KIR2DL2 Enhances Protective and Detrimental HLA Class I-Mediated Immunity in Chronic Viral Infection
Figure 3
The impact of HLA-B*57 and KIR2DL2 on HCV viral load.
In HCV infection, B*57 is associated with a reduced HCV viral load. This protective effect is enhanced in KIR2DL2+ individuals and reduced or absent in KIR2DL2- individuals. The cohorts were analysed separately as viral load was measured using different assays. Two cohorts, MHCS and ALIVE, had enough individuals with measurements for all factors to perform this analysis. HIV-1 status was a significant determinant of viral load in the ALIVE cohort, including HIV status in the model as a covariate did not change any of our conclusions (ALL p = 0.3; KIR2DL2+ p = 0.05; KIR2DL2- p = 0.4). Summary data from these plots is provided in Table 2. The p-values are derived based on the regression model.