Rational Engineering of Recombinant Picornavirus Capsids to Produce Safe, Protective Vaccine Antigen

Claudine Porta; Abhay Kotecha; Alison Burman; Terry Jackson; Jingshan Ren; Silvia Loureiro; Ian M. Jones; Elizabeth E. Fry; David I. Stuart; Bryan Charleston

doi:10.1371/journal.ppat.1003255

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Open Access

Peer-reviewed

Research Article

Rational Engineering of Recombinant Picornavirus Capsids to Produce Safe, Protective Vaccine Antigen

Claudine Porta ,

Contributed equally to this work with: Claudine Porta, Abhay Kotecha

Affiliations The Pirbright Insitute, Pirbright, Woking, United Kingdom, Division of Structural Biology, The Henry Wellcome Building for Genomic Medicine, Headington, University of Oxford, Oxford, United Kingdom
⨯
Abhay Kotecha ,

Contributed equally to this work with: Claudine Porta, Abhay Kotecha

Affiliation Division of Structural Biology, The Henry Wellcome Building for Genomic Medicine, Headington, University of Oxford, Oxford, United Kingdom
⨯
Alison Burman,

Affiliation The Pirbright Insitute, Pirbright, Woking, United Kingdom
⨯
Terry Jackson,

Affiliation The Pirbright Insitute, Pirbright, Woking, United Kingdom
⨯
Jingshan Ren,

Affiliation Division of Structural Biology, The Henry Wellcome Building for Genomic Medicine, Headington, University of Oxford, Oxford, United Kingdom
⨯
Silvia Loureiro,

Affiliation Animal and Microbial Sciences, University of Reading, Whiteknights, Reading, United Kingdom
⨯
Ian M. Jones,

Affiliation Animal and Microbial Sciences, University of Reading, Whiteknights, Reading, United Kingdom
⨯
Elizabeth E. Fry ,

* E-mail: liz@strubi.ox.ac.uk (EEF); dave@strubi.ox.ac.uk (DIS); Bryan.Charleston@pirbright.ac.uk (BC)

Affiliation Division of Structural Biology, The Henry Wellcome Building for Genomic Medicine, Headington, University of Oxford, Oxford, United Kingdom
⨯
David I. Stuart ,

* E-mail: liz@strubi.ox.ac.uk (EEF); dave@strubi.ox.ac.uk (DIS); Bryan.Charleston@pirbright.ac.uk (BC)

Affiliations Division of Structural Biology, The Henry Wellcome Building for Genomic Medicine, Headington, University of Oxford, Oxford, United Kingdom, Diamond Light Source, Harwell Science and Innovation Campus, Didcot, United Kingdom
⨯
Bryan Charleston

* E-mail: liz@strubi.ox.ac.uk (EEF); dave@strubi.ox.ac.uk (DIS); Bryan.Charleston@pirbright.ac.uk (BC)

Affiliation The Pirbright Insitute, Pirbright, Woking, United Kingdom
⨯

Rational Engineering of Recombinant Picornavirus Capsids to Produce Safe, Protective Vaccine Antigen

Claudine Porta,
Abhay Kotecha,
Alison Burman,
Terry Jackson,
Jingshan Ren,
Silvia Loureiro,
Ian M. Jones,
Elizabeth E. Fry,
David I. Stuart,
Bryan Charleston

Published: March 27, 2013
https://doi.org/10.1371/journal.ppat.1003255

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22 Apr 2013
09:41 GMT
Most Recent

Comparison with normal vaccine Posted by AldoDekker on 17 Apr 2013 at 13:26 GMT

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