Fig 1.
Overview of the systematic literature screening pipeline.
Pubmed, Web of Science, BioRxiv and MedRxiv were used as database sources for the time period January 1st—June 23rd 2020 and for the retrieval of SARS-CoV-2 reservoir studies.
Fig 2.
Overview of organ systems studied in SARS-CoV-2 human reservoir studies for the time period January 1st to June 23rd 2020.
Next to the widespread use of nasopharyngeal or oropharyngeal swabs (not included in the graph), a full range of SARS-CoV-2 reservoir studies were identified which examined a vast array of human tissues and body fluids.
Fig 3.
Overview of SARS-CoV-2 presence in the human body.
Gradient color (purple) indicates low to high evidence for SARS-CoV-2 detection in this organ, tissue or body fluid. Highest expression was found in upper airways, lungs and oral cavity together with the gastrointestinal tract and urinary system. This figure was created with BioRender.com.
Fig 4.
Overview of ACE2 expression levels in the human body.
Gradient color (orange) indicates low to high evidence for ACE2 expression in this tissue or body fluid. Highest expression was detected in the oral cavity, gastrointestinal tract and the male reproductive system. This figure was created with BioRender.com.
Table 1.
Overview of SARS-CoV-2 detection in the human body, organized per organ system.
Organ systems are shown on the left, followed by type of virus detection and amount of positive samples.