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Open Access
Peer-reviewed
Research Article
Exhaustion of Activated CD8 T Cells Predicts Disease Progression in Primary HIV-1 Infection
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Matthias Hoffmann ,
Contributed equally to this work with: Matthias Hoffmann, Nikos Pantazis, Genevieve E. Martin
Affiliations Peter Medawar Building for Pathogen Research, Nuffield Department of Medicine, Oxford, United Kingdom, Division of Infectious Diseases and Hospital Epidemiology, Kantonsspital, St. Gallen, Switzerland
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Nikos Pantazis ,
Contributed equally to this work with: Matthias Hoffmann, Nikos Pantazis, Genevieve E. Martin
Affiliations Department of Hygiene, Epidemiology & Medical Statistics, Athens University Medical School, Athens, Greece, MRC Clinical Trials Unit at UCL Institute of Clinical Trials & Methodology, London, United Kingdom
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Genevieve E. Martin ,
Contributed equally to this work with: Matthias Hoffmann, Nikos Pantazis, Genevieve E. Martin
Affiliation Peter Medawar Building for Pathogen Research, Nuffield Department of Medicine, Oxford, United Kingdom
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Stephen Hickling,
Affiliation Peter Medawar Building for Pathogen Research, Nuffield Department of Medicine, Oxford, United Kingdom
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Jacob Hurst,
Affiliations Peter Medawar Building for Pathogen Research, Nuffield Department of Medicine, Oxford, United Kingdom, The Oxford Martin School, Oxford, United Kingdom
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Jodi Meyerowitz,
Affiliation Peter Medawar Building for Pathogen Research, Nuffield Department of Medicine, Oxford, United Kingdom
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Christian B. Willberg,
Affiliations Peter Medawar Building for Pathogen Research, Nuffield Department of Medicine, Oxford, United Kingdom, Oxford National Institute of Health Research Biomedical Research Centre, Oxford, United Kingdom
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Nicola Robinson,
Affiliations Peter Medawar Building for Pathogen Research, Nuffield Department of Medicine, Oxford, United Kingdom, Oxford National Institute of Health Research Biomedical Research Centre, Oxford, United Kingdom
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Helen Brown,
Affiliations Peter Medawar Building for Pathogen Research, Nuffield Department of Medicine, Oxford, United Kingdom, Oxford National Institute of Health Research Biomedical Research Centre, Oxford, United Kingdom
⨯ - Martin Fisher †,
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Sabine Kinloch,
Affiliation Division of Infection and Immunity, University College London, London, United Kingdom
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Abdel Babiker,
Affiliation MRC Clinical Trials Unit at UCL Institute of Clinical Trials & Methodology, London, United Kingdom
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Jonathan Weber,
Affiliation Division of Medicine, Wright Fleming Institute, Imperial College, London, United Kingdom
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Nneka Nwokolo,
Affiliation Chelsea and Westminster Hospital, London, United Kingdom
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Julie Fox,
Affiliation Department of Genitourinary Medicine and Infectious Disease, Guys and St Thomas' NHS Trust, London, United Kingdom
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Sarah Fidler ,
¶‡ These authors also contributed equally to this work.
Affiliation Division of Medicine, Wright Fleming Institute, Imperial College, London, United Kingdom
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Rodney Phillips ,
¶‡ These authors also contributed equally to this work.
Affiliations Peter Medawar Building for Pathogen Research, Nuffield Department of Medicine, Oxford, United Kingdom, The Oxford Martin School, Oxford, United Kingdom, Oxford National Institute of Health Research Biomedical Research Centre, Oxford, United Kingdom
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John Frater ,
* E-mail: john.frater@ndm.ox.ac.uk
¶‡ These authors also contributed equally to this work.
Affiliations Peter Medawar Building for Pathogen Research, Nuffield Department of Medicine, Oxford, United Kingdom, The Oxford Martin School, Oxford, United Kingdom, Oxford National Institute of Health Research Biomedical Research Centre, Oxford, United Kingdom
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SPARTAC and CHERUB Investigators
¶Membership of the SPARTAC and CHERUB Investigators is provided in the Acknowledgments.
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Exhaustion of Activated CD8 T Cells Predicts Disease Progression in Primary HIV-1 Infection
- Matthias Hoffmann,
- Nikos Pantazis,
- Genevieve E. Martin,
- Stephen Hickling,
- Jacob Hurst,
- Jodi Meyerowitz,
- Christian B. Willberg,
- Nicola Robinson,
- Helen Brown,
- Martin Fisher
- Published: July 14, 2016
- https://doi.org/10.1371/journal.ppat.1005661