A Crystal Structure of the Dengue Virus NS5 Protein Reveals a Novel Inter-domain Interface Essential for Protein Flexibility and Virus Replication
Fig 2
The dynamics of NS5 in solution probed by HDX-MS.
(A) Heat map data overlaid onto a crystal structure for the DENV3 NS5. The color key indicates the extent of the deuterium uptake (%), in which blue means the lowest deuterium uptake. Peptides in gray are regions where information of deuterium uptake is missing. F: motif F; G: motif G. (B) Putty cartoon view of temperature factor variation on the crystal structure of DENV3 NS5, colored from low to high values (20~180 Å2 as blue to red).