HTLV-1 Tax-Mediated Inhibition of FOXO3a Activity Is Critical for the Persistence of Terminally Differentiated CD4+ T Cells

David Olagnier; Alexandre Sze; Samar Bel Hadj; Cindy Chiang; Courtney Steel; Xiaoying Han; Jean-Pierre Routy; Rongtuan Lin; John Hiscott; Julien van Grevenynghe

doi:10.1371/journal.ppat.1004575

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Open Access

Peer-reviewed

Research Article

HTLV-1 Tax-Mediated Inhibition of FOXO3a Activity Is Critical for the Persistence of Terminally Differentiated CD4⁺ T Cells

David Olagnier ,

Contributed equally to this work with: David Olagnier, Alexandre Sze

Affiliations Lady Davis Institute-Jewish General Hospital, McGill University, Montreal, Quebec, Canada, VGTI Florida, Port St. Lucie, Florida, United States of America
⨯
Alexandre Sze ,

Contributed equally to this work with: David Olagnier, Alexandre Sze

Affiliation Lady Davis Institute-Jewish General Hospital, McGill University, Montreal, Quebec, Canada
⨯
Samar Bel Hadj,

Affiliation Lady Davis Institute-Jewish General Hospital, McGill University, Montreal, Quebec, Canada
⨯
Cindy Chiang,

Affiliation VGTI Florida, Port St. Lucie, Florida, United States of America
⨯
Courtney Steel,

Affiliation VGTI Florida, Port St. Lucie, Florida, United States of America
⨯
Xiaoying Han,

Affiliation Lady Davis Institute-Jewish General Hospital, McGill University, Montreal, Quebec, Canada
⨯
Jean-Pierre Routy,

Affiliation Immunodeficiency Service and Division of Haematology, Royal Victoria Hospital, McGill University Health Center, McGill University, Montreal, Quebec, Canada
⨯
Rongtuan Lin,

Affiliation Lady Davis Institute-Jewish General Hospital, McGill University, Montreal, Quebec, Canada
⨯
John Hiscott ,

* E-mail: jhiscott@vgtifl.org (JH); julien.vangreve@hotmail.com (JvG)

Affiliations Lady Davis Institute-Jewish General Hospital, McGill University, Montreal, Quebec, Canada, VGTI Florida, Port St. Lucie, Florida, United States of America
⨯
Julien van Grevenynghe

* E-mail: jhiscott@vgtifl.org (JH); julien.vangreve@hotmail.com (JvG)

Affiliations Lady Davis Institute-Jewish General Hospital, McGill University, Montreal, Quebec, Canada, VGTI Florida, Port St. Lucie, Florida, United States of America
⨯

HTLV-1 Tax-Mediated Inhibition of FOXO3a Activity Is Critical for the Persistence of Terminally Differentiated CD4⁺ T Cells

David Olagnier,
Alexandre Sze,
Samar Bel Hadj,
Cindy Chiang,
Courtney Steel,
Xiaoying Han,
Jean-Pierre Routy,
Rongtuan Lin,
John Hiscott,
Julien van Grevenynghe

Published: December 18, 2014
https://doi.org/10.1371/journal.ppat.1004575

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