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Open Access
Peer-reviewed
Research Article
Structural evidence for the critical role of the prion protein hydrophobic region in forming an infectious prion
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Romany Abskharon,
Roles Data curation, Formal analysis, Investigation, Writing – original draft, Writing – review & editing
Affiliations Structural Biology Brussels, Vrije Universiteit Brussel (VUB), Brussels, Belgium, VIB-VUB Center for Structural Biology, Vlaams Instituut Biotechnologie (VIB), Brussels, Belgium, Center for Neurodegenerative Science, Van Andel Institute, Grand Rapids, Michigan, United States of America, National Institute of Oceanography and Fisheries (NIOF), Cairo, Egypt
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Fei Wang ,
Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Supervision, Validation, Writing – original draft, Writing – review & editing
* E-mail: Fei.Wang.1@uth.tmc.edu (FW); jiyan.ma@vai.org (JM); jan.steyaert@vub.ac.be (JS)
Current address: Mitchell Center for Alzheimer’s Disease and Related Brain Disorders, Department of Neurology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, Texas, United States of America
Affiliation Center for Neurodegenerative Science, Van Andel Institute, Grand Rapids, Michigan, United States of America
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Alexandre Wohlkonig,
Roles Data curation, Formal analysis
Affiliations Structural Biology Brussels, Vrije Universiteit Brussel (VUB), Brussels, Belgium, VIB-VUB Center for Structural Biology, Vlaams Instituut Biotechnologie (VIB), Brussels, Belgium
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Juxin Ruan,
Roles Data curation, Formal analysis, Investigation
Affiliation Center for Neurodegenerative Science, Van Andel Institute, Grand Rapids, Michigan, United States of America
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Sameh Soror,
Roles Data curation, Formal analysis
Affiliations Structural Biology Brussels, Vrije Universiteit Brussel (VUB), Brussels, Belgium, VIB-VUB Center for Structural Biology, Vlaams Instituut Biotechnologie (VIB), Brussels, Belgium, Center of Excellence, Helwan Structural Biology Research, Faculty of Pharmacy, Helwan University, Cairo, Egypt
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Gabriele Giachin,
Roles Formal analysis
Affiliation Structural Biology Group, European Synchrotron Radiation Facility, Grenoble, France
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Els Pardon,
Roles Investigation
Affiliations Structural Biology Brussels, Vrije Universiteit Brussel (VUB), Brussels, Belgium, VIB-VUB Center for Structural Biology, Vlaams Instituut Biotechnologie (VIB), Brussels, Belgium
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Wenquan Zou,
Roles Formal analysis
Affiliation Departments of Pathology and Neurology, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America
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Giuseppe Legname,
Roles Formal analysis
Affiliation Laboratory of Prion Biology, Department of Neuroscience, Scuola Internazionale Superiore di Studi Avanzati (SISSA), Trieste, Italy
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Jiyan Ma ,
Roles Conceptualization, Formal analysis, Funding acquisition, Writing – review & editing
* E-mail: Fei.Wang.1@uth.tmc.edu (FW); jiyan.ma@vai.org (JM); jan.steyaert@vub.ac.be (JS)
Affiliation Center for Neurodegenerative Science, Van Andel Institute, Grand Rapids, Michigan, United States of America
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Jan Steyaert
Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Supervision, Writing – review & editing
* E-mail: Fei.Wang.1@uth.tmc.edu (FW); jiyan.ma@vai.org (JM); jan.steyaert@vub.ac.be (JS)
Affiliations Structural Biology Brussels, Vrije Universiteit Brussel (VUB), Brussels, Belgium, VIB-VUB Center for Structural Biology, Vlaams Instituut Biotechnologie (VIB), Brussels, Belgium
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Structural evidence for the critical role of the prion protein hydrophobic region in forming an infectious prion
- Romany Abskharon,
- Fei Wang,
- Alexandre Wohlkonig,
- Juxin Ruan,
- Sameh Soror,
- Gabriele Giachin,
- Els Pardon,
- Wenquan Zou,
- Giuseppe Legname,
- Jiyan Ma
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- Published: December 9, 2019
- https://doi.org/10.1371/journal.ppat.1008139