The Binding of Triclosan to SmeT, the Repressor of the Multidrug Efflux Pump SmeDEF, Induces Antibiotic Resistance in Stenotrophomonas maltophilia
Figure 6
Structural comparison between the apo SmeT (in red) and the SmeT-Triclosan complex (in grey) structures.
(A) The binding of triclosan (shown in stick representation) induces the stabilization of the loop connecting helices α6 and α7 in the subunit A (box A). This loop stabilizes through H-bonds the loop connecting helix α1 and α2 (box B), making more stable the N terminal domain of the second subunit, in particular the helix α3 (box C). (B) Close-up view of the SmeT dimer interface in the N-terminal domain showing the interactions between the loop connecting helices a6 and α7 and the loop connecting helices α1 and α2, a region poorly defined in the SmeT structure.