Lymph nodes are sites of prolonged bacterial persistence during Mycobacterium tuberculosis infection in macaques
Fig 4
Most peripheral lymph nodes that had detectable Mtb genome were sterile.
A. The majority of peripheral lymph nodes assayed were CEQ- and CFU- (sterile). B, C. Live Mtb burden (CFU)(B) and total (live+dead, CEQ) Mtb burden (C) are significantly lower in peripheral lymph nodes than in thoracic lymph nodes. D. CFU/CEQ for thoracic and peripheral LNs. Killing capacity of peripheral lymph nodes is significantly higher (lower CFU/CEQ) compared to thoracic lymph nodes. These are data from 10 monkeys that had CEQ in both thoracic and peripheral lymph nodes. Each data point is one lymph node. Open symbols are sterile (CFU-) lymph nodes. The CFU was transformed by adding 1 to reflect sterile but CEQ+ LNs. Statistics are Mann-Whitney.