Zn2+ Inhibits Coronavirus and Arterivirus RNA Polymerase Activity In Vitro and Zinc Ionophores Block the Replication of These Viruses in Cell Culture
Figure 2
Inhibition of the in vitro RNA-synthesizing activity of isolated RTCs by Zn2+.
Incorporation of [α-32P]CMP into viral RNA by EAV (A) and SARS-CoV (B) in RTC assays in the presence of various Zn2+ concentrations, as indicated above each lane.