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Open Access
Peer-reviewed
Research Article
Inhibitors of ApiAP2 protein DNA binding exhibit multistage activity against Plasmodium parasites
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Timothy James Russell,
Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing
Affiliations Department of Biochemistry and Molecular Biology, Pennsylvania State University, State College, Pennsylvania, United States of America, Huck Institutes Center for Eukaryotic Gene Regulation (CEGR), Pennsylvania State University, State College, Pennsylvania, United States of America, Huck Institutes Center for Malaria Research (CMaR), Pennsylvania State University, State College, Pennsylvania, United States of America, Huck Institutes Center for Infectious Disease Dynamics, Pennsylvania State University, State College, Pennsylvania, United States of America
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Erandi K. De Silva,
Roles Methodology, Resources, Writing – original draft
Affiliation Lewis-Singler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America
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Valerie M. Crowley,
Roles Investigation
Affiliation Department of Biochemistry and Molecular Biology, Pennsylvania State University, State College, Pennsylvania, United States of America
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Kathryn Shaw-Saliba,
Roles Conceptualization, Investigation, Methodology
Affiliation Department of Molecular Biology and Immunology, Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America
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Namita Dube,
Roles Methodology, Software, Visualization
Affiliation Department of Biochemistry and Molecular Biology, Pennsylvania State University, State College, Pennsylvania, United States of America
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Gabrielle Josling,
Roles Resources
Affiliations Department of Biochemistry and Molecular Biology, Pennsylvania State University, State College, Pennsylvania, United States of America, Huck Institutes Center for Malaria Research (CMaR), Pennsylvania State University, State College, Pennsylvania, United States of America, Huck Institutes Center for Infectious Disease Dynamics, Pennsylvania State University, State College, Pennsylvania, United States of America
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Charisse Flerida A. Pasaje,
Roles Methodology, Resources
Affiliation Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
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Irene Kouskoumvekaki,
Roles Software
Affiliation Department of Systems Biology, Technical University of Denmark, Kongens Lyngby, Denmark
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Gianni Panagiotou,
Roles Conceptualization, Investigation, Software
Affiliations Systems Biology and Bioinformatics, Leibniz Institute for Natural Products Research and Infection Biology, Hans Knöll Institute, Jena, Germany, Department of Medicine, the University of Hong Kong, Hong Kong SAR, China
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Jacquin C. Niles,
Roles Resources, Supervision
Affiliation Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
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Marcelo Jacobs-Lorena,
Roles Resources, Supervision
Affiliation Department of Molecular Biology and Immunology, Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America
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C. Denise Okafor,
Roles Software, Supervision, Visualization
Affiliations Department of Biochemistry and Molecular Biology, Pennsylvania State University, State College, Pennsylvania, United States of America, Department of Chemistry, Pennsylvania State University, State College, Pennsylvania, United States of America
⨯ - Francisco-Javier Gamo,
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Manuel Llinás
Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing
* E-mail: manuel@psu.edu
Affiliations Department of Biochemistry and Molecular Biology, Pennsylvania State University, State College, Pennsylvania, United States of America, Huck Institutes Center for Eukaryotic Gene Regulation (CEGR), Pennsylvania State University, State College, Pennsylvania, United States of America, Huck Institutes Center for Malaria Research (CMaR), Pennsylvania State University, State College, Pennsylvania, United States of America, Huck Institutes Center for Infectious Disease Dynamics, Pennsylvania State University, State College, Pennsylvania, United States of America, Department of Chemistry, Pennsylvania State University, State College, Pennsylvania, United States of America
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Inhibitors of ApiAP2 protein DNA binding exhibit multistage activity against Plasmodium parasites
- Timothy James Russell,
- Erandi K. De Silva,
- Valerie M. Crowley,
- Kathryn Shaw-Saliba,
- Namita Dube,
- Gabrielle Josling,
- Charisse Flerida A. Pasaje,
- Irene Kouskoumvekaki,
- Gianni Panagiotou,
- Jacquin C. Niles
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- Published: October 12, 2022
- https://doi.org/10.1371/journal.ppat.1010887