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PLoS Pathogens Issue Image | Vol. 15(12) January 2020

PLoS Pathogens Issue Image | Vol. 15(12) January 2020

PLOS
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A prion-inhibition Nanobody, Nb484, does not induce neurotoxicity in organotypic cultured slice

Anti-PrP monoclonal antibody POM1, which binds to a discontinuous epitope of the C-terminal globular domain of mouse PrP, induces strong neurotoxicity in mice and cerebellar organotypic cultured slices. A cultured cerebellar organotypic cultured slice from tga20 transgenic mice remains healthy after being treated with Nb484, a Nanobody that inhibits prion propagation through binding to both the hydrophobic region and C-terminal domain of PrP, which highlights the great therapeutic potential of Nb484. Abskharon et al.

Image Credit: J Ruan, and R Abskharon (2019)

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A prion-inhibition Nanobody, Nb484, does not induce neurotoxicity in organotypic cultured slice

Anti-PrP monoclonal antibody POM1, which binds to a discontinuous epitope of the C-terminal globular domain of mouse PrP, induces strong neurotoxicity in mice and cerebellar organotypic cultured slices. A cultured cerebellar organotypic cultured slice from tga20 transgenic mice remains healthy after being treated with Nb484, a Nanobody that inhibits prion propagation through binding to both the hydrophobic region and C-terminal domain of PrP, which highlights the great therapeutic potential of Nb484. Abskharon et al.

Image Credit: J Ruan, and R Abskharon (2019)

https://doi.org/10.1371/image.ppat.v15.i12.g001