About the Authors

Merika Treants Koday

Affiliation Department of Microbiology, University of Washington, Seattle, Washington, United States of America

Jorgen Nelson

Affiliation Institute for Protein Design, Department of Biochemistry, University of Washington, Seattle, Washington, United States of America

Aaron Chevalier

Affiliation Institute for Protein Design, Department of Biochemistry, University of Washington, Seattle, Washington, United States of America

Michael Koday

Affiliation Washington National Primate Research Center, University of Washington, Seattle, Washington, United States of America

Hannah Kalinoski

Affiliation Department of Microbiology, University of Washington, Seattle, Washington, United States of America

Lance Stewart

Affiliation Institute for Protein Design, Department of Biochemistry, University of Washington, Seattle, Washington, United States of America

Lauren Carter

Affiliation Institute for Protein Design, Department of Biochemistry, University of Washington, Seattle, Washington, United States of America

Travis Nieusma

Affiliation Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America

Peter S. Lee

Affiliation Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America

Andrew B. Ward

Affiliation Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America

Ian A. Wilson

Affiliations Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America, Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California, United States of America

Ashley Dagley

Affiliation Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, Utah, United States of America

Donald F. Smee

Affiliation Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, Utah, United States of America

David Baker

Affiliations Institute for Protein Design, Department of Biochemistry, University of Washington, Seattle, Washington, United States of America, Howard Hughes Medical Institute, University of Washington, Seattle, Washington, United States of America

Deborah Heydenburg Fuller

fullerdh@u.washington.edu

Affiliations Department of Microbiology, University of Washington, Seattle, Washington, United States of America, Washington National Primate Research Center, University of Washington, Seattle, Washington, United States of America

Competing Interests

I have read the journal's policy and the authors of this manuscript have the following competing interests: We declare an affiliation of Virvio, Inc. and Drs. Baker, Chevalier, Fuller and Treants (co-founders). We also declare that Drs. Baker, Chevalier, Fuller and Treants have pending patents pertinent to this article (61/968,874 and 62/028,139). We confirm that this does not alter our adherence to all PLoS Pathogens policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: MTK JN AC DB DHF. Performed the experiments: MTK JN MK HK TN PSL DFS AD. Analyzed the data: MTK JN AC DB DHF. Contributed reagents/materials/analysis tools: LS LC ABW IAW. Wrote the paper: MTK JN IAW DB DHF.