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Zn2+ Inhibits Coronavirus and Arterivirus RNA Polymerase Activity In Vitro and Zinc Ionophores Block the Replication of These Viruses in Cell Culture

Figure 2

Inhibition of the in vitro RNA-synthesizing activity of isolated RTCs by Zn2+.

Incorporation of [α-32P]CMP into viral RNA by EAV (A) and SARS-CoV (B) in RTC assays in the presence of various Zn2+ concentrations, as indicated above each lane.

Figure 2

doi: https://doi.org/10.1371/journal.ppat.1001176.g002