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Recombinant PrPSc shares structural features with brain-derived PrPSc: Insights from limited proteolysis

Fig 5

Analysis of PK-resistant fragments of recBVPrPSc.

A) Coomassie-stained SDS-PAGE of recBVPrPSc treated with PK (see text for more details); numbered bands were excised, digested with trypsin in gel and analyzed as described in the Materials and Methods section. B) MALDI spectrum of the same PK-treated sample; the horizontal line in B indicates unassigned peaks perhaps corresponding to N-,C- doubly truncated fragments.

Fig 5