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Detection of Inferred CCR5- and CXCR4-Using HIV-1 Variants and Evolutionary Intermediates Using Ultra-Deep Pyrosequencing

Figure 2

Increasing percentage of predicted CXCR4-using variants over time following their appearance during natural HIV-1 infection.

The median percentage si/x4 sequences generated from PBMC (light grey) and serum (dark grey) by deep sequencing at time points up to one year before the first phenotypic detection of CXCR4-using variants in the MT-2 assay in eight participants are shown. Error bars represent the interquartile ranges.

Figure 2

doi: https://doi.org/10.1371/journal.ppat.1002106.g002