September 2024

Recent research has uncovered the important role of lipid droplets in pathogen replication. In the case of hepatitis C virus (HCV), lipid droplets (depicted here in yellow) are entangled in the viral replication organelle and support virus morphogenesis. In this context, it was unexpected that excessive expression of DGAT2 (magenta), which boosts lipid droplet accumulation, strongly impaired HCV replication. This study indicates that lipid fluxes between endoplasmic reticulum (ER) and lipid droplets affect the formation of HCV replication organelle. Reichert et al., 2024.

Image Credit: Isabelle Reichert

Pearls

Repurposing methuosis-inducing anticancer drugs for anthelmintic therapy

Satish Kumar Rajasekharan, Vinothkannan Ravichandran, Bharath Reddy Boya, Anirudh Jayachandran, Jintae Lee

PLOS Pathogens: published September 5, 2024 | https://doi.org/10.1371/journal.ppat.1012475

Unveiling the viroporin arsenal in plant viruses: Implications for the future

Guanwei Wu, Jianping Chen, Aiming Wang, Fei Yan

PLOS Pathogens: published September 5, 2024 | https://doi.org/10.1371/journal.ppat.1012473

New approaches to tackle a rising problem: Large-scale methods to study antifungal resistance

Philippe C. Després, Rebecca S. Shapiro, Christina A. Cuomo

PLOS Pathogens: published September 5, 2024 | https://doi.org/10.1371/journal.ppat.1012478

The unappreciated role of developing B cells in chronic gammaherpesvirus infections

Yiping Wang, April Feswick, Vasiliki Apostolou, Scott A. Tibbetts

PLOS Pathogens: published September 19, 2024 | https://doi.org/10.1371/journal.ppat.1012445

Transcription modulation of pathogenic streptococcal and enterococcal species using CRISPRi technology

Natalie G. Alexander, William D. Cutts, Thomas A. Hooven, Brandon J. Kim

PLOS Pathogens: published September 19, 2024 | https://doi.org/10.1371/journal.ppat.1012520

Exploring viral respiratory coinfections: Shedding light on pathogen interactions

Kylian Trepat, Aurélien Gibeaud, Sophie Trouillet-Assant, Olivier Terrier

PLOS Pathogens: published September 24, 2024 | https://doi.org/10.1371/journal.ppat.1012556

Fungal pathogens and symbionts: Living off the fat of the land

Olga A. Nev, Márcia David-Palma, Joseph Heitman, Alistair J. P. Brown, Marco A. Coelho

PLOS Pathogens: published September 26, 2024 | https://doi.org/10.1371/journal.ppat.1012551

Put a little doxy-PEP in your step: Using doxycycline to prevent chlamydia, syphilis, and gonorrhea infections

Eric A. Meyerowitz, Rina Liang, Derek Bishop, Caroline E. Mullis

PLOS Pathogens: published September 30, 2024 | https://doi.org/10.1371/journal.ppat.1012575

Reviews

Disease tolerance as immune defense strategy in bats: One size fits all?

Gang Pei, Anne Balkema-Buschmann, Anca Dorhoi

PLOS Pathogens: published September 5, 2024 | https://doi.org/10.1371/journal.ppat.1012471

Drivers of diversification in fungal pathogen populations

Daniel Murante, Deborah Ann Hogan

PLOS Pathogens: published September 12, 2024 | https://doi.org/10.1371/journal.ppat.1012430

Turning the needle into the haystack: Culture-independent amplification of complex microbial genomes directly from their native environment

Olivia A. Pilling, Sesh A. Sundararaman, Dustin Brisson, Daniel P. Beiting

PLOS Pathogens: published September 12, 2024 | https://doi.org/10.1371/journal.ppat.1012418

Understanding the significance of oxygen tension on the biology of Plasmodium falciparum blood stages: From the human body to the laboratory

Dinah S. Nahid, Kevin A. Coffey, Amy K. Bei, Regina Joice Cordy

PLOS Pathogens: published September 19, 2024 | https://doi.org/10.1371/journal.ppat.1012514

Research Articles

A nonhuman primate model for genital herpes simplex virus 2 infection that results in vaginal vesicular lesions, virus shedding, and seroconversion

Kening Wang, Tristan Jordan, Kennichi Dowdell, Richard Herbert, Ian N. Moore, David M. Koelle, Jeffrey I. Cohen

PLOS Pathogens: published September 3, 2024 | https://doi.org/10.1371/journal.ppat.1012477

The HIV-1 capsid serves as a nanoscale reaction vessel for reverse transcription

Jordan Jennings, Harrison Bracey, Jun Hong, Danny T. Nguyen, Rishav Dasgupta, Alondra Vázquez Rivera, Nicolas Sluis-Cremer, Jiong Shi, Christopher Aiken

PLOS Pathogens: published September 3, 2024 | https://doi.org/10.1371/journal.ppat.1011810

Norovirus-mediated translation repression promotes macrophage cell death

Turgut E. Aktepe, Joshua M. Deerain, Jennifer L. Hyde, Svenja Fritzlar, Eleanor M. Mead, Julio Carrera Montoya, Abderrahman Hachani, Jaclyn S. Pearson, Peter A. White, Jason M. Mackenzie

PLOS Pathogens: published September 3, 2024 | https://doi.org/10.1371/journal.ppat.1012480

Increased Susceptibility of WHIM Mice to Papillomavirus-induced Disease is Dependent upon Immune Cell Dysfunction

Wei Wang, Ali Pope, Ella Ward-Shaw, Darya Buehler, Francoise Bachelerie, Paul F. Lambert

PLOS Pathogens: published September 3, 2024 | https://doi.org/10.1371/journal.ppat.1012472

Genomic transfers help to decipher the ancient evolution of filoviruses and interactions with vertebrate hosts

Derek J. Taylor, Max H. Barnhart

PLOS Pathogens: published September 3, 2024 | https://doi.org/10.1371/journal.ppat.1011864

Phosphorylated vimentin-triggered fibronectin matrix disaggregation enhances the dissemination of Treponema pallidum subsp. pallidum across the microvascular endothelial barrier

Xi Luo, Litian Zhang, Xiaoyuan Xie, Liyan Yuan, Yanqiang Shi, Yinbo Jiang, Wujian Ke, Bin Yang

PLOS Pathogens: published September 3, 2024 | https://doi.org/10.1371/journal.ppat.1012483

Stenotrophomonas maltophilia uses a c-di-GMP module to sense the mammalian body temperature during infection

Yan Wang, Kai-Ming Wang, Xin Zhang, Wenzhao Wang, Wei Qian, Fang-Fang Wang

PLOS Pathogens: published September 4, 2024 | https://doi.org/10.1371/journal.ppat.1012533

Prior exposure to pathogens augments host heterogeneity in susceptibility and has key epidemiological consequences

Dana M. Hawley, Anna A. Pérez-Umphrey, James S. Adelman, Arietta E. Fleming-Davies, Jesse Garrett-Larsen, Steven J. Geary, Lauren M. Childs, Kate E. Langwig

PLOS Pathogens: published September 4, 2024 | https://doi.org/10.1371/journal.ppat.1012092

Dual-role epitope on SARS-CoV-2 spike enhances and neutralizes viral entry across different variants

Gang Ye, Fan Bu, Ruangang Pan, Alise Mendoza, Divyasha Saxena, Jian Zheng, Stanley Perlman, Bin Liu, Fang Li

PLOS Pathogens: published September 5, 2024 | https://doi.org/10.1371/journal.ppat.1012493

ATRX restricts Human Cytomegalovirus (HCMV) viral DNA replication through heterochromatinization and minimizes unpackaged viral genomes

Ryan M. Walter, Kinjal Majumder, Robert F. Kalejta

PLOS Pathogens: published September 5, 2024 | https://doi.org/10.1371/journal.ppat.1012516

Cyclic AMP is a global virulence regulator governing inter and intrabacterial signalling in Acinetobacter baumannii

Lyuboslava G. Harkova, Rubén de Dios, Alejandro Rubio-Valle, Antonio J. Pérez-Pulido, Ronan R. McCarthy

PLOS Pathogens: published September 6, 2024 | https://doi.org/10.1371/journal.ppat.1012529

The triglyceride-synthesizing enzyme diacylglycerol acyltransferase 2 modulates the formation of the hepatitis C virus replication organelle

Isabelle Reichert, Ji-Young Lee, Laura Weber, Marceline M. Fuh, Lina Schlaeger, Stefanie Rößler, Volker Kinast, Sarah Schlienkamp, Janina Conradi, Florian W. R. Vondran, Stephanie Pfaender, Pietro Scaturro, Eike Steinmann, Ralf Bartenschlager, Thomas Pietschmann, Joerg Heeren, Chris Lauber, Gabrielle Vieyres

PLOS Pathogens: published September 6, 2024 | https://doi.org/10.1371/journal.ppat.1012509

The role of bacterial size, shape and surface in macrophage engulfment of uropathogenic E. coli cells

Elizabeth Peterson, Bill Söderström, Nienke Prins, Giang H. B. Le, Lauren E. Hartley-Tassell, Chris Evenhuis, Rasmus Birkholm Grønnemose, Thomas Emil Andersen, Jakob Møller-Jensen, Gregory Iosifidis, Iain G. Duggin, Bernadette Saunders, Elizabeth J. Harry, Amy L. Bottomley

PLOS Pathogens: published September 6, 2024 | https://doi.org/10.1371/journal.ppat.1012458

Apicoplast-derived isoprenoids are essential for biosynthesis of GPI protein anchors, and consequently for egress and invasion in Plasmodium falciparum

Michaela S. Bulloch, Long K. Huynh, Kit Kennedy, Julie E. Ralton, Malcolm J. McConville, Stuart A. Ralph

PLOS Pathogens: published September 6, 2024 | https://doi.org/10.1371/journal.ppat.1012484

Immunization of cows with HIV envelope trimers generates broadly neutralizing antibodies to the V2-apex from the ultralong CDRH3 repertoire

Pilar X. Altman, Gabriel Ozorowski, Robyn L. Stanfield, Jeremy Haakenson, Michael Appel, Mara Parren, Wen-Hsin Lee, Huldah Sang, Jordan Woehl, Karen Saye-Francisco, Leigh M. Sewall, Collin Joyce, Ge Song, Katelyn Porter, Elise Landais, Raiees Andrabi, Ian A. Wilson, Andrew B. Ward, Waithaka Mwangi, Vaughn V. Smider, Dennis R. Burton, Devin Sok

PLOS Pathogens: published September 9, 2024 | https://doi.org/10.1371/journal.ppat.1012042

Oxaloacetate anaplerosis differently contributes to pathogenicity in plant pathogenic fungi Fusarium graminearum and F. oxysporum

Soobin Shin, Seonghun Bong, Heeji Moon, Hosung Jeon, Hun Kim, Gyung Ja Choi, Do Yup Lee, Hokyoung Son

PLOS Pathogens: published September 9, 2024 | https://doi.org/10.1371/journal.ppat.1012544

NLRP1-dependent activation of Gasdermin D in neutrophils controls cutaneous leishmaniasis

Michiel Goris, Katiuska Passelli, Sanam Peyvandi, Miriam Díaz-Varela, Oaklyne Billion, Borja Prat-Luri, Benjamin Demarco, Chantal Desponds, Manon Termote, Eva Iniguez, Somaditya Dey, Bernard Malissen, Shaden Kamhawi, Benjamin P. Hurrell, Petr Broz, Fabienne Tacchini-Cottier

PLOS Pathogens: published September 9, 2024 | https://doi.org/10.1371/journal.ppat.1012527

Multi-omics analysis of SIV-specific CD8⁺ T cells in multiple anatomical sites

Jennifer Simpson, Brittany Dulek, Paul Schaughency, Jason M. Brenchley

PLOS Pathogens: published September 9, 2024 | https://doi.org/10.1371/journal.ppat.1012545

Lactobacillus gasseri ATCC33323 affects the intestinal mucosal barrier to ameliorate DSS-induced colitis through the NR1I3-mediated regulation of E-cadherin

Guanru Qian, Hui Zang, Jingtong Tang, Hao Zhang, Jiankang Yu, Huibiao Jia, Xinzhuang Zhang, Jianping Zhou

PLOS Pathogens: published September 9, 2024 | https://doi.org/10.1371/journal.ppat.1012541

Evolutionary dynamics in gut-colonizing Candida glabrata during caspofungin therapy: Emergence of clinically important mutations in sphingolipid biosynthesis

Yasmine Hassoun, Ariel A. Aptekmann, Mikhail V. Keniya, Rosa Y. Gomez, Nicole Alayo, Giovanna Novi, Christopher Quinteros, Firat Kaya, Matthew Zimmerman, Diego H. Caceres, Nancy A. Chow, David S. Perlin, Erika Shor

PLOS Pathogens: published September 9, 2024 | https://doi.org/10.1371/journal.ppat.1012521

Trem2/Syk/PI3K axis contributes to the host protection against Toxoplasma gondii-induced adverse pregnancy outcomes via modulating decidual macrophages

Qing Wang, Yining Cao, Songyi Ye, Maoyuan Ding, Wenliang Ge, Yuejin Liang, Jinling Chen

PLOS Pathogens: published September 9, 2024 | https://doi.org/10.1371/journal.ppat.1012543

SDE19, a SEC-dependent effector from ‘Candidatus Liberibacter asiaticus’ suppresses plant immunity and targets Citrus sinensis Sec12 to interfere with vesicle trafficking

Guiyan Huang, Xiaopeng Chang, Yanan Hu, Fuxuan Li, Nian Wang, Ruimin Li

PLOS Pathogens: published September 10, 2024 | https://doi.org/10.1371/journal.ppat.1012542

Methylation of KSHV vCyclin by PRMT5 contributes to cell cycle progression and cell proliferation

Danping Niu, Yuanming Ma, Pengyu Ren, Sijia Chang, Chenhui Li, Yong Jiang, Chunyan Han, Ke Lan

PLOS Pathogens: published September 10, 2024 | https://doi.org/10.1371/journal.ppat.1012535

The molecular determinants of a universal prion acceptor

Hamza Arshad, Zeel Patel, Zaid A. M. Al-Azzawi, Genki Amano, Leyao Li, Surabhi Mehra, Shehab Eid, Gerold Schmitt-Ulms, Joel C. Watts

PLOS Pathogens: published September 10, 2024 | https://doi.org/10.1371/journal.ppat.1012538

Elasticity of the HIV-1 core facilitates nuclear entry and infection

Akshay Deshpande, Alexander J. Bryer, Jonathan R. Andino-Moncada, Jiong Shi, Jun Hong, Cameron Torres, Shimon Harel, Ashwanth C. Francis, Juan R. Perilla, Christopher Aiken, Itay Rousso

PLOS Pathogens: published September 11, 2024 | https://doi.org/10.1371/journal.ppat.1012537

A comprehensive study of SARS-CoV-2 main protease (M^pro) inhibitor-resistant mutants selected in a VSV-based system

Francesco Costacurta, Andrea Dodaro, David Bante, Helge Schöppe, Ju-Yi Peng, Bernhard Sprenger, Xi He, Seyed Arad Moghadasi, Lisa Maria Egger, Jakob Fleischmann, Matteo Pavan, Davide Bassani, Silvia Menin, Stefanie Rauch, Laura Krismer, Anna Sauerwein, Anne Heberle, Toni Rabensteiner, Joses Ho, Reuben S. Harris, Eduard Stefan, Rainer Schneider, Theresia Dunzendorfer-Matt, Andreas Naschberger, Dai Wang, Teresa Kaserer, Stefano Moro, Dorothee von Laer, Emmanuel Heilmann

PLOS Pathogens: published September 11, 2024 | https://doi.org/10.1371/journal.ppat.1012522

The unique Legionella longbeachae capsule favors intracellular replication and immune evasion

Silke Schmidt, Sonia Mondino, Laura Gomez-Valero, Pedro Escoll, Danielle P. A. Mascarenhas, Augusto Gonçalves, Pedro H. M. Camara, Francisco J. Garcia Rodriguez, Christophe Rusniok, Martin Sachse, Maryse Moya-Nilges, Thierry Fontaine, Dario S. Zamboni, Carmen Buchrieser

PLOS Pathogens: published September 11, 2024 | https://doi.org/10.1371/journal.ppat.1012534

Prion diseases disrupt glutamate/glutamine metabolism in skeletal muscle

Davide Caredio, Maruša Koderman, Karl J. Frontzek, Silvia Sorce, Mario Nuvolone, Juliane Bremer, Giovanni Mariutti, Petra Schwarz, Lidia Madrigal, Marija Mitrovic, Stefano Sellitto, Nathalie Streichenberger, Claudia Scheckel, Adriano Aguzzi

PLOS Pathogens: published September 11, 2024 | https://doi.org/10.1371/journal.ppat.1012552

Release of P-TEFb from the Super Elongation Complex promotes HIV-1 latency reversal

William J. Cisneros, Shimaa H. A. Soliman, Miriam Walter, Lacy M. Simons, Daphne Cornish, Simone De Fabritiis, Ariel W. Halle, Eun-Young Kim, Steven M. Wolinsky, Ramon Lorenzo-Redondo, Ali Shilatifard, Judd F. Hultquist

PLOS Pathogens: published September 11, 2024 | https://doi.org/10.1371/journal.ppat.1012083

NEDD4 family ubiquitin ligase AIP4 interacts with Alix to enable HBV naked capsid egress in an Alix ubiquitination-independent manner

Sheng Shen, Dawei Cai, Hongyan Liang, Ge Zeng, Wendong Liu, Ran Yan, Xiaoyang Yu, Hu Zhang, Shi Liu, Wanying Li, Rui Deng, Xingyu Lu, Yuanjie Liu, Jian Sun, Haitao Guo

PLOS Pathogens: published September 11, 2024 | https://doi.org/10.1371/journal.ppat.1012485

Glaesserella parasuis serotype 4 exploits fibronectin via RlpA for tracheal colonization following porcine circovirus type 2 infection

Mengru Guo, Yuhui Li, Jinsheng Tang, Qing Wang, Qiancheng Wang, Hong Zhou, Huixing Lin, Zhe Ma, Hongjie Fan

PLOS Pathogens: published September 12, 2024 | https://doi.org/10.1371/journal.ppat.1012513

α-Synuclein strain propagation is independent of cellular prion protein expression in a transgenic synucleinopathy mouse model

Raphaella W. L. So, Genki Amano, Erica Stuart, Aeen Ebrahim Amini, Adriano Aguzzi, Graham L. Collingridge, Joel C. Watts

PLOS Pathogens: published September 12, 2024 | https://doi.org/10.1371/journal.ppat.1012517

Repeat modules and N-linked glycans define structure and antigenicity of a critical enterotoxigenic E. coli adhesin

Zachary T. Berndsen, Marjahan Akhtar, Mahima Thapa, Tim J. Vickers, Aaron Schmitz, Jonathan L. Torres, Sabyasachi Baboo, Pardeep Kumar, Nazia Khatoon, Alaullah Sheikh, Melissa Hamrick, Jolene K. Diedrich, Salvador Martinez-Bartolome, Patrick T. Garrett, John R. Yates III, Jackson S. Turner, Renee M. Laird, Frédéric Poly, Chad K. Porter, Jeffrey Copps, Ali H. Ellebedy, Andrew B. Ward, James M. Fleckenstein

PLOS Pathogens: published September 16, 2024 | https://doi.org/10.1371/journal.ppat.1012241

Microglia and macrophages alterations in the CNS during acute SIV infection: A single-cell analysis in rhesus macaques

Xiaoke Xu, Meng Niu, Benjamin G. Lamberty, Katy Emanuel, Shawn Ramachandran, Andrew J. Trease, Mehnaz Tabassum, Jeffrey D. Lifson, Howard S. Fox

PLOS Pathogens: published September 16, 2024 | https://doi.org/10.1371/journal.ppat.1012168

Clostridium perfringens chitinases, key enzymes during early stages of necrotic enteritis in broiler chickens

Evelien Dierick, Chana Callens, Yehudi Bloch, Savvas N. Savvides, Sarah Hark, Stefan Pelzer, Richard Ducatelle, Filip Van Immerseel, Evy Goossens

PLOS Pathogens: published September 16, 2024 | https://doi.org/10.1371/journal.ppat.1012560

Generation of antigen-specific memory CD4 T cells by heterologous immunization enhances the magnitude of the germinal center response upon influenza infection

Linda M. Sircy, Andrew G. Ramstead, Lisa C. Gibbs, Hemant Joshi, Andrew Baessler, Ignacio Mena, Adolfo García-Sastre, Lyska L. Emerson, Keke C. Fairfax, Matthew A. Williams, J. Scott Hale

PLOS Pathogens: published September 16, 2024 | https://doi.org/10.1371/journal.ppat.1011639

Multifaceted activation of STING axis upon Nipah and measles virus-induced syncytia formation

Lucia Amurri, Claire Dumont, Rodolphe Pelissier, Olivier Reynard, Cyrille Mathieu, Julia Spanier, Bernadett Pályi, Daniel Déri, Ludovic Karkowski, Claudia Gonzalez, Jennifer Skerra, Zoltán Kis, Ulrich Kalinke, Branka Horvat, Mathieu Iampietro

PLOS Pathogens: published September 16, 2024 | https://doi.org/10.1371/journal.ppat.1012569

Peculiar transcriptional reprogramming with functional impairment of dendritic cells upon exposure to transformed HTLV-1-infected cells

Auriane Carcone, Franck Mortreux, Sandrine Alais, Cyrille Mathieu, Chloé Journo, Hélène Dutartre

PLOS Pathogens: published September 16, 2024 | https://doi.org/10.1371/journal.ppat.1012555

HIV-1 diversity in viral reservoirs obtained from circulating T-cell subsets during early ART and beyond

Yuepeng Zhang, Fabian Otte, Marcel Stoeckle, Alexander Thielen, Martin Däumer, Rolf Kaiser, Katharina Kusejko, Karin J. Metzner, Thomas Klimkait, and the Swiss HIV Cohort Study

PLOS Pathogens: published September 18, 2024 | https://doi.org/10.1371/journal.ppat.1012526

Isolation and characterization of IgG3 glycan-targeting antibodies with exceptional cross-reactivity for diverse viral families

Matthew J. Vukovich, Andrea R. Shiakolas, Jared Lindenberger, Robert A. Richardson, Lindsay E. Bass, Maggie Barr, Yanshun Liu, Eden P. Go, Chan Soo Park, Aaron J. May, Salam Sammour, Chipo Kambarami, Xiao Huang, Katarzyna Janowska, Robert J. Edwards, Katayoun Mansouri, Taylor N. Spence, Alexandra A. Abu-Shmais, Nelia P. Manamela, Simone I. Richardson, Sabina E. W. Leonard, Kathryn R. Gripenstraw, Ian Setliff, Kevin O. Saunders, Rachel H. Bonami, Ted M. Ross, Heather Desaire, Penny L. Moore, Robert Parks, Barton F. Haynes, Daniel J. Sheward, Priyamvada Acharya, Giuseppe A. Sautto, Ivelin S. Georgiev

PLOS Pathogens: published September 18, 2024 | https://doi.org/10.1371/journal.ppat.1012499

Mechanism of enterovirus VP0 maturation cleavage based on the structure of a stabilised assembly intermediate

Natalie J. Kingston, Joseph S. Snowden, Keith Grehan, Philippa K. Hall, Eero V. Hietanen, Tim C. Passchier, Stephen J. Polyak, David J. Filman, James M. Hogle, David J. Rowlands, Nicola J. Stonehouse

PLOS Pathogens: published September 19, 2024 | https://doi.org/10.1371/journal.ppat.1012511

Purified CDT toxins and a clean deletion within the CDT locus provide novel insights into the contribution of binary toxin in cellular inflammation and Clostridioides difficile infection

Kateryna Nabukhotna, Shannon L. Kordus, John A. Shupe, Rubén Cano Rodríguez, Anna Smith, Julia K. Bohannon, M. Kay Washington, D. Borden Lacy

PLOS Pathogens: published September 19, 2024 | https://doi.org/10.1371/journal.ppat.1012568

A chimeric mRNA vaccine of S-RBD with HA conferring broad protection against influenza and COVID-19 variants

Tianjiao Hao, Yulei Li, Peipei Liu, Xi Wang, Ke Xu, Wenwen Lei, Ying Li, Rong Zhang, Xiaoyan Li, Xin Zhao, Kun Xu, Xuancheng Lu, Yuhai Bi, Hao Song, Guizhen Wu, Baoli Zhu, George F. Gao

PLOS Pathogens: published September 20, 2024 | https://doi.org/10.1371/journal.ppat.1012508

Enhanced quantitation of pathological α-synuclein in patient biospecimens by RT-QuIC seed amplification assays

Ankit Srivastava, Qinlu Wang, Christina D. Orrù, Manel Fernandez, Yaroslau Compta, Bernardino Ghetti, Gianluigi Zanusso, Wen-Quan Zou, Byron Caughey, Catherine A. A. Beauchemin

PLOS Pathogens: published September 20, 2024 | https://doi.org/10.1371/journal.ppat.1012554

Lectins and polysaccharide EPS I have flow-responsive roles in the attachment and biofilm mechanics of plant pathogenic Ralstonia

Mariama D. Carter, Tuan M. Tran, Matthew L. Cope-Arguello, Sofia Weinstein, Hanlei Li, Connor G. Hendrich, Jessica L. Prom, Jiayu Li, Lan Thanh Chu, Loan Bui, Harishankar Manikantan, Tiffany M. Lowe-Power, Caitilyn Allen

PLOS Pathogens: published September 23, 2024 | https://doi.org/10.1371/journal.ppat.1012358

HIV reservoir and premature aging: risk factors for aging-associated illnesses in adolescents and young adults with perinatally acquired HIV

Maria Raffaella Petrara, Elena Ruffoni, Francesco Carmona, Ilaria Cavallari, Sandra Zampieri, Marzia Morello, Paola Del Bianco, Osvalda Rampon, Nicola Cotugno, Paolo Palma, Paolo Rossi, Carlo Giaquinto, Silvia Giunco, Anita De Rossi

PLOS Pathogens: published September 23, 2024 | https://doi.org/10.1371/journal.ppat.1012547

Application of optical tweezer technology reveals that PfEBA and PfRH ligands, not PfMSP1, play a central role in Plasmodium falciparum merozoite-erythrocyte attachment

Emma Kals, Morten Kals, Rebecca A. Lees, Viola Introini, Alison Kemp, Eleanor Silvester, Christine R. Collins, Trishant Umrekar, Jurij Kotar, Pietro Cicuta, Julian C. Rayner

PLOS Pathogens: published September 23, 2024 | https://doi.org/10.1371/journal.ppat.1012041

Regulatory insight for a Zn₂Cys₆ transcription factor controlling effector-mediated virulence in a fungal pathogen of wheat

Evan John, Callum Verdonk, Karam B. Singh, Richard P. Oliver, Leon Lenzo, Shota Morikawa, Jessica L. Soyer, Jordi Muria-Gonzalez, Daniel Soo, Carl Mousley, Silke Jacques, Kar-Chun Tan

PLOS Pathogens: published September 23, 2024 | https://doi.org/10.1371/journal.ppat.1012536

Exploring the metabolic profile of A. baumannii for antimicrobial development using genome-scale modeling

Nantia Leonidou, Yufan Xia, Lea Friedrich, Monika S. Schütz, Andreas Dräger

PLOS Pathogens: published September 23, 2024 | https://doi.org/10.1371/journal.ppat.1012528

Genomic epidemiology demonstrates spatially clustered, local transmission of Plasmodium falciparum in forest-going populations in southern Lao PDR

Ying-An Chen, Eric Neubauer Vickers, Andres Aranda-Diaz, Maxwell Murphy, Inna Gerlovina, Francois Rerolle, Emily Dantzer, Bouasy Hongvanthong, Hsiao-Han Chang, Andrew A. Lover, Nicholas J. Hathaway, Adam Bennett, Bryan Greenhouse

PLOS Pathogens: published September 23, 2024 | https://doi.org/10.1371/journal.ppat.1012194

The novel roles of RNA m⁶A modification in regulating the development, infection, and oxidative DNA damage repair of Phytophthora sojae

Fan Zhang, Borui Zhang, Tongshan Cui, Shanshan Chen, Can Zhang, Zhiwen Wang, Xili Liu

PLOS Pathogens: published September 23, 2024 | https://doi.org/10.1371/journal.ppat.1012553

Pseudorabies Virus UL4 protein promotes the ASC-dependent inflammasome activation and pyroptosis to exacerbate inflammation

Xiaohua Zhang, Guiyuan Chen, Junqing Yin, Lichen Nie, Linghao Li, Qian Du, Dewen Tong, Yong Huang

PLOS Pathogens: published September 24, 2024 | https://doi.org/10.1371/journal.ppat.1012546

Changes in cerebrospinal fluid proteins across the spectrum of untreated and treated chronic HIV-1 infection

Zicheng Hu, Paola Cinque, Ameet Dravid, Lars Hagberg, Aylin Yilmaz, Henrik Zetterberg, Dietmar Fuchs, Johanna Gostner, Kaj Blennow, Serena S. Spudich, Laura Kincer, Shuntai Zhou, Sarah Beth Joseph, Ronald Swanstrom, Richard W. Price, Magnus Gisslén

PLOS Pathogens: published September 24, 2024 | https://doi.org/10.1371/journal.ppat.1012470

Experimental genital tract infection demonstrates Neisseria gonorrhoeae MtrCDE efflux pump is not required for in vivo human infection and identifies gonococcal colonization bottleneck

Andreea Waltmann, Jacqueline T. Balthazar, Afrin A. Begum, Nancy Hua, Ann E. Jerse, William M. Shafer, Marcia M. Hobbs, Joseph A. Duncan

PLOS Pathogens: published September 25, 2024 | https://doi.org/10.1371/journal.ppat.1012578

Molecular mechanism and structure-guided humanization of a broadly neutralizing antibody against SFTSV

Pinyi Yang, Xiaoli Wu, Hang Shang, Zixian Sun, Zhiying Wang, Zidan Song, Hong Yuan, Fei Deng, Shu Shen, Yu Guo, Nan Zhang

PLOS Pathogens: published September 25, 2024 | https://doi.org/10.1371/journal.ppat.1012550

DNA methylation profiling identifies TBKBP1 as potent amplifier of cytotoxic activity in CMV-specific human CD8⁺ T cells

Zheng Yu, Varun Sasidharan-Nair, Thalea Buchta, Agnes Bonifacius, Fawad Khan, Beate Pietzsch, Hosein Ahmadi, Michael Beckstette, Jana Niemz, Philipp Hilgendorf, Philip Mausberg, Andreas Keller, Christine Falk, Dirk H. Busch, Kilian Schober, Luka Cicin-Sain, Fabian Müller, Melanie M. Brinkmann, Britta Eiz-Vesper, Stefan Floess, Jochen Huehn

PLOS Pathogens: published September 26, 2024 | https://doi.org/10.1371/journal.ppat.1012581

Combination of bortezomib and venetoclax targets the pro-survival function of LMP-1 and EBNA-3C of Epstein-Barr virus in spontaneous lymphoblastoid cell lines

Kam Pui Tam, Jia Xie, Rex Kwok Him Au-Yeung, Alan K. S. Chiang

PLOS Pathogens: published September 26, 2024 | https://doi.org/10.1371/journal.ppat.1012250

The I7L protein of African swine fever virus is involved in viral pathogenicity by antagonizing the IFN-γ-triggered JAK-STAT signaling pathway through inhibiting the phosphorylation of STAT1

Meilin Li, Xinyuan Liu, Dingkun Peng, Meng Yao, Tao Wang, Yijing Wang, Hongwei Cao, Yanjin Wang, Jingwen Dai, Rui Luo, Hao Deng, Jiaqi Li, Yuzi Luo, Yongfeng Li, Yuan Sun, Su Li, Hua-Ji Qiu, Lian-Feng Li

PLOS Pathogens: published September 26, 2024 | https://doi.org/10.1371/journal.ppat.1012576

Structure-guided in vitro evolution of nanobodies targeting new viral variants

Gang Ye, Fan Bu, Ruangang Pan, Alise Mendoza, Ge Yang, Benjamin Spiller, Brian E. Wadzinski, Lanying Du, Stanley Perlman, Bin Liu, Fang Li

PLOS Pathogens: published September 26, 2024 | https://doi.org/10.1371/journal.ppat.1012600

Development of Glycan-masked SARS-CoV-2 RBD vaccines against SARS-related coronaviruses

Zuxin Liang, Chunhui Li, Xiaohua Gong, Guoguo Ye, Yushan Jiang, Huiping Shi, Abid Hussain, Mengyuan Zhao, Mengjun Li, Yuxin Tian, Wei Zhao, Yang Yang, Yuanyu Huang, Chenguang Shen, Minghui Yang

PLOS Pathogens: published September 26, 2024 | https://doi.org/10.1371/journal.ppat.1012599

Altered hepatic metabolic landscape and insulin sensitivity in response to pulmonary tuberculosis

Mrinal K. Das, Ben Savidge, John E. Pearl, Thomas Yates, Gareth Miles, Manish Pareek, Pranabashis Haldar, Andrea M. Cooper

PLOS Pathogens: published September 27, 2024 | https://doi.org/10.1371/journal.ppat.1012565

RNA structures within Venezuelan equine encephalitis virus E1 alter macrophage replication fitness and contribute to viral emergence

Sarah E. Hickson, Jennifer L. Hyde

PLOS Pathogens: published September 27, 2024 | https://doi.org/10.1371/journal.ppat.1012179

Cellular dynamics shape recombination frequency in coronaviruses

Cassandra M. Bonavita, Heather L. Wells, Simon J. Anthony

PLOS Pathogens: published September 27, 2024 | https://doi.org/10.1371/journal.ppat.1012596

N⁴-Hydroxycytidine/molnupiravir inhibits RNA virus-induced encephalitis by producing less fit mutated viruses

Durbadal Ojha, Collin S. Hill, Shuntai Zhou, Alyssa Evans, Jacqueline M. Leung, Christine A. Schneider, Franck Amblard, Tyson A. Woods, Raymond F. Schinazi, Ralph S. Baric, Karin E. Peterson, Ronald Swanstrom

PLOS Pathogens: published September 30, 2024 | https://doi.org/10.1371/journal.ppat.1012574

TRIM56 restricts Coxsackievirus B infection by mediating the ubiquitination of viral RNA-dependent RNA polymerase 3D

Yao Wang, Yanyan Dong, Tian Luan, Yang Chen, Lexun Lin, Siwei Li, Danxiang Feng, Jianwei Wei, Yanru Fei, Guangtian Wang, Jiahui Pan, Yan Wang, Zhaohua Zhong, Wenran Zhao

PLOS Pathogens: published September 30, 2024 | https://doi.org/10.1371/journal.ppat.1012594

Phytophthora zoospores display klinokinetic behaviour in response to a chemoattractant

Michiel Kasteel, Tharun P. Rajamuthu, Joris Sprakel, Tijs Ketelaar, Francine Govers

PLOS Pathogens: published September 30, 2024 | https://doi.org/10.1371/journal.ppat.1012577

Rhesus rotavirus NSP1 mediates extra-intestinal infection and is a contributing factor for biliary obstruction

Enkai Li, Ningguo Feng, Qiru Zeng, Liliana Sanchez-Tacuba, Takahiro Kawagishi, Grace Branham, Gaopeng Hou, Zemin Wang, Harry B. Greenberg, Siyuan Ding

PLOS Pathogens: published September 30, 2024 | https://doi.org/10.1371/journal.ppat.1012609

ATM1, an essential conserved transporter in Apicomplexa, bridges mitochondrial and cytosolic [Fe-S] biogenesis

Deepti Shrivastava, Ernest Abboud, Jadhav Prasad Ramchandra, Akanksha Jha, Jean-Baptiste Marq, Animesh Chaurasia, Kalyan Mitra, Mohammad Sadik, Mohammad Imran Siddiqi, Dominique Soldati-Favre, Joachim Kloehn, Saman Habib

PLOS Pathogens: published September 30, 2024 | https://doi.org/10.1371/journal.ppat.1012593

Pathogen contingency loci and the evolution of host specificity: Simple sequence repeats mediate Bartonella adaptation to a wild rodent host

Ruth Rodríguez-Pastor, Nadav Knossow, Naama Shahar, Adam Z. Hasik, Daniel E. Deatherage, Ricardo Gutiérrez, Shimon Harrus, Luis Zaman, Richard E. Lenski, Jeffrey E. Barrick, Hadas Hawlena

PLOS Pathogens: published September 30, 2024 | https://doi.org/10.1371/journal.ppat.1012591

Novel multiphoton intravital imaging enables real-time study of Helicobacter pylori interaction with neutrophils and macrophages in the mouse stomach

Hellen Ishikawa-Ankerhold, Benjamin Busch, Almke Bader, Daniela Maier-Begandt, Flavio Dionisio, Sukumar Namineni, Mykhailo Vladymyrov, Ute Harrison, Dominic van den Heuvel, Lukas Tomas, Barbara Walzog, Steffen Massberg, Christian Schulz, Rainer Haas

PLOS Pathogens: published September 30, 2024 | https://doi.org/10.1371/journal.ppat.1012580

Short Reports

The DNA loop release factor WAPL suppresses Epstein-Barr virus latent membrane protein expression to maintain the highly restricted latency I program

Laura A. Murray-Nerger, Davide Maestri, Xiang Liu, Zhixuan Li, Nina R. Auld, Italo Tempera, Mingxiang Teng, Benjamin E. Gewurz

PLOS Pathogens: published September 6, 2024 | https://doi.org/10.1371/journal.ppat.1012525

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DGAT2 modulates the hepatitis C virus replication organelle.

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