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De novo GTP Biosynthesis Is Critical for Virulence of the Fungal Pathogen Cryptococcus neoformans

Figure 5

The C. gattii VGIV molecular type is resistant to MPA.

(A) Resistance to the IMPDH inhibitor MPA was assessed in all haploid molecular types of the pathogenic C. neoformans/C. gattii species complex using a serial dilution spotting assay on YNB plus 5 µg/mL MPA. (B) Precise sensitivity to MPA was determined via MIC broth microdilution assay. MIC50 and MIC90 are the concentrations at which growth was inhibited by 50% or 90%, respectively. Standard error bars are displayed for all strains.

Figure 5