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Open Access
Peer-reviewed
Research Article
Nlrp3 inflammasome activation and Gasdermin D-driven pyroptosis are immunopathogenic upon gastrointestinal norovirus infection
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Hanne Dubois,
Roles Formal analysis, Investigation, Methodology, Writing – original draft
Affiliations Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium, VIB-UGent Center for Inflammation Research, VIB, Ghent, Belgium
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Frederic Sorgeloos,
Roles Methodology, Writing – review & editing
Affiliation Division of Virology, Department of Pathology, University of Cambridge, Addenbrooke’s Hospital, Cambridge, United Kingdom
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Soroush T. Sarvestani,
Roles Investigation, Methodology
Affiliation Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia
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Liesbet Martens,
Roles Methodology
Affiliations VIB-UGent Center for Inflammation Research, VIB, Ghent, Belgium, Department of Applied Mathematics, Computer Science and Statistics, Ghent University, Ghent, Belgium
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Yvan Saeys,
Roles Methodology, Supervision
Affiliations VIB-UGent Center for Inflammation Research, VIB, Ghent, Belgium, Department of Applied Mathematics, Computer Science and Statistics, Ghent University, Ghent, Belgium
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Jason M. Mackenzie,
Roles Conceptualization, Formal analysis, Funding acquisition, Supervision, Writing – review & editing
Affiliation Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia
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Mohamed Lamkanfi,
Roles Conceptualization, Formal analysis, Funding acquisition, Supervision, Writing – review & editing
Affiliations Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium, VIB-UGent Center for Inflammation Research, VIB, Ghent, Belgium, Janssen Immunosciences, World Without Disease Accelerator, Janssen Pharmaceutica, Pharmaceutical Companies of Johnson & Johnson, Beerse, Belgium
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Geert van Loo,
Roles Supervision
Affiliations VIB-UGent Center for Inflammation Research, VIB, Ghent, Belgium, Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium
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Ian Goodfellow,
Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing
Affiliation Division of Virology, Department of Pathology, University of Cambridge, Addenbrooke’s Hospital, Cambridge, United Kingdom
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Andy Wullaert
Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Supervision, Writing – original draft
* E-mail: andy.wullaert@ugent.be
Affiliations Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium, VIB-UGent Center for Inflammation Research, VIB, Ghent, Belgium, Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium, Ghent Gut Inflammation Group (GGIG), Ghent University, Ghent, Belgium
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Nlrp3 inflammasome activation and Gasdermin D-driven pyroptosis are immunopathogenic upon gastrointestinal norovirus infection
- Hanne Dubois,
- Frederic Sorgeloos,
- Soroush T. Sarvestani,
- Liesbet Martens,
- Yvan Saeys,
- Jason M. Mackenzie,
- Mohamed Lamkanfi,
- Geert van Loo,
- Ian Goodfellow,
- Andy Wullaert
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- Published: April 24, 2019
- https://doi.org/10.1371/journal.ppat.1007709