen, Stephanie Gras, Patrick Bertolino, Irina Caminschi, Mireille H. Lahoud, Katsuyuki Yui, Geoffrey I. McFadden, Lynette Beattie, William R. Heath, Daniel Fernandez-Ruiz

PLOS Pathogens: published May 27, 2025 | https://doi.org/10.1371/journal.ppat.1012731

TRIM14 restricts tembusu virus infection through degrading viral NS1 protein and activating type I interferon signaling

Peng Zhou, Qingxiang Zhang, Yueshan Yang, Dan Liu, Wanrong Wu, Anan Jongkaewwattana, Hui Jin, Hongbo Zhou, Rui Luo

PLOS Pathogens: published May 28, 2025 | https://doi.org/10.1371/journal.ppat.1013200

An insect symbiotic virus promotes the transmission of a phytoarbovirus via inhibiting E3 ubiquitin ligase Sina

Hui Wang, Jieting Zhang, Runfa Liu, You Li, Yu Du, Taiyun Wei

PLOS Pathogens: published May 29, 2025 | https://doi.org/10.1371/journal.ppat.1013178

Increased immunogen valency improves the maturation of vaccine-elicited HIV-1 VRC01-like antibodies

Parul Agrawal, Arineh Khechaduri, Kelsey R. Salladay, Anna MacCamy, Duncan K. Ralph, Andrew Riker, Andrew B. Stuart, Latha Kallur Siddaramaiah, Xiaoying Shen, Frederick A. Matsen, David Montefiori, Leonidas Stamatatos

PLOS Pathogens: published May 29, 2025 | https://doi.org/10.1371/journal.ppat.1013039

Mutations in the transcriptional regulator MAB_2885 confer tedizolid and linezolid resistance through the MmpS-MmpL efflux pump MAB_2302-MAB_2303 in Mycobacterium abscessus

Huiyun Zhang, Shiyong Wang, Yu Zhang, Wenya Hua, Siran Lin, Xinchang Chen, Tao Xu, Jiazhen Chen, Wenhong Zhang

PLOS Pathogens: published May 30, 2025 | https://doi.org/10.1371/journal.ppat.1013190

Genome-scale CRISPR screen identifies TMEM198 driving double membrane vesicle formation in swine alphacoronavirus and murine betacoronavirus infected cells

Lei Shi, Yu Zhang, Yueyue Duan, Maowen Sun, Cong Yuan, Liyan Cao, Xiangyu Kong, Wenlong Zhang, Haixue Zheng, Qi Wang

PLOS Pathogens: published May 30, 2025 | https://doi.org/10.1371/journal.ppat.1013211

Extracellular vesicles from diverse fungal pathogens induce species-specific and endocytosis-dependent immunomodulation

Geneva N. Kwaku, Kirstine Nolling Jensen, Patricia Simaku, Daniel J. Floyd, Joseph W. Saelens, Christopher M. Reardon, Rebecca A. Ward, Kyle J. Basham, Olivia W. Hepworth, Tammy D. Vyas, Daniel Zamith-Miranda, Joshua D. Nosanchuk, Jatin M. Vyas, Hannah Brown Harding

PLOS Pathogens: published May 30, 2025 | https://doi.org/10.1371/journal.ppat.1012879

Temporal gating of nuclear import: How Merkel cell polyomavirus exploits the cell cycle for nuclear entry

Karen Wang, Adrienne N. Eady, Isabel Amaya, Alina Stanczak, Chelsey C. Spriggs

PLOS Pathogens: published May 30, 2025 | https://doi.org/10.1371/journal.ppat.1013217

Correction: Generality of toxins in defensive symbiosis: Ribosome-inactivating proteins and defense against parasitic wasps in Drosophila

Matthew J. Ballinger, Steve J. Perlman

PLOS Pathogens: published May 20, 2025 | https://doi.org/10.1371/journal.ppat.1013193

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Herpes simplex virus type-1 infection and spread in a novel porcine corneal explant model is restricted to the epithelium

Sana Arshad, Hafsa Rana, Naomi R. Truong, Ushasree Pattamatta, Kirstie M. Bertram, Andrew White, Holly R. Chinnery, Nicole A. Carnt, Anthony L. Cunningham

PLOS Pathogens: published May 2, 2025 | https://doi.org/10.1371/journal.ppat.1013162