A Novel Mouse Model of Schistosoma haematobium Egg-Induced Immunopathology
Egg-injected bladders demonstrate histologically-apparent fibrosis within granulomata beginning at post-injection day 7 (A, Masson's trichrome stain, collagen stains blue). Later time points demonstrate increased collagen staining area and intensity (B). Total bladder soluble collagen content correlates with histologic evaluation (C). Egg-injected mice demonstrate increased urinary frequency (1 week post injection, D).