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The anti-immune dengue subgenomic flaviviral RNA is present in vesicles in mosquito saliva and is associated with increased infectivity

Fig 6

Model: sfRNA in salivary vesicles is transported into cells to enhance infection at the biting site.

sfRNA packaged inside extracellular vesicles in infectious mosquito saliva is transferred to human skin cells during biting. sfRNA inhibits the antiviral innate immune response (interferon (IFN) system) to enhance skin cell virus infection. Created with BioRender.com.

Fig 6

doi: https://doi.org/10.1371/journal.ppat.1011224.g006