Caspase-11-dependent pyroptosis of lung epithelial cells protects from melioidosis while caspase-1 mediates macrophage pyroptosis and production of IL-18
Fig 5
IFNγ is necessary and sufficient for the protective effect of IL-18 in melioidosis.
Mice of shown genotype were infected intranasaly with B. thailandensis (5x105 CFU) and treated with IFNγ (A) or IL-18 (B). Mice were sacrificed 48 hours p.i. and the organ bacterial burdens were measured. (C) IFNγ was measured in the BALF and serum of mice from B. One representative experiment of two is shown. Data are expressed as mean ± S.D. *p<0.05, **p<0.01. (A, B) Mann-Whitney U test (C) Unpaired t-test.