Inhibition of the H3K27 demethylase UTX enhances the epigenetic silencing of HIV proviruses and induces HIV-1 DNA hypermethylation but fails to permanently block HIV reactivation

• Kien Nguyen ,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – original draft, Writing – review & editing

  * E-mail: Kien.Nguyen@case.edu

  Affiliation Department of Molecular Biology and Microbiology, Case Western Reserve University Medical School, Cleveland, Ohio, United States of America

  https://orcid.org/0000-0002-7088-3457

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• Curtis Dobrowolski,

  Roles Methodology

  Affiliation Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory School of Medicine, Atlanta, Georgia, United States of America

  https://orcid.org/0000-0001-6576-8318

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• Meenakshi Shukla,

  Roles Methodology

  Affiliation Department of Molecular Biology and Microbiology, Case Western Reserve University Medical School, Cleveland, Ohio, United States of America

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• Won-Kyung Cho,

  Roles Investigation, Methodology

  Affiliation Korean Medicine (KM)-Application Center, Korea Institute of Oriental Medicine (KIOM), Dong-gu, Daegu, Republic of Korea

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• Benjamin Luttge,

  Roles Methodology

  Affiliation Department of Molecular Biology and Microbiology, Case Western Reserve University Medical School, Cleveland, Ohio, United States of America

  https://orcid.org/0000-0002-1296-8014

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• Jonathan Karn

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Supervision, Validation, Writing – original draft, Writing – review & editing

  Affiliation Department of Molecular Biology and Microbiology, Case Western Reserve University Medical School, Cleveland, Ohio, United States of America

  https://orcid.org/0000-0002-2900-094X

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