A Single Mutation in the PB1-F2 of H5N1 (HK/97) and 1918 Influenza A Viruses Contributes to Increased Virulence

Gina M Conenello; Dmitriy Zamarin; Lucy A Perrone; Terrence Tumpey; Peter Palese

doi:10.1371/journal.ppat.0030141

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Peer-reviewed

Research Article

A Single Mutation in the PB1-F2 of H5N1 (HK/97) and 1918 Influenza A Viruses Contributes to Increased Virulence

Gina M Conenello,

Affiliation Department of Microbiology, Mount Sinai School of Medicine, New York, New York, United States of America
⨯
Dmitriy Zamarin,

Affiliation Department of Microbiology, Mount Sinai School of Medicine, New York, New York, United States of America
⨯
Lucy A Perrone,

Affiliation Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
⨯
Terrence Tumpey,

Affiliation Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
⨯
Peter Palese

*To whom correspondence should be addressed. E-mail: peter.palese@mssm.edu

Affiliations Department of Microbiology, Mount Sinai School of Medicine, New York, New York, United States of America , Department of Medicine, Mount Sinai School of Medicine, New York, New York, United States of America
⨯

A Single Mutation in the PB1-F2 of H5N1 (HK/97) and 1918 Influenza A Viruses Contributes to Increased Virulence

Gina M Conenello,
Dmitriy Zamarin,
Lucy A Perrone,
Terrence Tumpey,
Peter Palese

Published: October 5, 2007
https://doi.org/10.1371/journal.ppat.0030141

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Publisher's Note: Correction to Results

Posted by PLOS_Pathogens on 19 May 2009 at 22:49 GMT

Levels of TNF-α in the lung also showed significant differences late in infection. At days 7 and 8 after infection, TNF-α levels in mice infected with WH N66S virus had a two times higher increase over levels in WH-infected mice (Figure 5B).
http://plospathogens.org/article/info:doi/10.1371/journal.ppat.0030141#article1.body1.sec3.sec3.p1

There was an error in the third sentence of the third section of the Results. The correct sentence should read: Levels of TNF-a in the lung also showed a significant difference. Day 5 post infection levels of TNF-a are statistically higher in WH N66S infected mice when compared to WH infected mice and PBS inoculated mice (Figure 5B).

No competing interests declared.

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A Single Mutation in the PB1-F2 of H5N1 (HK/97) and 1918 Influenza A Viruses Contributes to Increased Virulence

A Single Mutation in the PB1-F2 of H5N1 (HK/97) and 1918 Influenza A Viruses Contributes to Increased Virulence

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Publisher's Note: Correction to Results

Posted by PLOS_Pathogens on 19 May 2009 at 22:49 GMT