Zn2+ Inhibits Coronavirus and Arterivirus RNA Polymerase Activity In Vitro and Zinc Ionophores Block the Replication of These Viruses in Cell Culture

Open Access

Peer-reviewed

Research Article

Zn²⁺ Inhibits Coronavirus and Arterivirus RNA Polymerase Activity In Vitro and Zinc Ionophores Block the Replication of These Viruses in Cell Culture

Aartjan J. W. te Velthuis,

Affiliation Molecular Virology Laboratory, Department of Medical Microbiology, Center of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
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Sjoerd H. E. van den Worm,

Affiliation Molecular Virology Laboratory, Department of Medical Microbiology, Center of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
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Amy C. Sims,

Affiliation Departments of Epidemiology and Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
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Ralph S. Baric,

Affiliation Departments of Epidemiology and Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
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Eric J. Snijder ,

* E-mail: e.j.snijder@lumc.nl (ES); m.j.van_hemert@lumc.nl (MJvH)

Affiliation Molecular Virology Laboratory, Department of Medical Microbiology, Center of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
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Martijn J. van Hemert

* E-mail: e.j.snijder@lumc.nl (ES); m.j.van_hemert@lumc.nl (MJvH)

Affiliation Molecular Virology Laboratory, Department of Medical Microbiology, Center of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
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Zinc
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SARS coronavirus
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RNA synthesis
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Viral replication
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Coronaviruses
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Cell cultures
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RNA viruses
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Radiolabeling
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