Fab-based inhibitors reveal ubiquitin independent functions for HIV Vif neutralization of APOBEC3 restriction factors
(A) Schematic representation of the Vif E3-ligase with the VCBC components denoted in gray. (B) Overview of Fab panning pipeline. (C) Binding affinities for VCBC-Fab interactions measured by BLI. Consensus Vif was obtained from the Los Alamos National Lab HIV Sequence Database (Alignment ID: 104CP14).