Evidence and Role for Bacterial Mucin Degradation in Cystic Fibrosis Airway Disease

Jeffrey M. Flynn; David Niccum; Jordan M. Dunitz; Ryan C. Hunter

doi:10.1371/journal.ppat.1005846

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Open Access

Peer-reviewed

Research Article

Evidence and Role for Bacterial Mucin Degradation in Cystic Fibrosis Airway Disease

Jeffrey M. Flynn,

Affiliation Department of Microbiology & Immunology, University of Minnesota, Minneapolis, Minnesota, United States of America
⨯
David Niccum,

Affiliation Division of Pulmonary, Allergy, Critical Care & Sleep Medicine, University of Minnesota, Minneapolis, Minnesota, United States of America
⨯
Jordan M. Dunitz,

Affiliation Division of Pulmonary, Allergy, Critical Care & Sleep Medicine, University of Minnesota, Minneapolis, Minnesota, United States of America
⨯
Ryan C. Hunter

* E-mail: rchunter@umn.edu

Affiliation Department of Microbiology & Immunology, University of Minnesota, Minneapolis, Minnesota, United States of America

http://orcid.org/0000-0003-3841-1676

⨯

Evidence and Role for Bacterial Mucin Degradation in Cystic Fibrosis Airway Disease

Jeffrey M. Flynn,
David Niccum,
Jordan M. Dunitz,
Ryan C. Hunter

Published: August 22, 2016
https://doi.org/10.1371/journal.ppat.1005846
See the preprint

About the Authors

Jeffrey M. Flynn

Affiliation Department of Microbiology & Immunology, University of Minnesota, Minneapolis, Minnesota, United States of America

David Niccum

Affiliation Division of Pulmonary, Allergy, Critical Care & Sleep Medicine, University of Minnesota, Minneapolis, Minnesota, United States of America

Jordan M. Dunitz

Affiliation Division of Pulmonary, Allergy, Critical Care & Sleep Medicine, University of Minnesota, Minneapolis, Minnesota, United States of America

Ryan C. Hunter

* E-mail: rchunter@umn.edu

Affiliation Department of Microbiology & Immunology, University of Minnesota, Minneapolis, Minnesota, United States of America

http://orcid.org/0000-0003-3841-1676

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceptualization: JMF RCH. Formal analysis: JMF RCH. Funding acquisition: JMF JMD RCH. Investigation: JMF DN RCH. Methodology: JMF JMD RCH. Project administration: JMF RCH. Resources: JMF DN JMD RCH. Supervision: JMD RCH. Validation: JMF RCH. Visualization: JMF RCH. Writing - original draft: JMF RCH. Writing - review & editing: JMF RCH.

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Mucin
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Pseudomonas aeruginosa
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Sputum
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Anaerobic bacteria
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Propionates
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Bacterial pathogens
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Fermentation
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Cystic fibrosis
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