Figures
Newly forming HIV virions embedded in the leading edge of dynamic filopodia.
HIV infection of dendritic cells and other cells of myeloid lineage provides a potent reservoir from which HIV can later seed CD4 T cells. In dissecting the mechanisms of viral transfer from HIV-infected dendritic cells to CD4 T cells, a dynamic structure consisting of newly formed HIV virions being launched by probing filopodia was observed (see Aggarwal et al., doi:10.1371/journal.ppat.1002762). HIV incorporation into the tips of dendritic cell filopodia is observed in the image, with HIV particles in white and filopodial networks in red visualised by F-actin staining. Nuclear staining by DAPI is presented in blue.
Image Credit: Anupriya Aggarwal and Stuart Turville, Kirby Institute, University of New South Wales
Citation: (2012) PLoS Pathogens Issue Image | Vol. 8(6) June 2012. PLoS Pathog 8(6): ev08.i06. https://doi.org/10.1371/image.ppat.v08.i06
Published: June 28, 2012
Copyright: © 2012 Aggarwal and Turville. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
HIV infection of dendritic cells and other cells of myeloid lineage provides a potent reservoir from which HIV can later seed CD4 T cells. In dissecting the mechanisms of viral transfer from HIV-infected dendritic cells to CD4 T cells, a dynamic structure consisting of newly formed HIV virions being launched by probing filopodia was observed (see Aggarwal et al., doi:10.1371/journal.ppat.1002762). HIV incorporation into the tips of dendritic cell filopodia is observed in the image, with HIV particles in white and filopodial networks in red visualised by F-actin staining. Nuclear staining by DAPI is presented in blue.
Image Credit: Anupriya Aggarwal and Stuart Turville, Kirby Institute, University of New South Wales