%PDF-1.6
%
1 0 obj
<>
endobj
2 0 obj
<>stream
Amit Kumar, Claire E. P. Smith, Elena E. Giorgi, Joshua Eudailey, David R. Martinez, Karina Yusim, Ayooluwa O. Douglas, Lisa Stamper, Erin McGuire, Celia C. LaBranche, David C. Montefiori, Genevieve G. Fouda, Feng Gao, Sallie R. Permar
Infant transmitted/founder HIV-1 viruses from peripartum transmission are neutralization resistant to paired maternal plasma
www.plospathogens.org
www.plospathogens.org
endstream
endobj
3 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 12 0 R/Annots 13 0 R/Contents 14 0 R/TrimBox[0 0 612 792]>>
endobj
13 0 obj
[15 0 R 16 0 R 17 0 R 18 0 R 19 0 R 20 0 R 21 0 R 22 0 R 23 0 R 24 0 R 25 0 R 26 0 R 27 0 R 28 0 R 29 0 R 30 0 R]
endobj
15 0 obj
<>/Border[0 0 0]/Dest(Rppat.1006944.ref001)>>
endobj
16 0 obj
<>/Border[0 0 0]/Dest(Rppat.1006944.ref002)>>
endobj
17 0 obj
<>/Border[0 0 0]/Dest(Rppat.1006944.ref003)>>
endobj
18 0 obj
<>/Border[0 0 0]/Dest(Rppat.1006944.ref004)>>
endobj
19 0 obj
<>/Border[0 0 0]/Dest(Rppat.1006944.ref005)>>
endobj
20 0 obj
<>/Border[0 0 0]/Dest(Rppat.1006944.ref007)>>
endobj
21 0 obj
<>/Border[0 0 0]/Dest(Rppat.1006944.ref008)>>
endobj
22 0 obj
<>/Border[0 0 0]/Dest(Rppat.1006944.ref010)>>
endobj
23 0 obj
<>/Border[0 0 0]/Dest(Rppat.1006944.ref011)>>
endobj
24 0 obj
<>/Border[0 0 0]/Dest(Rppat.1006944.ref015)>>
endobj
25 0 obj
<>/Border[0 0 0]/Dest(Rppat.1006944.ref016)>>
endobj
26 0 obj
<>/Border[0 0 0]/Dest(Rppat.1006944.ref017)>>
endobj
27 0 obj
<>/Border[0 0 0]/Dest(Rppat.1006944.ref019)>>
endobj
28 0 obj
<>/Border[0 0 0]/Dest(Rppat.1006944.ref020)>>
endobj
29 0 obj
<>/Border[0 0 0]/Dest(Rppat.1006944.ref021)>>
endobj
30 0 obj
<>/Border[0 0 0]/A 31 0 R>>
endobj
31 0 obj
<>
endobj
14 0 obj
[32 0 R 33 0 R 34 0 R 35 0 R 36 0 R 37 0 R 38 0 R 39 0 R 40 0 R 41 0 R 42 0 R 43 0 R 44 0 R 45 0 R 46 0 R 47 0 R 48 0 R]
endobj
32 0 obj
<>stream
q
0.955 g
0 w
199.9998 713.9999 m
575.9997 713.9999 l
575.9997 423.0006 l
199.9998 423.0006 l
f*
0.83 0.64 0.02 0 k
282.2173 341.915 m
286.9228 341.915 l
h
f*
393.789 328.9323 m
398.5512 328.9323 l
h
f*
403.0299 328.9323 m
407.7921 328.9323 l
h
f*
283.011 250.9228 m
287.7732 250.9228 l
h
f*
440.1638 211.9181 m
444.926 211.9181 l
h
f*
450.1417 211.9181 m
454.8472 211.9181 l
h
f*
391.011 172.9134 m
395.7732 172.9134 l
h
f*
400.9323 172.9134 m
410.4567 172.9134 l
h
f*
286.9228 159.9307 m
296.4472 159.9307 l
h
f*
301.6063 159.9307 m
311.1307 159.9307 l
h
f*
445.0394 146.948 m
454.5638 146.948 l
h
f*
349.115 133.9087 m
358.6394 133.9087 l
h
f*
363.7984 133.9087 m
373.3228 133.9087 l
h
f*
510.5197 94.9039 m
520.0441 94.9039 l
h
f*
524.4661 94.9039 m
533.9906 94.9039 l
h
f*
0 g
1 j
1 J
11.9999 0 0 11.9999 209.9905 696.0188 cm
BT
/F0 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Author)Tj
3.137 0 Td
(summary)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 209.9905 677.9905 cm
BT
/F7 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Mother)Tj
3.2428 0 Td
(to)Tj
1.0261 0 Td
(child)Tj
2.211 0 Td
(transmission)Tj
5.3631 0 Td
(\(MTCT\))Tj
3.6794 0 Td
(of)Tj
1.0148 0 Td
(HIV-1)Tj
2.8459 0 Td
(can)Tj
1.6271 0 Td
(occur)Tj
2.4718 0 Td
(during)Tj
2.931 0 Td
(pregnancy)Tj
4.405 0 Td
(\()Tj
/F11 1 Tf
[()12()]TJ
1.355 0 Td
[()14()11()2()20()]TJ
/F7 1 Tf
(\),)Tj
2.8289 0 Td
(at)Tj
-35.0019 -1.2982 Td
(the)Tj
1.4683 0 Td
(time)Tj
2.0296 0 Td
(of)Tj
1.0148 0 Td
(delivery)Tj
3.3902 0 Td
(\(peripartum\))Tj
5.4481 0 Td
(or)Tj
1.0999 0 Td
(by)Tj
1.1792 0 Td
(breastfeeding)Tj
5.5615 0 Td
(\(postpartum\).)Tj
5.777 0 Td
(With)Tj
2.279 0 Td
(the)Tj
1.4684 0 Td
(availability)Tj
-30.716 -1.2983 Td
(of)Tj
1.0147 0 Td
(anti-retroviral)Tj
5.8621 0 Td
(therapy)Tj
3.2484 0 Td
(\(ART\),)Tj
3.0444 0 Td
(rate)Tj
1.7462 0 Td
(of)Tj
1.0148 0 Td
(MTCT)Tj
2.999 0 Td
(of)Tj
1.0148 0 Td
(HIV-1)Tj
2.846 0 Td
(have)Tj
2.0636 0 Td
(been)Tj
2.1203 0 Td
(significantly)Tj
5.091 0 Td
(lowered.)Tj
-32.0653 -1.3039 Td
(However,)Tj
4.0761 0 Td
(significant)Tj
4.388 0 Td
(implementation)Tj
6.6387 0 Td
(challenges)Tj
4.32 0 Td
(remain)Tj
3.0841 0 Td
(in)Tj
1.0375 0 Td
(resource-poor)Tj
5.879 0 Td
(areas,)Tj
2.4718 0 Td
(making)Tj
3.2485 0 Td
(it)Tj
-35.1437 -1.2983 Td
(difficult)Tj
3.3561 0 Td
(to)Tj
1.0262 0 Td
(eliminate)Tj
3.9458 0 Td
(pediatric)Tj
3.7474 0 Td
(HIV.)Tj
2.2507 0 Td
(An)Tj
1.4513 0 Td
(improved)Tj
4.1102 0 Td
(understanding)Tj
6.0661 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.474 0 Td
(viral)Tj
1.9899 0 Td
(population)Tj
-30.4325 -1.2982 Td
(\(escape)Tj
3.1464 0 Td
(variants)Tj
3.3845 0 Td
(from)Tj
2.2054 0 Td
(autologous)Tj
4.6034 0 Td
(neutralizing)Tj
5.0286 0 Td
(antibodies\))Tj
4.7055 0 Td
(that)Tj
1.7745 0 Td
(lead)Tj
1.8538 0 Td
(to)Tj
1.0262 0 Td
(infection)Tj
3.787 0 Td
(of)Tj
1.0148 0 Td
(infants)Tj
-32.5301 -1.3039 Td
(at)Tj
0.9524 0 Td
(time)Tj
2.0296 0 Td
(of)Tj
1.0148 0 Td
(transmission)Tj
5.3631 0 Td
(will)Tj
1.6668 0 Td
(help)Tj
1.9332 0 Td
(in)Tj
1.0374 0 Td
(designing)Tj
4.0932 0 Td
(immune)Tj
3.6227 0 Td
(interventions)Tj
5.5389 0 Td
(to)Tj
1.0261 0 Td
(reduce)Tj
2.9197 0 Td
(perinatal)Tj
-31.1979 -1.2983 Td
(HIV-1)Tj
2.8516 0 Td
(transmission.)Tj
5.5899 0 Td
(Here,)Tj
2.4264 0 Td
(we)Tj
1.3323 0 Td
(selected)Tj
3.3448 0 Td
(16)Tj
1.1736 0 Td
(HIV-1-infected)Tj
6.3949 0 Td
(mother-infant)Tj
5.9074 0 Td
(pairs)Tj
2.1656 0 Td
(from)Tj
2.2054 0 Td
(WITS)Tj
-33.3919 -1.2983 Td
(cohort)Tj
2.8573 0 Td
(\(from)Tj
2.5455 0 Td
(pre)Tj
1.5306 0 Td
(anti-retroviral)Tj
5.8621 0 Td
(era\),)Tj
2.0182 0 Td
(where)Tj
2.6476 0 Td
(infants)Tj
2.965 0 Td
(became)Tj
3.2541 0 Td
(infected)Tj
3.4186 0 Td
(peripartum.)Tj
4.9946 0 Td
(HIV-1)Tj
/F11 1 Tf
-32.0936 -1.3039 Td
[()2()24()]TJ
/F7 1 Tf
1.576 0 Td
(gene)Tj
2.0806 0 Td
(sequences)Tj
4.2179 0 Td
(were)Tj
2.1203 0 Td
(obtained)Tj
3.7361 0 Td
(by)Tj
1.1792 0 Td
(the)Tj
1.474 0 Td
(single)Tj
2.5285 0 Td
(genome)Tj
3.4072 0 Td
(amplification)Tj
5.5389 0 Td
(\(SGA\))Tj
2.7722 0 Td
(method.)Tj
3.549 0 Td
(The)Tj
-34.1799 -1.2983 Td
(sensitivity)Tj
4.2235 0 Td
(of)Tj
1.0148 0 Td
(these)Tj
2.2507 0 Td
(infant)Tj
2.6079 0 Td
(Env)Tj
1.7915 0 Td
(pseudoviruses)Tj
5.8507 0 Td
(against)Tj
3.0273 0 Td
(paired)Tj
2.761 0 Td
(maternal)Tj
3.7984 0 Td
(plasma)Tj
3.0273 0 Td
(and)Tj
1.7348 0 Td
(a)Tj
0.652 0 Td
(panel)Tj
-32.7399 -1.2982 Td
(of)Tj
1.0147 0 Td
(broadly)Tj
3.2712 0 Td
(neutralizing)Tj
5.0286 0 Td
(monoclonal)Tj
5.006 0 Td
(antibodies)Tj
4.3596 0 Td
(\(bNAbs\))Tj
3.6964 0 Td
(was)Tj
1.7008 0 Td
(analyzed.)Tj
3.9288 0 Td
(We)Tj
1.61 0 Td
(demonstrated)Tj
-29.6161 -1.2983 Td
(that)Tj
1.7801 0 Td
(the)Tj
1.4683 0 Td
(infant)Tj
2.6079 0 Td
(T/F)Tj
1.6838 0 Td
(viruses)Tj
2.9877 0 Td
(were)Tj
2.1203 0 Td
(more)Tj
2.3414 0 Td
(resistant)Tj
3.5886 0 Td
(against)Tj
3.0274 0 Td
(maternal)Tj
3.7927 0 Td
(plasma)Tj
3.0331 0 Td
(than)Tj
2.0296 0 Td
(non-trans-)Tj
-30.4609 -1.3039 Td
(mitted)Tj
2.8573 0 Td
(maternal)Tj
3.7927 0 Td
(variants,)Tj
3.617 0 Td
(but)Tj
1.5533 0 Td
(sensitive)Tj
3.6227 0 Td
(to)Tj
1.0261 0 Td
(most)Tj
2.2054 0 Td
(\(bNAbs\).)Tj
3.9231 0 Td
(Signature)Tj
4.0308 0 Td
(sequence)Tj
3.8551 0 Td
(analysis)Tj
3.3279 0 Td
(of)Tj
-33.8114 -1.2983 Td
(infant)Tj
2.6078 0 Td
(T/F)Tj
1.6838 0 Td
(and)Tj
1.7348 0 Td
(non-transmitted)Tj
6.8201 0 Td
(maternal)Tj
3.7984 0 Td
(variants)Tj
3.3845 0 Td
(revealed)Tj
3.5263 0 Td
(the)Tj
1.4683 0 Td
(potential)Tj
3.7644 0 Td
(importance)Tj
4.8302 0 Td
(of)Tj
-33.6186 -1.2982 Td
(V3)Tj
1.3889 0 Td
(and)Tj
1.7348 0 Td
(MPER)Tj
2.863 0 Td
(region)Tj
2.8006 0 Td
(for)Tj
1.3833 0 Td
(resistance)Tj
4.1329 0 Td
(against)Tj
3.0274 0 Td
(paired)Tj
2.7609 0 Td
(maternal)Tj
3.7984 0 Td
(plasma.)Tj
3.2541 0 Td
(These)Tj
2.5682 0 Td
(findings)Tj
3.4923 0 Td
(pro-)Tj
-33.2048 -1.3039 Td
(vide)Tj
1.8935 0 Td
(insights)Tj
3.3165 0 Td
(for)Tj
1.3833 0 Td
(the)Tj
1.474 0 Td
(design)Tj
2.812 0 Td
(of)Tj
1.0147 0 Td
(maternal)Tj
3.7928 0 Td
(immunization)Tj
5.9414 0 Td
(strategies)Tj
3.9231 0 Td
(to)Tj
1.0261 0 Td
(enhance)Tj
3.549 0 Td
(neutralizing)Tj
-30.1264 -1.2983 Td
(antibodies)Tj
4.3596 0 Td
(that)Tj
1.7802 0 Td
(target)Tj
2.5114 0 Td
(V3)Tj
1.389 0 Td
(region)Tj
2.8063 0 Td
(of)Tj
1.0148 0 Td
(autologous)Tj
4.5977 0 Td
(virus)Tj
2.1997 0 Td
(populations,)Tj
5.1817 0 Td
(which)Tj
2.6476 0 Td
(could)Tj
2.4547 0 Td
(work)Tj
2.2791 0 Td
(syner-)Tj
-33.2218 -1.2983 Td
(gistically)Tj
3.685 0 Td
(with)Tj
1.9955 0 Td
(maternal)Tj
3.7984 0 Td
(ARVs)Tj
2.5796 0 Td
(to)Tj
1.0261 0 Td
(further)Tj
3.0274 0 Td
(reduce)Tj
2.9196 0 Td
(the)Tj
1.4684 0 Td
(rate)Tj
1.7461 0 Td
(of)Tj
1.0148 0 Td
(peripartum)Tj
4.7678 0 Td
(HIV-1)Tj
-28.0287 -1.3039 Td
(transmission.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 386.022 cm
BT
/F2 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Introduction)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 369.0141 cm
BT
/F7 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Despite)Tj
3.2484 0 Td
(the)Tj
1.4684 0 Td
(wide)Tj
2.1203 0 Td
(success)Tj
3.1011 0 Td
(of)Tj
1.0148 0 Td
(antiretroviral)Tj
5.5161 0 Td
(therapy)Tj
3.2429 0 Td
(\(ART\))Tj
2.8176 0 Td
(in)Tj
1.0374 0 Td
(lowering)Tj
3.7304 0 Td
(mother-to-child)Tj
6.6671 0 Td
(trans-)Tj
-33.9645 -1.3039 Td
(mission)Tj
3.3505 0 Td
(\(MTCT\))Tj
3.6793 0 Td
(risk)Tj
1.7121 0 Td
(of)Tj
1.0148 0 Td
(HIV-1)Tj
2.8517 0 Td
(below)Tj
2.5852 0 Td
(2%,)Tj
1.6781 0 Td
(each)Tj
2.0295 0 Td
(year)Tj
1.9049 0 Td
(more)Tj
2.3414 0 Td
(than)Tj
2.0296 0 Td
(150,000)Tj
3.2995 0 Td
(children)Tj
3.5546 0 Td
(become)Tj
-32.0312 -1.2982 Td
(infected)Tj
3.4185 0 Td
(worldwide)Tj
4.4617 0 Td
([)Tj
0.83 0.64 0.02 0 k
(1)Tj
0 g
(].)Tj
1.5987 0 Td
(Even)Tj
2.2167 0 Td
(if)Tj
0.7767 0 Td
(90%)Tj
1.9276 0 Td
(maternal)Tj
3.7927 0 Td
(ART)Tj
2.1373 0 Td
(coverage)Tj
3.7247 0 Td
(is)Tj
0.8447 0 Td
(reached,)Tj
3.5773 0 Td
(approximately)Tj
5.9754 0 Td
(138,000)Tj
-34.452 -1.2983 Td
(infant)Tj
2.6021 0 Td
(HIV-1)Tj
2.8517 0 Td
(infections)Tj
4.1499 0 Td
(will)Tj
1.6667 0 Td
(still)Tj
1.6384 0 Td
(occur)Tj
2.4718 0 Td
(annually)Tj
3.6567 0 Td
([)Tj
0.83 0.64 0.02 0 k
(2)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.2643 0 Td
(3)Tj
0 g
(])Tj
1.0374 0 Td
(due)Tj
1.6951 0 Td
(to)Tj
1.0262 0 Td
(factors)Tj
2.9026 0 Td
(that)Tj
1.7802 0 Td
(include:)Tj
3.4072 0 Td
(drug)Tj
2.1146 0 Td
(non-)Tj
-34.2649 -1.2983 Td
(adherence,)Tj
4.5467 0 Td
(breakthrough)Tj
5.6806 0 Td
(infections,)Tj
4.3767 0 Td
(development)Tj
5.4084 0 Td
(of)Tj
1.0148 0 Td
(drug)Tj
2.1147 0 Td
(resistant)Tj
3.5829 0 Td
(viral)Tj
1.9899 0 Td
(strains,)Tj
3.0898 0 Td
(late)Tj
1.6214 0 Td
(presenta-)Tj
-33.4259 -1.3039 Td
(tion)Tj
1.8425 0 Td
(of)Tj
1.0148 0 Td
(pregnant)Tj
3.8267 0 Td
(women)Tj
3.1975 0 Td
(to)Tj
1.0261 0 Td
(clinical)Tj
3.0784 0 Td
(care,)Tj
2.0976 0 Td
(and)Tj
1.7292 0 Td
(acute)Tj
2.33 0 Td
(infection)Tj
3.7871 0 Td
(during)Tj
2.931 0 Td
(late)Tj
1.6214 0 Td
(pregnancy)Tj
4.405 0 Td
(or)Tj
1.0998 0 Td
(breast-)Tj
-33.9871 -1.2982 Td
(feeding.)Tj
3.3902 0 Td
(Mother)Tj
3.2371 0 Td
(to)Tj
1.0261 0 Td
(child)Tj
2.2111 0 Td
(transmission)Tj
5.3631 0 Td
(of)Tj
1.0148 0 Td
(HIV)Tj
2.0239 0 Td
(can)Tj
1.6271 0 Td
(occur)Tj
2.4718 0 Td
(through)Tj
3.4469 0 Td
(three)Tj
2.262 0 Td
(distinct)Tj
3.2145 0 Td
(modes:)Tj
-31.2886 -1.2983 Td
(antepartum)Tj
4.8925 0 Td
(\()Tj
/F11 1 Tf
[()12()]TJ
1.355 0 Td
[()14()11()2()20( )]TJ
/F7 1 Tf
(,)Tj
2.8063 0 Td
(peripartum)Tj
4.7678 0 Td
(\(around)Tj
3.4752 0 Td
(the)Tj
1.4741 0 Td
(time)Tj
2.0295 0 Td
(of)Tj
1.0148 0 Td
(delivery\),)Tj
3.9515 0 Td
(or)Tj
1.0999 0 Td
(postpartum)Tj
4.8698 0 Td
(\(via)Tj
1.7178 0 Td
(breast-)Tj
-33.4542 -1.3039 Td
(feeding\).)Tj
3.7303 0 Td
(Interestingly,)Tj
5.4879 0 Td
(only)Tj
1.9785 0 Td
(3040%)Tj
3.3959 0 Td
(of)Tj
1.0148 0 Td
(infants)Tj
2.965 0 Td
(born)Tj
2.1543 0 Td
(to)Tj
1.0262 0 Td
(HIV)Tj
2.0239 0 Td
(infected)Tj
3.4186 0 Td
(mothers)Tj
3.5262 0 Td
(acquire)Tj
3.1748 0 Td
(HIV-1)Tj
2.8517 0 Td
(in)Tj
-36.7481 -1.2983 Td
(the)Tj
1.4683 0 Td
(absence)Tj
3.3392 0 Td
(of)Tj
1.0148 0 Td
(ART)Tj
2.1373 0 Td
([)Tj
0.83 0.64 0.02 0 k
(4)Tj
0 g
(].)Tj
1.6044 0 Td
(Thus,)Tj
2.4718 0 Td
(maternal)Tj
3.7927 0 Td
(factors,)Tj
3.1294 0 Td
(such)Tj
2.0636 0 Td
(as)Tj
1.0148 0 Td
(maternal)Tj
3.7928 0 Td
(Env-specific)Tj
5.1136 0 Td
(antibodies,)Tj
4.5865 0 Td
(may)Tj
-35.5292 -1.2983 Td
(contribute)Tj
4.3936 0 Td
(to)Tj
1.0205 0 Td
(protecting)Tj
4.3426 0 Td
(infants)Tj
2.9651 0 Td
(from)Tj
2.2053 0 Td
(HIV)Tj
2.0239 0 Td
(infection.)Tj
4.0139 0 Td
(Maternal)Tj
3.8721 0 Td
(factors)Tj
2.9026 0 Td
(that)Tj
1.7745 0 Td
(are)Tj
1.4513 0 Td
(associated)Tj
4.2576 0 Td
(with)Tj
-35.223 -1.3039 Td
(HIV)Tj
2.0182 0 Td
(transmission)Tj
5.3688 0 Td
(risk)Tj
1.7121 0 Td
(include:)Tj
3.4129 0 Td
(low)Tj
1.6554 0 Td
(maternal)Tj
3.7984 0 Td
(peripheral)Tj
4.32 0 Td
(CD4+)Tj
2.6702 0 Td
(T)Tj
0.8334 0 Td
(cell)Tj
1.559 0 Td
(count,)Tj
2.7496 0 Td
(and)Tj
1.7292 0 Td
(high)Tj
2.0125 0 Td
(maternal)Tj
-33.8397 -1.2982 Td
(plasma)Tj
3.033 0 Td
(viral)Tj
1.9899 0 Td
(load,)Tj
2.16 0 Td
(delivery)Tj
3.3902 0 Td
(mode,)Tj
2.7213 0 Td
(and)Tj
1.7347 0 Td
(infant)Tj
2.6022 0 Td
(gestational)Tj
4.5014 0 Td
(age)Tj
1.5421 0 Td
([)Tj
0.83 0.64 0.02 0 k
(5)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(7)Tj
0 g
(].)Tj
2.5965 0 Td
(Yet,)Tj
1.7971 0 Td
(the)Tj
1.474 0 Td
(role)Tj
1.7632 0 Td
(of)Tj
1.0148 0 Td
(maternal)Tj
-32.3204 -1.2983 Td
(Env-specific)Tj
5.1136 0 Td
(antibody)Tj
3.7644 0 Td
(responses)Tj
4.0932 0 Td
(and)Tj
1.7291 0 Td
(their)Tj
2.109 0 Td
(association)Tj
4.6261 0 Td
(with)Tj
2.0013 0 Td
(reduced)Tj
3.4412 0 Td
(MTCT)Tj
2.999 0 Td
(risk)Tj
1.7178 0 Td
(still)Tj
1.6384 0 Td
(remains)Tj
-33.2331 -1.3039 Td
(unclear.)Tj
3.4185 0 Td
(Previous)Tj
3.6907 0 Td
(studies)Tj
2.9877 0 Td
(have)Tj
2.0579 0 Td
(reported)Tj
3.6624 0 Td
(an)Tj
1.2019 0 Td
(association)Tj
4.6261 0 Td
(between)Tj
3.5319 0 Td
(the)Tj
1.4684 0 Td
(magnitude)Tj
4.5297 0 Td
(of)Tj
1.0148 0 Td
(maternal)Tj
-32.19 -1.2983 Td
(antibody)Tj
3.7643 0 Td
(responses)Tj
4.0932 0 Td
(and)Tj
1.7292 0 Td
(reduced)Tj
3.4469 0 Td
(risk)Tj
1.7121 0 Td
(of)Tj
1.0148 0 Td
(MTCT)Tj
2.999 0 Td
([)Tj
0.83 0.64 0.02 0 k
(8)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(10)Tj
0 g
(].)Tj
3.0728 0 Td
(However,)Tj
4.0761 0 Td
(this)Tj
1.6725 0 Td
(association)Tj
4.6318 0 Td
(has)Tj
1.542 0 Td
(not)Tj
1.5704 0 Td
(been)Tj
-35.3251 -1.2982 Td
(universally)Tj
4.5524 0 Td
(observed)Tj
3.7984 0 Td
([)Tj
0.83 0.64 0.02 0 k
(11)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(15)Tj
0 g
(].)Tj
3.5432 0 Td
(Moreover,)Tj
4.3994 0 Td
(it)Tj
0.7823 0 Td
(has)Tj
1.5421 0 Td
(been)Tj
2.126 0 Td
(observed)Tj
3.7927 0 Td
(that)Tj
1.7801 0 Td
(variants)Tj
3.3902 0 Td
(transmitted)Tj
4.8643 0 Td
(to)Tj
-34.5711 -1.2983 Td
(infants)Tj
2.965 0 Td
(can)Tj
1.627 0 Td
(be)Tj
1.1509 0 Td
(resistant)Tj
3.583 0 Td
(to)Tj
1.0204 0 Td
(neutralization)Tj
5.8054 0 Td
(by)Tj
1.1848 0 Td
(maternal)Tj
3.7928 0 Td
(plasma)Tj
3.033 0 Td
([)Tj
0.83 0.64 0.02 0 k
(16)Tj
0 g
(],)Tj
2.075 0 Td
(although)Tj
3.7587 0 Td
(other)Tj
2.3471 0 Td
(studies)Tj
2.982 0 Td
(have)Tj
-35.3251 -1.3039 Td
(failed)Tj
2.4037 0 Td
(to)Tj
1.0261 0 Td
(replicate)Tj
3.6227 0 Td
(these)Tj
2.2564 0 Td
(observations)Tj
5.261 0 Td
([)Tj
0.83 0.64 0.02 0 k
(17)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(19)Tj
0 g
(].)Tj
3.5433 0 Td
(These)Tj
2.5682 0 Td
(conflicting)Tj
4.5014 0 Td
(results)Tj
2.8119 0 Td
(may)Tj
1.9276 0 Td
(be)Tj
1.1508 0 Td
(due)Tj
1.7008 0 Td
(to)Tj
1.0205 0 Td
(the)Tj
1.474 0 Td
(small)Tj
-35.2684 -1.2983 Td
(number)Tj
3.4185 0 Td
(of)Tj
1.0148 0 Td
(subjects)Tj
3.3789 0 Td
(included)Tj
3.7077 0 Td
(in)Tj
1.0375 0 Td
(these)Tj
2.2563 0 Td
(studies)Tj
2.982 0 Td
(and)Tj
1.7348 0 Td
(study)Tj
2.3868 0 Td
(designs)Tj
3.1748 0 Td
(that)Tj
1.7801 0 Td
(inconsistently)Tj
5.7713 0 Td
(control)Tj
3.1238 0 Td
(for)Tj
-35.7673 -1.2983 Td
(viral)Tj
1.9899 0 Td
(and)Tj
1.7348 0 Td
(host)Tj
1.9105 0 Td
(factors)Tj
2.9026 0 Td
(known)Tj
3.0048 0 Td
(to)Tj
1.0261 0 Td
(impact)Tj
2.982 0 Td
(transmission)Tj
5.3631 0 Td
(risk,)Tj
1.9389 0 Td
(such)Tj
2.0636 0 Td
(as)Tj
1.0148 0 Td
(maternal)Tj
3.7928 0 Td
(peripheral)Tj
4.3199 0 Td
(CD4+)Tj
2.6759 0 Td
(T)Tj
-36.7197 -1.3039 Td
(cell)Tj
1.559 0 Td
(counts,)Tj
3.1124 0 Td
(plasma)Tj
3.0274 0 Td
(viral)Tj
1.9956 0 Td
(load,)Tj
2.16 0 Td
(non-identification)Tj
7.5401 0 Td
(of)Tj
1.0148 0 Td
(T/F)Tj
1.6894 0 Td
(viruses,)Tj
3.2145 0 Td
(and)Tj
1.7291 0 Td
(ART)Tj
2.1373 0 Td
(use)Tj
1.5307 0 Td
([)Tj
0.83 0.64 0.02 0 k
(20)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.7348 0 Td
(21)Tj
0 g
(].)Tj
1.7405 0 Td
(More-)Tj
-34.1856 -1.2982 Td
(over,)Tj
2.1996 0 Td
(autologous)Tj
4.6035 0 Td
(viruses)Tj
2.982 0 Td
(from)Tj
2.211 0 Td
(a)Tj
0.652 0 Td
(large)Tj
2.1599 0 Td
(cohort)Tj
2.8517 0 Td
(of)Tj
1.0148 0 Td
(HIV-1)Tj
2.8516 0 Td
(infected,)Tj
3.6453 0 Td
(transmitting)Tj
5.1988 0 Td
(mothers)Tj
3.5262 0 Td
(for)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 144.5669 23.6976 re
W* n
q
144.5102 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 449.1779 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Mother)Tj
3.2811 0 Td
(to)Tj
1.0417 0 Td
(child)Tj
2.2323 0 Td
(transmis)Tj
3.7134 0 Td
(sion)Tj
2.0197 0 Td
(of)Tj
1.0418 0 Td
(HIV-1)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
0.83 0.64 0.02 0 k
102.0472 34.9228 m
256.1953 34.9228 l
h
f*
0 g
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(Pathogens)Tj
4.9252 0 Td
(|)Tj
0.83 0.64 0.02 0 k
0.4748 0 Td
(https://)Tj
2.9552 0 Td
(doi.org/10.13)Tj
5.7331 0 Td
(71/journal.p)Tj
5.1236 0 Td
(pat.1006)Tj
3.8198 0 Td
(944)Tj
0 g
2.6362 0 Td
(April)Tj
2.1756 0 Td
(19,)Tj
1.5874 0 Td
(2018)Tj
32.8538 0 Td
(2)Tj
0.7654 0 Td
(/)Tj
0.496 0 Td
(26)Tj
/F9 1 Tf
-0.025 Tc
-66.402 84.0904 Td
(Competing)Tj
4.3795 0 Td
(interests)Tj
3.3307 0 Td
(:)Tj
/F10 1 Tf
0.4819 0 Td
(The)Tj
1.5875 0 Td
(authors)Tj
3.0401 0 Td
(have)Tj
1.963 0 Td
(declared)Tj
-14.7827 -1.3748 Td
(that)Tj
1.6228 0 Td
(no)Tj
1.1693 0 Td
(competing)Tj
4.1599 0 Td
(interests)Tj
ET
endstream
endobj
33 0 obj
<>stream
endstream
endobj
34 0 obj
<>stream
endstream
endobj
35 0 obj
<>stream
endstream
endobj
36 0 obj
<>stream
endstream
endobj
37 0 obj
<>stream
endstream
endobj
38 0 obj
<>stream
endstream
endobj
39 0 obj
<>stream
endstream
endobj
40 0 obj
<>stream
endstream
endobj
41 0 obj
<>stream
endstream
endobj
42 0 obj
<>stream
endstream
endobj
43 0 obj
<>stream
endstream
endobj
44 0 obj
<>stream
endstream
endobj
45 0 obj
<>stream
endstream
endobj
46 0 obj
<>stream
endstream
endobj
47 0 obj
<>stream
endstream
endobj
48 0 obj
<>stream
BT
10.3394 82.7156 Td
(exist.)Tj
ET
Q
endstream
endobj
49 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 12 0 R/Annots 50 0 R/Contents 51 0 R/TrimBox[0 0 612 792]>>
endobj
50 0 obj
[52 0 R 53 0 R 54 0 R 55 0 R 56 0 R 57 0 R 58 0 R 59 0 R 60 0 R 61 0 R 62 0 R 63 0 R 64 0 R 65 0 R 66 0 R 67 0 R 68 0 R 69 0 R 70 0 R 71 0 R 72 0 R]
endobj
52 0 obj
<>/Border[0 0 0]/Dest(Rppat.1006944.ref022)>>
endobj
53 0 obj
<>/Border[0 0 0]/Dest(Rppat.1006944.ref023)>>
endobj
54 0 obj
<>/Border[0 0 0]/Dest(Rppat.1006944.ref024)>>
endobj
55 0 obj
<>/Border[0 0 0]/Dest(Rppat.1006944.ref022)>>
endobj
56 0 obj
<>/Border[0 0 0]/Dest(Rppat.1006944.ref017)>>
endobj
57 0 obj
<>/Border[0 0 0]/Dest(Rppat.1006944.ref025)>>
endobj
58 0 obj
<>/Border[0 0 0]/Dest(Rppat.1006944.ref028)>>
endobj
59 0 obj
<>/Border[0 0 0]/Dest(Rppat.1006944.ref022)>>
endobj
60 0 obj
<>/Border[0 0 0]/Dest(Rppat.1006944.ref029)>>
endobj
61 0 obj
<>/Border[0 0 0]/Dest(Rppat.1006944.ref017)>>
endobj
62 0 obj
<>/Border[0 0 0]/Dest(Rppat.1006944.ref018)>>
endobj
63 0 obj
<>/Border[0 0 0]/Dest(Rppat.1006944.ref030)>>
endobj
64 0 obj
<>/Border[0 0 0]/Dest(Rppat.1006944.ref033)>>
endobj
65 0 obj
<>/Border[0 0 0]/Dest(Rppat.1006944.ref004)>>
endobj
66 0 obj
<>/Border[0 0 0]/Dest(Rppat.1006944.ref034)>>
endobj
67 0 obj
<>/Border[0 0 0]/Dest(Rppat.1006944.ref035)>>
endobj
68 0 obj
<>/Border[0 0 0]/Dest(Rppat.1006944.ref036)>>
endobj
69 0 obj
<>/Border[0 0 0]/Dest(Rppat.1006944.ref037)>>
endobj
70 0 obj
<>/Border[0 0 0]/Dest(Rppat.1006944.ref038)>>
endobj
71 0 obj
<>/Border[0 0 0]/Dest(Rppat.1006944.ref039)>>
endobj
72 0 obj
<>/Border[0 0 0]/A 73 0 R>>
endobj
73 0 obj
<>
endobj
51 0 obj
[74 0 R 75 0 R 76 0 R 77 0 R 78 0 R 79 0 R 80 0 R 81 0 R 82 0 R 83 0 R 84 0 R 85 0 R 86 0 R 87 0 R 88 0 R 89 0 R 90 0 R 91 0 R]
endobj
74 0 obj
<>stream
q
0.83 0.64 0.02 0 k
227.2819 615.3449 m
236.8063 615.3449 l
h
f*
526.337 589.3228 m
535.8614 589.3228 l
h
f*
540.3402 589.3228 m
549.8079 589.3228 l
h
f*
439.4835 511.3134 m
449.0079 511.3134 l
h
f*
301.7764 459.326 m
311.3008 459.326 l
h
f*
315.7228 459.326 m
325.2472 459.326 l
h
f*
330.463 459.326 m
339.9307 459.326 l
h
f*
476.6173 420.3213 m
486.1417 420.3213 l
h
f*
347.4142 381.3165 m
356.9386 381.3165 l
h
f*
510.4063 277.3417 m
519.9307 277.3417 l
h
f*
524.3528 277.3417 m
533.8772 277.3417 l
h
f*
538.3559 277.3417 m
547.8236 277.3417 l
h
f*
553.0394 277.3417 m
562.5071 277.3417 l
h
f*
269.5181 251.3197 m
274.2803 251.3197 l
h
f*
203.4142 225.2976 m
212.9386 225.2976 l
h
f*
419.3575 134.3055 m
428.8819 134.3055 l
h
f*
433.3039 134.3055 m
442.8283 134.3055 l
h
f*
291.0047 108.3402 m
300.4724 108.3402 l
h
f*
304.9512 108.3402 m
314.4756 108.3402 l
h
f*
433.8709 82.3181 m
443.3953 82.3181 l
h
f*
0 g
1 j
1 J
0 w
10 0 0 10 200.0125 707.4141 cm
BT
/F7 1 Tf
1 TL
-0.004 Tc
0 0 Td
(assessment)Tj
4.6091 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(impact)Tj
2.982 0 Td
(of)Tj
1.0148 0 Td
(maternal)Tj
3.7984 0 Td
(plasma)Tj
3.0274 0 Td
(neutralization)Tj
5.8053 0 Td
(activity)Tj
3.1181 0 Td
(against)Tj
3.0274 0 Td
(her)Tj
1.542 0 Td
(own)Tj
1.9616 0 Td
(viruses)Tj
-33.3692 -1.3039 Td
(has)Tj
1.542 0 Td
(not)Tj
1.5704 0 Td
(to)Tj
1.0261 0 Td
(our)Tj
1.6271 0 Td
(knowledge,)Tj
4.7678 0 Td
(been)Tj
2.126 0 Td
(investigated.)Tj
5.21 0 Td
(Thus,)Tj
2.4718 0 Td
(despite)Tj
3.0388 0 Td
(considerable)Tj
5.261 0 Td
(effort,)Tj
2.6249 0 Td
(it)Tj
0.7824 0 Td
(remains)Tj
-32.0483 -1.2982 Td
(unclear)Tj
3.1917 0 Td
(whether)Tj
3.481 0 Td
(maternal)Tj
3.7927 0 Td
(antibody)Tj
3.7644 0 Td
(responses)Tj
4.0932 0 Td
(impact)Tj
2.982 0 Td
(the)Tj
1.4683 0 Td
(risk)Tj
1.7178 0 Td
(of)Tj
1.0148 0 Td
(perinatal)Tj
3.7587 0 Td
(transmission)Tj
5.3632 0 Td
(of)Tj
-34.6278 -1.2983 Td
(HIV.)Tj
1.1962 -1.2983 Td
(We)Tj
1.61 0 Td
(recently)Tj
3.4129 0 Td
(completed)Tj
4.405 0 Td
(a)Tj
0.652 0 Td
(maternal)Tj
3.7984 0 Td
(humoral)Tj
3.651 0 Td
(immune)Tj
3.6283 0 Td
(correlates)Tj
4.0819 0 Td
(of)Tj
1.0148 0 Td
(protection)Tj
4.3823 0 Td
(analysis)Tj
3.3222 0 Td
(to)Tj
-35.155 -1.3039 Td
(identify)Tj
3.2938 0 Td
(maternal)Tj
3.7984 0 Td
(humoral)Tj
3.651 0 Td
(immune)Tj
3.6283 0 Td
(responses)Tj
4.0932 0 Td
(associated)Tj
4.2576 0 Td
(with)Tj
1.9956 0 Td
(protection)Tj
4.3823 0 Td
(against)Tj
3.0274 0 Td
(peripartum)Tj
-32.1276 -1.2982 Td
(HIV-1)Tj
2.8459 0 Td
(infection)Tj
3.7927 0 Td
(using)Tj
2.3868 0 Td
(samples)Tj
3.3846 0 Td
(from)Tj
2.2053 0 Td
(the)Tj
1.4683 0 Td
(US-based)Tj
4.0365 0 Td
(Women)Tj
3.4866 0 Td
(and)Tj
1.7292 0 Td
(Infants)Tj
3.0387 0 Td
(Transmission)Tj
5.6749 0 Td
(\(WITS\))Tj
-34.0495 -1.2983 Td
(study)Tj
2.3867 0 Td
([)Tj
0.83 0.64 0.02 0 k
(22)Tj
0 g
(].)Tj
2.0806 0 Td
(The)Tj
1.7802 0 Td
(WITS)Tj
2.6135 0 Td
(cohort)Tj
2.8516 0 Td
(was)Tj
1.7008 0 Td
(enrolled)Tj
3.5149 0 Td
(prior)Tj
2.2507 0 Td
(to)Tj
1.0262 0 Td
(the)Tj
1.474 0 Td
(availability)Tj
4.5297 0 Td
(of)Tj
1.0148 0 Td
(ART)Tj
2.1373 0 Td
(prophylaxis)Tj
4.8869 0 Td
(as)Tj
1.0148 0 Td
(the)Tj
-35.2627 -1.3039 Td
(clinical)Tj
3.0727 0 Td
(standard)Tj
3.7247 0 Td
(of)Tj
1.0148 0 Td
(care)Tj
1.8708 0 Td
(in)Tj
1.0375 0 Td
(HIV-infected)Tj
5.5729 0 Td
(pregnant)Tj
3.8267 0 Td
(mothers)Tj
3.5263 0 Td
(and)Tj
1.7348 0 Td
(their)Tj
2.1033 0 Td
(infants,)Tj
3.1918 0 Td
(thereby)Tj
3.2258 0 Td
(eliminat-)Tj
-33.9021 -1.2983 Td
(ing)Tj
1.5023 0 Td
(the)Tj
1.4683 0 Td
(strong)Tj
2.7723 0 Td
(impact)Tj
2.9764 0 Td
(of)Tj
1.0148 0 Td
(ART)Tj
2.1373 0 Td
(on)Tj
1.2756 0 Td
(perinatal)Tj
3.7587 0 Td
(HIV-1)Tj
2.8516 0 Td
(transmission)Tj
5.3631 0 Td
(risk)Tj
1.7178 0 Td
(and)Tj
1.7291 0 Td
(outcome)Tj
3.7247 0 Td
([)Tj
0.83 0.64 0.02 0 k
(23)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.7405 0 Td
(24)Tj
0 g
(].)Tj
-34.0325 -1.2983 Td
(Additionally,)Tj
5.4538 0 Td
(we)Tj
1.3266 0 Td
(controlled)Tj
4.32 0 Td
(for)Tj
1.3833 0 Td
(established)Tj
4.5977 0 Td
(maternal)Tj
3.7984 0 Td
(and)Tj
1.7291 0 Td
(infant)Tj
2.6022 0 Td
(risk)Tj
1.7178 0 Td
(factors)Tj
2.9027 0 Td
(associated)Tj
4.2576 0 Td
(with)Tj
-34.0892 -1.3039 Td
(perinatal)Tj
3.7587 0 Td
(transmission,)Tj
5.5899 0 Td
(including)Tj
4.0421 0 Td
(maternal)Tj
3.7928 0 Td
(peripheral)Tj
4.3199 0 Td
(CD4+)Tj
2.6759 0 Td
(T)Tj
0.8334 0 Td
(cell)Tj
1.5591 0 Td
(count,)Tj
2.7495 0 Td
(maternal)Tj
3.7984 0 Td
(plasma)Tj
-33.1197 -1.2982 Td
(HIV-1)Tj
2.8459 0 Td
(viral)Tj
1.9956 0 Td
(load,)Tj
2.16 0 Td
(infant)Tj
2.6022 0 Td
(gestational)Tj
4.507 0 Td
(age,)Tj
1.7632 0 Td
(and)Tj
1.7348 0 Td
(delivery)Tj
3.3845 0 Td
(mode)Tj
2.5001 0 Td
(by)Tj
1.1793 0 Td
(propensity)Tj
4.49 0 Td
(score)Tj
2.3017 0 Td
(matching)Tj
4.0082 0 Td
(of)Tj
-35.4725 -1.2983 Td
(transmitting)Tj
5.1987 0 Td
(and)Tj
1.7291 0 Td
(non-transmitting)Tj
7.1489 0 Td
(women.)Tj
3.4299 0 Td
(The)Tj
1.7802 0 Td
(results)Tj
2.8119 0 Td
(of)Tj
1.0148 0 Td
(this)Tj
1.6724 0 Td
(immune)Tj
3.6284 0 Td
(correlate)Tj
3.719 0 Td
(analysis)Tj
-32.1333 -1.3039 Td
(indicated)Tj
3.9344 0 Td
(an)Tj
1.2019 0 Td
(association)Tj
4.6318 0 Td
(between)Tj
3.5263 0 Td
(high)Tj
2.0069 0 Td
(levels)Tj
2.3754 0 Td
(of)Tj
1.0148 0 Td
(maternal)Tj
3.7984 0 Td
(antibodies)Tj
4.3596 0 Td
(against)Tj
3.0274 0 Td
(the)Tj
1.4684 0 Td
(HIV-1)Tj
2.8516 0 Td
(Env)Tj
1.7915 0 Td
(gly-)Tj
-35.9884 -1.2983 Td
(coprotein)Tj
4.0818 0 Td
(third)Tj
2.211 0 Td
(variable)Tj
3.3619 0 Td
(loop)Tj
1.9956 0 Td
(\(V3\))Tj
2.0692 0 Td
(and)Tj
1.7292 0 Td
(reduced)Tj
3.4469 0 Td
(MTCT)Tj
2.999 0 Td
(risk)Tj
1.7121 0 Td
([)Tj
0.83 0.64 0.02 0 k
(22)Tj
0 g
(].)Tj
2.0806 0 Td
(In)Tj
1.1056 0 Td
(addition,)Tj
3.8267 0 Td
(and)Tj
1.7291 0 Td
(more)Tj
2.3414 0 Td
(sur-)Tj
-34.6901 -1.2982 Td
(prisingly,)Tj
3.9401 0 Td
(the)Tj
1.474 0 Td
(ability)Tj
2.6929 0 Td
(of)Tj
1.0148 0 Td
(maternal)Tj
3.7927 0 Td
(plasma)Tj
3.0331 0 Td
(to)Tj
1.0261 0 Td
(neutralize)Tj
4.1726 0 Td
(tier)Tj
1.5817 0 Td
(1)Tj
0.6973 0 Td
(\(easy-to-neutralize\))Tj
8.0333 0 Td
(viruses)Tj
2.9821 0 Td
(but)Tj
1.5534 0 Td
(not)Tj
-35.9941 -1.2983 Td
(tier)Tj
1.5817 0 Td
(2)Tj
0.6916 0 Td
(\(difficult-to-)Tj
5.1987 0 Td
(neutralize\))Tj
4.5184 0 Td
(viruses,)Tj
3.2088 0 Td
(also)Tj
1.7688 0 Td
(predicted)Tj
4.0025 0 Td
(decreased)Tj
4.1329 0 Td
(risk)Tj
1.7178 0 Td
(of)Tj
1.0148 0 Td
(perinatal)Tj
3.7587 0 Td
(transmission)Tj
-31.5947 -1.3039 Td
(of)Tj
1.0147 0 Td
(HIV-1.)Tj
3.0728 0 Td
(Yet,)Tj
1.7971 0 Td
(vertically)Tj
3.8438 0 Td
(transmitted)Tj
4.8642 0 Td
(HIV)Tj
2.0239 0 Td
(variants)Tj
3.3903 0 Td
(have)Tj
2.0579 0 Td
(been)Tj
2.1203 0 Td
(characterized)Tj
5.5615 0 Td
(as)Tj
1.0148 0 Td
(more)Tj
2.3414 0 Td
(difficult)Tj
3.3562 0 Td
(to)Tj
-36.4589 -1.2983 Td
(neutralize)Tj
4.1725 0 Td
(tier)Tj
1.5817 0 Td
(2)Tj
0.6917 0 Td
(variants)Tj
3.3902 0 Td
([)Tj
0.83 0.64 0.02 0 k
(17)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.7348 0 Td
(25)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(28)Tj
0 g
(].)Tj
3.2088 0 Td
(Thus,)Tj
2.4718 0 Td
(it)Tj
0.788 0 Td
(was)Tj
1.6951 0 Td
(surprising)Tj
4.2803 0 Td
(that)Tj
1.7802 0 Td
(tier)Tj
1.576 0 Td
(1)Tj
0.6973 0 Td
(virus)Tj
2.1997 0 Td
(neutralizing)Tj
5.0343 0 Td
(anti-)Tj
-35.3024 -1.2983 Td
(bodies)Tj
2.8119 0 Td
(were)Tj
2.1203 0 Td
(associated)Tj
4.2576 0 Td
(with)Tj
2.0013 0 Td
(decreased)Tj
4.1328 0 Td
(transmission)Tj
5.3632 0 Td
(risk.)Tj
1.9445 0 Td
(More)Tj
2.4151 0 Td
(interestingly,)Tj
5.4142 0 Td
(maternal)Tj
3.7984 0 Td
(V3-spe-)Tj
-34.2593 -1.3039 Td
(cific)Tj
1.8878 0 Td
(monoclonal)Tj
5.006 0 Td
(IgG)Tj
1.7404 0 Td
(antibodies)Tj
4.3654 0 Td
(obtained)Tj
3.7303 0 Td
(from)Tj
2.2054 0 Td
(a)Tj
0.6519 0 Td
(non-transmitting)Tj
7.1546 0 Td
(mother)Tj
3.1691 0 Td
(neutralized)Tj
4.6999 0 Td
(a)Tj
0.6519 0 Td
(large)Tj
-35.2627 -1.2982 Td
(proportion)Tj
4.6317 0 Td
(of)Tj
1.0148 0 Td
(maternal)Tj
3.7928 0 Td
(autologous)Tj
4.6034 0 Td
(viruses)Tj
2.9877 0 Td
(obtained)Tj
3.7304 0 Td
(from)Tj
2.2053 0 Td
(her)Tj
1.542 0 Td
(plasma[)Tj
0.83 0.64 0.02 0 k
(22)Tj
0 g
(],)Tj
4.8926 0 Td
(leading)Tj
3.1294 0 Td
(to)Tj
1.0262 0 Td
(the)Tj
1.4683 0 Td
(con-)Tj
-35.0246 -1.2983 Td
(clusion)Tj
3.101 0 Td
(that)Tj
1.7745 0 Td
(maternal)Tj
3.7984 0 Td
(V3-specific)Tj
4.7112 0 Td
(non-broadly)Tj
5.2213 0 Td
(neutralizing)Tj
5.0343 0 Td
(antibodies,)Tj
4.5865 0 Td
(which)Tj
2.6475 0 Td
(were)Tj
2.1203 0 Td
(previously)Tj
-32.995 -1.3039 Td
(thought)Tj
3.3732 0 Td
(to)Tj
1.0204 0 Td
(be)Tj
1.1509 0 Td
(ineffective)Tj
4.3256 0 Td
(at)Tj
0.9525 0 Td
(preventing)Tj
4.541 0 Td
(HIV-1)Tj
2.846 0 Td
(transmission,)Tj
5.5899 0 Td
(might)Tj
2.6022 0 Td
(indeed)Tj
2.9366 0 Td
(play)Tj
1.8709 0 Td
(a)Tj
0.652 0 Td
(role)Tj
1.7688 0 Td
(in)Tj
1.0374 0 Td
(pre-)Tj
-34.6674 -1.2983 Td
(venting)Tj
3.2258 0 Td
(MTCT.)Tj
3.2201 0 Td
(In)Tj
1.1112 0 Td
(fact,)Tj
1.8878 0 Td
(Moody)Tj
3.1125 0 Td
(et.al)Tj
1.8425 0 Td
([)Tj
0.83 0.64 0.02 0 k
(29)Tj
0 g
(])Tj
1.8538 0 Td
(showed)Tj
3.2485 0 Td
(that)Tj
1.7801 0 Td
(V3)Tj
1.389 0 Td
(and)Tj
1.7348 0 Td
(CD4)Tj
2.092 0 Td
(binding)Tj
3.3505 0 Td
(site)Tj
1.5704 0 Td
(\(CD4bs\))Tj
-31.419 -1.2983 Td
(specific)Tj
3.1917 0 Td
(monoclonal)Tj
5.006 0 Td
(antibodies)Tj
4.3597 0 Td
(obtained)Tj
3.736 0 Td
(from)Tj
2.2053 0 Td
(non-pregnant)Tj
5.777 0 Td
(chronically)Tj
4.6715 0 Td
(HIV-infected)Tj
5.5728 0 Td
(indi-)Tj
-34.52 -1.2982 Td
(viduals)Tj
3.0387 0 Td
(could)Tj
2.4491 0 Td
(neutralize)Tj
4.1726 0 Td
(a)Tj
0.6576 0 Td
(large)Tj
2.16 0 Td
(proportion)Tj
4.6318 0 Td
(of)Tj
1.0148 0 Td
(autologous)Tj
4.5977 0 Td
(circulating)Tj
4.4957 0 Td
(viruses)Tj
2.9877 0 Td
(obtained)Tj
3.7304 0 Td
(from)Tj
-33.9361 -1.3039 Td
(plasma.)Tj
3.2541 0 Td
(These)Tj
2.5682 0 Td
(V3)Tj
1.3889 0 Td
(and)Tj
1.7348 0 Td
(CD4bs-specific)Tj
6.2816 0 Td
(autologous)Tj
4.6034 0 Td
(virus-neutralizing)Tj
7.3587 0 Td
(mAbs)Tj
2.5965 0 Td
(exhibited)Tj
3.9231 0 Td
(tier)Tj
1.5818 0 Td
(1)Tj
-35.2911 -1.2983 Td
(neutralization)Tj
5.7996 0 Td
(activity)Tj
3.1124 0 Td
(but)Tj
1.5477 0 Td
(limited)Tj
3.0671 0 Td
(heterologous)Tj
5.3801 0 Td
(tier)Tj
1.5761 0 Td
(2)Tj
0.6916 0 Td
(virus)Tj
2.194 0 Td
(neutralization,)Tj
6.0264 0 Td
(suggesting)Tj
4.3994 0 Td
(that)Tj
1.7745 0 Td
(mea-)Tj
-35.5689 -1.2983 Td
(surement)Tj
3.9911 0 Td
(of)Tj
1.0148 0 Td
(tier)Tj
1.5817 0 Td
(2)Tj
0.6973 0 Td
(heterologous)Tj
5.3858 0 Td
(virus)Tj
2.1997 0 Td
(neutralization)Tj
5.8053 0 Td
(potency)Tj
3.3902 0 Td
(of)Tj
1.0148 0 Td
(mAbs)Tj
2.5966 0 Td
(or)Tj
1.0941 0 Td
(plasma)Tj
3.0331 0 Td
(does)Tj
2.0409 0 Td
(not)Tj
1.5704 0 Td
(pre-)Tj
-35.4158 -1.3039 Td
(dict)Tj
1.7347 0 Td
(autologous)Tj
4.6035 0 Td
(virus)Tj
2.1996 0 Td
(neutralization)Tj
5.8054 0 Td
(capacity.)Tj
-13.147 -1.2982 Td
(In)Tj
1.1111 0 Td
(contrast)Tj
3.464 0 Td
(to)Tj
1.0261 0 Td
(the)Tj
1.4683 0 Td
(extensive)Tj
3.8835 0 Td
(genetic)Tj
3.0727 0 Td
(diversity)Tj
3.6453 0 Td
(of)Tj
1.0148 0 Td
(HIV-1)Tj
2.846 0 Td
(variants)Tj
3.3902 0 Td
(in)Tj
1.0318 0 Td
(a)Tj
0.6576 0 Td
(chronically)Tj
4.6715 0 Td
(infected)Tj
-32.4791 -1.2983 Td
(host,)Tj
2.1373 0 Td
(acute)Tj
2.33 0 Td
(HIV)Tj
2.0183 0 Td
(infections)Tj
4.1555 0 Td
(are)Tj
1.4457 0 Td
(established)Tj
4.5978 0 Td
(by)Tj
1.1848 0 Td
(a)Tj
0.652 0 Td
(limited)Tj
3.0671 0 Td
(number)Tj
3.4185 0 Td
(of)Tj
1.0148 0 Td
(T/F)Tj
1.6895 0 Td
(viruses)Tj
2.9877 0 Td
([)Tj
0.83 0.64 0.02 0 k
(17)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.7348 0 Td
(18)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.4003 0 Td
(30)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(33)Tj
0 g
(].)Tj
-33.8341 -1.3039 Td
(This)Tj
1.9842 0 Td
(viral)Tj
1.9956 0 Td
(genetic)Tj
3.067 0 Td
(bottleneck)Tj
4.3937 0 Td
(suggests)Tj
3.4809 0 Td
(the)Tj
1.474 0 Td
(selective)Tj
3.5377 0 Td
(transmission)Tj
5.3687 0 Td
(of)Tj
1.0148 0 Td
(a)Tj
0.652 0 Td
(single)Tj
2.5285 0 Td
(or)Tj
1.0998 0 Td
(homogeneous)Tj
-30.5969 -1.2983 Td
(group)Tj
2.6078 0 Td
(of)Tj
1.0148 0 Td
(viruses)Tj
2.9877 0 Td
([)Tj
0.83 0.64 0.02 0 k
(4)Tj
0 g
(].)Tj
1.5987 0 Td
(In)Tj
1.1112 0 Td
(the)Tj
1.4683 0 Td
(setting)Tj
2.88 0 Td
(of)Tj
1.0148 0 Td
(MTCT,)Tj
3.2258 0 Td
(maternal)Tj
3.7928 0 Td
(or)Tj
1.0998 0 Td
(infant)Tj
2.6079 0 Td
(immunologic)Tj
5.6182 0 Td
(and)Tj
1.7291 0 Td
(virologic)Tj
-32.7569 -1.2983 Td
(factors)Tj
2.9026 0 Td
(that)Tj
1.7802 0 Td
(drive)Tj
2.262 0 Td
(the)Tj
1.4683 0 Td
(selective)Tj
3.5433 0 Td
(transmission)Tj
5.3631 0 Td
(of)Tj
1.0148 0 Td
(one)Tj
1.7008 0 Td
(or)Tj
1.0942 0 Td
(a)Tj
0.6576 0 Td
(few)Tj
1.6157 0 Td
(HIV)Tj
2.0183 0 Td
(variants)Tj
3.3902 0 Td
(are)Tj
1.4513 0 Td
(not)Tj
1.5704 0 Td
(established)Tj
-31.8328 -1.3039 Td
([)Tj
0.83 0.64 0.02 0 k
(34)Tj
0 g
(].)Tj
2.0749 0 Td
(As)Tj
1.2642 0 Td
(maternal)Tj
3.7984 0 Td
(viruses)Tj
2.9877 0 Td
(co-circulate)Tj
4.9153 0 Td
(with)Tj
1.9956 0 Td
(maternal)Tj
3.7927 0 Td
(HIV)Tj
2.0239 0 Td
(Env-specific)Tj
5.1137 0 Td
(antibodies,)Tj
4.5864 0 Td
(it)Tj
0.788 0 Td
(is)Tj
0.8448 0 Td
(possible)Tj
-34.1856 -1.2982 Td
(that)Tj
1.7744 0 Td
(maternal)Tj
3.7984 0 Td
(antibodies)Tj
4.3597 0 Td
(play)Tj
1.8708 0 Td
(a)Tj
0.6577 0 Td
(role)Tj
1.7688 0 Td
(in)Tj
1.0318 0 Td
(selecting)Tj
3.6793 0 Td
(maternal)Tj
3.7928 0 Td
(escape)Tj
2.8062 0 Td
(viruses)Tj
2.9877 0 Td
(that)Tj
1.7745 0 Td
(may)Tj
1.9276 0 Td
(initiate)Tj
3.0274 0 Td
(infec-)Tj
-35.2571 -1.2983 Td
(tion)Tj
1.8425 0 Td
(in)Tj
1.0318 0 Td
(the)Tj
1.4683 0 Td
(infant.)Tj
2.8346 0 Td
(Therefore,)Tj
4.388 0 Td
(studying)Tj
3.6737 0 Td
(unique)Tj
3.0217 0 Td
(features)Tj
3.3449 0 Td
(of)Tj
1.0148 0 Td
(infant)Tj
2.6078 0 Td
(T/F)Tj
1.6838 0 Td
(viruses)Tj
2.9877 0 Td
(and)Tj
1.7291 0 Td
(their)Tj
2.109 0 Td
(neutrali-)Tj
-33.7377 -1.2983 Td
(zation-sensitivity)Tj
7.0412 0 Td
(determinants)Tj
5.5388 0 Td
(to)Tj
1.0262 0 Td
(maternal)Tj
3.7927 0 Td
(autologous)Tj
4.6034 0 Td
(virus)Tj
2.1997 0 Td
(neutralizing)Tj
5.0343 0 Td
(antibodies)Tj
4.3597 0 Td
(may)Tj
-33.596 -1.3039 Td
(provide)Tj
3.2881 0 Td
(insights)Tj
3.3165 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(molecular)Tj
4.2179 0 Td
(events)Tj
2.7326 0 Td
(that)Tj
1.7745 0 Td
(lead)Tj
1.8538 0 Td
(to)Tj
1.0261 0 Td
(virus)Tj
2.1997 0 Td
(escape)Tj
2.8063 0 Td
(from)Tj
2.2053 0 Td
(maternal)Tj
3.7928 0 Td
(humoral)Tj
-31.6968 -1.2983 Td
(responses.)Tj
1.1962 -1.2982 Td
(The)Tj
1.7858 0 Td
(use)Tj
1.5307 0 Td
(of)Tj
1.0148 0 Td
(broadly)Tj
3.2711 0 Td
(neutralizing)Tj
5.0287 0 Td
(antibodies)Tj
4.3596 0 Td
(as)Tj
1.0148 0 Td
(a)Tj
0.652 0 Td
(treatment)Tj
4.1385 0 Td
(and/or)Tj
2.9367 0 Td
(prevention)Tj
4.5808 0 Td
(strategy)Tj
3.3278 0 Td
(is)Tj
0.8447 0 Td
(cur-)Tj
-35.6822 -1.3039 Td
(rently)Tj
2.5625 0 Td
(being)Tj
2.4321 0 Td
(explored)Tj
3.702 0 Td
(in)Tj
1.0318 0 Td
(adult)Tj
2.2564 0 Td
(and)Tj
1.7291 0 Td
(infant)Tj
2.6078 0 Td
(clinical)Tj
3.0728 0 Td
(trials)Tj
2.1996 0 Td
([)Tj
0.83 0.64 0.02 0 k
(35)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.7348 0 Td
(36)Tj
0 g
(].)Tj
1.7348 0 Td
(Among)Tj
3.2485 0 Td
(the)Tj
1.4683 0 Td
(new)Tj
1.8766 0 Td
(generation)Tj
4.507 0 Td
(of)Tj
-36.1641 -1.2983 Td
(bNAbs,)Tj
3.2371 0 Td
(VRC01)Tj
3.1521 0 Td
(\(antibody)Tj
4.1045 0 Td
(recognizing)Tj
4.921 0 Td
(CD4bs)Tj
2.965 0 Td
(region\))Tj
3.1407 0 Td
(has)Tj
1.5421 0 Td
(been)Tj
2.1203 0 Td
(able)Tj
1.8312 0 Td
(to)Tj
1.0261 0 Td
(neutralize)Tj
4.1726 0 Td
(about)Tj
2.4944 0 Td
(80%)Tj
1.9276 0 Td
(of)Tj
-36.6347 -1.2983 Td
(diverse)Tj
3.05 0 Td
(HIV-1)Tj
2.846 0 Td
(strains)Tj
2.8629 0 Td
([)Tj
0.83 0.64 0.02 0 k
(37)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.7348 0 Td
(38)Tj
0 g
(].)Tj
1.7348 0 Td
(This)Tj
1.9899 0 Td
(has)Tj
1.5421 0 Td
(led)Tj
1.4173 0 Td
(to)Tj
1.0261 0 Td
(studies)Tj
2.9877 0 Td
(of)Tj
1.0148 0 Td
(VRC01)Tj
3.1465 0 Td
(impact)Tj
2.982 0 Td
(on)Tj
1.2756 0 Td
(HIV-1)Tj
2.8459 0 Td
(infection)Tj
3.7928 0 Td
(in)Tj
-36.2492 -1.3039 Td
(adults)Tj
2.6135 0 Td
(and)Tj
1.7291 0 Td
(infants)Tj
2.965 0 Td
(when)Tj
2.4038 0 Td
(infused)Tj
3.1634 0 Td
(passively,)Tj
3.9685 0 Td
(with)Tj
1.9956 0 Td
(a)Tj
0.652 0 Td
(phase)Tj
2.4831 0 Td
(I)Tj
0.5612 0 Td
(study)Tj
2.3925 0 Td
(of)Tj
1.0148 0 Td
(pharmacokinetics)Tj
7.336 0 Td
(and)Tj
1.7348 0 Td
(safety)Tj
-35.0133 -1.2982 Td
(of)Tj
1.0147 0 Td
(VRC01)Tj
3.1522 0 Td
(in)Tj
1.0318 0 Td
(HIV-exposed)Tj
5.6012 0 Td
(newborns)Tj
4.1669 0 Td
(currently)Tj
3.8891 0 Td
(underway)Tj
4.1896 0 Td
([)Tj
0.83 0.64 0.02 0 k
(39)Tj
0 g
(].)Tj
2.0749 0 Td
(However,)Tj
4.0819 0 Td
(the)Tj
1.4683 0 Td
(susceptibility)Tj
5.4368 0 Td
(of)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 144.5669 23.6976 re
W* n
q
144.5102 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 449.1779 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Mother)Tj
3.2811 0 Td
(to)Tj
1.0417 0 Td
(child)Tj
2.2323 0 Td
(transmis)Tj
3.7134 0 Td
(sion)Tj
2.0197 0 Td
(of)Tj
1.0418 0 Td
(HIV-1)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
0.83 0.64 0.02 0 k
102.0472 34.9228 m
256.1953 34.9228 l
h
f*
0 g
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(Pathogens)Tj
4.9252 0 Td
(|)Tj
0.83 0.64 0.02 0 k
0.4748 0 Td
(https://)Tj
2.9552 0 Td
(doi.org/10.13)Tj
5.7331 0 Td
(71/journal.p)Tj
5.1236 0 Td
(pat.1006)Tj
3.8198 0 Td
(944)Tj
0 g
2.6362 0 Td
(April)Tj
2.1756 0 Td
(19,)Tj
1.5874 0 Td
(2018)Tj
32.8538 0 Td
(3)Tj
0.7654 0 Td
(/)Tj
ET
endstream
endobj
75 0 obj
<>stream
endstream
endobj
76 0 obj
<>stream
endstream
endobj
77 0 obj
<>stream
endstream
endobj
78 0 obj
<>stream
endstream
endobj
79 0 obj
<>stream
endstream
endobj
80 0 obj
<>stream
endstream
endobj
81 0 obj
<>stream
endstream
endobj
82 0 obj
<>stream
endstream
endobj
83 0 obj
<>stream
endstream
endobj
84 0 obj
<>stream
endstream
endobj
85 0 obj
<>stream
endstream
endobj
86 0 obj
<>stream
endstream
endobj
87 0 obj
<>stream
endstream
endobj
88 0 obj
<>stream
endstream
endobj
89 0 obj
<>stream
endstream
endobj
90 0 obj
<>stream
endstream
endobj
91 0 obj
<>stream
BT
66.402 0 Td
(26)Tj
ET
Q
endstream
endobj
92 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 12 0 R/Annots 95 0 R/Contents 96 0 R/TrimBox[0 0 612 792]>>
endobj
95 0 obj
[97 0 R 98 0 R 99 0 R 100 0 R 101 0 R 102 0 R 103 0 R 104 0 R]
endobj
97 0 obj
<>/Border[0 0 0]/Dest(Rppat.1006944.ref017)>>
endobj
98 0 obj
<>/Border[0 0 0]/Dest(Rppat.1006944.ref036)>>
endobj
99 0 obj
<>/Border[0 0 0]/Dest(Rppat.1006944.ref040)>>
endobj
100 0 obj
<>/Border[0 0 0]/Dest(Rppat.1006944.t001)>>
endobj
101 0 obj
<>/Border[0 0 0]/Dest(Rppat.1006944.ref024)>>
endobj
102 0 obj
<>/Border[0 0 0]/Dest(Lppat.1006944.t001)>>
endobj
103 0 obj
<>/Border[0 0 0]/A 105 0 R>>
endobj
105 0 obj
<>
endobj
104 0 obj
<>/Border[0 0 0]/A 106 0 R>>
endobj
106 0 obj
<>
endobj
96 0 obj
[107 0 R 108 0 R 109 0 R 110 0 R 111 0 R 112 0 R 113 0 R 114 0 R 115 0 R]
endobj
107 0 obj
<>stream
q
0.83 0.64 0.02 0 k
339.4205 693.2976 m
348.9449 693.2976 l
h
f*
463.0677 680.315 m
472.5354 680.315 l
h
f*
477.0142 680.315 m
486.5386 680.315 l
h
f*
541.3039 474.2929 m
570.1039 474.2929 l
h
f*
447.5906 461.3102 m
456.9449 461.3102 l
h
f*
0 g
1 j
1 J
0 w
10 0 0 10 200.0125 707.4141 cm
BT
/F7 1 Tf
1 TL
-0.004 Tc
0 0 Td
(infant)Tj
2.6021 0 Td
(T/F)Tj
1.6895 0 Td
(viruses)Tj
2.9877 0 Td
(to)Tj
1.0261 0 Td
(bNAbs)Tj
3.0104 0 Td
(like)Tj
1.6554 0 Td
(VRC01)Tj
3.1521 0 Td
(does)Tj
2.0409 0 Td
(not)Tj
1.5704 0 Td
(seem)Tj
2.2507 0 Td
(to)Tj
1.0205 0 Td
(define)Tj
2.6986 0 Td
(infant)Tj
2.6078 0 Td
(T/F)Tj
1.6895 0 Td
(viruses)Tj
2.982 0 Td
(from)Tj
-32.9837 -1.3039 Td
(maternal)Tj
3.7927 0 Td
(non-transmitted)Tj
6.8258 0 Td
(viruses)Tj
2.982 0 Td
([)Tj
0.83 0.64 0.02 0 k
(17)Tj
0 g
(])Tj
1.8538 0 Td
(and)Tj
1.7292 0 Td
(administration)Tj
6.1738 0 Td
(of)Tj
1.0148 0 Td
(a)Tj
0.6519 0 Td
(bNAb)Tj
2.6533 0 Td
(to)Tj
1.0261 0 Td
(chronically-infected)Tj
-28.7034 -1.2982 Td
(mothers)Tj
3.5262 0 Td
(is)Tj
0.8504 0 Td
(likely)Tj
2.3528 0 Td
(to)Tj
1.0261 0 Td
(lead)Tj
1.8482 0 Td
(to)Tj
1.0261 0 Td
(rapid)Tj
2.3414 0 Td
(development)Tj
5.4085 0 Td
(of)Tj
1.0148 0 Td
(resistant)Tj
3.5829 0 Td
(viruses)Tj
2.9877 0 Td
([)Tj
0.83 0.64 0.02 0 k
(36)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.7348 0 Td
(40)Tj
0 g
(].)Tj
1.7348 0 Td
(Thus,)Tj
2.4775 0 Td
(defining)Tj
3.5546 0 Td
(the)Tj
-35.4668 -1.2983 Td
(role)Tj
1.7688 0 Td
(of)Tj
1.0148 0 Td
(autologous)Tj
4.5977 0 Td
(neutralization)Tj
5.8053 0 Td
(in)Tj
1.0375 0 Td
(MTCT)Tj
2.999 0 Td
(is)Tj
0.8448 0 Td
(critical)Tj
2.9536 0 Td
(to)Tj
1.0262 0 Td
(establishing)Tj
4.9266 0 Td
(the)Tj
1.4683 0 Td
(utility)Tj
2.5795 0 Td
(of)Tj
1.0148 0 Td
(active)Tj
2.5228 0 Td
(mater-)Tj
-34.5597 -1.2983 Td
(nal)Tj
1.4456 0 Td
(vaccination)Tj
4.8302 0 Td
(to)Tj
1.0205 0 Td
(further)Tj
3.033 0 Td
(reduce)Tj
2.914 0 Td
(and)Tj
1.7292 0 Td
(eliminate)Tj
3.9514 0 Td
(infant)Tj
2.6022 0 Td
(HIV)Tj
2.0239 0 Td
(infections.)Tj
-22.3538 -1.3039 Td
(In)Tj
1.1111 0 Td
(this)Tj
1.6725 0 Td
(study,)Tj
2.6192 0 Td
(we)Tj
1.3266 0 Td
(characterized)Tj
5.5558 0 Td
(maternal)Tj
3.7984 0 Td
(non-transmitting)Tj
7.149 0 Td
(and)Tj
1.7348 0 Td
(infant)Tj
2.6022 0 Td
(T/F)Tj
1.6894 0 Td
(viruses)Tj
2.9877 0 Td
(from)Tj
2.2053 0 Td
(16)Tj
-35.6482 -1.2982 Td
(HIV-1)Tj
2.8459 0 Td
(clade)Tj
2.2734 0 Td
(B)Tj
0.805 0 Td
(infected)Tj
3.4186 0 Td
(peripartum)Tj
4.7678 0 Td
(transmission)Tj
5.3631 0 Td
(mother-infant)Tj
5.9017 0 Td
(pairs)Tj
2.1714 0 Td
(from)Tj
2.2053 0 Td
(the)Tj
1.4683 0 Td
(WITS)Tj
2.6136 0 Td
(cohort)Tj
-33.8341 -1.2983 Td
(and)Tj
1.7291 0 Td
(defined)Tj
3.2258 0 Td
(the)Tj
1.4683 0 Td
(role)Tj
1.7688 0 Td
(of)Tj
1.0148 0 Td
(concurrent)Tj
4.6658 0 Td
(maternal)Tj
3.7928 0 Td
(autologous)Tj
4.6034 0 Td
(neutralizing)Tj
5.0286 0 Td
(antibodies)Tj
4.3597 0 Td
(in)Tj
1.0374 0 Td
(selecting)Tj
3.6794 0 Td
(for)Tj
-36.3739 -1.3039 Td
(infant)Tj
2.6021 0 Td
(T/F)Tj
1.6895 0 Td
(viruses.)Tj
3.2144 0 Td
(We)Tj
1.6044 0 Td
(sought)Tj
2.9084 0 Td
(to)Tj
1.0261 0 Td
(define)Tj
2.6986 0 Td
(if)Tj
0.7767 0 Td
(neutralization)Tj
5.8053 0 Td
(resistance)Tj
4.1272 0 Td
(to)Tj
1.0261 0 Td
(paired)Tj
2.761 0 Td
(maternal)Tj
3.7984 0 Td
(plasma)Tj
-34.0382 -1.2983 Td
(was)Tj
1.6951 0 Td
(a)Tj
0.6576 0 Td
(defining)Tj
3.5546 0 Td
(feature)Tj
2.9877 0 Td
(of)Tj
1.0148 0 Td
(infant)Tj
2.6022 0 Td
(T/F)Tj
1.6894 0 Td
(viruses)Tj
2.9877 0 Td
(compared)Tj
4.2406 0 Td
(to)Tj
1.0262 0 Td
(other)Tj
2.347 0 Td
(circulating)Tj
4.4958 0 Td
(non-transmitted)Tj
-29.2987 -1.2983 Td
(maternal)Tj
3.7927 0 Td
(variants,)Tj
3.617 0 Td
(which)Tj
2.6475 0 Td
(will)Tj
1.6668 0 Td
(inform)Tj
3.0217 0 Td
(the)Tj
1.4683 0 Td
(development)Tj
5.4085 0 Td
(of)Tj
1.0148 0 Td
(maternal)Tj
3.7984 0 Td
(or)Tj
1.0942 0 Td
(infant)Tj
2.6078 0 Td
(vaccination)Tj
4.8245 0 Td
(strate-)Tj
-34.9622 -1.3039 Td
(gies)Tj
1.7347 0 Td
(to)Tj
1.0262 0 Td
(further)Tj
3.0274 0 Td
(reduced)Tj
3.4469 0 Td
(MTCT)Tj
2.999 0 Td
(risk)Tj
1.7121 0 Td
(to)Tj
1.0262 0 Td
(achieve)Tj
3.1747 0 Td
(an)Tj
1.2019 0 Td
(HIV-free)Tj
3.8778 0 Td
(generation.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 536.3716 cm
BT
/F2 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Results)Tj
/F12 1 Tf
0 -1.5023 Td
(Maternal)Tj
4.0441 0 Td
(and)Tj
1.7905 0 Td
(infant)Tj
2.7591 0 Td
(sample)Tj
3.1701 0 Td
(characteristics)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 501.3354 cm
BT
/F7 1 Tf
1 TL
-0.01 Tc
0 0 Td
(We)Tj
1.5987 0 Td
(selected)Tj
3.2938 0 Td
(HIV-1)Tj
2.8233 0 Td
(infected)Tj
3.3675 0 Td
(mother-infant)Tj
5.828 0 Td
(transmission)Tj
5.2951 0 Td
(pairs)Tj
2.1373 0 Td
(from)Tj
2.1827 0 Td
(the)Tj
1.4513 0 Td
(WITS)Tj
2.5909 0 Td
(cohort)Tj
2.8176 0 Td
(that)Tj
1.7518 0 Td
(met)Tj
-35.138 -1.2982 Td
(the)Tj
1.4513 0 Td
(inclusion)Tj
3.8607 0 Td
(criteria)Tj
3.0274 0 Td
(of)Tj
1.0035 0 Td
(peripartum)Tj
4.7111 0 Td
(transmission)Tj
5.2895 0 Td
(\(infants)Tj
3.2598 0 Td
(tested)Tj
2.5171 0 Td
(negative)Tj
3.4866 0 Td
(for)Tj
1.3663 0 Td
(HIV-1)Tj
2.8176 0 Td
(infection)Tj
3.7417 0 Td
(at)Tj
-36.5326 -1.2983 Td
(birth)Tj
2.1599 0 Td
(by)Tj
1.1679 0 Td
(HIV-1)Tj
2.8233 0 Td
(DNA)Tj
2.3584 0 Td
(PCR,)Tj
2.262 0 Td
(yet)Tj
1.3777 0 Td
(had)Tj
1.6951 0 Td
(HIV-1)Tj
2.8176 0 Td
(DNA)Tj
2.3584 0 Td
(detectable)Tj
4.1669 0 Td
(at)Tj
0.9411 0 Td
(one)Tj
1.6781 0 Td
(week)Tj
2.2223 0 Td
(of)Tj
1.0035 0 Td
(age)Tj
1.525 0 Td
(or)Tj
1.0885 0 Td
(older;)Tj
0.83 0.64 0.02 0 k
2.4832 0 Td
(Table)Tj
2.4151 0 Td
(1)Tj
0 g
(\).)Tj
-36.544 -1.2982 Td
(These)Tj
2.5341 0 Td
(HIV-exposed)Tj
5.5275 0 Td
(infants)Tj
2.9254 0 Td
(had)Tj
1.6894 0 Td
(not)Tj
1.5534 0 Td
(reportedly)Tj
4.2973 0 Td
(been)Tj
2.0976 0 Td
(breastfed)Tj
3.7984 0 Td
([)Tj
0.83 0.64 0.02 0 k
(24)Tj
0 g
(].)Tj
2.0409 0 Td
(Infant)Tj
2.6419 0 Td
(plasma)Tj
2.9934 0 Td
(samples)Tj
3.3392 0 Td
(avail-)Tj
-35.4385 -1.304 Td
(able)Tj
1.8028 0 Td
(for)Tj
1.3719 0 Td
(sequencing)Tj
4.6545 0 Td
(were)Tj
2.0976 0 Td
(between)Tj
3.4866 0 Td
(1674)Tj
2.6135 0 Td
(days)Tj
1.9729 0 Td
(of)Tj
1.0035 0 Td
(age.)Tj
1.7405 0 Td
(Five)Tj
1.8708 0 Td
(HIV-infected)Tj
5.4992 0 Td
(infants)Tj
2.9253 0 Td
(with)Tj
1.9729 0 Td
(heteroge-)Tj
-33.012 -1.2982 Td
(neous)Tj
2.5568 0 Td
(virus)Tj
2.1713 0 Td
(populations)Tj
4.8869 0 Td
(were)Tj
2.0976 0 Td
(excluded)Tj
3.7361 0 Td
(from)Tj
2.1826 0 Td
(the)Tj
1.4514 0 Td
(study)Tj
2.3584 0 Td
(due)Tj
1.6837 0 Td
(to)Tj
1.0148 0 Td
(our)Tj
1.6044 0 Td
(inability)Tj
3.4583 0 Td
(to)Tj
1.0148 0 Td
(confidently)Tj
4.6828 0 Td
(infer)Tj
-34.8999 -1.2983 Td
(the)Tj
1.4513 0 Td
(infant)Tj
2.5682 0 Td
(T/F)Tj
1.6724 0 Td
(viral)Tj
1.9615 0 Td
(sequences,)Tj
4.3824 0 Td
(and)Tj
1.7121 0 Td
(selected)Tj
3.2995 0 Td
(a)Tj
0.652 0 Td
(total)Tj
1.9729 0 Td
(of)Tj
1.0034 0 Td
(16)Tj
1.1566 0 Td
(mother-infant)Tj
5.8279 0 Td
(transmission)Tj
5.2895 0 Td
(pairs)Tj
2.1429 0 Td
(for)Tj
-35.0926 -1.3039 Td
(this)Tj
1.6497 0 Td
(study.)Tj
2.5795 0 Td
(The)Tj
1.7632 0 Td
(maternal)Tj
3.7473 0 Td
(plasma)Tj
2.9991 0 Td
(viral)Tj
1.9615 0 Td
(load)Tj
1.9106 0 Td
(of)Tj
1.0034 0 Td
(the)Tj
1.4514 0 Td
(selected)Tj
3.2995 0 Td
(transmitting)Tj
5.125 0 Td
(women)Tj
3.1748 0 Td
(ranged)Tj
2.9536 0 Td
(from)Tj
ET
Q
q
0.45 0.36 0.35 0.01 k
1 j
1 J
0 w
36 382.2517 m
576 382.2517 l
576 381.7517 l
36 381.7517 l
f*
79.5407 381.7517 m
79.5407 340.7516 l
79.0407 340.7516 l
79.0407 381.7517 l
f*
79.0407 340.7516 m
36 340.7516 l
36 341.2517 l
79.0407 341.2517 l
f*
101.7408 381.7517 m
101.7408 340.7516 l
101.2408 340.7516 l
101.2408 381.7517 l
f*
101.2408 340.7516 m
79.5407 340.7516 l
79.5407 341.2517 l
101.2408 341.2517 l
f*
154.4958 381.7517 m
154.4958 340.7516 l
153.9958 340.7516 l
153.9958 381.7517 l
f*
153.9958 340.7516 m
101.7408 340.7516 l
101.7408 341.2517 l
153.9958 341.2517 l
f*
211.6057 381.7517 m
211.6057 340.7516 l
211.1057 340.7516 l
211.1057 381.7517 l
f*
211.1057 340.7516 m
154.4958 340.7516 l
154.4958 341.2517 l
211.1057 341.2517 l
f*
267.3179 381.7517 m
267.3179 340.7516 l
266.8178 340.7516 l
266.8178 381.7517 l
f*
266.8178 340.7516 m
211.6057 340.7516 l
211.6057 341.2517 l
266.8178 341.2517 l
f*
326.2671 381.7517 m
326.2671 340.7516 l
325.7671 340.7516 l
325.7671 381.7517 l
f*
325.7671 340.7516 m
267.3179 340.7516 l
267.3179 341.2517 l
325.7671 341.2517 l
f*
368.778 381.7517 m
368.778 340.7516 l
368.278 340.7516 l
368.278 381.7517 l
f*
368.278 340.7516 m
326.2671 340.7516 l
326.2671 341.2517 l
368.278 341.2517 l
f*
411.6609 381.7517 m
411.6609 340.7516 l
411.1608 340.7516 l
411.1608 381.7517 l
f*
411.1608 340.7516 m
368.778 340.7516 l
368.778 341.2517 l
411.1608 341.2517 l
f*
464.3141 381.7517 m
464.3141 340.7516 l
463.8141 340.7516 l
463.8141 381.7517 l
f*
463.8141 340.7516 m
411.6609 340.7516 l
411.6609 341.2517 l
463.8141 341.2517 l
f*
512.515 381.7517 m
512.515 340.7516 l
512.015 340.7516 l
512.015 381.7517 l
f*
512.015 340.7516 m
464.3141 340.7516 l
464.3141 341.2517 l
512.015 341.2517 l
f*
576 340.7516 m
512.515 340.7516 l
512.515 341.2517 l
576 341.2517 l
f*
79.5407 340.7516 m
79.5407 328.2517 l
79.0407 328.2517 l
79.0407 340.7516 l
f*
79.0407 328.2517 m
36 328.2517 l
36 328.7517 l
79.0407 328.7517 l
f*
101.7408 340.7516 m
101.7408 328.2517 l
101.2408 328.2517 l
101.2408 340.7516 l
f*
101.2408 328.2517 m
79.5407 328.2517 l
79.5407 328.7517 l
101.2408 328.7517 l
f*
154.4958 340.7516 m
154.4958 328.2517 l
153.9958 328.2517 l
153.9958 340.7516 l
f*
153.9958 328.2517 m
101.7408 328.2517 l
101.7408 328.7517 l
153.9958 328.7517 l
f*
211.6057 340.7516 m
211.6057 328.2517 l
211.1057 328.2517 l
211.1057 340.7516 l
f*
211.1057 328.2517 m
154.4958 328.2517 l
154.4958 328.7517 l
211.1057 328.7517 l
f*
267.3179 340.7516 m
267.3179 328.2517 l
266.8178 328.2517 l
266.8178 340.7516 l
f*
266.8178 328.2517 m
211.6057 328.2517 l
211.6057 328.7517 l
266.8178 328.7517 l
f*
326.2671 340.7516 m
326.2671 328.2517 l
325.7671 328.2517 l
325.7671 340.7516 l
f*
325.7671 328.2517 m
267.3179 328.2517 l
267.3179 328.7517 l
325.7671 328.7517 l
f*
368.778 340.7516 m
368.778 328.2517 l
368.278 328.2517 l
368.278 340.7516 l
f*
368.278 328.2517 m
326.2671 328.2517 l
326.2671 328.7517 l
368.278 328.7517 l
f*
411.6609 340.7516 m
411.6609 328.2517 l
411.1608 328.2517 l
411.1608 340.7516 l
f*
411.1608 328.2517 m
368.778 328.2517 l
368.778 328.7517 l
411.1608 328.7517 l
f*
464.3141 340.7516 m
464.3141 328.2517 l
463.8141 328.2517 l
463.8141 340.7516 l
f*
463.8141 328.2517 m
411.6609 328.2517 l
411.6609 328.7517 l
463.8141 328.7517 l
f*
512.515 340.7516 m
512.515 328.2517 l
512.015 328.2517 l
512.015 340.7516 l
f*
512.015 328.2517 m
464.3141 328.2517 l
464.3141 328.7517 l
512.015 328.7517 l
f*
576 328.2517 m
512.515 328.2517 l
512.515 328.7517 l
576 328.7517 l
f*
79.5407 328.2517 m
79.5407 315.7517 l
79.0407 315.7517 l
79.0407 328.2517 l
f*
79.0407 315.7517 m
36 315.7517 l
36 316.2518 l
79.0407 316.2518 l
f*
101.7408 328.2517 m
101.7408 315.7517 l
101.2408 315.7517 l
101.2408 328.2517 l
f*
101.2408 315.7517 m
79.5407 315.7517 l
79.5407 316.2518 l
101.2408 316.2518 l
f*
154.4958 328.2517 m
154.4958 315.7517 l
153.9958 315.7517 l
153.9958 328.2517 l
f*
153.9958 315.7517 m
101.7408 315.7517 l
101.7408 316.2518 l
153.9958 316.2518 l
f*
211.6057 328.2517 m
211.6057 315.7517 l
211.1057 315.7517 l
211.1057 328.2517 l
f*
211.1057 315.7517 m
154.4958 315.7517 l
154.4958 316.2518 l
211.1057 316.2518 l
f*
267.3179 328.2517 m
267.3179 315.7517 l
266.8178 315.7517 l
266.8178 328.2517 l
f*
266.8178 315.7517 m
211.6057 315.7517 l
211.6057 316.2518 l
266.8178 316.2518 l
f*
326.2671 328.2517 m
326.2671 315.7517 l
325.7671 315.7517 l
325.7671 328.2517 l
f*
325.7671 315.7517 m
267.3179 315.7517 l
267.3179 316.2518 l
325.7671 316.2518 l
f*
368.778 328.2517 m
368.778 315.7517 l
368.278 315.7517 l
368.278 328.2517 l
f*
368.278 315.7517 m
326.2671 315.7517 l
326.2671 316.2518 l
368.278 316.2518 l
f*
411.6609 328.2517 m
411.6609 315.7517 l
411.1608 315.7517 l
411.1608 328.2517 l
f*
411.1608 315.7517 m
368.778 315.7517 l
368.778 316.2518 l
411.1608 316.2518 l
f*
464.3141 328.2517 m
464.3141 315.7517 l
463.8141 315.7517 l
463.8141 328.2517 l
f*
463.8141 315.7517 m
411.6609 315.7517 l
411.6609 316.2518 l
463.8141 316.2518 l
f*
512.515 328.2517 m
512.515 315.7517 l
512.015 315.7517 l
512.015 328.2517 l
f*
512.015 315.7517 m
464.3141 315.7517 l
464.3141 316.2518 l
512.015 316.2518 l
f*
576 315.7517 m
512.515 315.7517 l
512.515 316.2518 l
576 316.2518 l
f*
79.5407 315.7517 m
79.5407 303.2518 l
79.0407 303.2518 l
79.0407 315.7517 l
f*
79.0407 303.2518 m
36 303.2518 l
36 303.7518 l
79.0407 303.7518 l
f*
101.7408 315.7517 m
101.7408 303.2518 l
101.2408 303.2518 l
101.2408 315.7517 l
f*
101.2408 303.2518 m
79.5407 303.2518 l
79.5407 303.7518 l
101.2408 303.7518 l
f*
154.4958 315.7517 m
154.4958 303.2518 l
153.9958 303.2518 l
153.9958 315.7517 l
f*
153.9958 303.2518 m
101.7408 303.2518 l
101.7408 303.7518 l
153.9958 303.7518 l
f*
211.6057 315.7517 m
211.6057 303.2518 l
211.1057 303.2518 l
211.1057 315.7517 l
f*
211.1057 303.2518 m
154.4958 303.2518 l
154.4958 303.7518 l
211.1057 303.7518 l
f*
267.3179 315.7517 m
267.3179 303.2518 l
266.8178 303.2518 l
266.8178 315.7517 l
f*
266.8178 303.2518 m
211.6057 303.2518 l
211.6057 303.7518 l
266.8178 303.7518 l
f*
326.2671 315.7517 m
326.2671 303.2518 l
325.7671 303.2518 l
325.7671 315.7517 l
f*
325.7671 303.2518 m
267.3179 303.2518 l
267.3179 303.7518 l
325.7671 303.7518 l
f*
368.778 315.7517 m
368.778 303.2518 l
368.278 303.2518 l
368.278 315.7517 l
f*
368.278 303.2518 m
326.2671 303.2518 l
326.2671 303.7518 l
368.278 303.7518 l
f*
411.6609 315.7517 m
411.6609 303.2518 l
411.1608 303.2518 l
411.1608 315.7517 l
f*
411.1608 303.2518 m
368.778 303.2518 l
368.778 303.7518 l
411.1608 303.7518 l
f*
464.3141 315.7517 m
464.3141 303.2518 l
463.8141 303.2518 l
463.8141 315.7517 l
f*
463.8141 303.2518 m
411.6609 303.2518 l
411.6609 303.7518 l
463.8141 303.7518 l
f*
512.515 315.7517 m
512.515 303.2518 l
512.015 303.2518 l
512.015 315.7517 l
f*
512.015 303.2518 m
464.3141 303.2518 l
464.3141 303.7518 l
512.015 303.7518 l
f*
576 303.2518 m
512.515 303.2518 l
512.515 303.7518 l
576 303.7518 l
f*
79.5407 303.2518 m
79.5407 290.7519 l
79.0407 290.7519 l
79.0407 303.2518 l
f*
79.0407 290.7519 m
36 290.7519 l
36 291.2519 l
79.0407 291.2519 l
f*
101.7408 303.2518 m
101.7408 290.7519 l
101.2408 290.7519 l
101.2408 303.2518 l
f*
101.2408 290.7519 m
79.5407 290.7519 l
79.5407 291.2519 l
101.2408 291.2519 l
f*
154.4958 303.2518 m
154.4958 290.7519 l
153.9958 290.7519 l
153.9958 303.2518 l
f*
153.9958 290.7519 m
101.7408 290.7519 l
101.7408 291.2519 l
153.9958 291.2519 l
f*
211.6057 303.2518 m
211.6057 290.7519 l
211.1057 290.7519 l
211.1057 303.2518 l
f*
211.1057 290.7519 m
154.4958 290.7519 l
154.4958 291.2519 l
211.1057 291.2519 l
f*
267.3179 303.2518 m
267.3179 290.7519 l
266.8178 290.7519 l
266.8178 303.2518 l
f*
266.8178 290.7519 m
211.6057 290.7519 l
211.6057 291.2519 l
266.8178 291.2519 l
f*
326.2671 303.2518 m
326.2671 290.7519 l
325.7671 290.7519 l
325.7671 303.2518 l
f*
325.7671 290.7519 m
267.3179 290.7519 l
267.3179 291.2519 l
325.7671 291.2519 l
f*
368.778 303.2518 m
368.778 290.7519 l
368.278 290.7519 l
368.278 303.2518 l
f*
368.278 290.7519 m
326.2671 290.7519 l
326.2671 291.2519 l
368.278 291.2519 l
f*
411.6609 303.2518 m
411.6609 290.7519 l
411.1608 290.7519 l
411.1608 303.2518 l
f*
411.1608 290.7519 m
368.778 290.7519 l
368.778 291.2519 l
411.1608 291.2519 l
f*
464.3141 303.2518 m
464.3141 290.7519 l
463.8141 290.7519 l
463.8141 303.2518 l
f*
463.8141 290.7519 m
411.6609 290.7519 l
411.6609 291.2519 l
463.8141 291.2519 l
f*
512.515 303.2518 m
512.515 290.7519 l
512.015 290.7519 l
512.015 303.2518 l
f*
512.015 290.7519 m
464.3141 290.7519 l
464.3141 291.2519 l
512.015 291.2519 l
f*
576 290.7519 m
512.515 290.7519 l
512.515 291.2519 l
576 291.2519 l
f*
79.5407 290.7519 m
79.5407 278.2519 l
79.0407 278.2519 l
79.0407 290.7519 l
f*
79.0407 278.2519 m
36 278.2519 l
36 278.752 l
79.0407 278.752 l
f*
101.7408 290.7519 m
101.7408 278.2519 l
101.2408 278.2519 l
101.2408 290.7519 l
f*
101.2408 278.2519 m
79.5407 278.2519 l
79.5407 278.752 l
101.2408 278.752 l
f*
154.4958 290.7519 m
154.4958 278.2519 l
153.9958 278.2519 l
153.9958 290.7519 l
f*
153.9958 278.2519 m
101.7408 278.2519 l
101.7408 278.752 l
153.9958 278.752 l
f*
211.6057 290.7519 m
211.6057 278.2519 l
211.1057 278.2519 l
211.1057 290.7519 l
f*
211.1057 278.2519 m
154.4958 278.2519 l
154.4958 278.752 l
211.1057 278.752 l
f*
267.3179 290.7519 m
267.3179 278.2519 l
266.8178 278.2519 l
266.8178 290.7519 l
f*
266.8178 278.2519 m
211.6057 278.2519 l
211.6057 278.752 l
266.8178 278.752 l
f*
326.2671 290.7519 m
326.2671 278.2519 l
325.7671 278.2519 l
325.7671 290.7519 l
f*
325.7671 278.2519 m
267.3179 278.2519 l
267.3179 278.752 l
325.7671 278.752 l
f*
368.778 290.7519 m
368.778 278.2519 l
368.278 278.2519 l
368.278 290.7519 l
f*
368.278 278.2519 m
326.2671 278.2519 l
326.2671 278.752 l
368.278 278.752 l
f*
411.6609 290.7519 m
411.6609 278.2519 l
411.1608 278.2519 l
411.1608 290.7519 l
f*
411.1608 278.2519 m
368.778 278.2519 l
368.778 278.752 l
411.1608 278.752 l
f*
464.3141 290.7519 m
464.3141 278.2519 l
463.8141 278.2519 l
463.8141 290.7519 l
f*
463.8141 278.2519 m
411.6609 278.2519 l
411.6609 278.752 l
463.8141 278.752 l
f*
512.515 290.7519 m
512.515 278.2519 l
512.015 278.2519 l
512.015 290.7519 l
f*
512.015 278.2519 m
464.3141 278.2519 l
464.3141 278.752 l
512.015 278.752 l
f*
576 278.2519 m
512.515 278.2519 l
512.515 278.752 l
576 278.752 l
f*
79.5407 278.2519 m
79.5407 265.752 l
79.0407 265.752 l
79.0407 278.2519 l
f*
79.0407 265.752 m
36 265.752 l
36 266.252 l
79.0407 266.252 l
f*
101.7408 278.2519 m
101.7408 265.752 l
101.2408 265.752 l
101.2408 278.2519 l
f*
101.2408 265.752 m
79.5407 265.752 l
79.5407 266.252 l
101.2408 266.252 l
f*
154.4958 278.2519 m
154.4958 265.752 l
153.9958 265.752 l
153.9958 278.2519 l
f*
153.9958 265.752 m
101.7408 265.752 l
101.7408 266.252 l
153.9958 266.252 l
f*
211.6057 278.2519 m
211.6057 265.752 l
211.1057 265.752 l
211.1057 278.2519 l
f*
211.1057 265.752 m
154.4958 265.752 l
154.4958 266.252 l
211.1057 266.252 l
f*
267.3179 278.2519 m
267.3179 265.752 l
266.8178 265.752 l
266.8178 278.2519 l
f*
266.8178 265.752 m
211.6057 265.752 l
211.6057 266.252 l
266.8178 266.252 l
f*
326.2671 278.2519 m
326.2671 265.752 l
325.7671 265.752 l
325.7671 278.2519 l
f*
325.7671 265.752 m
267.3179 265.752 l
267.3179 266.252 l
325.7671 266.252 l
f*
368.778 278.2519 m
368.778 265.752 l
368.278 265.752 l
368.278 278.2519 l
f*
368.278 265.752 m
326.2671 265.752 l
326.2671 266.252 l
368.278 266.252 l
f*
411.6609 278.2519 m
411.6609 265.752 l
411.1608 265.752 l
411.1608 278.2519 l
f*
411.1608 265.752 m
368.778 265.752 l
368.778 266.252 l
411.1608 266.252 l
f*
464.3141 278.2519 m
464.3141 265.752 l
463.8141 265.752 l
463.8141 278.2519 l
f*
463.8141 265.752 m
411.6609 265.752 l
411.6609 266.252 l
463.8141 266.252 l
f*
512.515 278.2519 m
512.515 265.752 l
512.015 265.752 l
512.015 278.2519 l
f*
512.015 265.752 m
464.3141 265.752 l
464.3141 266.252 l
512.015 266.252 l
f*
576 265.752 m
512.515 265.752 l
512.515 266.252 l
576 266.252 l
f*
79.5407 265.752 m
79.5407 253.2521 l
79.0407 253.2521 l
79.0407 265.752 l
f*
79.0407 253.2521 m
36 253.2521 l
36 253.7521 l
79.0407 253.7521 l
f*
101.7408 265.752 m
101.7408 253.2521 l
101.2408 253.2521 l
101.2408 265.752 l
f*
101.2408 253.2521 m
79.5407 253.2521 l
79.5407 253.7521 l
101.2408 253.7521 l
f*
154.4958 265.752 m
154.4958 253.2521 l
153.9958 253.2521 l
153.9958 265.752 l
f*
153.9958 253.2521 m
101.7408 253.2521 l
101.7408 253.7521 l
153.9958 253.7521 l
f*
211.6057 265.752 m
211.6057 253.2521 l
211.1057 253.2521 l
211.1057 265.752 l
f*
211.1057 253.2521 m
154.4958 253.2521 l
154.4958 253.7521 l
211.1057 253.7521 l
f*
267.3179 265.752 m
267.3179 253.2521 l
266.8178 253.2521 l
266.8178 265.752 l
f*
266.8178 253.2521 m
211.6057 253.2521 l
211.6057 253.7521 l
266.8178 253.7521 l
f*
326.2671 265.752 m
326.2671 253.2521 l
325.7671 253.2521 l
325.7671 265.752 l
f*
325.7671 253.2521 m
267.3179 253.2521 l
267.3179 253.7521 l
325.7671 253.7521 l
f*
368.778 265.752 m
368.778 253.2521 l
368.278 253.2521 l
368.278 265.752 l
f*
368.278 253.2521 m
326.2671 253.2521 l
326.2671 253.7521 l
368.278 253.7521 l
f*
411.6609 265.752 m
411.6609 253.2521 l
411.1608 253.2521 l
411.1608 265.752 l
f*
411.1608 253.2521 m
368.778 253.2521 l
368.778 253.7521 l
411.1608 253.7521 l
f*
464.3141 265.752 m
464.3141 253.2521 l
463.8141 253.2521 l
463.8141 265.752 l
f*
463.8141 253.2521 m
411.6609 253.2521 l
411.6609 253.7521 l
463.8141 253.7521 l
f*
512.515 265.752 m
512.515 253.2521 l
512.015 253.2521 l
512.015 265.752 l
f*
512.015 253.2521 m
464.3141 253.2521 l
464.3141 253.7521 l
512.015 253.7521 l
f*
576 253.2521 m
512.515 253.2521 l
512.515 253.7521 l
576 253.7521 l
f*
79.5407 253.2521 m
79.5407 240.7521 l
79.0407 240.7521 l
79.0407 253.2521 l
f*
79.0407 240.7521 m
36 240.7521 l
36 241.2522 l
79.0407 241.2522 l
f*
101.7408 253.2521 m
101.7408 240.7521 l
101.2408 240.7521 l
101.2408 253.2521 l
f*
101.2408 240.7521 m
79.5407 240.7521 l
79.5407 241.2522 l
101.2408 241.2522 l
f*
154.4958 253.2521 m
154.4958 240.7521 l
153.9958 240.7521 l
153.9958 253.2521 l
f*
153.9958 240.7521 m
101.7408 240.7521 l
101.7408 241.2522 l
153.9958 241.2522 l
f*
211.6057 253.2521 m
211.6057 240.7521 l
211.1057 240.7521 l
211.1057 253.2521 l
f*
211.1057 240.7521 m
154.4958 240.7521 l
154.4958 241.2522 l
211.1057 241.2522 l
f*
267.3179 253.2521 m
267.3179 240.7521 l
266.8178 240.7521 l
266.8178 253.2521 l
f*
266.8178 240.7521 m
211.6057 240.7521 l
211.6057 241.2522 l
266.8178 241.2522 l
f*
326.2671 253.2521 m
326.2671 240.7521 l
325.7671 240.7521 l
325.7671 253.2521 l
f*
325.7671 240.7521 m
267.3179 240.7521 l
267.3179 241.2522 l
325.7671 241.2522 l
f*
368.778 253.2521 m
368.778 240.7521 l
368.278 240.7521 l
368.278 253.2521 l
f*
368.278 240.7521 m
326.2671 240.7521 l
326.2671 241.2522 l
368.278 241.2522 l
f*
411.6609 253.2521 m
411.6609 240.7521 l
411.1608 240.7521 l
411.1608 253.2521 l
f*
411.1608 240.7521 m
368.778 240.7521 l
368.778 241.2522 l
411.1608 241.2522 l
f*
464.3141 253.2521 m
464.3141 240.7521 l
463.8141 240.7521 l
463.8141 253.2521 l
f*
463.8141 240.7521 m
411.6609 240.7521 l
411.6609 241.2522 l
463.8141 241.2522 l
f*
512.515 253.2521 m
512.515 240.7521 l
512.015 240.7521 l
512.015 253.2521 l
f*
512.015 240.7521 m
464.3141 240.7521 l
464.3141 241.2522 l
512.015 241.2522 l
f*
576 240.7521 m
512.515 240.7521 l
512.515 241.2522 l
576 241.2522 l
f*
79.5407 240.7521 m
79.5407 228.2522 l
79.0407 228.2522 l
79.0407 240.7521 l
f*
79.0407 228.2522 m
36 228.2522 l
36 228.7522 l
79.0407 228.7522 l
f*
101.7408 240.7521 m
101.7408 228.2522 l
101.2408 228.2522 l
101.2408 240.7521 l
f*
101.2408 228.2522 m
79.5407 228.2522 l
79.5407 228.7522 l
101.2408 228.7522 l
f*
154.4958 240.7521 m
154.4958 228.2522 l
153.9958 228.2522 l
153.9958 240.7521 l
f*
153.9958 228.2522 m
101.7408 228.2522 l
101.7408 228.7522 l
153.9958 228.7522 l
f*
211.6057 240.7521 m
211.6057 228.2522 l
211.1057 228.2522 l
211.1057 240.7521 l
f*
211.1057 228.2522 m
154.4958 228.2522 l
154.4958 228.7522 l
211.1057 228.7522 l
f*
267.3179 240.7521 m
267.3179 228.2522 l
266.8178 228.2522 l
266.8178 240.7521 l
f*
266.8178 228.2522 m
211.6057 228.2522 l
211.6057 228.7522 l
266.8178 228.7522 l
f*
326.2671 240.7521 m
326.2671 228.2522 l
325.7671 228.2522 l
325.7671 240.7521 l
f*
325.7671 228.2522 m
267.3179 228.2522 l
267.3179 228.7522 l
325.7671 228.7522 l
f*
368.778 240.7521 m
368.778 228.2522 l
368.278 228.2522 l
368.278 240.7521 l
f*
368.278 228.2522 m
326.2671 228.2522 l
326.2671 228.7522 l
368.278 228.7522 l
f*
411.6609 240.7521 m
411.6609 228.2522 l
411.1608 228.2522 l
411.1608 240.7521 l
f*
411.1608 228.2522 m
368.778 228.2522 l
368.778 228.7522 l
411.1608 228.7522 l
f*
464.3141 240.7521 m
464.3141 228.2522 l
463.8141 228.2522 l
463.8141 240.7521 l
f*
463.8141 228.2522 m
411.6609 228.2522 l
411.6609 228.7522 l
463.8141 228.7522 l
f*
512.515 240.7521 m
512.515 228.2522 l
512.015 228.2522 l
512.015 240.7521 l
f*
512.015 228.2522 m
464.3141 228.2522 l
464.3141 228.7522 l
512.015 228.7522 l
f*
576 228.2522 m
512.515 228.2522 l
512.515 228.7522 l
576 228.7522 l
f*
79.5407 228.2522 m
79.5407 215.7523 l
79.0407 215.7523 l
79.0407 228.2522 l
f*
79.0407 215.7523 m
36 215.7523 l
36 216.2523 l
79.0407 216.2523 l
f*
101.7408 228.2522 m
101.7408 215.7523 l
101.2408 215.7523 l
101.2408 228.2522 l
f*
101.2408 215.7523 m
79.5407 215.7523 l
79.5407 216.2523 l
101.2408 216.2523 l
f*
154.4958 228.2522 m
154.4958 215.7523 l
153.9958 215.7523 l
153.9958 228.2522 l
f*
153.9958 215.7523 m
101.7408 215.7523 l
101.7408 216.2523 l
153.9958 216.2523 l
f*
211.6057 228.2522 m
211.6057 215.7523 l
211.1057 215.7523 l
211.1057 228.2522 l
f*
211.1057 215.7523 m
154.4958 215.7523 l
154.4958 216.2523 l
211.1057 216.2523 l
f*
267.3179 228.2522 m
267.3179 215.7523 l
266.8178 215.7523 l
266.8178 228.2522 l
f*
266.8178 215.7523 m
211.6057 215.7523 l
211.6057 216.2523 l
266.8178 216.2523 l
f*
326.2671 228.2522 m
326.2671 215.7523 l
325.7671 215.7523 l
325.7671 228.2522 l
f*
325.7671 215.7523 m
267.3179 215.7523 l
267.3179 216.2523 l
325.7671 216.2523 l
f*
368.778 228.2522 m
368.778 215.7523 l
368.278 215.7523 l
368.278 228.2522 l
f*
368.278 215.7523 m
326.2671 215.7523 l
326.2671 216.2523 l
368.278 216.2523 l
f*
411.6609 228.2522 m
411.6609 215.7523 l
411.1608 215.7523 l
411.1608 228.2522 l
f*
411.1608 215.7523 m
368.778 215.7523 l
368.778 216.2523 l
411.1608 216.2523 l
f*
464.3141 228.2522 m
464.3141 215.7523 l
463.8141 215.7523 l
463.8141 228.2522 l
f*
463.8141 215.7523 m
411.6609 215.7523 l
411.6609 216.2523 l
463.8141 216.2523 l
f*
512.515 228.2522 m
512.515 215.7523 l
512.015 215.7523 l
512.015 228.2522 l
f*
512.015 215.7523 m
464.3141 215.7523 l
464.3141 216.2523 l
512.015 216.2523 l
f*
576 215.7523 m
512.515 215.7523 l
512.515 216.2523 l
576 216.2523 l
f*
79.5407 215.7523 m
79.5407 203.2523 l
79.0407 203.2523 l
79.0407 215.7523 l
f*
79.0407 203.2523 m
36 203.2523 l
36 203.7523 l
79.0407 203.7523 l
f*
101.7408 215.7523 m
101.7408 203.2523 l
101.2408 203.2523 l
101.2408 215.7523 l
f*
101.2408 203.2523 m
79.5407 203.2523 l
79.5407 203.7523 l
101.2408 203.7523 l
f*
154.4958 215.7523 m
154.4958 203.2523 l
153.9958 203.2523 l
153.9958 215.7523 l
f*
153.9958 203.2523 m
101.7408 203.2523 l
101.7408 203.7523 l
153.9958 203.7523 l
f*
211.6057 215.7523 m
211.6057 203.2523 l
211.1057 203.2523 l
211.1057 215.7523 l
f*
211.1057 203.2523 m
154.4958 203.2523 l
154.4958 203.7523 l
211.1057 203.7523 l
f*
267.3179 215.7523 m
267.3179 203.2523 l
266.8178 203.2523 l
266.8178 215.7523 l
f*
266.8178 203.2523 m
211.6057 203.2523 l
211.6057 203.7523 l
266.8178 203.7523 l
f*
326.2671 215.7523 m
326.2671 203.2523 l
325.7671 203.2523 l
325.7671 215.7523 l
f*
325.7671 203.2523 m
267.3179 203.2523 l
267.3179 203.7523 l
325.7671 203.7523 l
f*
368.778 215.7523 m
368.778 203.2523 l
368.278 203.2523 l
368.278 215.7523 l
f*
368.278 203.2523 m
326.2671 203.2523 l
326.2671 203.7523 l
368.278 203.7523 l
f*
411.6609 215.7523 m
411.6609 203.2523 l
411.1608 203.2523 l
411.1608 215.7523 l
f*
411.1608 203.2523 m
368.778 203.2523 l
368.778 203.7523 l
411.1608 203.7523 l
f*
464.3141 215.7523 m
464.3141 203.2523 l
463.8141 203.2523 l
463.8141 215.7523 l
f*
463.8141 203.2523 m
411.6609 203.2523 l
411.6609 203.7523 l
463.8141 203.7523 l
f*
512.515 215.7523 m
512.515 203.2523 l
512.015 203.2523 l
512.015 215.7523 l
f*
512.015 203.2523 m
464.3141 203.2523 l
464.3141 203.7523 l
512.015 203.7523 l
f*
576 203.2523 m
512.515 203.2523 l
512.515 203.7523 l
576 203.7523 l
f*
79.5407 203.2523 m
79.5407 190.7524 l
79.0407 190.7524 l
79.0407 203.2523 l
f*
79.0407 190.7524 m
36 190.7524 l
36 191.2524 l
79.0407 191.2524 l
f*
101.7408 203.2523 m
101.7408 190.7524 l
101.2408 190.7524 l
101.2408 203.2523 l
f*
101.2408 190.7524 m
79.5407 190.7524 l
79.5407 191.2524 l
101.2408 191.2524 l
f*
154.4958 203.2523 m
154.4958 190.7524 l
153.9958 190.7524 l
153.9958 203.2523 l
f*
153.9958 190.7524 m
101.7408 190.7524 l
101.7408 191.2524 l
153.9958 191.2524 l
f*
211.6057 203.2523 m
211.6057 190.7524 l
211.1057 190.7524 l
211.1057 203.2523 l
f*
211.1057 190.7524 m
154.4958 190.7524 l
154.4958 191.2524 l
211.1057 191.2524 l
f*
267.3179 203.2523 m
267.3179 190.7524 l
266.8178 190.7524 l
266.8178 203.2523 l
f*
266.8178 190.7524 m
211.6057 190.7524 l
211.6057 191.2524 l
266.8178 191.2524 l
f*
326.2671 203.2523 m
326.2671 190.7524 l
325.7671 190.7524 l
325.7671 203.2523 l
f*
325.7671 190.7524 m
267.3179 190.7524 l
267.3179 191.2524 l
325.7671 191.2524 l
f*
368.778 203.2523 m
368.778 190.7524 l
368.278 190.7524 l
368.278 203.2523 l
f*
368.278 190.7524 m
326.2671 190.7524 l
326.2671 191.2524 l
368.278 191.2524 l
f*
411.6609 203.2523 m
411.6609 190.7524 l
411.1608 190.7524 l
411.1608 203.2523 l
f*
411.1608 190.7524 m
368.778 190.7524 l
368.778 191.2524 l
411.1608 191.2524 l
f*
464.3141 203.2523 m
464.3141 190.7524 l
463.8141 190.7524 l
463.8141 203.2523 l
f*
463.8141 190.7524 m
411.6609 190.7524 l
411.6609 191.2524 l
463.8141 191.2524 l
f*
512.515 203.2523 m
512.515 190.7524 l
512.015 190.7524 l
512.015 203.2523 l
f*
512.015 190.7524 m
464.3141 190.7524 l
464.3141 191.2524 l
512.015 191.2524 l
f*
576 190.7524 m
512.515 190.7524 l
512.515 191.2524 l
576 191.2524 l
f*
79.5407 190.7524 m
79.5407 178.2524 l
79.0407 178.2524 l
79.0407 190.7524 l
f*
79.0407 178.2524 m
36 178.2524 l
36 178.7525 l
79.0407 178.7525 l
f*
101.7408 190.7524 m
101.7408 178.2524 l
101.2408 178.2524 l
101.2408 190.7524 l
f*
101.2408 178.2524 m
79.5407 178.2524 l
79.5407 178.7525 l
101.2408 178.7525 l
f*
154.4958 190.7524 m
154.4958 178.2524 l
153.9958 178.2524 l
153.9958 190.7524 l
f*
153.9958 178.2524 m
101.7408 178.2524 l
101.7408 178.7525 l
153.9958 178.7525 l
f*
211.6057 190.7524 m
211.6057 178.2524 l
211.1057 178.2524 l
211.1057 190.7524 l
f*
211.1057 178.2524 m
154.4958 178.2524 l
154.4958 178.7525 l
211.1057 178.7525 l
f*
267.3179 190.7524 m
267.3179 178.2524 l
266.8178 178.2524 l
266.8178 190.7524 l
f*
266.8178 178.2524 m
211.6057 178.2524 l
211.6057 178.7525 l
266.8178 178.7525 l
f*
326.2671 190.7524 m
326.2671 178.2524 l
325.7671 178.2524 l
325.7671 190.7524 l
f*
325.7671 178.2524 m
267.3179 178.2524 l
267.3179 178.7525 l
325.7671 178.7525 l
f*
368.778 190.7524 m
368.778 178.2524 l
368.278 178.2524 l
368.278 190.7524 l
f*
368.278 178.2524 m
326.2671 178.2524 l
326.2671 178.7525 l
368.278 178.7525 l
f*
411.6609 190.7524 m
411.6609 178.2524 l
411.1608 178.2524 l
411.1608 190.7524 l
f*
411.1608 178.2524 m
368.778 178.2524 l
368.778 178.7525 l
411.1608 178.7525 l
f*
464.3141 190.7524 m
464.3141 178.2524 l
463.8141 178.2524 l
463.8141 190.7524 l
f*
463.8141 178.2524 m
411.6609 178.2524 l
411.6609 178.7525 l
463.8141 178.7525 l
f*
512.515 190.7524 m
512.515 178.2524 l
512.015 178.2524 l
512.015 190.7524 l
f*
512.015 178.2524 m
464.3141 178.2524 l
464.3141 178.7525 l
512.015 178.7525 l
f*
576 178.2524 m
512.515 178.2524 l
512.515 178.7525 l
576 178.7525 l
f*
79.5407 178.2524 m
79.5407 165.7525 l
79.0407 165.7525 l
79.0407 178.2524 l
f*
79.0407 165.7525 m
36 165.7525 l
36 166.2525 l
79.0407 166.2525 l
f*
101.7408 178.2524 m
101.7408 165.7525 l
101.2408 165.7525 l
101.2408 178.2524 l
f*
101.2408 165.7525 m
79.5407 165.7525 l
79.5407 166.2525 l
101.2408 166.2525 l
f*
154.4958 178.2524 m
154.4958 165.7525 l
153.9958 165.7525 l
153.9958 178.2524 l
f*
153.9958 165.7525 m
101.7408 165.7525 l
101.7408 166.2525 l
153.9958 166.2525 l
f*
211.6057 178.2524 m
211.6057 165.7525 l
211.1057 165.7525 l
211.1057 178.2524 l
f*
211.1057 165.7525 m
154.4958 165.7525 l
154.4958 166.2525 l
211.1057 166.2525 l
f*
267.3179 178.2524 m
267.3179 165.7525 l
266.8178 165.7525 l
266.8178 178.2524 l
f*
266.8178 165.7525 m
211.6057 165.7525 l
211.6057 166.2525 l
266.8178 166.2525 l
f*
326.2671 178.2524 m
326.2671 165.7525 l
325.7671 165.7525 l
325.7671 178.2524 l
f*
325.7671 165.7525 m
267.3179 165.7525 l
267.3179 166.2525 l
325.7671 166.2525 l
f*
368.778 178.2524 m
368.778 165.7525 l
368.278 165.7525 l
368.278 178.2524 l
f*
368.278 165.7525 m
326.2671 165.7525 l
326.2671 166.2525 l
368.278 166.2525 l
f*
411.6609 178.2524 m
411.6609 165.7525 l
411.1608 165.7525 l
411.1608 178.2524 l
f*
411.1608 165.7525 m
368.778 165.7525 l
368.778 166.2525 l
411.1608 166.2525 l
f*
464.3141 178.2524 m
464.3141 165.7525 l
463.8141 165.7525 l
463.8141 178.2524 l
f*
463.8141 165.7525 m
411.6609 165.7525 l
411.6609 166.2525 l
463.8141 166.2525 l
f*
512.515 178.2524 m
512.515 165.7525 l
512.015 165.7525 l
512.015 178.2524 l
f*
512.015 165.7525 m
464.3141 165.7525 l
464.3141 166.2525 l
512.015 166.2525 l
f*
576 165.7525 m
512.515 165.7525 l
512.515 166.2525 l
576 166.2525 l
f*
79.5407 165.7525 m
79.5407 153.2526 l
79.0407 153.2526 l
79.0407 165.7525 l
f*
79.0407 153.2526 m
36 153.2526 l
36 153.7526 l
79.0407 153.7526 l
f*
101.7408 165.7525 m
101.7408 153.2526 l
101.2408 153.2526 l
101.2408 165.7525 l
f*
101.2408 153.2526 m
79.5407 153.2526 l
79.5407 153.7526 l
101.2408 153.7526 l
f*
154.4958 165.7525 m
154.4958 153.2526 l
153.9958 153.2526 l
153.9958 165.7525 l
f*
153.9958 153.2526 m
101.7408 153.2526 l
101.7408 153.7526 l
153.9958 153.7526 l
f*
211.6057 165.7525 m
211.6057 153.2526 l
211.1057 153.2526 l
211.1057 165.7525 l
f*
211.1057 153.2526 m
154.4958 153.2526 l
154.4958 153.7526 l
211.1057 153.7526 l
f*
267.3179 165.7525 m
267.3179 153.2526 l
266.8178 153.2526 l
266.8178 165.7525 l
f*
266.8178 153.2526 m
211.6057 153.2526 l
211.6057 153.7526 l
266.8178 153.7526 l
f*
326.2671 165.7525 m
326.2671 153.2526 l
325.7671 153.2526 l
325.7671 165.7525 l
f*
325.7671 153.2526 m
267.3179 153.2526 l
267.3179 153.7526 l
325.7671 153.7526 l
f*
368.778 165.7525 m
368.778 153.2526 l
368.278 153.2526 l
368.278 165.7525 l
f*
368.278 153.2526 m
326.2671 153.2526 l
326.2671 153.7526 l
368.278 153.7526 l
f*
411.6609 165.7525 m
411.6609 153.2526 l
411.1608 153.2526 l
411.1608 165.7525 l
f*
411.1608 153.2526 m
368.778 153.2526 l
368.778 153.7526 l
411.1608 153.7526 l
f*
464.3141 165.7525 m
464.3141 153.2526 l
463.8141 153.2526 l
463.8141 165.7525 l
f*
463.8141 153.2526 m
411.6609 153.2526 l
411.6609 153.7526 l
463.8141 153.7526 l
f*
512.515 165.7525 m
512.515 153.2526 l
512.015 153.2526 l
512.015 165.7525 l
f*
512.015 153.2526 m
464.3141 153.2526 l
464.3141 153.7526 l
512.015 153.7526 l
f*
576 153.2526 m
512.515 153.2526 l
512.515 153.7526 l
576 153.7526 l
f*
79.5407 153.2526 m
79.5407 140.7526 l
79.0407 140.7526 l
79.0407 153.2526 l
f*
79.0407 140.7526 m
36 140.7526 l
36 141.2527 l
79.0407 141.2527 l
f*
101.7408 153.2526 m
101.7408 140.7526 l
101.2408 140.7526 l
101.2408 153.2526 l
f*
101.2408 140.7526 m
79.5407 140.7526 l
79.5407 141.2527 l
101.2408 141.2527 l
f*
154.4958 153.2526 m
154.4958 140.7526 l
153.9958 140.7526 l
153.9958 153.2526 l
f*
153.9958 140.7526 m
101.7408 140.7526 l
101.7408 141.2527 l
153.9958 141.2527 l
f*
211.6057 153.2526 m
211.6057 140.7526 l
211.1057 140.7526 l
211.1057 153.2526 l
f*
211.1057 140.7526 m
154.4958 140.7526 l
154.4958 141.2527 l
211.1057 141.2527 l
f*
267.3179 153.2526 m
267.3179 140.7526 l
266.8178 140.7526 l
266.8178 153.2526 l
f*
266.8178 140.7526 m
211.6057 140.7526 l
211.6057 141.2527 l
266.8178 141.2527 l
f*
326.2671 153.2526 m
326.2671 140.7526 l
325.7671 140.7526 l
325.7671 153.2526 l
f*
325.7671 140.7526 m
267.3179 140.7526 l
267.3179 141.2527 l
325.7671 141.2527 l
f*
368.778 153.2526 m
368.778 140.7526 l
368.278 140.7526 l
368.278 153.2526 l
f*
368.278 140.7526 m
326.2671 140.7526 l
326.2671 141.2527 l
368.278 141.2527 l
f*
411.6609 153.2526 m
411.6609 140.7526 l
411.1608 140.7526 l
411.1608 153.2526 l
f*
411.1608 140.7526 m
368.778 140.7526 l
368.778 141.2527 l
411.1608 141.2527 l
f*
464.3141 153.2526 m
464.3141 140.7526 l
463.8141 140.7526 l
463.8141 153.2526 l
f*
463.8141 140.7526 m
411.6609 140.7526 l
411.6609 141.2527 l
463.8141 141.2527 l
f*
512.515 153.2526 m
512.515 140.7526 l
512.015 140.7526 l
512.015 153.2526 l
f*
512.015 140.7526 m
464.3141 140.7526 l
464.3141 141.2527 l
512.015 141.2527 l
f*
576 140.7526 m
512.515 140.7526 l
512.515 141.2527 l
576 141.2527 l
f*
576 95.0026 m
36 95.0026 l
36 95.5026 l
576 95.5026 l
f*
0.83 0.64 0.02 0 k
36 81.9213 m
185.0457 81.9213 l
h
f*
0 g
7.9999 0 0 7.9999 36 387.0992 cm
BT
/F12 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Table)Tj
2.5512 0 Td
(1.)Tj
1.1763 0 Td
(Maternal)Tj
4.0253 0 Td
(and)Tj
1.7787 0 Td
(infant)Tj
2.7496 0 Td
(pair)Tj
1.9134 0 Td
(clinical)Tj
3.2032 0 Td
(character)Tj
3.8764 0 Td
(istics)Tj
2.3103 0 Td
(around)Tj
3.2386 0 Td
(delivery.)Tj
0 Tc
-26.2419 -1.8567 Td
(Maternal)Tj
-0.3048 -1.1834 Td
(and)Tj
1.8142 0 Td
(Infant)Tj
-0.1559 -1.1906 Td
(ID)Tj
3.8835 2.374 Td
(Year)Tj
3.7418 0 Td
(Maternal)Tj
0.3756 -1.1834 Td
(Visit)Tj
2.2464 0 Td
(of)Tj
-2.1756 -1.1906 Td
(sample)Tj
-0.5598 -1.1906 Td
(collectio)Tj
3.515 0 Td
(n)Tj
3.6567 3.5646 Td
(Mode)Tj
2.615 0 Td
(of)Tj
-3.7489 -1.1834 Td
(Transmiss)Tj
4.3583 0 Td
(ion)Tj
3.6355 1.1834 Td
(Maternal)Tj
-0.7583 -1.1834 Td
(plasma)Tj
3.2174 0 Td
(Viral)Tj
-3.3379 -1.1906 Td
(Load)Tj
2.3174 0 Td
(\(copies/)Tj
-0.3898 -1.1906 Td
(mL\))Tj
6.1229 3.5646 Td
(Matern)Tj
3.0898 0 Td
(al)Tj
-4.4646 -1.1834 Td
(Peripheral)Tj
4.6559 0 Td
(CD4)Tj
-4.2803 -1.1906 Td
(+)Tj
0.8008 0 Td
(T-cell)Tj
2.6362 0 Td
(count)Tj
-2.9622 -1.1906 Td
(\(cells/m)Tj
3.3165 0 Td
(m)Tj
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.3325 310.2803 347.3007 cm
BT
/F12 1 Tf
1 TL
0 0 Td
(3)Tj
ET
Q
q
1 j
1 J
0 w
7.9999 0 0 7.9999 313.285 343.7291 cm
BT
/F12 1 Tf
1 TL
0 0 Td
(\))Tj
2.5157 3.5645 Td
(Mode)Tj
2.615 0 Td
(of)Tj
-2.6504 -1.1834 Td
(Deliver)Tj
3.0685 0 Td
(y)Tj
2.6646 1.1834 Td
(Weeks)Tj
-0.6661 -1.1834 Td
(Gestation)Tj
5.237 1.1834 Td
(Infant)Tj
2.8701 0 Td
(Age)Tj
1.8638 0 Td
(at)Tj
-3.4441 -1.1834 Td
(sample)Tj
-0.6803 -1.1906 Td
(Collecti)Tj
3.2457 0 Td
(on)Tj
-2.367 -1.1905 Td
(\(days\))Tj
5.0811 3.5645 Td
(Infant)Tj
2.8631 0 Td
(Viral)Tj
-1.4032 -1.1834 Td
(Load)Tj
-1.4669 -1.1906 Td
(\(copies/mL)Tj
4.6701 0 Td
(\))Tj
1.2118 2.374 Td
(Infant)Tj
2.863 0 Td
(Peripheral)Tj
-1.7929 -1.1834 Td
(CD4+)Tj
2.7354 0 Td
(T-cell)Tj
-2.7142 -1.1906 Td
(count)Tj
2.6221 0 Td
(\(cells/)Tj
-1.2756 -1.1905 Td
(mm)Tj
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.3325 548.0503 347.3007 cm
BT
/F12 1 Tf
1 TL
0 0 Td
(3)Tj
ET
Q
q
1 j
1 J
0 w
7.9999 0 0 7.9999 551.0551 343.7291 cm
BT
/F12 1 Tf
1 TL
0 0 Td
(\))Tj
/F7 1 Tf
-63.3123 -1.559 Td
(100002)Tj
4.7765 0 Td
(1993)Tj
3.9401 0 Td
(Delivery)Tj
6.2576 0 Td
(Peripartum)Tj
7.8095 0 Td
(305,213)Tj
8.0008 0 Td
(221)Tj
5.4993 0 Td
(Vaginal)Tj
6.4134 0 Td
(38)Tj
5.9741 0 Td
(16)Tj
4.8827 0 Td
(1,230,00)Tj
3.3166 0 Td
(0)Tj
4.6346 0 Td
(3326)Tj
-61.5052 -1.5662 Td
(100014)Tj
4.7765 0 Td
(1993)Tj
3.9401 0 Td
(Delivery)Tj
6.2576 0 Td
(Peripartum)Tj
8.0504 0 Td
(21,918)Tj
7.5544 0 Td
(692)Tj
ET
Q
q
1 j
1 J
0 w
5.5998 0 0 5.5998 300.6425 321.6755 cm
BT
/F13 1 Tf
1 TL
0 0 Td
()Tj
ET
Q
q
1 j
1 J
0 w
7.9999 0 0 7.9999 331.8236 318.7275 cm
BT
/F7 1 Tf
1 TL
0 0 Td
(C-section)Tj
6.789 0 Td
(31)Tj
5.974 0 Td
(66)Tj
5.23 0 Td
(120,000)Tj
7.604 0 Td
(2012)Tj
-61.5051 -1.559 Td
(100046)Tj
4.7764 0 Td
(1993)Tj
3.9402 0 Td
(Delivery)Tj
6.2575 0 Td
(Peripartum)Tj
8.0505 0 Td
(12,635)Tj
7.7599 0 Td
(707)Tj
5.4991 0 Td
(Vaginal)Tj
6.4135 0 Td
(40)Tj
5.974 0 Td
(63)Tj
4.8828 0 Td
(1,025,45)Tj
3.3165 0 Td
(8)Tj
4.6347 0 Td
(2509)Tj
-61.5051 -1.5662 Td
(100052)Tj
4.7764 0 Td
(1993)Tj
3.9402 0 Td
(Delivery)Tj
6.2575 0 Td
(Peripartum)Tj
8.0505 0 Td
(23,750)Tj
7.7599 0 Td
(450)Tj
5.4991 0 Td
(Vaginal)Tj
6.4135 0 Td
(40)Tj
5.974 0 Td
(34)Tj
5.23 0 Td
(333,142)Tj
7.604 0 Td
(3219)Tj
-61.5051 -1.559 Td
(100155)Tj
4.7764 0 Td
(1992)Tj
3.9402 0 Td
(Delivery)Tj
6.5197 0 Td
(Unknown)Tj
7.7883 0 Td
(87,193)Tj
7.7599 0 Td
(318)Tj
5.067 0 Td
(C-Sectio)Tj
3.4227 0 Td
(n)Tj
3.4229 0 Td
(36)Tj
5.974 0 Td
(60)Tj
6.0662 0 Td
(NA)Tj
6.7678 0 Td
(3609)Tj
-61.5051 -1.5662 Td
(100307)Tj
4.7764 0 Td
(1991)Tj
3.9402 0 Td
(Delivery)Tj
6.5197 0 Td
(Unknown)Tj
7.5473 0 Td
(139,053)Tj
7.7954 0 Td
(467)Tj
ET
Q
q
1 j
1 J
0 w
5.5998 0 0 5.5998 300.6425 271.6724 cm
BT
/F13 1 Tf
1 TL
0 0 Td
()Tj
ET
Q
q
1 j
1 J
0 w
7.9999 0 0 7.9999 331.8236 268.7244 cm
BT
/F7 1 Tf
1 TL
0 0 Td
(C-section)Tj
6.789 0 Td
(36)Tj
5.974 0 Td
(32)Tj
5.23 0 Td
(905,079)Tj
7.604 0 Td
(2308)Tj
-61.5051 -1.559 Td
(100383)Tj
4.7764 0 Td
(1991)Tj
3.9402 0 Td
(Delivery)Tj
6.2575 0 Td
(Peripartum)Tj
7.8095 0 Td
(358,602)Tj
8.0009 0 Td
(244)Tj
5.4991 0 Td
(Vaginal)Tj
6.4135 0 Td
(37)Tj
5.974 0 Td
(74)Tj
5.23 0 Td
(338,000)Tj
7.4197 0 Td
(2071)Tj
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.3325 550.4314 259.8236 cm
BT
/F7 1 Tf
1 TL
0 0 Td
()Tj
ET
Q
q
1 j
1 J
0 w
7.9999 0 0 7.9999 44.5606 243.7795 cm
BT
/F7 1 Tf
1 TL
0 0 Td
(100504)Tj
4.7764 0 Td
(1993)Tj
4.9252 0 Td
(NA)Tj
5.5347 0 Td
(Unknown)Tj
7.9016 0 Td
(68287)Tj
7.4056 0 Td
(1049)Tj
5.3079 0 Td
(C-Sectio)Tj
3.4229 0 Td
(n)Tj
3.4228 0 Td
(39)Tj
5.9741 0 Td
(30)Tj
6.0662 0 Td
(NA)Tj
6.7678 0 Td
(2742)Tj
-61.5052 -1.5661 Td
(100711)Tj
4.7764 0 Td
(1990)Tj
3.9402 0 Td
(Delivery)Tj
6.5197 0 Td
(Unknown)Tj
7.8237 0 Td
(4,104)Tj
ET
Q
q
1 j
1 J
0 w
5.5998 0 0 5.5998 246.1039 234.1417 cm
BT
/F13 1 Tf
1 TL
0 0 Td
()Tj
ET
Q
q
1 j
1 J
0 w
7.9999 0 0 7.9999 289.1905 231.2503 cm
BT
/F7 1 Tf
1 TL
0 0 Td
(571)Tj
ET
Q
q
1 j
1 J
0 w
5.5998 0 0 5.5998 300.6425 234.1417 cm
BT
/F13 1 Tf
1 TL
0 0 Td
()Tj
ET
Q
q
1 j
1 J
0 w
7.9999 0 0 7.9999 334.8283 231.2503 cm
BT
/F7 1 Tf
1 TL
0 0 Td
(Vaginal)Tj
6.4134 0 Td
(39)Tj
5.974 0 Td
(64)Tj
5.23 0 Td
(341,691)Tj
7.4198 0 Td
(1872)Tj
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.3325 550.4314 234.822 cm
BT
/F7 1 Tf
1 TL
0 0 Td
()Tj
ET
Q
q
1 j
1 J
0 w
7.9999 0 0 7.9999 44.5606 218.7779 cm
BT
/F7 1 Tf
1 TL
0 0 Td
(100890)Tj
4.7764 0 Td
(1991)Tj
3.9402 0 Td
(Delivery)Tj
6.2575 0 Td
(Peripartum)Tj
7.8095 0 Td
(368,471)Tj
8.0008 0 Td
(409)Tj
5.4993 0 Td
(Vaginal)Tj
6.4134 0 Td
(39)Tj
5.9741 0 Td
(26)Tj
5.0457 0 Td
(192,000)Tj
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.3325 499.0677 222.2929 cm
BT
/F7 1 Tf
1 TL
0 0 Td
()Tj
ET
Q
q
1 j
1 J
0 w
7.9999 0 0 7.9999 536.5984 218.7779 cm
BT
/F7 1 Tf
1 TL
0 0 Td
(2598)Tj
-61.5052 -1.5661 Td
(100997)Tj
4.7765 0 Td
(1991)Tj
3.9401 0 Td
(Delivery)Tj
6.2576 0 Td
(Peripartum)Tj
7.8095 0 Td
(175,526)Tj
8.0008 0 Td
(413)Tj
5.4993 0 Td
(Vaginal)Tj
6.4134 0 Td
(38)Tj
5.9741 0 Td
(20)Tj
5.2866 0 Td
(46,289)Tj
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.3325 497.1401 209.8204 cm
BT
/F7 1 Tf
1 TL
0 0 Td
()Tj
ET
Q
q
1 j
1 J
0 w
7.9999 0 0 7.9999 536.5984 206.2488 cm
BT
/F7 1 Tf
1 TL
0 0 Td
(7048)Tj
-61.5052 -1.559 Td
(101421)Tj
4.7765 0 Td
(1991)Tj
3.9401 0 Td
(Delivery)Tj
6.2576 0 Td
(Peripartum)Tj
8.0504 0 Td
(17,370)Tj
7.7599 0 Td
(760)Tj
5.4993 0 Td
(Vaginal)Tj
6.4134 0 Td
(37)Tj
5.9741 0 Td
(29)Tj
5.4709 0 Td
(48,783)Tj
7.363 0 Td
(7628)Tj
-61.5052 -1.5662 Td
(101984)Tj
4.7765 0 Td
(1991)Tj
3.9401 0 Td
(Delivery)Tj
6.2576 0 Td
(Peripartum)Tj
8.0504 0 Td
(94,087)Tj
7.7599 0 Td
(107)Tj
5.4993 0 Td
(Vaginal)Tj
6.4134 0 Td
(36)Tj
5.9741 0 Td
(30)Tj
5.3433 0 Td
(317969)Tj
7.4906 0 Td
(1980)Tj
-61.5052 -1.559 Td
(102149)Tj
4.7765 0 Td
(1993)Tj
3.9401 0 Td
(Delivery)Tj
6.5198 0 Td
(Unknown)Tj
7.5473 0 Td
(253,906)Tj
8.0008 0 Td
(373)Tj
5.4993 0 Td
(Vaginal)Tj
6.4134 0 Td
(34)Tj
5.9741 0 Td
(33)Tj
4.8827 0 Td
(2,042,12)Tj
3.3166 0 Td
(4)Tj
4.6346 0 Td
(3181)Tj
-61.5052 -1.5662 Td
(102407)Tj
4.7765 0 Td
(1993)Tj
3.9401 0 Td
(Delivery)Tj
6.2576 0 Td
(Peripartum)Tj
7.8095 0 Td
(104,922)Tj
8.0008 0 Td
(422)Tj
5.4993 0 Td
(Vaginal)Tj
6.4134 0 Td
(40)Tj
5.9741 0 Td
(35)Tj
5.4709 0 Td
(11,100)Tj
7.363 0 Td
(4677)Tj
-61.5052 -1.5591 Td
(102605)Tj
4.7765 0 Td
(1992)Tj
4.9252 0 Td
(NA)Tj
5.5347 0 Td
(Unknown)Tj
8.1426 0 Td
(5684)Tj
7.4055 0 Td
(337)Tj
5.4993 0 Td
(Vaginal)Tj
6.4134 0 Td
(39)Tj
5.9741 0 Td
(60)Tj
5.3433 0 Td
(156639)Tj
7.4906 0 Td
(1360)Tj
ET
Q
q
1 j
1 J
0 w
5.5998 0 0 5.5998 36 127.8992 cm
BT
/F13 1 Tf
1 TL
0 0 Td
()Tj
ET
Q
q
1 j
1 J
0 w
7.9999 0 0 7.9999 39.2881 125.0078 cm
BT
/F7 1 Tf
1 TL
0 0 Td
(Periphera)Tj
3.9118 0 Td
(l)Tj
0.4819 0 Td
(CD4+)Tj
2.6929 0 Td
(T)Tj
0.8433 0 Td
(cell)Tj
1.5804 0 Td
(count)Tj
2.5441 0 Td
(and/or)Tj
2.9622 0 Td
(viral)Tj
2.0126 0 Td
(load)Tj
1.9559 0 Td
(reported)Tj
3.6851 0 Td
(from)Tj
2.2252 0 Td
(next)Tj
1.9772 0 Td
(available)Tj
3.6922 0 Td
(visit,)Tj
2.126 0 Td
(within)Tj
2.8346 0 Td
(2)Tj
0.7087 0 Td
(months)Tj
3.3024 0 Td
(from)Tj
2.2252 0 Td
(the)Tj
1.4811 0 Td
(sample)Tj
3.0473 0 Td
(that)Tj
1.8 0 Td
(was)Tj
1.715 0 Td
(obtained)Tj
3.7559 0 Td
(for)Tj
1.4032 0 Td
(sequencing.)Tj
4.9748 0 Td
(NA)Tj
1.6583 0 Td
(=)Tj
0.8079 0 Td
(Not)Tj
-62.8162 -1.5023 Td
(Available.)Tj
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.3325 36 104.5417 cm
BT
/F7 1 Tf
1 TL
0 0 Td
()Tj
ET
Q
q
1 j
1 J
0 w
7.9999 0 0 7.9999 38.948 101.0267 cm
BT
/F7 1 Tf
1 TL
0 0 Td
(Periphera)Tj
3.9118 0 Td
(l)Tj
0.4819 0 Td
(CD4+)Tj
2.6929 0 Td
(T)Tj
0.8362 0 Td
(cell)Tj
1.5804 0 Td
(count)Tj
2.5512 0 Td
(and/or)Tj
2.9551 0 Td
(viral)Tj
2.0197 0 Td
(load)Tj
1.9559 0 Td
(reported)Tj
3.6851 0 Td
(from)Tj
2.2252 0 Td
(25)Tj
1.1835 0 Td
(weeks)Tj
2.6292 0 Td
(of)Tj
1.0275 0 Td
(gestation,)Tj
4.0819 0 Td
(as)Tj
1.0347 0 Td
(CD4+)Tj
2.6858 0 Td
(T)Tj
0.8434 0 Td
(cell)Tj
1.5803 0 Td
(count)Tj
2.5441 0 Td
(and/or)Tj
2.9622 0 Td
(viral)Tj
2.0197 0 Td
(load)Tj
1.9489 0 Td
(was)Tj
1.7149 0 Td
(not)Tj
1.5945 0 Td
(available)Tj
3.6993 0 Td
(at)Tj
0.9638 0 Td
(time)Tj
2.048 0 Td
(of)Tj
1.0276 0 Td
(delivery.)Tj
0.83 0.64 0.02 0 k
/F10 1 Tf
-0.025 Tc
-60.8532 -2.2535 Td
(https://do)Tj
3.5575 0 Td
(i.org/10.1371/j)Tj
5.4425 0 Td
(ournal.ppa)Tj
3.9331 0 Td
(t.1006944.t0)Tj
4.7481 0 Td
(01)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 144.5669 23.6976 re
W* n
q
144.5102 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 449.1779 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Mother)Tj
3.2811 0 Td
(to)Tj
1.0417 0 Td
(child)Tj
2.2323 0 Td
(transmis)Tj
3.7134 0 Td
(sion)Tj
2.0197 0 Td
(of)Tj
1.0418 0 Td
(HIV-1)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
0.83 0.64 0.02 0 k
102.0472 34.9228 m
256.1953 34.9228 l
h
f*
0 g
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(Pathogens)Tj
4.9252 0 Td
(|)Tj
0.83 0.64 0.02 0 k
0.4748 0 Td
(https://)Tj
2.9552 0 Td
(doi.org/10.13)Tj
5.7331 0 Td
(71/journal.p)Tj
5.1236 0 Td
(pat.1006)Tj
3.8198 0 Td
(944)Tj
0 g
2.6362 0 Td
(April)Tj
2.1756 0 Td
(19,)Tj
1.5874 0 Td
(2018)Tj
32.8538 0 Td
(4)Tj
0.7654 0 Td
(/)Tj
ET
endstream
endobj
108 0 obj
<>stream
endstream
endobj
109 0 obj
<>stream
endstream
endobj
110 0 obj
<>stream
endstream
endobj
111 0 obj
<>stream
endstream
endobj
112 0 obj
<>stream
endstream
endobj
113 0 obj
<>stream
endstream
endobj
114 0 obj
<>stream
endstream
endobj
115 0 obj
<>stream
BT
66.402 0 Td
(26)Tj
ET
Q
endstream
endobj
116 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 12 0 R/Annots 118 0 R/Contents 119 0 R/TrimBox[0 0 612 792]>>
endobj
118 0 obj
[120 0 R 121 0 R 122 0 R 123 0 R 124 0 R 125 0 R 126 0 R 127 0 R 128 0 R]
endobj
120 0 obj
<>/Border[0 0 0]/Dest(Rppat.1006944.t002)>>
endobj
121 0 obj
<>/Border[0 0 0]/Dest(Rppat.1006944.g001)>>
endobj
122 0 obj
<>/Border[0 0 0]/Dest(Rppat.1006944.s001)>>
endobj
123 0 obj
<>/Border[0 0 0]/Dest(Rppat.1006944.s002)>>
endobj
124 0 obj
<>/Border[0 0 0]/Dest(Lppat.1006944.t002)>>
endobj
125 0 obj
<>/Border[0 0 0]/A 129 0 R>>
endobj
129 0 obj
<>
endobj
126 0 obj
<>/Border[0 0 0]/A 130 0 R>>
endobj
130 0 obj
<>
endobj
127 0 obj
<>/Border[0 0 0]/A 131 0 R>>
endobj
131 0 obj
<>
endobj
128 0 obj
<>/Border[0 0 0]/A 132 0 R>>
endobj
132 0 obj
<>
endobj
119 0 obj
[133 0 R 134 0 R 135 0 R 136 0 R 137 0 R 138 0 R 139 0 R]
endobj
133 0 obj
<>stream
q
0.83 0.64 0.02 0 k
468.8504 569.9906 m
497.9906 569.9906 l
h
f*
519.137 530.9858 m
538.6961 530.9858 l
h
f*
543.1748 530.9858 m
567.4961 530.9858 l
h
f*
217.3039 518.0031 m
241.6252 518.0031 l
h
f*
0 g
1 j
1 J
0 w
10 0 0 10 200.0125 707.4141 cm
BT
/F7 1 Tf
1 TL
-0.01 Tc
0 0 Td
(4,104)Tj
2.3187 0 Td
(to)Tj
1.0091 0 Td
(368,471)Tj
3.2598 0 Td
(copies/mL,)Tj
4.5694 0 Td
(and)Tj
1.7122 0 Td
(peripheral)Tj
4.2632 0 Td
(blood)Tj
2.4832 0 Td
(CD4)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 414.7653 711.8362 cm
BT
/F7 1 Tf
1 TL
-0.0133 Tc
0 0 Td
(+)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 421.2283 707.4141 cm
BT
/F7 1 Tf
1 TL
-0.01 Tc
0 0 Td
(T-cell)Tj
2.4831 0 Td
(counts)Tj
2.8516 0 Td
(ranged)Tj
2.9537 0 Td
(from)Tj
2.1827 0 Td
(107)Tj
1.627 0 Td
(to)Tj
1.0148 0 Td
(760)Tj
-35.2343 -1.3039 Td
(cell/mm)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 232.6677 698.8535 cm
BT
/F7 1 Tf
1 TL
-0.0133 Tc
0 0 Td
(3)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 236.1826 694.3748 cm
BT
/F7 1 Tf
1 TL
-0.01 Tc
0 0 Td
(.)Tj
0.4365 0 Td
(Infant)Tj
2.6419 0 Td
(plasma)Tj
2.999 0 Td
(viral)Tj
1.9616 0 Td
(loads)Tj
2.2677 0 Td
(varied)Tj
2.6588 0 Td
(between)Tj
3.4866 0 Td
(11,110)Tj
2.7893 0 Td
(and)Tj
1.7121 0 Td
(2,042,124)Tj
3.9458 0 Td
(copies/mL,)Tj
4.5751 0 Td
(and)Tj
1.7121 0 Td
(CD4)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 566.5889 698.8535 cm
BT
/F7 1 Tf
1 TL
-0.0133 Tc
0 0 Td
(+)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 681.3921 cm
BT
/F7 1 Tf
1 TL
-0.01 Tc
0 0 Td
(T-cell)Tj
2.4831 0 Td
(counts)Tj
2.8516 0 Td
(were)Tj
2.0976 0 Td
(between)Tj
3.4866 0 Td
(1,872)Tj
2.3188 0 Td
(and)Tj
1.7121 0 Td
(7,628)Tj
2.3187 0 Td
(cell/mm)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 405.3543 685.8708 cm
BT
/F7 1 Tf
1 TL
-0.0133 Tc
0 0 Td
(3)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 408.8692 681.3921 cm
BT
/F7 1 Tf
1 TL
-0.01 Tc
0 0 Td
(.)Tj
0.4365 0 Td
(All)Tj
1.3776 0 Td
(infants)Tj
2.9253 0 Td
(were)Tj
2.0977 0 Td
(born)Tj
2.1316 0 Td
(via)Tj
1.355 0 Td
(vaginal)Tj
3.033 0 Td
(delivery)Tj
-34.2422 -1.2982 Td
(except)Tj
2.7326 0 Td
(for)Tj
1.372 0 Td
(three)Tj
2.2336 0 Td
(infants)Tj
2.9197 0 Td
(\(100014,)Tj
3.5943 0 Td
(100155,)Tj
3.2598 0 Td
(100307\))Tj
3.3676 0 Td
(born)Tj
2.1315 0 Td
(via)Tj
1.355 0 Td
(Cesarean)Tj
3.8324 0 Td
(section,)Tj
3.2258 0 Td
(thus)Tj
1.9105 0 Td
(potentially)Tj
-31.9348 -1.2983 Td
(representing)Tj
5.1647 0 Td
(late)Tj
/F11 1 Tf
1.5987 0 Td
[()12()]TJ
1.0035 0 Td
[()14()11()2()20()]TJ
/F7 1 Tf
2.2337 0 Td
(transmission.)Tj
5.5105 0 Td
(Five)Tj
1.8709 0 Td
(infants)Tj
2.9253 0 Td
(\(100014,)Tj
3.5885 0 Td
(100155,)Tj
3.2598 0 Td
(100307,)Tj
3.2542 0 Td
(102149,)Tj
3.2598 0 Td
(and)Tj
-33.6696 -1.3039 Td
(101984\))Tj
3.3732 0 Td
(were)Tj
2.0976 0 Td
(born)Tj
2.126 0 Td
(prematurely)Tj
5.0457 0 Td
(\(31,)Tj
1.7121 0 Td
(34)Tj
1.1565 0 Td
(and)Tj
1.7121 0 Td
(36)Tj
1.1622 0 Td
(weeks)Tj
2.5794 0 Td
(respectively\),)Tj
5.3631 0 Td
(and)Tj
1.7122 0 Td
(the)Tj
1.4513 0 Td
(remaining)Tj
4.3143 0 Td
(infants)Tj
-33.8057 -1.2983 Td
(were)Tj
2.0976 0 Td
(born)Tj
2.1317 0 Td
(between)Tj
3.4866 0 Td
(37)Tj
1.1565 0 Td
(and)Tj
1.7121 0 Td
(40)Tj
1.1622 0 Td
(weeks)Tj
2.5739 0 Td
(of)Tj
1.0034 0 Td
(gestation.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 602.0787 cm
BT
/F12 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Characterization)Tj
7.2756 0 Td
(of)Tj
1.063 0 Td
(the)Tj
1.5449 0 Td
(complete)Tj
/F14 1 Tf
4.0347 0 Td
[()-7()23()]TJ
/F12 1 Tf
1.6252 0 Td
(gene)Tj
2.1307 0 Td
(sequences)Tj
4.3418 0 Td
(from)Tj
2.3102 0 Td
(paired)Tj
2.9056 0 Td
(mother-)Tj
-27.2317 -1.1669 Td
(infant)Tj
2.759 0 Td
(plasma)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 571.0677 cm
BT
/F7 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Infant)Tj
2.6702 0 Td
(plasma)Tj
3.0274 0 Td
(samples)Tj
3.3788 0 Td
(were)Tj
2.1147 0 Td
(used)Tj
2.0579 0 Td
(to)Tj
1.0205 0 Td
(obtain)Tj
2.7779 0 Td
(465)Tj
/F11 1 Tf
1.6384 0 Td
[()2()24()]TJ
/F7 1 Tf
1.5704 0 Td
(gene)Tj
2.0749 0 Td
(sequences)Tj
4.218 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(Table)Tj
2.7722 0 Td
(2)Tj
0 g
(\).)Tj
1.2586 0 Td
(Neighbor-joining)Tj
-30.5799 -1.2982 Td
(phylogenetic)Tj
5.3234 0 Td
(trees)Tj
2.0976 0 Td
(and)Tj
1.7291 0 Td
(highlighter)Tj
4.6091 0 Td
(plots)Tj
2.1487 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
/F11 1 Tf
1.4683 0 Td
[()2()24()]TJ
/F7 1 Tf
1.5761 0 Td
(sequences)Tj
4.2179 0 Td
(from)Tj
2.2053 0 Td
(each)Tj
2.0296 0 Td
(infant)Tj
2.6022 0 Td
(were)Tj
2.126 0 Td
(used)Tj
2.0579 0 Td
(to)Tj
-35.206 -1.2983 Td
(define)Tj
2.6985 0 Td
(infant)Tj
2.6022 0 Td
(T/F)Tj
1.6894 0 Td
(viruses.)Tj
3.2145 0 Td
(These)Tj
2.5625 0 Td
(analyses)Tj
3.4866 0 Td
(showed)Tj
3.2485 0 Td
(within-lineage)Tj
5.9697 0 Td
(low)Tj
1.6611 0 Td
(diversity)Tj
3.6453 0 Td
(populations)Tj
4.9493 0 Td
(in)Tj
-35.7276 -1.3039 Td
(infant)Tj
2.6021 0 Td
(Env)Tj
1.7915 0 Td
(sequences)Tj
4.2236 0 Td
(and)Tj
1.7291 0 Td
(high)Tj
2.007 0 Td
(diversity)Tj
3.6453 0 Td
(populations)Tj
4.9492 0 Td
(in)Tj
1.0375 0 Td
(maternal)Tj
/F11 1 Tf
3.7984 0 Td
[()2()24()]TJ
/F7 1 Tf
1.5704 0 Td
(sequences)Tj
4.2179 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(Fig)Tj
1.8199 0 Td
(1)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
0.9241 0 Td
(S1)Tj
1.1735 0 Td
(Fig)Tj
0 g
-35.4895 -1.2983 Td
(and)Tj
0.83 0.64 0.02 0 k
1.7291 0 Td
(S2)Tj
1.1735 0 Td
(Fig)Tj
0 g
(\).)Tj
2.0409 0 Td
(In)Tj
1.1112 0 Td
(6)Tj
0.6973 0 Td
(out)Tj
1.5534 0 Td
(of)Tj
1.0148 0 Td
(16)Tj
1.1679 0 Td
(\(37%\))Tj
2.6078 0 Td
(infants)Tj
2.9651 0 Td
(we)Tj
1.3322 0 Td
(detected)Tj
3.566 0 Td
(2)Tj
0.6916 0 Td
(or)Tj
1.0999 0 Td
(3)Tj
0.6973 0 Td
(\(in)Tj
1.372 0 Td
(case)Tj
1.8651 0 Td
(of)Tj
1.0148 0 Td
(100002\))Tj
3.4129 0 Td
(genetically)Tj
4.4504 0 Td
(dis-)Tj
-35.5632 -1.2982 Td
(tinct)Tj
2.0522 0 Td
(T/F)Tj
1.6895 0 Td
(variants,)Tj
3.6169 0 Td
(one)Tj
1.6952 0 Td
(of)Tj
1.0147 0 Td
(which)Tj
2.6533 0 Td
(was)Tj
1.7007 0 Td
(present)Tj
3.1635 0 Td
(at)Tj
0.9524 0 Td
(higher)Tj
2.8006 0 Td
(frequency)Tj
4.1896 0 Td
(\(primary)Tj
3.7927 0 Td
(T/F\),)Tj
2.2564 0 Td
(while)Tj
2.3698 0 Td
(the)Tj
1.4683 0 Td
(rest)Tj
-35.4158 -1.3039 Td
(were)Tj
2.1203 0 Td
(present)Tj
3.1634 0 Td
(at)Tj
0.9524 0 Td
(lower)Tj
2.4548 0 Td
(frequency)Tj
4.1839 0 Td
(\(secondary)Tj
4.6148 0 Td
(T/Fs\).)Tj
2.6135 0 Td
(In)Tj
1.1112 0 Td
(10)Tj
1.1679 0 Td
(other)Tj
2.347 0 Td
(infants)Tj
2.9651 0 Td
(\(67%\),)Tj
2.8346 0 Td
(we)Tj
1.3266 0 Td
(observed)Tj
3.7984 0 Td
(only)Tj
ET
Q
q
0.45 0.36 0.35 0.01 k
1 j
1 J
0 w
36 464.976 m
576 464.976 l
576 464.476 l
36 464.476 l
f*
103.3004 464.476 m
103.3004 432.976 l
102.8004 432.976 l
102.8004 464.476 l
f*
102.8004 432.976 m
36 432.976 l
36 433.476 l
102.8004 433.476 l
f*
190.0562 464.476 m
190.0562 432.976 l
189.5562 432.976 l
189.5562 464.476 l
f*
189.5562 432.976 m
103.3004 432.976 l
103.3004 433.476 l
189.5562 433.476 l
f*
283.3308 464.476 m
283.3308 432.976 l
282.8307 432.976 l
282.8307 464.476 l
f*
282.8307 432.976 m
190.0562 432.976 l
190.0562 433.476 l
282.8307 433.476 l
f*
357.5985 464.476 m
357.5985 432.976 l
357.0985 432.976 l
357.0985 464.476 l
f*
357.0985 432.976 m
283.3308 432.976 l
283.3308 433.476 l
357.0985 433.476 l
f*
472.1465 464.476 m
472.1465 432.976 l
471.6465 432.976 l
471.6465 464.476 l
f*
471.6465 432.976 m
357.5985 432.976 l
357.5985 433.476 l
471.6465 433.476 l
f*
576 432.976 m
472.1465 432.976 l
472.1465 433.476 l
576 433.476 l
f*
103.3004 432.976 m
103.3004 410.976 l
102.8004 410.976 l
102.8004 432.976 l
f*
102.8004 410.976 m
36 410.976 l
36 411.476 l
102.8004 411.476 l
f*
190.0562 432.976 m
190.0562 410.976 l
189.5562 410.976 l
189.5562 432.976 l
f*
189.5562 410.976 m
103.3004 410.976 l
103.3004 411.476 l
189.5562 411.476 l
f*
283.3308 432.976 m
283.3308 410.976 l
282.8307 410.976 l
282.8307 432.976 l
f*
282.8307 410.976 m
190.0562 410.976 l
190.0562 411.476 l
282.8307 411.476 l
f*
357.5985 432.976 m
357.5985 410.976 l
357.0985 410.976 l
357.0985 432.976 l
f*
357.0985 410.976 m
283.3308 410.976 l
283.3308 411.476 l
357.0985 411.476 l
f*
472.1465 432.976 m
472.1465 410.976 l
471.6465 410.976 l
471.6465 432.976 l
f*
471.6465 410.976 m
357.5985 410.976 l
357.5985 411.476 l
471.6465 411.476 l
f*
576 410.976 m
472.1465 410.976 l
472.1465 411.476 l
576 411.476 l
f*
103.3004 410.976 m
103.3004 398.4761 l
102.8004 398.4761 l
102.8004 410.976 l
f*
102.8004 398.4761 m
36 398.4761 l
36 398.9761 l
102.8004 398.9761 l
f*
190.0562 410.976 m
190.0562 398.4761 l
189.5562 398.4761 l
189.5562 410.976 l
f*
189.5562 398.4761 m
103.3004 398.4761 l
103.3004 398.9761 l
189.5562 398.9761 l
f*
283.3308 410.976 m
283.3308 398.4761 l
282.8307 398.4761 l
282.8307 410.976 l
f*
282.8307 398.4761 m
190.0562 398.4761 l
190.0562 398.9761 l
282.8307 398.9761 l
f*
357.5985 410.976 m
357.5985 398.4761 l
357.0985 398.4761 l
357.0985 410.976 l
f*
357.0985 398.4761 m
283.3308 398.4761 l
283.3308 398.9761 l
357.0985 398.9761 l
f*
472.1465 410.976 m
472.1465 398.4761 l
471.6465 398.4761 l
471.6465 410.976 l
f*
471.6465 398.4761 m
357.5985 398.4761 l
357.5985 398.9761 l
471.6465 398.9761 l
f*
576 398.4761 m
472.1465 398.4761 l
472.1465 398.9761 l
576 398.9761 l
f*
103.3004 398.4761 m
103.3004 376.4761 l
102.8004 376.4761 l
102.8004 398.4761 l
f*
102.8004 376.4761 m
36 376.4761 l
36 376.9761 l
102.8004 376.9761 l
f*
190.0562 398.4761 m
190.0562 376.4761 l
189.5562 376.4761 l
189.5562 398.4761 l
f*
189.5562 376.4761 m
103.3004 376.4761 l
103.3004 376.9761 l
189.5562 376.9761 l
f*
283.3308 398.4761 m
283.3308 376.4761 l
282.8307 376.4761 l
282.8307 398.4761 l
f*
282.8307 376.4761 m
190.0562 376.4761 l
190.0562 376.9761 l
282.8307 376.9761 l
f*
357.5985 398.4761 m
357.5985 376.4761 l
357.0985 376.4761 l
357.0985 398.4761 l
f*
357.0985 376.4761 m
283.3308 376.4761 l
283.3308 376.9761 l
357.0985 376.9761 l
f*
472.1465 398.4761 m
472.1465 376.4761 l
471.6465 376.4761 l
471.6465 398.4761 l
f*
471.6465 376.4761 m
357.5985 376.4761 l
357.5985 376.9761 l
471.6465 376.9761 l
f*
576 376.4761 m
472.1465 376.4761 l
472.1465 376.9761 l
576 376.9761 l
f*
103.3004 376.4761 m
103.3004 354.4761 l
102.8004 354.4761 l
102.8004 376.4761 l
f*
102.8004 354.4761 m
36 354.4761 l
36 354.9762 l
102.8004 354.9762 l
f*
190.0562 376.4761 m
190.0562 354.4761 l
189.5562 354.4761 l
189.5562 376.4761 l
f*
189.5562 354.4761 m
103.3004 354.4761 l
103.3004 354.9762 l
189.5562 354.9762 l
f*
283.3308 376.4761 m
283.3308 354.4761 l
282.8307 354.4761 l
282.8307 376.4761 l
f*
282.8307 354.4761 m
190.0562 354.4761 l
190.0562 354.9762 l
282.8307 354.9762 l
f*
357.5985 376.4761 m
357.5985 354.4761 l
357.0985 354.4761 l
357.0985 376.4761 l
f*
357.0985 354.4761 m
283.3308 354.4761 l
283.3308 354.9762 l
357.0985 354.9762 l
f*
472.1465 376.4761 m
472.1465 354.4761 l
471.6465 354.4761 l
471.6465 376.4761 l
f*
471.6465 354.4761 m
357.5985 354.4761 l
357.5985 354.9762 l
471.6465 354.9762 l
f*
576 354.4761 m
472.1465 354.4761 l
472.1465 354.9762 l
576 354.9762 l
f*
103.3004 354.4761 m
103.3004 341.9762 l
102.8004 341.9762 l
102.8004 354.4761 l
f*
102.8004 341.9762 m
36 341.9762 l
36 342.4762 l
102.8004 342.4762 l
f*
190.0562 354.4761 m
190.0562 341.9762 l
189.5562 341.9762 l
189.5562 354.4761 l
f*
189.5562 341.9762 m
103.3004 341.9762 l
103.3004 342.4762 l
189.5562 342.4762 l
f*
283.3308 354.4761 m
283.3308 341.9762 l
282.8307 341.9762 l
282.8307 354.4761 l
f*
282.8307 341.9762 m
190.0562 341.9762 l
190.0562 342.4762 l
282.8307 342.4762 l
f*
357.5985 354.4761 m
357.5985 341.9762 l
357.0985 341.9762 l
357.0985 354.4761 l
f*
357.0985 341.9762 m
283.3308 341.9762 l
283.3308 342.4762 l
357.0985 342.4762 l
f*
472.1465 354.4761 m
472.1465 341.9762 l
471.6465 341.9762 l
471.6465 354.4761 l
f*
471.6465 341.9762 m
357.5985 341.9762 l
357.5985 342.4762 l
471.6465 342.4762 l
f*
576 341.9762 m
472.1465 341.9762 l
472.1465 342.4762 l
576 342.4762 l
f*
103.3004 341.9762 m
103.3004 319.9762 l
102.8004 319.9762 l
102.8004 341.9762 l
f*
102.8004 319.9762 m
36 319.9762 l
36 320.4763 l
102.8004 320.4763 l
f*
190.0562 341.9762 m
190.0562 319.9762 l
189.5562 319.9762 l
189.5562 341.9762 l
f*
189.5562 319.9762 m
103.3004 319.9762 l
103.3004 320.4763 l
189.5562 320.4763 l
f*
283.3308 341.9762 m
283.3308 319.9762 l
282.8307 319.9762 l
282.8307 341.9762 l
f*
282.8307 319.9762 m
190.0562 319.9762 l
190.0562 320.4763 l
282.8307 320.4763 l
f*
357.5985 341.9762 m
357.5985 319.9762 l
357.0985 319.9762 l
357.0985 341.9762 l
f*
357.0985 319.9762 m
283.3308 319.9762 l
283.3308 320.4763 l
357.0985 320.4763 l
f*
472.1465 341.9762 m
472.1465 319.9762 l
471.6465 319.9762 l
471.6465 341.9762 l
f*
471.6465 319.9762 m
357.5985 319.9762 l
357.5985 320.4763 l
471.6465 320.4763 l
f*
576 319.9762 m
472.1465 319.9762 l
472.1465 320.4763 l
576 320.4763 l
f*
103.3004 319.9762 m
103.3004 307.4763 l
102.8004 307.4763 l
102.8004 319.9762 l
f*
102.8004 307.4763 m
36 307.4763 l
36 307.9763 l
102.8004 307.9763 l
f*
190.0562 319.9762 m
190.0562 307.4763 l
189.5562 307.4763 l
189.5562 319.9762 l
f*
189.5562 307.4763 m
103.3004 307.4763 l
103.3004 307.9763 l
189.5562 307.9763 l
f*
283.3308 319.9762 m
283.3308 307.4763 l
282.8307 307.4763 l
282.8307 319.9762 l
f*
282.8307 307.4763 m
190.0562 307.4763 l
190.0562 307.9763 l
282.8307 307.9763 l
f*
357.5985 319.9762 m
357.5985 307.4763 l
357.0985 307.4763 l
357.0985 319.9762 l
f*
357.0985 307.4763 m
283.3308 307.4763 l
283.3308 307.9763 l
357.0985 307.9763 l
f*
472.1465 319.9762 m
472.1465 307.4763 l
471.6465 307.4763 l
471.6465 319.9762 l
f*
471.6465 307.4763 m
357.5985 307.4763 l
357.5985 307.9763 l
471.6465 307.9763 l
f*
576 307.4763 m
472.1465 307.4763 l
472.1465 307.9763 l
576 307.9763 l
f*
103.3004 307.4763 m
103.3004 285.4763 l
102.8004 285.4763 l
102.8004 307.4763 l
f*
102.8004 285.4763 m
36 285.4763 l
36 285.9763 l
102.8004 285.9763 l
f*
190.0562 307.4763 m
190.0562 285.4763 l
189.5562 285.4763 l
189.5562 307.4763 l
f*
189.5562 285.4763 m
103.3004 285.4763 l
103.3004 285.9763 l
189.5562 285.9763 l
f*
283.3308 307.4763 m
283.3308 285.4763 l
282.8307 285.4763 l
282.8307 307.4763 l
f*
282.8307 285.4763 m
190.0562 285.4763 l
190.0562 285.9763 l
282.8307 285.9763 l
f*
357.5985 307.4763 m
357.5985 285.4763 l
357.0985 285.4763 l
357.0985 307.4763 l
f*
357.0985 285.4763 m
283.3308 285.4763 l
283.3308 285.9763 l
357.0985 285.9763 l
f*
472.1465 307.4763 m
472.1465 285.4763 l
471.6465 285.4763 l
471.6465 307.4763 l
f*
471.6465 285.4763 m
357.5985 285.4763 l
357.5985 285.9763 l
471.6465 285.9763 l
f*
576 285.4763 m
472.1465 285.4763 l
472.1465 285.9763 l
576 285.9763 l
f*
103.3004 285.4763 m
103.3004 263.4763 l
102.8004 263.4763 l
102.8004 285.4763 l
f*
102.8004 263.4763 m
36 263.4763 l
36 263.9764 l
102.8004 263.9764 l
f*
190.0562 285.4763 m
190.0562 263.4763 l
189.5562 263.4763 l
189.5562 285.4763 l
f*
189.5562 263.4763 m
103.3004 263.4763 l
103.3004 263.9764 l
189.5562 263.9764 l
f*
283.3308 285.4763 m
283.3308 263.4763 l
282.8307 263.4763 l
282.8307 285.4763 l
f*
282.8307 263.4763 m
190.0562 263.4763 l
190.0562 263.9764 l
282.8307 263.9764 l
f*
357.5985 285.4763 m
357.5985 263.4763 l
357.0985 263.4763 l
357.0985 285.4763 l
f*
357.0985 263.4763 m
283.3308 263.4763 l
283.3308 263.9764 l
357.0985 263.9764 l
f*
472.1465 285.4763 m
472.1465 263.4763 l
471.6465 263.4763 l
471.6465 285.4763 l
f*
471.6465 263.4763 m
357.5985 263.4763 l
357.5985 263.9764 l
471.6465 263.9764 l
f*
576 263.4763 m
472.1465 263.4763 l
472.1465 263.9764 l
576 263.9764 l
f*
103.3004 263.4763 m
103.3004 241.4764 l
102.8004 241.4764 l
102.8004 263.4763 l
f*
102.8004 241.4764 m
36 241.4764 l
36 241.9764 l
102.8004 241.9764 l
f*
190.0562 263.4763 m
190.0562 241.4764 l
189.5562 241.4764 l
189.5562 263.4763 l
f*
189.5562 241.4764 m
103.3004 241.4764 l
103.3004 241.9764 l
189.5562 241.9764 l
f*
283.3308 263.4763 m
283.3308 241.4764 l
282.8307 241.4764 l
282.8307 263.4763 l
f*
282.8307 241.4764 m
190.0562 241.4764 l
190.0562 241.9764 l
282.8307 241.9764 l
f*
357.5985 263.4763 m
357.5985 241.4764 l
357.0985 241.4764 l
357.0985 263.4763 l
f*
357.0985 241.4764 m
283.3308 241.4764 l
283.3308 241.9764 l
357.0985 241.9764 l
f*
472.1465 263.4763 m
472.1465 241.4764 l
471.6465 241.4764 l
471.6465 263.4763 l
f*
471.6465 241.4764 m
357.5985 241.4764 l
357.5985 241.9764 l
471.6465 241.9764 l
f*
576 241.4764 m
472.1465 241.4764 l
472.1465 241.9764 l
576 241.9764 l
f*
103.3004 241.4764 m
103.3004 219.4764 l
102.8004 219.4764 l
102.8004 241.4764 l
f*
102.8004 219.4764 m
36 219.4764 l
36 219.9764 l
102.8004 219.9764 l
f*
190.0562 241.4764 m
190.0562 219.4764 l
189.5562 219.4764 l
189.5562 241.4764 l
f*
189.5562 219.4764 m
103.3004 219.4764 l
103.3004 219.9764 l
189.5562 219.9764 l
f*
283.3308 241.4764 m
283.3308 219.4764 l
282.8307 219.4764 l
282.8307 241.4764 l
f*
282.8307 219.4764 m
190.0562 219.4764 l
190.0562 219.9764 l
282.8307 219.9764 l
f*
357.5985 241.4764 m
357.5985 219.4764 l
357.0985 219.4764 l
357.0985 241.4764 l
f*
357.0985 219.4764 m
283.3308 219.4764 l
283.3308 219.9764 l
357.0985 219.9764 l
f*
472.1465 241.4764 m
472.1465 219.4764 l
471.6465 219.4764 l
471.6465 241.4764 l
f*
471.6465 219.4764 m
357.5985 219.4764 l
357.5985 219.9764 l
471.6465 219.9764 l
f*
576 219.4764 m
472.1465 219.4764 l
472.1465 219.9764 l
576 219.9764 l
f*
103.3004 219.4764 m
103.3004 206.9765 l
102.8004 206.9765 l
102.8004 219.4764 l
f*
102.8004 206.9765 m
36 206.9765 l
36 207.4765 l
102.8004 207.4765 l
f*
190.0562 219.4764 m
190.0562 206.9765 l
189.5562 206.9765 l
189.5562 219.4764 l
f*
189.5562 206.9765 m
103.3004 206.9765 l
103.3004 207.4765 l
189.5562 207.4765 l
f*
283.3308 219.4764 m
283.3308 206.9765 l
282.8307 206.9765 l
282.8307 219.4764 l
f*
282.8307 206.9765 m
190.0562 206.9765 l
190.0562 207.4765 l
282.8307 207.4765 l
f*
357.5985 219.4764 m
357.5985 206.9765 l
357.0985 206.9765 l
357.0985 219.4764 l
f*
357.0985 206.9765 m
283.3308 206.9765 l
283.3308 207.4765 l
357.0985 207.4765 l
f*
472.1465 219.4764 m
472.1465 206.9765 l
471.6465 206.9765 l
471.6465 219.4764 l
f*
471.6465 206.9765 m
357.5985 206.9765 l
357.5985 207.4765 l
471.6465 207.4765 l
f*
576 206.9765 m
472.1465 206.9765 l
472.1465 207.4765 l
576 207.4765 l
f*
103.3004 206.9765 m
103.3004 184.9765 l
102.8004 184.9765 l
102.8004 206.9765 l
f*
102.8004 184.9765 m
36 184.9765 l
36 185.4765 l
102.8004 185.4765 l
f*
190.0562 206.9765 m
190.0562 184.9765 l
189.5562 184.9765 l
189.5562 206.9765 l
f*
189.5562 184.9765 m
103.3004 184.9765 l
103.3004 185.4765 l
189.5562 185.4765 l
f*
283.3308 206.9765 m
283.3308 184.9765 l
282.8307 184.9765 l
282.8307 206.9765 l
f*
282.8307 184.9765 m
190.0562 184.9765 l
190.0562 185.4765 l
282.8307 185.4765 l
f*
357.5985 206.9765 m
357.5985 184.9765 l
357.0985 184.9765 l
357.0985 206.9765 l
f*
357.0985 184.9765 m
283.3308 184.9765 l
283.3308 185.4765 l
357.0985 185.4765 l
f*
472.1465 206.9765 m
472.1465 184.9765 l
471.6465 184.9765 l
471.6465 206.9765 l
f*
471.6465 184.9765 m
357.5985 184.9765 l
357.5985 185.4765 l
471.6465 185.4765 l
f*
576 184.9765 m
472.1465 184.9765 l
472.1465 185.4765 l
576 185.4765 l
f*
103.3004 184.9765 m
103.3004 162.9765 l
102.8004 162.9765 l
102.8004 184.9765 l
f*
102.8004 162.9765 m
36 162.9765 l
36 163.4766 l
102.8004 163.4766 l
f*
190.0562 184.9765 m
190.0562 162.9765 l
189.5562 162.9765 l
189.5562 184.9765 l
f*
189.5562 162.9765 m
103.3004 162.9765 l
103.3004 163.4766 l
189.5562 163.4766 l
f*
283.3308 184.9765 m
283.3308 162.9765 l
282.8307 162.9765 l
282.8307 184.9765 l
f*
282.8307 162.9765 m
190.0562 162.9765 l
190.0562 163.4766 l
282.8307 163.4766 l
f*
357.5985 184.9765 m
357.5985 162.9765 l
357.0985 162.9765 l
357.0985 184.9765 l
f*
357.0985 162.9765 m
283.3308 162.9765 l
283.3308 163.4766 l
357.0985 163.4766 l
f*
472.1465 184.9765 m
472.1465 162.9765 l
471.6465 162.9765 l
471.6465 184.9765 l
f*
471.6465 162.9765 m
357.5985 162.9765 l
357.5985 163.4766 l
471.6465 163.4766 l
f*
576 162.9765 m
472.1465 162.9765 l
472.1465 163.4766 l
576 163.4766 l
f*
103.3004 162.9765 m
103.3004 150.4766 l
102.8004 150.4766 l
102.8004 162.9765 l
f*
102.8004 150.4766 m
36 150.4766 l
36 150.9766 l
102.8004 150.9766 l
f*
190.0562 162.9765 m
190.0562 150.4766 l
189.5562 150.4766 l
189.5562 162.9765 l
f*
189.5562 150.4766 m
103.3004 150.4766 l
103.3004 150.9766 l
189.5562 150.9766 l
f*
283.3308 162.9765 m
283.3308 150.4766 l
282.8307 150.4766 l
282.8307 162.9765 l
f*
282.8307 150.4766 m
190.0562 150.4766 l
190.0562 150.9766 l
282.8307 150.9766 l
f*
357.5985 162.9765 m
357.5985 150.4766 l
357.0985 150.4766 l
357.0985 162.9765 l
f*
357.0985 150.4766 m
283.3308 150.4766 l
283.3308 150.9766 l
357.0985 150.9766 l
f*
472.1465 162.9765 m
472.1465 150.4766 l
471.6465 150.4766 l
471.6465 162.9765 l
f*
471.6465 150.4766 m
357.5985 150.4766 l
357.5985 150.9766 l
471.6465 150.9766 l
f*
576 150.4766 m
472.1465 150.4766 l
472.1465 150.9766 l
576 150.9766 l
f*
103.3004 150.4766 m
103.3004 128.4766 l
102.8004 128.4766 l
102.8004 150.4766 l
f*
102.8004 128.4766 m
36 128.4766 l
36 128.9767 l
102.8004 128.9767 l
f*
190.0562 150.4766 m
190.0562 128.4766 l
189.5562 128.4766 l
189.5562 150.4766 l
f*
189.5562 128.4766 m
103.3004 128.4766 l
103.3004 128.9767 l
189.5562 128.9767 l
f*
283.3308 150.4766 m
283.3308 128.4766 l
282.8307 128.4766 l
282.8307 150.4766 l
f*
282.8307 128.4766 m
190.0562 128.4766 l
190.0562 128.9767 l
282.8307 128.9767 l
f*
357.5985 150.4766 m
357.5985 128.4766 l
357.0985 128.4766 l
357.0985 150.4766 l
f*
357.0985 128.4766 m
283.3308 128.4766 l
283.3308 128.9767 l
357.0985 128.9767 l
f*
472.1465 150.4766 m
472.1465 128.4766 l
471.6465 128.4766 l
471.6465 150.4766 l
f*
471.6465 128.4766 m
357.5985 128.4766 l
357.5985 128.9767 l
471.6465 128.9767 l
f*
576 128.4766 m
472.1465 128.4766 l
472.1465 128.9767 l
576 128.9767 l
f*
576 82.7266 m
36 82.7266 l
36 83.2266 l
576 83.2266 l
f*
0.83 0.64 0.02 0 k
369.3543 99.6661 m
575.3197 99.6661 l
h
f*
36 87.6472 m
72.9071 87.6472 l
h
f*
36 69.6756 m
185.0457 69.6756 l
h
f*
0 g
7.9999 0 0 7.9999 36 469.8141 cm
BT
/F12 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Table)Tj
2.5512 0 Td
(2.)Tj
1.1763 0 Td
(Number)Tj
3.6922 0 Td
(of)Tj
1.063 0 Td
(sequence)Tj
3.7134 0 Td
(s,)Tj
0.8433 0 Td
(T/F)Tj
1.7221 0 Td
(viruses,)Tj
3.352 0 Td
(and)Tj
1.7787 0 Td
(estimated)Tj
4.2662 0 Td
(days)Tj
2.0693 0 Td
(since)Tj
2.2961 0 Td
(most)Tj
2.2819 0 Td
(common)Tj
3.8977 0 Td
(recent)Tj
2.7992 0 Td
(ancestor)Tj
3.7205 0 Td
(\(MRCA\))Tj
3.8126 0 Td
(in)Tj
1.063 0 Td
(infants.)Tj
0 Tc
-44.9365 -1.8567 Td
(Maternal)Tj
4.0748 0 Td
(and)Tj
-4.2237 -1.1834 Td
(Infant)Tj
2.8701 0 Td
(pair)Tj
1.9418 0 Td
(ID)Tj
4.252 1.1834 Td
(Number)Tj
3.7347 0 Td
(of)Tj
1.0771 0 Td
(Infant)Tj
-5.2795 -1.1834 Td
(envelope)Tj
3.9189 0 Td
(gene)Tj
2.1544 0 Td
(SGAs)Tj
4.8472 1.1834 Td
(Estimated)Tj
4.4717 0 Td
(Numbe)Tj
3.0898 0 Td
(r)Tj
0.6378 0 Td
(of)Tj
-7.604 -1.1834 Td
(infant)Tj
2.7851 0 Td
(T/F)Tj
1.7433 0 Td
(viruses)Tj
ET
Q
q
1 j
1 J
0 w
5.5998 0 0 5.5998 264.5858 448.3842 cm
BT
/F13 1 Tf
1 TL
0 0 Td
()Tj
ET
Q
q
1 j
1 J
0 w
7.9999 0 0 7.9999 286.2425 454.9606 cm
BT
/F12 1 Tf
1 TL
0 0 Td
(Infant)Tj
2.8701 0 Td
(age)Tj
1.6228 0 Td
(at)Tj
1.0417 0 Td
(sample)Tj
-3.3307 -1.1834 Td
(collection)Tj
0.7583 -1.1906 Td
(\(days\))Tj
7.5189 2.374 Td
(Estimat)Tj
3.2457 0 Td
(ed)Tj
1.2189 0 Td
(days)Tj
2.0977 0 Td
(Since)Tj
2.4449 0 Td
(Most)Tj
-8.9646 -1.1834 Td
(Recent)Tj
3.0827 0 Td
(Common)Tj
4.1882 0 Td
(Ancestor)Tj
-3.7985 -1.1906 Td
(\(95%)Tj
2.3386 0 Td
(CI\))Tj
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.3325 428.0881 439.5401 cm
BT
/F12 1 Tf
1 TL
0 0 Td
()Tj
ET
Q
q
1 j
1 J
0 w
7.9999 0 0 7.9999 514.3748 454.9606 cm
BT
/F12 1 Tf
1 TL
0 0 Td
(Notes)Tj
/F7 1 Tf
-57.2461 -3.9331 Td
(100002)Tj
10.7718 0 Td
(43)Tj
11.4945 0 Td
(3)Tj
10.2332 0 Td
(16)Tj
10.2757 0 Td
(21)Tj
1.1834 0 Td
(\(14,28\))Tj
8.6741 0 Td
(Fits)Tj
1.6937 0 Td
(a)Tj
0.6662 0 Td
(Poisson)Tj
3.359 0 Td
(after)Tj
2.0551 0 Td
(removing)Tj
-4.833 -1.1905 Td
(recombinant)Tj
5.1732 0 Td
(s.)Tj
-60.7469 -1.5591 Td
(100014)Tj
10.7718 0 Td
(26)Tj
11.4945 0 Td
(1)Tj
10.2332 0 Td
(66)Tj
10.2757 0 Td
(35)Tj
1.1834 0 Td
(\(28,42\))Tj
11.6434 0 Td
(Fits)Tj
1.6937 0 Td
(a)Tj
0.6661 0 Td
(Poisson.)Tj
-57.9618 -1.5661 Td
(100046)Tj
10.7718 0 Td
(33)Tj
11.4945 0 Td
(1)Tj
10.2332 0 Td
(63)Tj
10.2757 0 Td
(77)Tj
1.1834 0 Td
(\(65,89\))Tj
8.6741 0 Td
(Fits)Tj
1.6937 0 Td
(a)Tj
0.6662 0 Td
(Poisson)Tj
3.359 0 Td
(after)Tj
2.0551 0 Td
(removing)Tj
-5.074 -1.1835 Td
(hypermut)Tj
3.9543 0 Td
(ation.)Tj
-59.287 -1.5662 Td
(100052)Tj
10.7718 0 Td
(27)Tj
11.4945 0 Td
(1)Tj
10.2332 0 Td
(34)Tj
10.2757 0 Td
(58)Tj
1.1834 0 Td
(\(41,75\))Tj
8.6741 0 Td
(Fits)Tj
1.6937 0 Td
(a)Tj
0.6662 0 Td
(Poisson)Tj
3.359 0 Td
(after)Tj
2.0551 0 Td
(removing)Tj
-5.074 -1.1905 Td
(hypermut)Tj
3.9543 0 Td
(ation.)Tj
-59.287 -1.5591 Td
(100155)Tj
10.7718 0 Td
(23)Tj
11.4945 0 Td
(1)Tj
10.2332 0 Td
(60)Tj
10.2757 0 Td
(63)Tj
1.1834 0 Td
(\(50,76\))Tj
11.6434 0 Td
(Fits)Tj
1.6937 0 Td
(a)Tj
0.6661 0 Td
(Poisson.)Tj
-57.9618 -1.5591 Td
(100307)Tj
10.7718 0 Td
(31)Tj
11.4945 0 Td
(2)Tj
10.2332 0 Td
(32)Tj
10.2757 0 Td
(27)Tj
1.1834 0 Td
(\(18,36\))Tj
8.6741 0 Td
(Fits)Tj
1.6937 0 Td
(a)Tj
0.6662 0 Td
(Poisson)Tj
3.359 0 Td
(after)Tj
2.0551 0 Td
(removing)Tj
-4.833 -1.1905 Td
(recombinant)Tj
5.1732 0 Td
(s.)Tj
-60.7469 -1.5662 Td
(100383)Tj
10.7718 0 Td
(24)Tj
11.4945 0 Td
(1)Tj
10.2332 0 Td
(74)Tj
10.2757 0 Td
(80)Tj
1.1834 0 Td
(\(67,92\))Tj
11.6434 0 Td
(Fits)Tj
1.6937 0 Td
(a)Tj
0.6661 0 Td
(Poisson.)Tj
-57.9618 -1.559 Td
(100504)Tj
10.7718 0 Td
(44)Tj
11.4945 0 Td
(1)Tj
10.2332 0 Td
(30)Tj
10.5095 0 Td
(13)Tj
1.1906 0 Td
(\(8,18\))Tj
8.4331 0 Td
(Fits)Tj
1.6937 0 Td
(a)Tj
0.6662 0 Td
(Poisson)Tj
3.359 0 Td
(after)Tj
2.0551 0 Td
(removing)Tj
-5.074 -1.1906 Td
(hypermut)Tj
3.9543 0 Td
(ation.)Tj
-59.287 -1.5591 Td
(100711)Tj
10.7718 0 Td
(26)Tj
11.4945 0 Td
(1)Tj
10.2332 0 Td
(64)Tj
10.2757 0 Td
(27)Tj
1.1834 0 Td
(\(17,37\))Tj
8.6741 0 Td
(Fits)Tj
1.6937 0 Td
(a)Tj
0.6662 0 Td
(Poisson)Tj
3.359 0 Td
(after)Tj
2.0551 0 Td
(removing)Tj
-5.074 -1.1905 Td
(hypermut)Tj
3.9543 0 Td
(ation.)Tj
-59.287 -1.5591 Td
(100890)Tj
10.7718 0 Td
(18)Tj
11.4945 0 Td
(2)Tj
10.2332 0 Td
(26)Tj
10.2757 0 Td
(35)Tj
1.1834 0 Td
(\(17,54\))Tj
8.6741 0 Td
(Fits)Tj
1.6937 0 Td
(a)Tj
0.6662 0 Td
(Poisson)Tj
3.359 0 Td
(after)Tj
2.0551 0 Td
(removing)Tj
-4.833 -1.1906 Td
(recombinant)Tj
5.1732 0 Td
(s.)Tj
-60.7469 -1.559 Td
(100997)Tj
10.7718 0 Td
(32)Tj
11.4945 0 Td
(2)Tj
10.2332 0 Td
(20)Tj
10.2757 0 Td
(19)Tj
1.1834 0 Td
(\(13,25\))Tj
8.6741 0 Td
(Fits)Tj
1.6937 0 Td
(a)Tj
0.6662 0 Td
(Poisson)Tj
3.359 0 Td
(after)Tj
2.0551 0 Td
(removing)Tj
-4.833 -1.1906 Td
(recombinant)Tj
5.1732 0 Td
(s.)Tj
-60.7469 -1.5591 Td
(101421)Tj
10.7718 0 Td
(22)Tj
11.4945 0 Td
(2)Tj
10.2332 0 Td
(29)Tj
10.2757 0 Td
(20)Tj
1.1834 0 Td
(\(11,29\))Tj
11.6434 0 Td
(Fits)Tj
1.6937 0 Td
(a)Tj
0.6661 0 Td
(Poisson.)Tj
-57.9618 -1.5661 Td
(101984)Tj
10.7718 0 Td
(34)Tj
11.4945 0 Td
(2)Tj
10.2332 0 Td
(30)Tj
10.2757 0 Td
(14)Tj
1.1834 0 Td
(\(10,19\))Tj
8.6741 0 Td
(Fits)Tj
1.6937 0 Td
(a)Tj
0.6662 0 Td
(Poisson)Tj
3.359 0 Td
(after)Tj
2.0551 0 Td
(removing)Tj
-5.074 -1.1835 Td
(hypermut)Tj
3.9543 0 Td
(ation.)Tj
-59.287 -1.5661 Td
(102149)Tj
10.7718 0 Td
(27)Tj
11.4945 0 Td
(1)Tj
10.2332 0 Td
(33)Tj
10.2757 0 Td
(43)Tj
1.1834 0 Td
(\(31,55\))Tj
8.6741 0 Td
(Fits)Tj
1.6937 0 Td
(a)Tj
0.6662 0 Td
(Poisson)Tj
3.359 0 Td
(after)Tj
2.0551 0 Td
(removing)Tj
-5.074 -1.1835 Td
(hypermut)Tj
3.9543 0 Td
(ation.)Tj
-59.287 -1.5662 Td
(102407)Tj
10.7718 0 Td
(15)Tj
11.4945 0 Td
(1)Tj
10.2332 0 Td
(35)Tj
10.5095 0 Td
(15)Tj
1.1906 0 Td
(\(9,22\))Tj
11.4024 0 Td
(Fits)Tj
1.6937 0 Td
(a)Tj
0.6661 0 Td
(Poisson.)Tj
-57.9618 -1.559 Td
(102605)Tj
10.7718 0 Td
(40)Tj
11.4945 0 Td
(1)Tj
10.2332 0 Td
(60)Tj
11.5654 0 Td
(NA)Tj
9.9072 0 Td
(Does)Tj
2.2677 0 Td
(not)Tj
1.5874 0 Td
(fit)Tj
1.0913 0 Td
(a)Tj
0.6662 0 Td
(Poisson,)Tj
-5.5701 -1.1906 Td
(evidence)Tj
3.7346 0 Td
(for)Tj
1.4032 0 Td
(selection.)Tj
ET
Q
q
1 j
1 J
0 w
5.5998 0 0 5.5998 36 115.6535 cm
BT
/F13 1 Tf
1 TL
0 0 Td
()Tj
ET
Q
q
1 j
1 J
0 w
7.9999 0 0 7.9999 39.2881 112.7055 cm
BT
/F7 1 Tf
1 TL
0 0 Td
(Number)Tj
3.6283 0 Td
(of)Tj
1.0276 0 Td
(T/Fs)Tj
2.0693 0 Td
(were)Tj
2.1402 0 Td
(estimated)Tj
4.1032 0 Td
(through)Tj
3.4653 0 Td
(visual)Tj
2.5371 0 Td
(analysis)Tj
3.359 0 Td
(of)Tj
1.0276 0 Td
(highlighter)Tj
4.6418 0 Td
(plots)Tj
2.1756 0 Td
(and)Tj
1.7433 0 Td
(phylogene)Tj
4.1315 0 Td
(tic)Tj
1.226 0 Td
(trees)Tj
2.1189 0 Td
(after)Tj
2.0623 0 Td
(eliminatin)Tj
4.1386 0 Td
(g)Tj
0.7016 0 Td
(recombina)Tj
4.3157 0 Td
(nts)Tj
1.4457 0 Td
(and)Tj
1.7504 0 Td
(hypermu)Tj
3.6497 0 Td
(tated)Tj
2.2252 0 Td
(sequences.)Tj
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.3325 36 104.2582 cm
BT
/F7 1 Tf
1 TL
0 0 Td
()Tj
ET
Q
q
1 j
1 J
0 w
7.9999 0 0 7.9999 38.948 100.7433 cm
BT
/F7 1 Tf
1 TL
0 0 Td
(Days)Tj
2.2252 0 Td
(since)Tj
2.2606 0 Td
(most)Tj
2.2252 0 Td
(recent)Tj
2.7355 0 Td
(common)Tj
3.8622 0 Td
(ancestor)Tj
3.6142 0 Td
(\(MRCA\))Tj
3.7843 0 Td
(were)Tj
2.1402 0 Td
(calculat)Tj
3.0472 0 Td
(ed)Tj
1.1906 0 Td
(using)Tj
2.4095 0 Td
(the)Tj
1.4882 0 Td
(LANL)Tj
2.7283 0 Td
(tool)Tj
1.8001 0 Td
(Poisson)Tj
3.3519 0 Td
(Fitter)Tj
0.83 0.64 0.02 0 k
2.4379 0 Td
(https://w)Tj
3.5858 0 Td
(ww.hiv.lanl.)Tj
4.7977 0 Td
(gov/content/se)Tj
5.9528 0 Td
(quence/P)Tj
3.7559 0 Td
(OISSON_FITT)Tj
6.13 0 Td
(ER/)Tj
-65.8918 -1.5023 Td
(pfitter.htm)Tj
4.3582 0 Td
(l)Tj
/F10 1 Tf
-0.025 Tc
-4.3582 -2.2465 Td
(https://do)Tj
3.5575 0 Td
(i.org/10.1371/j)Tj
5.4425 0 Td
(ournal.ppa)Tj
3.9331 0 Td
(t.1006944.t0)Tj
4.7481 0 Td
(02)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 144.5669 23.6976 re
W* n
q
144.5102 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 449.1779 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Mother)Tj
3.2811 0 Td
(to)Tj
1.0417 0 Td
(child)Tj
2.2323 0 Td
(transmis)Tj
3.7134 0 Td
(sion)Tj
2.0197 0 Td
(of)Tj
1.0418 0 Td
(HIV-1)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
0.83 0.64 0.02 0 k
102.0472 34.9228 m
256.1953 34.9228 l
h
f*
0 g
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(Pathogens)Tj
4.9252 0 Td
(|)Tj
0.83 0.64 0.02 0 k
0.4748 0 Td
(https://)Tj
2.9552 0 Td
(doi.org/10.13)Tj
5.7331 0 Td
(71/journal.p)Tj
5.1236 0 Td
(pat.1006)Tj
3.8198 0 Td
(944)Tj
0 g
2.6362 0 Td
(April)Tj
2.1756 0 Td
(19,)Tj
1.5874 0 Td
(2018)Tj
32.8538 0 Td
(5)Tj
0.7654 0 Td
(/)Tj
ET
endstream
endobj
134 0 obj
<>stream
endstream
endobj
135 0 obj
<>stream
endstream
endobj
136 0 obj
<>stream
endstream
endobj
137 0 obj
<>stream
endstream
endobj
138 0 obj
<>stream
endstream
endobj
139 0 obj
<>stream
BT
66.402 0 Td
(26)Tj
ET
Q
endstream
endobj
140 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 12 0 R/Annots 142 0 R/Contents 143 0 R/TrimBox[0 0 612 792]>>
endobj
142 0 obj
[144 0 R 145 0 R 146 0 R 147 0 R 148 0 R 149 0 R 150 0 R 151 0 R 152 0 R 153 0 R]
endobj
144 0 obj
<>/Border[0 0 0]/Dest(Rppat.1006944.ref026)>>
endobj
145 0 obj
<>/Border[0 0 0]/Dest(Rppat.1006944.ref026)>>
endobj
146 0 obj
<>/Border[0 0 0]/Dest(Rppat.1006944.ref041)>>
endobj
147 0 obj
<>/Border[0 0 0]/Dest(Rppat.1006944.ref026)>>
endobj
148 0 obj
<>/Border[0 0 0]/Dest(Rppat.1006944.ref041)>>
endobj
149 0 obj
<>/Border[0 0 0]/Dest(Rppat.1006944.t002)>>
endobj
150 0 obj
<>/Border[0 0 0]/Dest(Rppat.1006944.s003)>>
endobj
151 0 obj
<>/Border[0 0 0]/A 154 0 R>>
endobj
154 0 obj
<>
endobj
152 0 obj
<>/Border[0 0 0]/Dest(Rppat.1006944.g002)>>
endobj
153 0 obj
<>/Border[0 0 0]/A 155 0 R>>
endobj
155 0 obj
<>
endobj
143 0 obj
[156 0 R 157 0 R 158 0 R 159 0 R 160 0 R 161 0 R 162 0 R 163 0 R]
endobj
156 0 obj
<>stream
q
0.83 0.64 0.02 0 k
355.011 654.3496 m
364.5354 654.3496 l
h
f*
454.337 628.3276 m
463.8614 628.3276 l
h
f*
367.1433 517.6063 m
376.6677 517.6063 l
h
f*
384.6614 478.6016 m
394.1858 478.6016 l
h
f*
398.6646 478.6016 m
408.1323 478.6016 l
h
f*
203.4142 400.6488 m
232.5543 400.6488 l
h
f*
427.4646 309.6 m
451.7858 309.6 l
h
f*
293.6126 296.6173 m
505.5874 296.6173 l
h
f*
439.5969 120.926 m
459.1559 120.926 l
h
f*
0 g
1 j
1 J
0 w
10 0 0 10 200.0125 707.4141 cm
BT
/F7 1 Tf
1 TL
-0.004 Tc
0 0 Td
(one)Tj
1.6951 0 Td
(T/F)Tj
1.6894 0 Td
(virus.)Tj
2.4264 0 Td
(With)Tj
2.2791 0 Td
(the)Tj
1.474 0 Td
(exception)Tj
4.0932 0 Td
(of)Tj
1.0148 0 Td
(two)Tj
1.7064 0 Td
(infants,)Tj
3.1918 0 Td
(all)Tj
1.1452 0 Td
(of)Tj
1.0148 0 Td
(our)Tj
1.6271 0 Td
(samples)Tj
3.3845 0 Td
(had)Tj
1.7065 0 Td
(over)Tj
1.9785 0 Td
(20)Tj
1.1736 0 Td
(infant)Tj
-31.6004 -1.3039 Td
(sequences,)Tj
4.4446 0 Td
(giving)Tj
2.6873 0 Td
(us)Tj
1.1055 0 Td
(a)Tj
0.6576 0 Td
(90%)Tj
1.9276 0 Td
(confidence)Tj
4.5977 0 Td
(that)Tj
1.7802 0 Td
(we)Tj
1.3266 0 Td
(were)Tj
2.1259 0 Td
(able)Tj
1.8312 0 Td
(to)Tj
1.0205 0 Td
(sample)Tj
3.0217 0 Td
(all)Tj
1.1509 0 Td
(variants)Tj
3.3845 0 Td
(with)Tj
2.0012 0 Td
(a)Tj
0.652 0 Td
(popula-)Tj
-33.715 -1.2982 Td
(tion)Tj
1.8425 0 Td
(frequency)Tj
4.1839 0 Td
(of)Tj
1.0148 0 Td
(at)Tj
0.9524 0 Td
(least)Tj
1.9842 0 Td
(10%.)Tj
2.1544 0 Td
(For)Tj
1.627 0 Td
(the)Tj
1.4684 0 Td
(two)Tj
1.7064 0 Td
(infant)Tj
2.6079 0 Td
(samples)Tj
3.3789 0 Td
(in)Tj
1.0374 0 Td
(which)Tj
2.6532 0 Td
(we)Tj
1.3266 0 Td
(only)Tj
1.9729 0 Td
(had)Tj
1.7122 0 Td
(15)Tj
1.1735 0 Td
(and)Tj
1.7291 0 Td
(18)Tj
-34.5257 -1.2983 Td
(sequences)Tj
4.2179 0 Td
(respectively,)Tj
5.108 0 Td
(we)Tj
1.3323 0 Td
(were)Tj
2.1203 0 Td
(90%)Tj
1.9275 0 Td
(confident)Tj
4.0535 0 Td
(that)Tj
1.7802 0 Td
(we)Tj
1.3266 0 Td
(were)Tj
2.1203 0 Td
(able)Tj
1.8311 0 Td
(to)Tj
1.0262 0 Td
(sample)Tj
3.0217 0 Td
(all)Tj
1.1452 0 Td
(variants)Tj
3.3902 0 Td
(with)Tj
1.9956 0 Td
(a)Tj
-36.3966 -1.2983 Td
(population)Tj
4.5864 0 Td
(frequency)Tj
4.1896 0 Td
(of)Tj
1.0148 0 Td
(15%)Tj
1.9275 0 Td
(or)Tj
1.0998 0 Td
(more)Tj
2.3414 0 Td
([)Tj
0.83 0.64 0.02 0 k
(26)Tj
0 g
(].)Tj
-13.9633 -1.3039 Td
(A)Tj
0.907 0 Td
(total)Tj
2.0013 0 Td
(of)Tj
1.0148 0 Td
(463)Tj
/F11 1 Tf
1.6497 0 Td
[()2()24()]TJ
/F7 1 Tf
1.5704 0 Td
(genes)Tj
2.4435 0 Td
(were)Tj
2.1259 0 Td
(obtained)Tj
3.7304 0 Td
(from)Tj
2.2054 0 Td
(16)Tj
1.1735 0 Td
(maternal)Tj
3.7927 0 Td
(plasma)Tj
3.0331 0 Td
(samples)Tj
3.3845 0 Td
(\(collected)Tj
4.0762 0 Td
(at)Tj
0.9525 0 Td
(time)Tj
-35.2571 -1.2982 Td
(of)Tj
1.0147 0 Td
(delivery\))Tj
3.7304 0 Td
(from)Tj
2.2054 0 Td
(transmitting)Tj
5.193 0 Td
(mothers)Tj
3.5319 0 Td
(as)Tj
1.0148 0 Td
(previously)Tj
4.3484 0 Td
(described)Tj
4.0535 0 Td
([)Tj
0.83 0.64 0.02 0 k
(26)Tj
0 g
(].)Tj
2.0749 0 Td
(Using)Tj
2.6022 0 Td
(an)Tj
1.2019 0 Td
(algorithm)Tj
-30.9711 -1.2983 Td
(described)Tj
4.0535 0 Td
(in)Tj
1.0318 0 Td
(the)Tj
1.4683 0 Td
(Methods,)Tj
3.9855 0 Td
(out)Tj
1.5534 0 Td
(of)Tj
1.0148 0 Td
(these)Tj
2.2563 0 Td
(463)Tj
1.6441 0 Td
(maternal)Tj
/F11 1 Tf
3.7984 0 Td
[()2()24()]TJ
/F7 1 Tf
1.5704 0 Td
(variants,)Tj
3.617 0 Td
(we)Tj
1.3266 0 Td
(selected)Tj
3.3449 0 Td
(134)Tj
1.6497 0 Td
(SGA)Tj
2.092 0 Td
(variants)Tj
-34.4067 -1.3039 Td
(for)Tj
/F11 1 Tf
1.3832 0 Td
[()2()24()]TJ
/F7 1 Tf
1.5761 0 Td
(pseudovirus)Tj
5.0626 0 Td
(production)Tj
4.7169 0 Td
(\(512)Tj
2.5058 0 Td
(per)Tj
1.5307 0 Td
(mother\))Tj
3.5092 0 Td
(to)Tj
1.0262 0 Td
(represent)Tj
3.9571 0 Td
(the)Tj
/F11 1 Tf
1.4684 0 Td
[()2()24()]TJ
/F7 1 Tf
1.576 0 Td
(genetic)Tj
3.0671 0 Td
(diversity)Tj
3.6453 0 Td
(found)Tj
-35.0246 -1.2983 Td
(in)Tj
1.0318 0 Td
(the)Tj
1.474 0 Td
(plasma)Tj
3.033 0 Td
(of)Tj
1.0148 0 Td
(each)Tj
2.0239 0 Td
(transmitting)Tj
5.1987 0 Td
(mother)Tj
3.1692 0 Td
(at)Tj
0.9524 0 Td
(the)Tj
1.4683 0 Td
(time)Tj
2.0296 0 Td
(of)Tj
1.0148 0 Td
(delivery.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 561.7133 cm
BT
/F12 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Confirming)Tj
5.159 0 Td
(the)Tj
1.5449 0 Td
(timing)Tj
3.019 0 Td
(of)Tj
1.0677 0 Td
(infant)Tj
2.7591 0 Td
(HIV-1)Tj
2.9102 0 Td
(infection)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 544.7055 cm
BT
/F7 1 Tf
1 TL
-0.004 Tc
0 0 Td
(As)Tj
1.2642 0 Td
(the)Tj
1.4683 0 Td
(infants)Tj
2.9651 0 Td
(were)Tj
2.1259 0 Td
(selected)Tj
3.3449 0 Td
(for)Tj
1.389 0 Td
(peripartum)Tj
4.7678 0 Td
(transmission,)Tj
5.5899 0 Td
(their)Tj
2.1033 0 Td
(age)Tj
1.542 0 Td
(at)Tj
0.9524 0 Td
(sampling)Tj
3.8835 0 Td
(\(in)Tj
1.3719 0 Td
(days\))Tj
2.3415 0 Td
(was)Tj
-35.1097 -1.2982 Td
(also)Tj
1.7688 0 Td
(the)Tj
1.4683 0 Td
(post-infection)Tj
5.8223 0 Td
(time.)Tj
2.2564 0 Td
(To)Tj
1.3379 0 Td
(confirm)Tj
3.4469 0 Td
(the)Tj
1.4684 0 Td
(time)Tj
2.0296 0 Td
(of)Tj
1.0148 0 Td
(infection,)Tj
4.0138 0 Td
(all)Tj
1.1509 0 Td
(infant)Tj
2.6021 0 Td
(alignments)Tj
4.6318 0 Td
(were)Tj
2.1203 0 Td
(ana-)Tj
-35.1323 -1.3039 Td
(lyzed)Tj
2.2847 0 Td
(using)Tj
2.3867 0 Td
(the)Tj
1.474 0 Td
(LANL)Tj
2.7156 0 Td
(Poisson)Tj
3.3278 0 Td
(Fitter)Tj
2.4095 0 Td
(tool)Tj
1.7745 0 Td
([)Tj
0.83 0.64 0.02 0 k
(41)Tj
0 g
(].)Tj
2.0806 0 Td
(For)Tj
1.6271 0 Td
(infants)Tj
2.965 0 Td
(that)Tj
1.7745 0 Td
(had)Tj
1.7121 0 Td
(more)Tj
2.3414 0 Td
(than)Tj
2.0296 0 Td
(one)Tj
1.6951 0 Td
(T/F,)Tj
1.9162 0 Td
(only)Tj
-34.5144 -1.2983 Td
(the)Tj
1.4683 0 Td
(sequences)Tj
4.2179 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4683 0 Td
(major)Tj
2.6079 0 Td
(T/F)Tj
1.6894 0 Td
(lineage)Tj
3.0274 0 Td
(were)Tj
2.126 0 Td
(used)Tj
2.0579 0 Td
(for)Tj
1.3833 0 Td
(this)Tj
1.6781 0 Td
(analysis.)Tj
3.549 0 Td
(When)Tj
2.6872 0 Td
(recombinants)Tj
5.7316 0 Td
(and)Tj
-34.7298 -1.2983 Td
(APOBEC)Tj
4.0195 0 Td
(enrichment)Tj
4.8755 0 Td
(were)Tj
2.1203 0 Td
(detected,)Tj
3.7927 0 Td
(the)Tj
1.4684 0 Td
(timing)Tj
2.8856 0 Td
(was)Tj
1.7008 0 Td
(calculated)Tj
4.2009 0 Td
(after)Tj
2.0353 0 Td
(removing)Tj
4.0819 0 Td
(recombinants)Tj
-31.1809 -1.3039 Td
(and/or)Tj
2.9366 0 Td
(positions)Tj
3.8551 0 Td
(enriched)Tj
3.7304 0 Td
(for)Tj
1.389 0 Td
(hypermutation)Tj
6.2135 0 Td
([)Tj
0.83 0.64 0.02 0 k
(26)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.7404 0 Td
(41)Tj
0 g
(].)Tj
-18.6688 -1.2982 Td
(After)Tj
2.2903 0 Td
(removing)Tj
4.0762 0 Td
(hypermutated)Tj
5.845 0 Td
(sequences)Tj
4.218 0 Td
(and)Tj
1.7291 0 Td
(/or)Tj
1.4286 0 Td
(recombinants,)Tj
5.9528 0 Td
(all)Tj
1.1451 0 Td
(but)Tj
1.5534 0 Td
(one)Tj
1.7008 0 Td
(infant)Tj
2.6022 0 Td
(\(102605\))Tj
-33.7377 -1.2983 Td
(yielded)Tj
3.0897 0 Td
(a)Tj
0.652 0 Td
(good)Tj
2.228 0 Td
(Poisson)Tj
3.3278 0 Td
(fit,)Tj
1.304 0 Td
(indicating)Tj
4.2632 0 Td
(that)Tj
1.7802 0 Td
(the)Tj
1.4683 0 Td
(amount)Tj
3.3562 0 Td
(of)Tj
1.0148 0 Td
(diversity)Tj
3.6453 0 Td
(found)Tj
2.6192 0 Td
(in)Tj
1.0375 0 Td
(these)Tj
2.2507 0 Td
(samples)Tj
3.3846 0 Td
(was)Tj
-35.4215 -1.3039 Td
(compatible)Tj
4.6601 0 Td
(with)Tj
2.0012 0 Td
(a)Tj
0.652 0 Td
(random)Tj
3.4299 0 Td
(accumulation)Tj
5.6749 0 Td
(of)Tj
1.0148 0 Td
(mutations)Tj
4.2803 0 Td
(as)Tj
1.0148 0 Td
(observed)Tj
3.7984 0 Td
(in)Tj
1.0375 0 Td
(acute)Tj
2.3244 0 Td
(infections.)Tj
4.3766 0 Td
(The)Tj
-34.2649 -1.2983 Td
(time)Tj
2.0295 0 Td
(since)Tj
2.2394 0 Td
(the)Tj
1.474 0 Td
(most)Tj
2.2053 0 Td
(common)Tj
3.8438 0 Td
(ancestor)Tj
3.5886 0 Td
(was)Tj
1.6951 0 Td
(consistent)Tj
4.2577 0 Td
(with)Tj
2.0012 0 Td
(transmission)Tj
5.3631 0 Td
(at)Tj
0.9525 0 Td
(delivery)Tj
3.3845 0 Td
(in)Tj
1.0375 0 Td
(9)Tj
0.6973 0 Td
(out)Tj
1.5534 0 Td
(of)Tj
-36.3229 -1.2983 Td
(16)Tj
1.1678 0 Td
(pairs)Tj
2.1713 0 Td
(\(57%\),)Tj
2.8347 0 Td
(within)Tj
2.8119 0 Td
(the)Tj
1.474 0 Td
(95%)Tj
1.9276 0 Td
(confidence)Tj
4.5977 0 Td
(interval)Tj
3.2655 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(Poisson)Tj
3.3335 0 Td
(Fitter)Tj
2.4038 0 Td
(time)Tj
2.0295 0 Td
(estimate)Tj
-30.5005 -1.2982 Td
(\()Tj
0.83 0.64 0.02 0 k
(Table)Tj
2.7779 0 Td
(2)Tj
0 g
(\).)Tj
1.2642 0 Td
(For)Tj
1.6271 0 Td
(the)Tj
1.4683 0 Td
(remaining)Tj
4.3654 0 Td
(infants,)Tj
3.1918 0 Td
(discrepancies)Tj
5.5672 0 Td
(between)Tj
3.5262 0 Td
(actual)Tj
2.5852 0 Td
(vs.)Tj
1.2643 0 Td
(predicted)Tj
3.9968 0 Td
(transmission)Tj
-31.6344 -1.3039 Td
(timing)Tj
2.8856 0 Td
(could)Tj
2.4491 0 Td
(be)Tj
1.1509 0 Td
(due)Tj
1.7008 0 Td
(to)Tj
1.0261 0 Td
(a)Tj
0.652 0 Td
(number)Tj
3.4185 0 Td
(of)Tj
1.0148 0 Td
(factors,)Tj
3.1294 0 Td
(including)Tj
4.0422 0 Td
(late)Tj
/F11 1 Tf
1.6214 0 Td
[()12()]TJ
1.0148 0 Td
[()14()11()2()20()]TJ
/F7 1 Tf
2.2621 0 Td
(infection,)Tj
4.0195 0 Td
(postpartum)Tj
4.8699 0 Td
(infec-)Tj
-35.2571 -1.2983 Td
(tion)Tj
1.8425 0 Td
(from)Tj
2.2053 0 Td
(unreported)Tj
4.7338 0 Td
(breastfeeding,)Tj
5.7827 0 Td
(and)Tj
1.7291 0 Td
(the)Tj
1.474 0 Td
(model)Tj
2.7439 0 Td
(being)Tj
2.4321 0 Td
(designed)Tj
3.7644 0 Td
(to)Tj
1.0205 0 Td
(evaluate)Tj
3.4639 0 Td
(an)Tj
1.2019 0 Td
(adult)Tj
2.2563 0 Td
(rather)Tj
-34.6504 -1.2983 Td
(than)Tj
2.0295 0 Td
(infant)Tj
2.6022 0 Td
(HIV-1)Tj
2.846 0 Td
(evolution,)Tj
4.2293 0 Td
(which)Tj
2.6475 0 Td
(could)Tj
2.4548 0 Td
(gather)Tj
2.7382 0 Td
(mutations)Tj
4.2803 0 Td
(more)Tj
2.3414 0 Td
(rapidly)Tj
3.0388 0 Td
(due)Tj
1.7007 0 Td
(to)Tj
1.0262 0 Td
(more)Tj
2.3414 0 Td
(robust)Tj
-34.2763 -1.3039 Td
(T)Tj
0.8277 0 Td
(cell)Tj
1.559 0 Td
(responses.)Tj
-1.1905 -1.2982 Td
(Infant)Tj
2.6759 0 Td
(102605)Tj
/F11 1 Tf
3.0727 0 Td
[()2()24()]TJ
/F7 1 Tf
1.5704 0 Td
(SGA)Tj
2.0919 0 Td
(sequences)Tj
4.2123 0 Td
(did)Tj
1.542 0 Td
(not)Tj
1.5704 0 Td
(yield)Tj
2.1373 0 Td
(a)Tj
0.6463 0 Td
(good)Tj
2.228 0 Td
(Poisson)Tj
3.3222 0 Td
(fit)Tj
1.0715 0 Td
(due)Tj
1.6951 0 Td
(to)Tj
1.0261 0 Td
(non-random)Tj
5.3745 0 Td
(accu-)Tj
-35.4328 -1.2983 Td
(mulation)Tj
3.8664 0 Td
(of)Tj
1.0148 0 Td
(non-synonymous)Tj
7.268 0 Td
(mutations)Tj
4.2803 0 Td
(\(which)Tj
2.9877 0 Td
(breaks)Tj
2.8119 0 Td
(the)Tj
1.474 0 Td
(model)Tj
2.7439 0 Td
(assumption)Tj
4.8586 0 Td
(of)Tj
1.0148 0 Td
(random)Tj
-32.3204 -1.3039 Td
(accumulation)Tj
5.6749 0 Td
(of)Tj
1.0148 0 Td
(mutations\))Tj
4.6204 0 Td
(at)Tj
0.9524 0 Td
(HXB2)Tj
2.6986 0 Td
(positions)Tj
3.8551 0 Td
(752754)Tj
3.5886 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(S3)Tj
1.5137 0 Td
(Fig)Tj
0 g
(\).)Tj
2.0466 0 Td
(According)Tj
4.4334 0 Td
(to)Tj
1.0261 0 Td
(the)Tj
1.4684 0 Td
(LANL)Tj
-32.893 -1.2983 Td
(immunology)Tj
5.3801 0 Td
(database)Tj
3.6396 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(https://www.hiv.lanl.gov/c)Tj
10.8623 0 Td
(ontent/immunology/index)Tj
0 g
(\),)Tj
11.4633 0 Td
(there)Tj
2.262 0 Td
(are)Tj
1.4513 0 Td
(five)Tj
-35.0586 -1.2983 Td
(different)Tj
3.6566 0 Td
(human)Tj
3.0784 0 Td
(CTL)Tj
2.0296 0 Td
(epitopes)Tj
3.5376 0 Td
(in)Tj
1.0318 0 Td
(this)Tj
1.6781 0 Td
(region,)Tj
3.0274 0 Td
(suggesting)Tj
4.3994 0 Td
(that)Tj
1.7801 0 Td
(the)Tj
1.4683 0 Td
(non-random)Tj
5.3858 0 Td
(mutations)Tj
-31.0731 -1.3039 Td
(found)Tj
2.6191 0 Td
(in)Tj
1.0319 0 Td
(infant)Tj
2.6078 0 Td
(102605)Tj
3.0727 0 Td
(were)Tj
2.1203 0 Td
(likely)Tj
2.3585 0 Td
(due)Tj
1.6951 0 Td
(to)Tj
1.0261 0 Td
(selection)Tj
3.719 0 Td
(pressure)Tj
3.5773 0 Td
(by)Tj
1.1792 0 Td
(T)Tj
0.8334 0 Td
(cell)Tj
1.5591 0 Td
(responses.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 242.9858 cm
BT
/F12 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Neutralization)Tj
6.3213 0 Td
(sensitivity)Tj
4.4504 0 Td
(and)Tj
1.7953 0 Td
(tier)Tj
1.6819 0 Td
(classification)Tj
5.6504 0 Td
(of)Tj
1.063 0 Td
(the)Tj
1.5449 0 Td
(infant)Tj
2.7591 0 Td
(T/F)Tj
1.7291 0 Td
(viruses)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 225.9779 cm
BT
/F7 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Twenty-one)Tj
5.0683 0 Td
(infant)Tj
2.6022 0 Td
(T/F)Tj
/F11 1 Tf
1.6894 0 Td
[()2()24()]TJ
/F7 1 Tf
1.576 0 Td
(amplicons)Tj
4.3427 0 Td
(including)Tj
4.0422 0 Td
(16)Tj
1.1735 0 Td
(primary)Tj
3.4526 0 Td
(T/Fs)Tj
2.0523 0 Td
(and)Tj
1.7291 0 Td
(5)Tj
0.6973 0 Td
(secondary)Tj
4.2689 0 Td
(T/Fs)Tj
2.0523 0 Td
(were)Tj
-34.7468 -1.2982 Td
(used)Tj
2.0579 0 Td
(to)Tj
1.0261 0 Td
(generate)Tj
3.6057 0 Td
(pseudoviruses)Tj
5.8506 0 Td
(and)Tj
1.7348 0 Td
(their)Tj
2.1033 0 Td
(neutralization)Tj
5.8053 0 Td
(sensitivity)Tj
4.2236 0 Td
(to)Tj
1.0262 0 Td
(paired)Tj
2.7609 0 Td
(maternal)Tj
3.7927 0 Td
(plasma)Tj
-33.9871 -1.2983 Td
(\(collected)Tj
4.0761 0 Td
(at)Tj
0.9525 0 Td
(the)Tj
1.474 0 Td
(time)Tj
2.0239 0 Td
(of)Tj
1.0148 0 Td
(birth\))Tj
2.5342 0 Td
(and)Tj
1.7291 0 Td
(a)Tj
0.652 0 Td
(panel)Tj
2.3924 0 Td
(of)Tj
1.0148 0 Td
(bNAbs)Tj
3.016 0 Td
(was)Tj
1.7008 0 Td
(assessed.)Tj
3.6963 0 Td
(None)Tj
2.4322 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.474 0 Td
(mothers)Tj
3.5262 0 Td
(with)Tj
-34.7241 -1.3039 Td
(the)Tj
1.4683 0 Td
(exception)Tj
4.0932 0 Td
(of)Tj
1.0148 0 Td
(two)Tj
1.7121 0 Td
(\(100014)Tj
3.4129 0 Td
(and)Tj
1.7291 0 Td
(100504\))Tj
3.4129 0 Td
(had)Tj
1.7121 0 Td
(non-specific)Tj
5.142 0 Td
(neutralization)Tj
5.8054 0 Td
(activity)Tj
3.118 0 Td
(as)Tj
1.0148 0 Td
(assessed)Tj
-33.6356 -1.2983 Td
(by)Tj
1.1792 0 Td
(neutralization)Tj
5.8053 0 Td
(activity)Tj
3.1181 0 Td
(against)Tj
3.0273 0 Td
(a)Tj
0.6577 0 Td
(murine)Tj
3.1748 0 Td
(leukemia)Tj
3.8607 0 Td
(virus)Tj
2.1997 0 Td
(\(MLV\).)Tj
3.2485 0 Td
(Eighteen)Tj
3.7474 0 Td
(out)Tj
1.5533 0 Td
(of)Tj
1.0148 0 Td
(21)Tj
1.1679 0 Td
(infant)Tj
2.6079 0 Td
(T/)Tj
-36.3626 -1.2982 Td
(F)Tj
0.7483 0 Td
(Env)Tj
1.7915 0 Td
(pseudoviruses)Tj
5.8506 0 Td
(\(86%\))Tj
2.6079 0 Td
(were)Tj
2.1203 0 Td
(resistant)Tj
3.583 0 Td
(to)Tj
1.0261 0 Td
(paired)Tj
2.7609 0 Td
(maternal)Tj
3.7984 0 Td
(serum)Tj
2.7213 0 Td
(\(ID)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 484.2708 159.307 cm
BT
/F7 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(50)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 491.3574 161.0078 cm
BT
/F15 1 Tf
1 TL
0 0 Td
(<)Tj
/F7 1 Tf
-0.004 Tc
(40\).)Tj
2.5114 0 Td
(Sensitivity)Tj
4.337 0 Td
(of)Tj
1.0148 0 Td
(2)Tj
-36.9975 -1.2982 Td
(Infant)Tj
2.6759 0 Td
(T/F)Tj
1.6895 0 Td
(pseudoviruses')Tj
6.0661 0 Td
(\(100014)Tj
3.4129 0 Td
(and)Tj
1.7291 0 Td
(100504\))Tj
3.4129 0 Td
(against)Tj
3.0274 0 Td
(paired)Tj
2.7609 0 Td
(maternal)Tj
3.7984 0 Td
(plasma)Tj
3.0329 0 Td
(could)Tj
2.4492 0 Td
(not)Tj
1.576 0 Td
(be)Tj
-35.6312 -1.3039 Td
(determined)Tj
4.8473 0 Td
(with)Tj
2.0012 0 Td
(confidence)Tj
4.5978 0 Td
(due)Tj
1.7007 0 Td
(to)Tj
1.0262 0 Td
(higher)Tj
2.8006 0 Td
(plasma)Tj
3.033 0 Td
(reactivity)Tj
3.9118 0 Td
(against)Tj
3.0274 0 Td
(MLV.)Tj
2.5738 0 Td
(The)Tj
1.7801 0 Td
(T/F)Tj
1.6894 0 Td
(virus)Tj
2.1997 0 Td
(of)Tj
-35.189 -1.2983 Td
(infant)Tj
2.6022 0 Td
(100046)Tj
3.0728 0 Td
(was)Tj
1.7007 0 Td
(sensitive)Tj
3.6227 0 Td
(against)Tj
3.0331 0 Td
(paired)Tj
2.7609 0 Td
(maternal)Tj
3.7927 0 Td
(plasma)Tj
3.0331 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(Fig)Tj
1.8198 0 Td
(2)Tj
0 g
(\).)Tj
-24.2417 -1.2983 Td
(When)Tj
2.6872 0 Td
(infant)Tj
2.6078 0 Td
(T/F)Tj
1.6838 0 Td
(pseudoviruses)Tj
5.8507 0 Td
(were)Tj
2.126 0 Td
(tested)Tj
2.5511 0 Td
(against)Tj
3.0274 0 Td
(the)Tj
1.4683 0 Td
(autologous)Tj
4.6035 0 Td
(plasma)Tj
3.0329 0 Td
(\(plasma)Tj
3.3676 0 Td
(from)Tj
-34.2026 -1.3039 Td
(the)Tj
1.4684 0 Td
(same)Tj
2.2563 0 Td
(infant\),)Tj
3.1692 0 Td
(only)Tj
1.9785 0 Td
(2)Tj
0.6973 0 Td
(T/Fs)Tj
2.0467 0 Td
(\(from)Tj
2.5454 0 Td
(infants)Tj
2.9651 0 Td
(100046)Tj
3.0784 0 Td
(and)Tj
1.7291 0 Td
(100155\))Tj
3.4129 0 Td
(showed)Tj
3.2485 0 Td
(some)Tj
2.3356 0 Td
(sensitivity)Tj
4.2179 0 Td
(as)Tj
1.0148 0 Td
(per)Tj
-36.1641 -1.2982 Td
(our)Tj
1.6271 0 Td
(criteria)Tj
3.0728 0 Td
(\(ID)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 261.1842 81.3543 cm
BT
/F7 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(50)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 268.3275 82.9984 cm
BT
/F15 1 Tf
1 TL
0 0 Td
(>)Tj
/F7 1 Tf
-0.004 Tc
0.9864 0 Td
(3X)Tj
1.3493 0 Td
(that)Tj
1.7801 0 Td
(of)Tj
1.0148 0 Td
(MLV\),)Tj
2.9084 0 Td
(while)Tj
2.3697 0 Td
(others)Tj
2.7099 0 Td
(were)Tj
2.1203 0 Td
(completely)Tj
4.5808 0 Td
(resistant.)Tj
3.8097 0 Td
(Some)Tj
2.4435 0 Td
(infant)Tj
2.6078 0 Td
(T/F)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 144.5669 23.6976 re
W* n
q
144.5102 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 449.1779 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Mother)Tj
3.2811 0 Td
(to)Tj
1.0417 0 Td
(child)Tj
2.2323 0 Td
(transmis)Tj
3.7134 0 Td
(sion)Tj
2.0197 0 Td
(of)Tj
1.0418 0 Td
(HIV-1)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
0.83 0.64 0.02 0 k
102.0472 34.9228 m
256.1953 34.9228 l
h
f*
0 g
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(Pathogens)Tj
4.9252 0 Td
(|)Tj
0.83 0.64 0.02 0 k
0.4748 0 Td
(https://)Tj
2.9552 0 Td
(doi.org/10.13)Tj
5.7331 0 Td
(71/journal.p)Tj
5.1236 0 Td
(pat.1006)Tj
3.8198 0 Td
(944)Tj
0 g
2.6362 0 Td
(April)Tj
2.1756 0 Td
(19,)Tj
1.5874 0 Td
(2018)Tj
32.8538 0 Td
(6)Tj
0.7654 0 Td
(/)Tj
ET
endstream
endobj
157 0 obj
<>stream
endstream
endobj
158 0 obj
<>stream
endstream
endobj
159 0 obj
<>stream
endstream
endobj
160 0 obj
<>stream
endstream
endobj
161 0 obj
<>stream
endstream
endobj
162 0 obj
<>stream
endstream
endobj
163 0 obj
<>stream
BT
66.402 0 Td
(26)Tj
ET
Q
endstream
endobj
164 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 12 0 R/Annots 166 0 R/Contents 167 0 R/TrimBox[0 0 612 792]>>
endobj
165 0 obj
<>stream
x|TA!@jJQ@@kC/xST^B'l&ɦm|OXܜl
)[}={v;YϜ
T=cǎٳgo3/^ϯ2% pzP
:uGuiȑNO HHHHH!7!>|xHHHHH \|O>5ӓ'ONKKszN@$@$@$@$@$`N`۶m͚5EM82~& pn>EJo_~qnNl= 9OO.]Ԯ&322/g '&aÆkJ d4hW81'6HH@vvvbb"浓q\/(pCwMf̘?;w^ sff'p_|e˖8_ʰ}g͛7s*^T\ZZjꤨj)..ƫ