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Critical Role of IRF-5 in the Development of T helper 1 responses to Leishmania donovani infection

Figure 4

L. donovani fails to induce IL-12p35 expression in Irf5-/- mice.

WT and Irf5-/- mice were infected with L. donovani amistigotes. At 5 h, splenic cDCs were purified. IL-12p35 mRNA was detected by real time PCR. Data is shown for n = 3 WT samples and n = 4 Irf5-/- samples.* denotes p<0.05 and ** denotes p<0.01.

Figure 4