Down-Regulation of Shadoo in Prion Infections Traces a Pre-Clinical Event Inversely Related to PrP^Sc Accumulation

• David Westaway ,

  * E-mail: david.westaway@ualberta.ca (DW); gac@mri.montana.edu (GAC)

  Affiliations Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Alberta, Canada, Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada

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• Sacha Genovesi ,

  Contributed equally to this work with: Sacha Genovesi, Nathalie Daude, Rebecca Brown

  Affiliation Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Alberta, Canada

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• Nathalie Daude ,

  Contributed equally to this work with: Sacha Genovesi, Nathalie Daude, Rebecca Brown

  Affiliation Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Alberta, Canada

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• Rebecca Brown ,

  Contributed equally to this work with: Sacha Genovesi, Nathalie Daude, Rebecca Brown

  Affiliation McLaughlin Research Institute, Great Falls, Montana, United States of America

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• Agnes Lau,

  Affiliation Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Alberta, Canada

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• Inyoul Lee,

  Affiliation Institute for Systems Biology, University of Washington, Seattle, Washington, United States of America

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• Charles E. Mays,

  Affiliation Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Alberta, Canada

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• Janaky Coomaraswamy,

  Affiliation Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany

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• Brenda Canine,

  Affiliation McLaughlin Research Institute, Great Falls, Montana, United States of America

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• Rose Pitstick,

  Affiliation McLaughlin Research Institute, Great Falls, Montana, United States of America

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• Allen Herbst,

  Affiliation Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Alberta, Canada

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• Jing Yang,

  Affiliation Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Alberta, Canada

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• Kerry W. S. Ko,

  Affiliation Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Alberta, Canada

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• Gerold Schmitt-Ulms,

  Affiliations Centre for Research in Neurodegenerative Diseases, University of Toronto, Ontario, Canada, Department of Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Canada

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• Stephen J. DeArmond,

  Affiliation Department of Pathology, University of California San Francisco, San Francisco, California, United States of America

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• Debbie McKenzie,

  Affiliation Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Alberta, Canada

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• Leroy Hood,

  Affiliation Institute for Systems Biology, University of Washington, Seattle, Washington, United States of America

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•  [ ... ],
• George A. Carlson

  * E-mail: david.westaway@ualberta.ca (DW); gac@mri.montana.edu (GAC)

  Affiliation McLaughlin Research Institute, Great Falls, Montana, United States of America

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