Macrophage-derived LTB4 promotes abscess formation and clearance of Staphylococcus aureus skin infection in mice
Fig 7
Summary of LTB4-promoted MRSA skin infection clearance.
Left panel: MRSA skin infection requires tissue-resident macrophages for optimal LTB4 production and neutrophil recruitment. LTB4 provides direction to neutrophils to contain bacteria and form an abscess surrounded by fibrous collagen. Middle panel: Combination ointment with LTB4 + the topical antibiotic, mupirocin, is more efficient at eliminating the infection. Right panel: Mice lacking LTB4/BLT1 fail to contain bacteria or develop an abscess. All abbreviations are defined in Figs 1 and 2 legends.