Figures
Transmission phenotype of Mycobacterium tuberculosis strains is mechanistically linked to induction of distinct pulmonary pathology
Fig 5. Intracellular acid-fast bacteria within discrete granulomas in Mtb-HT infected mice.
In contrast to the diffuse lung pathology present in Mtb-LT infected mice, granulomas in Mtb-HT infected mice are compact aggregates of macrophages with few intracellular bacteria surrounded by lymphocytes. A fraction of these compact lesions expand and develop necrotic "caseous" centers in Mtb-HT infected mice which erode into the walls of adjacent intact airways, allowing high rates of transmission. Verma et al.
Image Credit: Durbin, J., Verma S. and Salgame, P. (2019)
Citation: (2019) PLoS Pathogens Issue Image | Vol. 15(3) March 2019. PLoS Pathog 15(3): ev15.i03. https://doi.org/10.1371/image.ppat.v15.i03
Published: March 31, 2019
Copyright: © 2019 Durbin, Verma and Salgame. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Fig 5. Intracellular acid-fast bacteria within discrete granulomas in Mtb-HT infected mice.
In contrast to the diffuse lung pathology present in Mtb-LT infected mice, granulomas in Mtb-HT infected mice are compact aggregates of macrophages with few intracellular bacteria surrounded by lymphocytes. A fraction of these compact lesions expand and develop necrotic "caseous" centers in Mtb-HT infected mice which erode into the walls of adjacent intact airways, allowing high rates of transmission. Verma et al.
Image Credit: Durbin, J., Verma S. and Salgame, P. (2019)