HIV infects astrocytes in vivo and egresses from the brain to the periphery

Victoria Lutgen; Srinivas D. Narasipura; Hannah J. Barbian; Maureen Richards; Jennillee Wallace; Roshanak Razmpour; Tetyana Buzhdygan; Servio H. Ramirez; Lisa Prevedel; Eliseo A. Eugenin; Lena Al-Harthi

doi:10.1371/journal.ppat.1008381

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Open Access

Peer-reviewed

Research Article

HIV infects astrocytes in vivo and egresses from the brain to the periphery

Victoria Lutgen,

Roles Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliation Department of Microbial Pathogens and Immunity, Rush University Medical Center, Chicago, Illinois, United States of America
⨯
Srinivas D. Narasipura,

Roles Data curation, Formal analysis, Investigation, Methodology, Project administration, Writing – review & editing

Affiliation Department of Microbial Pathogens and Immunity, Rush University Medical Center, Chicago, Illinois, United States of America
⨯
Hannah J. Barbian,

Roles Data curation, Investigation, Methodology, Writing – review & editing

Affiliation Department of Microbial Pathogens and Immunity, Rush University Medical Center, Chicago, Illinois, United States of America
⨯
Maureen Richards,

Roles Writing – review & editing

Affiliation Department of Microbial Pathogens and Immunity, Rush University Medical Center, Chicago, Illinois, United States of America
⨯
Jennillee Wallace,

Roles Formal analysis, Investigation, Writing – review & editing

Affiliation Department of Microbial Pathogens and Immunity, Rush University Medical Center, Chicago, Illinois, United States of America
⨯
Roshanak Razmpour,

Roles Data curation, Investigation

Affiliation Department of Pathology and Laboratory Medicine, The Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, United States of America
⨯
Tetyana Buzhdygan,

Roles Data curation, Investigation

Affiliation Department of Pathology and Laboratory Medicine, The Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, United States of America
⨯
Servio H. Ramirez,

Roles Formal analysis, Funding acquisition, Supervision, Writing – review & editing

Affiliation Department of Pathology and Laboratory Medicine, The Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, United States of America
⨯
Lisa Prevedel,

Roles Data curation, Investigation

Affiliation Department of Neuroscience, Cell Biology and Anatomy, The University of Texas Medical Branch, Galveston, Texas, United States of America
⨯
Eliseo A. Eugenin,

Roles Formal analysis, Supervision, Writing – review & editing

Affiliation Department of Neuroscience, Cell Biology and Anatomy, The University of Texas Medical Branch, Galveston, Texas, United States of America
⨯
Lena Al-Harthi

Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

* E-mail: Lena_Al-Harthi@rush.edu

Affiliation Department of Microbial Pathogens and Immunity, Rush University Medical Center, Chicago, Illinois, United States of America

http://orcid.org/0000-0003-3915-3904

⨯

HIV infects astrocytes in vivo and egresses from the brain to the periphery

Victoria Lutgen,
Srinivas D. Narasipura,
Hannah J. Barbian,
Maureen Richards,
Jennillee Wallace,
Roshanak Razmpour,
Tetyana Buzhdygan,
Servio H. Ramirez,
Lisa Prevedel,
Eliseo A. Eugenin

Published: June 11, 2020
https://doi.org/10.1371/journal.ppat.1008381

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HIV
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Astrocytes
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HIV infections
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Brain
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Polymerase chain reaction
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Central nervous system
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T cells
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Spleen
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