Zn²⁺ Inhibits Coronavirus and Arterivirus RNA Polymerase Activity In Vitro and Zinc Ionophores Block the Replication of These Viruses in Cell Culture

• Aartjan J. W. te Velthuis,

  Affiliation Molecular Virology Laboratory, Department of Medical Microbiology, Center of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands

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• Sjoerd H. E. van den Worm,

  Affiliation Molecular Virology Laboratory, Department of Medical Microbiology, Center of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands

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• Amy C. Sims,

  Affiliation Departments of Epidemiology and Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

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• Ralph S. Baric,

  Affiliation Departments of Epidemiology and Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

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• Eric J. Snijder ,

  * E-mail: e.j.snijder@lumc.nl (ES); m.j.van_hemert@lumc.nl (MJvH)

  Affiliation Molecular Virology Laboratory, Department of Medical Microbiology, Center of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands

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• Martijn J. van Hemert

  * E-mail: e.j.snijder@lumc.nl (ES); m.j.van_hemert@lumc.nl (MJvH)

  Affiliation Molecular Virology Laboratory, Department of Medical Microbiology, Center of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands

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