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Detection of Inferred CCR5- and CXCR4-Using HIV-1 Variants and Evolutionary Intermediates Using Ultra-Deep Pyrosequencing

Figure 1

Detection of predicted CXCR4-using variants that emerge during natural HIV-1 infection using deep sequencing.

For each participant, the percentage si/x4 sequences in PBMC (light grey bars) and serum (dark grey bars) at time points up to one year before the first phenotypic detection of CXCR4-using variants in the MT-2 assay are shown. Samples that have not been sequenced are indicated with an asterisk. In the top of each graph, the results of the MT-2 assay and the enhanced-sensitivity Trofile assay (ESTA) are given: a blue bar indicates NSI or R5, respectively, while a red bar indicates SI or D/M, respectively.

Figure 1

doi: https://doi.org/10.1371/journal.ppat.1002106.g001