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Human cytomegalovirus UL23 inhibits transcription of interferon-γ stimulated genes and blocks antiviral interferon-γ responses by interacting with human N-myc interactor protein

Fig 9

HCMV growth in different cells that were treated with and without IFN-γ.

U251, U251-C, and U251-UL23 cells were incubated in the absence (-IFN-γ)(A) and presence (+IFN-γ)(B) of IFN-γ (1000 U/ml) for 12 hours, and then mock-infected or infected with TowneBAC, ΔUL23, UL23stop, R-UL23, and R-stop (MOI = 1). Total infection cultures were collected at 5 days postinfection and viral titers were determined [39]. The analyses were repeated three times and the standard deviation is indicated by the error bar.

Fig 9

doi: https://doi.org/10.1371/journal.ppat.1006867.g009