Extensive C->U transition biases in the genomes of a wide range of mammalian RNA viruses; potential associations with transcriptional mutations, damage- or host-mediated editing of viral RNA
Fig 5
Influence of 5’ and 3’ bases on C->U mutation frequencies.
Influence of the identities of the immediate 5’ base and 3’ bases on C->U mutation frequencies in a range of RNA viruses showing C->U/U->C transition asymmetry. Normalised C->U/C->U transition asymmetries in each 5’ and 3’ context were adjusted to account for 5’ or 3’ base frequencies. The y-axis shows the over- or under-representation of the asymmetry values in each context relative to the value for all contexts; the null expectation (no effect of 5’ or 3’ base) was 1.0 (red dotted line). Distributions of values for each context were compared by Mann-Whitney U test; p values < 0.05 shown.