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PLoS Pathogens Issue Image | Vol. 15(8) August 2019

PLoS Pathogens Issue Image | Vol. 15(8) August 2019

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Macropinocytic entry of human respiratory syncytial virus (RSV) depends on cell signaling initiated by the cell surface ATP1A1 protein.

RSV infection (RSV fusion protein in red) induces clustering of the transmembrane cellular ATP1A1 protein (green, alpha-1 subunit of the Na+, K+-ATPase complex) on the apical surface of differentiated mucociliary human airway epithelial cells (nuclei in blue and F-actin in cyan). ATP1A1 initiates signaling that results in the macropinocytic uptake of RSV. The three-dimensional image was reconstructed from images of immunostained cells obtained by confocal microscopy (colors were modified for this illustration). Lingemann et al.

Image Credit: Matthias Lingemann (2019).

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Macropinocytic entry of human respiratory syncytial virus (RSV) depends on cell signaling initiated by the cell surface ATP1A1 protein.

RSV infection (RSV fusion protein in red) induces clustering of the transmembrane cellular ATP1A1 protein (green, alpha-1 subunit of the Na+, K+-ATPase complex) on the apical surface of differentiated mucociliary human airway epithelial cells (nuclei in blue and F-actin in cyan). ATP1A1 initiates signaling that results in the macropinocytic uptake of RSV. The three-dimensional image was reconstructed from images of immunostained cells obtained by confocal microscopy (colors were modified for this illustration). Lingemann et al.

Image Credit: Matthias Lingemann (2019).

https://doi.org/10.1371/image.ppat.v15.i08.g001