TY - JOUR T1 - Evolutionarily Conserved Herpesviral Protein Interaction Networks A1 - Fossum, Even A1 - Friedel, Caroline C. A1 - Rajagopala, Seesandra V. A1 - Titz, Björn A1 - Baiker, Armin A1 - Schmidt, Tina A1 - Kraus, Theo A1 - Stellberger, Thorsten A1 - Rutenberg, Christiane A1 - Suthram, Silpa A1 - Bandyopadhyay, Sourav A1 - Rose, Dietlind A1 - von Brunn, Albrecht A1 - Uhlmann, Mareike A1 - Zeretzke, Christine A1 - Dong, Yu-An A1 - Boulet, Hélène A1 - Koegl, Manfred A1 - Bailer, Susanne M. A1 - Koszinowski, Ulrich A1 - Ideker, Trey A1 - Uetz, Peter A1 - Zimmer, Ralf A1 - Haas, Jürgen Y1 - 2009/09/04 N2 - Author Summary Herpesvirus proteins interact with each other in a complex manner throughout the infectious cycle. This is probably best exemplified in the process where a large number of viral proteins come together to form new viral particles which are subsequently released from the infected cell. A more detailed understanding of how viral proteins interact with each other might assist the development of drugs which may inhibit these interactions and consequently block viral replication. Here we present three genome-wide studies of protein-protein interactions in the herpesviruses herpes simplex virus I, murine cytomegalovirus and Epstein-Barr virus. Altogether we identified 735 interactions in the three viruses, most of which have not previously been reported. By combining these studies with our previously published studies for Kaposi's sarcoma-associated herpesvirus and varicella-zoster virus we were able to perform a comparative analysis of interactions in five related viral species. We observed that a high proportion of interactions were conserved between the different species, despite a low degree of sequence conservation. This implies that by comparing interaction data, we were able to increase the coverage of our viral networks and thus obtain a better and more complete picture of interactions between herpesviral proteins. JF - PLOS Pathogens JA - PLOS Pathogens VL - 5 IS - 9 UR - https://doi.org/10.1371/journal.ppat.1000570 SP - e1000570 EP - PB - Public Library of Science M3 - doi:10.1371/journal.ppat.1000570 ER -