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Whole Genome Deep Sequencing of HIV-1 Reveals the Impact of Early Minor Variants Upon Immune Recognition During Acute Infection

Figure 8

Variant-specific CD8+ T cell Elispot responses.

Elispot responses in Spot Forming Cells (SFC) per million PBMC to wild-type and variant peptides for the two dominant epitopes (A) Vif B38-WI9 (WHLGQGVSI) and (B) Nef A24-RW8 (RYPLTFGW). Bars in black denote responses to clade B consensus epitopes. Bars in red, orange, and pink denote responses to epitopes containing escape variants.

Figure 8

doi: https://doi.org/10.1371/journal.ppat.1002529.g008