A Novel Mouse Model of Schistosoma haematobium Egg-Induced Immunopathology
Pelvic lymph nodes from egg-injected mice demonstrate persistently elevated expression of Type 2-associated cytokines (e.g. IL-4) without corresponding increases in the TH1-associated cytokines IFN-γ and IL-12. The TReg-associated marker FoxP3 is suppressed late in the experimental time course, while the immunosuppressive cytokines IL-10 and TGF-β remain unchanged. IL-17 was not detected (N.D.).