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The Mutational Robustness of Influenza A Virus

Fig 4

Fitness impact of mutations on HA.

Mutations were placed onto a structural model of the hemagglutinin protein (PBD 1RVX). Shown are mutations on the head and stem regions, HA1 and HA2. Non-coding mutations (HA-8) and mutations on the signal peptide (HA-11), splice site (HA-1), and transmembrane domain (HA-40, HA-15, HA-10, HA-20) are not shown. Mutations are color coded as follows according to their relative fitness: lethal mutations are red, 0.6–0.8 are orange, 0.8–1.0 are yellow, and 1.0–1.2 are green. We found no HA mutations with a fitness between 0–0.6.

Fig 4

doi: https://doi.org/10.1371/journal.ppat.1005856.g004