Development of a new largely scalable in vitro prion propagation method for the production of infectious recombinant prions for high resolution structural studies

• Hasier Eraña,

  Roles Conceptualization, Investigation, Writing – original draft, Writing – review & editing

  Affiliations CIC bioGUNE, Derio (Bizkaia), Spain, ATLAS Molecular Pharma S. L. Derio (Bizkaia), Spain

  http://orcid.org/0000-0001-8776-4211

  ⨯
• Jorge M. Charco,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliation CIC bioGUNE, Derio (Bizkaia), Spain

  http://orcid.org/0000-0003-3476-1855

  ⨯
• Michele A. Di Bari,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliation Department of Veterinary Public Health and Food Safety, Istituto Superiore di Sanità, Rome, Italy

  http://orcid.org/0000-0003-0943-6823

  ⨯
• Carlos M. Díaz-Domínguez,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliation CIC bioGUNE, Derio (Bizkaia), Spain

  http://orcid.org/0000-0002-0410-1963

  ⨯
• Rafael López-Moreno,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliation CIC bioGUNE, Derio (Bizkaia), Spain

  ⨯
• Enric Vidal,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliation Centre de Recerca en Sanitat Animal (CReSA), UAB-IRTA, Barcelona, Spain

  http://orcid.org/0000-0002-4965-3286

  ⨯
• Ezequiel González-Miranda,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliation CIC bioGUNE, Derio (Bizkaia), Spain

  ⨯
• Miguel A. Pérez-Castro,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliation CIC bioGUNE, Derio (Bizkaia), Spain

  http://orcid.org/0000-0003-2850-3470

  ⨯
• Sandra García-Martínez,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliations CIC bioGUNE, Derio (Bizkaia), Spain, ATLAS Molecular Pharma S. L. Derio (Bizkaia), Spain

  http://orcid.org/0000-0002-6910-9202

  ⨯
• Susana Bravo,

  Roles Investigation, Methodology

  Affiliation Proteomics Lab, IDIS, Santiago de Compostela, Spain

  http://orcid.org/0000-0001-7615-3079

  ⨯
• Natalia Fernández-Borges,

  Roles Conceptualization, Investigation, Writing – review & editing

  Affiliation CIC bioGUNE, Derio (Bizkaia), Spain

  ⨯
• Mariví Geijo,

  Roles Investigation, Methodology, Supervision

  Affiliation Animal Health Department, NEIKER-Instituto Vasco de Investigación y Desarrollo Agrario, Derio (Bizkaia), Spain

  http://orcid.org/0000-0002-3120-1038

  ⨯
• Claudia D’Agostino,

  Roles Investigation, Methodology

  Affiliation Department of Veterinary Public Health and Food Safety, Istituto Superiore di Sanità, Rome, Italy

  ⨯
• Joseba Garrido,

  Roles Methodology, Supervision, Writing – review & editing

  Affiliation Animal Health Department, NEIKER-Instituto Vasco de Investigación y Desarrollo Agrario, Derio (Bizkaia), Spain

  ⨯
• Jifeng Bian,

  Roles Investigation, Methodology

  Affiliation Prion Research Center (PRC), Colorado State University, Fort Collins, Colorado, United States of America

  ⨯
• Anna König,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliations Institute of Complex Systems (ICS-6) and Jülich Center for Structural Biology (JuStruct), Forschungszentrum Jülich, Jülich, Germany, Physikalische Biologie, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany

  ⨯
• Boran Uluca-Yazgi,

  Roles Investigation, Methodology

  Affiliations Institute of Complex Systems (ICS-6) and Jülich Center for Structural Biology (JuStruct), Forschungszentrum Jülich, Jülich, Germany, Physikalische Biologie, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany

  ⨯
• Raimon Sabate,

  Roles Investigation, Methodology

  Affiliations Department of Pharmacy and Pharmaceutical Technology and Physical-Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, Spain, Institute of Nanoscience and Nanotechnology (IN2UB), University of Barcelona, Spain

  http://orcid.org/0000-0003-3894-2362

  ⨯
• Vadim Khaychuk,

  Roles Investigation, Methodology

  Affiliation Prion Research Center (PRC), Colorado State University, Fort Collins, Colorado, United States of America

  ⨯
• Ilaria Vanni,

  Roles Investigation, Methodology

  Affiliation Department of Veterinary Public Health and Food Safety, Istituto Superiore di Sanità, Rome, Italy

  http://orcid.org/0000-0003-2617-4263

  ⨯
• Glenn C. Telling,

  Roles Investigation, Methodology, Supervision, Writing – review & editing

  Affiliation Prion Research Center (PRC), Colorado State University, Fort Collins, Colorado, United States of America

  ⨯
• Henrike Heise,

  Roles Investigation, Supervision, Writing – original draft, Writing – review & editing

  Affiliations Institute of Complex Systems (ICS-6) and Jülich Center for Structural Biology (JuStruct), Forschungszentrum Jülich, Jülich, Germany, Physikalische Biologie, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany

  http://orcid.org/0000-0002-9081-3894

  ⨯
• Romolo Nonno,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliation Department of Veterinary Public Health and Food Safety, Istituto Superiore di Sanità, Rome, Italy

  http://orcid.org/0000-0001-7556-1564

  ⨯
• Jesús R. Requena,

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Supervision, Writing – original draft, Writing – review & editing

  Affiliation CIMUS Biomedical Research Institute, University of Santiago de Compostela-IDIS, Spain

  ⨯
•  [ ... ],
• Joaquín Castilla

  Roles Conceptualization, Funding acquisition, Investigation, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: castilla@joaquincastilla.com

  Affiliations CIC bioGUNE, Derio (Bizkaia), Spain, IKERBasque, Basque Foundation for Science, Bilbao (Bizkaia), Spain

  http://orcid.org/0000-0002-2216-1361

  ⨯
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